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Results: 1-12 |
Results: 12
ANGIOGENESIS STIMULATED BY VEGF-SECRETING CELLS IN-VIVO - INHIBITION BY SYSTEMIC ANTI-VEGF ANTIBODY
Authors: HUCKLE WR LYLE EA MCFALL RC KENDALL RL THOMAS KA
Citation: Wr. Huckle et al., ANGIOGENESIS STIMULATED BY VEGF-SECRETING CELLS IN-VIVO - INHIBITION BY SYSTEMIC ANTI-VEGF ANTIBODY, Molecular biology of the cell, 9, 1998, pp. 653-653
L-374,087, AN EFFICACIOUS, ORALLY BIOAVAILABLE, PYRIDINONE ACETAMIDE THROMBIN INHIBITOR
Authors: SANDERSON PEJ CUTRONA KJ DORSEY BD DYER DL MCDONOUGH CM NAYLOROLSEN AM CHEN IW CHEN ZG COOK JJ GARDELL SJ KRUEGER JA LEWIS SD LIN JH LUCAS BJ LYLE EA LYNCH JJ STRANIERI MT VASTAG K SHAFER JA VACCA JP
Citation: Pej. Sanderson et al., L-374,087, AN EFFICACIOUS, ORALLY BIOAVAILABLE, PYRIDINONE ACETAMIDE THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 8(7), 1998, pp. 817-822
C6 MODIFICATION OF THE PYRIDINONE CORE OF THROMBIN INHIBITOR L-374,087 AS A MEANS OF ENHANCING ITS ORAL ABSORPTION
Authors: ISAACS RCA CUTRONA KJ NEWTON CL SANDERSON PEJ SOLINSKY MG BASKIN EP CHEN IW COOPER CM COOK JJ GARDELL SJ LEWIS SD LUCAS RJ LYLE EA LYNCH JJ NAYLOROLSEN AM STRANIERI MT VASTAG K VACCA JP
Citation: Rca. Isaacs et al., C6 MODIFICATION OF THE PYRIDINONE CORE OF THROMBIN INHIBITOR L-374,087 AS A MEANS OF ENHANCING ITS ORAL ABSORPTION, Bioorganic & medicinal chemistry letters, 8(13), 1998, pp. 1719-1724
DISCOVERY AND DEVELOPMENT OF THE NOVEL POTENT ORALLY-ACTIVE THROMBIN INHIBITOR N-(9-HYDROXY-9-FLUORENECARBOXY)PROLYL TRANS-4-AMINOCYCLOHEXYLMETHYL AMIDE (L-372,460) - COAPPLICATION OF STRUCTURE-BASED DESIGN AND RAPID MULTIPLE ANALOG SYNTHESIS ON SOLID SUPPORT
Authors: BRADY SF STAUFFER KJ LUMMA WC SMITH GM RAMJIT HG LEWIS SD LUCAS BJ GARDELL SJ LYLE EA APPLEBY SD COOK JJ HOLAHAN MA STRANIERI MT LYNCH JJ LIN JH CHEN IW VASTAG K NAYLOROLSEN AM VACCA JP
Citation: Sf. Brady et al., DISCOVERY AND DEVELOPMENT OF THE NOVEL POTENT ORALLY-ACTIVE THROMBIN INHIBITOR N-(9-HYDROXY-9-FLUORENECARBOXY)PROLYL TRANS-4-AMINOCYCLOHEXYLMETHYL AMIDE (L-372,460) - COAPPLICATION OF STRUCTURE-BASED DESIGN AND RAPID MULTIPLE ANALOG SYNTHESIS ON SOLID SUPPORT, Journal of medicinal chemistry, 41(3), 1998, pp. 401-406
EFFICACIOUS, ORALLY BIOAVAILABLE THROMBIN INHIBITORS BASED ON 3-AMINOPYRIDINONE OR 3-AMINOPYRAZINONE ACETAMIDE PEPTIDOMIMETIC TEMPLATES
Authors: SANDERSON PEJ LYLE TA CUTRONA KJ DYER DL DORSEY BD MCDONOUGH CM NAYLOROLSEN AM CHEN IW CHEN ZG COOK JJ COOPER CM GARDELL SJ HARE TR KRUEGER JA LEWIS SD LIN JH LUCAS BJ LYLE EA LYNCH JJ STRANIERI MT VASTAG K YAN YW SHAFER JA VACCA JP
Citation: Pej. Sanderson et al., EFFICACIOUS, ORALLY BIOAVAILABLE THROMBIN INHIBITORS BASED ON 3-AMINOPYRIDINONE OR 3-AMINOPYRAZINONE ACETAMIDE PEPTIDOMIMETIC TEMPLATES, Journal of medicinal chemistry, 41(23), 1998, pp. 4466-4474
DESIGN AND SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE NONBASIC GROUPS IN THE P1 POSITION
Authors: TUCKER TJ BRADY SF LUMMA WC LEWIS SD GARDELL SJ NAYLOROLSEN AM YAN YW SISKO JT STAUFFER KJ LUCAS BJ LYNCH JJ COOK JJ STRANIERI MT HOLAHAN MA LYLE EA BASKIN EP CHEN IW DANCHECK KB KRUEGER JA COOPER CM VACCA JP
Citation: Tj. Tucker et al., DESIGN AND SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE NONBASIC GROUPS IN THE P1 POSITION, Journal of medicinal chemistry, 41(17), 1998, pp. 3210-3219
L-373,890, AN ACHIRAL, NONCOVALENT, SUBNANOMOLAR THROMBIN INHIBITOR
Authors: SANDERSON PEJ DYER DL NAYLOROLSEN AM VACCA JP GARDELL SJ LEWIS SD LUCAS BJ LYLE EA LYNCH JJ MULICHAK AM
Citation: Pej. Sanderson et al., L-373,890, AN ACHIRAL, NONCOVALENT, SUBNANOMOLAR THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1497-1500
SYNTHESIS, EVALUATION, AND CRYSTALLOGRAPHIC ANALYSIS OF L-371,912 - APOTENT AND SELECTIVE ACTIVE-SITE THROMBIN INHIBITOR
Authors: LYLE TA CHEN ZG APPLEBY SD FREIDINGER RM GARDELL SJ LEWIS SD LI Y LYLE EA LYNCH JJ MULICHAK AM NG AS NAYLOROLSEN AM SANDERS WM
Citation: Ta. Lyle et al., SYNTHESIS, EVALUATION, AND CRYSTALLOGRAPHIC ANALYSIS OF L-371,912 - APOTENT AND SELECTIVE ACTIVE-SITE THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 7(1), 1997, pp. 67-72
SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE THROMBIN INHIBITORS THAT UTILIZE 3,3-DISUBSTITUTED PROPIONIC-ACID DERIVATIVES IN THE P-3 POSITION
Authors: TUCKER TJ LUMMA WC LEWIS SD GARDELL SJ LUCAS BJ SISKO JT LYNCH JJ LYLE EA BASKIN EP WOLTMANN RF APPLEBY SD
Citation: Tj. Tucker et al., SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE THROMBIN INHIBITORS THAT UTILIZE 3,3-DISUBSTITUTED PROPIONIC-ACID DERIVATIVES IN THE P-3 POSITION, Journal of medicinal chemistry, 40(22), 1997, pp. 3687-3693
POTENT NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE THE UNIQUE AMINO-ACID D-DICYCLOHEXYLALANINE IN THE P3 POSITION - IMPLICATIONS ON ORAL BIOAVAILABILITY AND ANTITHROMBOTIC EFFICACY
Authors: TUCKER TJ LUMMA WC LEWIS SD GARDELL SJ LUCAS BJ BASKIN EP WOLTMANN R LYNCH JJ LYLE EA APPLEBY SD CHEN IW DANCHECK KB VACCA JP
Citation: Tj. Tucker et al., POTENT NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE THE UNIQUE AMINO-ACID D-DICYCLOHEXYLALANINE IN THE P3 POSITION - IMPLICATIONS ON ORAL BIOAVAILABILITY AND ANTITHROMBOTIC EFFICACY, Journal of medicinal chemistry, 40(11), 1997, pp. 1565-1569
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .8. ANTIPLATELET ACTIVITYAND ORAL ANTITHROMBOTIC EFFICACY OF L-734,217/
Authors: COOK JJ HOLAHAN MA LYLE EA RAMJIT DR SITKO GR STRANIERI MT STUPIENSKI RF WALLACE AA HAND EL GEHRET JR KOTHSTEIN T DRAG MD MCCORMICK GY PERKINS JJ IHLE NC DUGGAN ME HARTMAN GD GOULD RJ LYNCH JJ
Citation: Jj. Cook et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .8. ANTIPLATELET ACTIVITYAND ORAL ANTITHROMBOTIC EFFICACY OF L-734,217/, The Journal of pharmacology and experimental therapeutics, 278(1), 1996, pp. 62-73
INHIBITION OF THROMBIN BY PEPTIDES CONTAINING LYSYL-ALPHA-KETO CARBONYL DERIVATIVES
Authors: LEWIS SD NG AS LYLE EA MELLOTT MJ APPLEBY SD BRADY SF STAUFFER KJ SISKO JT MAO SS VEBER DF NUTT RF LYNCH JJ COOK JJ GARDELL SJ SHAFER JA
Citation: Sd. Lewis et al., INHIBITION OF THROMBIN BY PEPTIDES CONTAINING LYSYL-ALPHA-KETO CARBONYL DERIVATIVES, Thrombosis and haemostasis, 74(4), 1995, pp. 1107-1112
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