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Results: 1-25 | 26-50 | 51-75 | 76-83
Results: 1-25/83
L-374,087, AN EFFICACIOUS, ORALLY BIOAVAILABLE, PYRIDINONE ACETAMIDE THROMBIN INHIBITOR
Authors: SANDERSON PEJ CUTRONA KJ DORSEY BD DYER DL MCDONOUGH CM NAYLOROLSEN AM CHEN IW CHEN ZG COOK JJ GARDELL SJ KRUEGER JA LEWIS SD LIN JH LUCAS BJ LYLE EA LYNCH JJ STRANIERI MT VASTAG K SHAFER JA VACCA JP
Citation: Pej. Sanderson et al., L-374,087, AN EFFICACIOUS, ORALLY BIOAVAILABLE, PYRIDINONE ACETAMIDE THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 8(7), 1998, pp. 817-822
C6 MODIFICATION OF THE PYRIDINONE CORE OF THROMBIN INHIBITOR L-374,087 AS A MEANS OF ENHANCING ITS ORAL ABSORPTION
Authors: ISAACS RCA CUTRONA KJ NEWTON CL SANDERSON PEJ SOLINSKY MG BASKIN EP CHEN IW COOPER CM COOK JJ GARDELL SJ LEWIS SD LUCAS RJ LYLE EA LYNCH JJ NAYLOROLSEN AM STRANIERI MT VASTAG K VACCA JP
Citation: Rca. Isaacs et al., C6 MODIFICATION OF THE PYRIDINONE CORE OF THROMBIN INHIBITOR L-374,087 AS A MEANS OF ENHANCING ITS ORAL ABSORPTION, Bioorganic & medicinal chemistry letters, 8(13), 1998, pp. 1719-1724
LACK OF BENEFICIAL-EFFECTS OF GROWTH-HORMONE TREATMENT IN CONSCIOUS DOGS DURING DEVELOPMENT OF HEART-FAILURE
Authors: SHEN YT WOLTMANN RF APPLEBY S PRAHALADA S KRAUSE SM KIVILGHN SD JOHNSON RG SIEGL PK LYNCH JJ
Citation: Yt. Shen et al., LACK OF BENEFICIAL-EFFECTS OF GROWTH-HORMONE TREATMENT IN CONSCIOUS DOGS DURING DEVELOPMENT OF HEART-FAILURE, American journal of physiology. Heart and circulatory physiology, 43(2), 1998, pp. 456-466
ASSESSMENT OF THROMBIN INHIBITOR EFFICACY IN A NOVEL RABBIT MODEL OF SIMULTANEOUS ARTERIAL AND VENOUS THROMBOSIS
Authors: LYLE EM LEWIS SD LEHMAN ED GARDELL SJ MOTZEL SL LYNCH JJ
Citation: Em. Lyle et al., ASSESSMENT OF THROMBIN INHIBITOR EFFICACY IN A NOVEL RABBIT MODEL OF SIMULTANEOUS ARTERIAL AND VENOUS THROMBOSIS, Thrombosis and haemostasis, 79(3), 1998, pp. 656-662
INHIBITION OF ADENOSINE KINASE DURING OXYGEN-GLUCOSE DEPRIVATION IN RAT CORTICAL NEURONAL CULTURES
Authors: LYNCH JJ ALEXANDER KM JARVIS MF KOWALUK EA
Citation: Jj. Lynch et al., INHIBITION OF ADENOSINE KINASE DURING OXYGEN-GLUCOSE DEPRIVATION IN RAT CORTICAL NEURONAL CULTURES, Neuroscience letters, 252(3), 1998, pp. 207-210
VENOUS AIR-EMBOLISM IN SITTING AND SUPINE PATIENTS UNDERGOING VESTIBULAR SCHWANNOMA RESECTION
Authors: DUKE DA LYNCH JJ HARNER SG FAUST RJ EBERSOLD MJ
Citation: Da. Duke et al., VENOUS AIR-EMBOLISM IN SITTING AND SUPINE PATIENTS UNDERGOING VESTIBULAR SCHWANNOMA RESECTION, Neurosurgery, 42(6), 1998, pp. 1282-1286
DIFFERENTIAL ATRIAL VERSUS VENTRICULAR ACTIVITIES OF CLASS-III POTASSIUM CHANNEL BLOCKERS
Authors: BASKIN EP LYNCH JJ
Citation: Ep. Baskin et Jj. Lynch, DIFFERENTIAL ATRIAL VERSUS VENTRICULAR ACTIVITIES OF CLASS-III POTASSIUM CHANNEL BLOCKERS, The Journal of pharmacology and experimental therapeutics, 285(1), 1998, pp. 135-142
DISCOVERY AND DEVELOPMENT OF THE NOVEL POTENT ORALLY-ACTIVE THROMBIN INHIBITOR N-(9-HYDROXY-9-FLUORENECARBOXY)PROLYL TRANS-4-AMINOCYCLOHEXYLMETHYL AMIDE (L-372,460) - COAPPLICATION OF STRUCTURE-BASED DESIGN AND RAPID MULTIPLE ANALOG SYNTHESIS ON SOLID SUPPORT
Authors: BRADY SF STAUFFER KJ LUMMA WC SMITH GM RAMJIT HG LEWIS SD LUCAS BJ GARDELL SJ LYLE EA APPLEBY SD COOK JJ HOLAHAN MA STRANIERI MT LYNCH JJ LIN JH CHEN IW VASTAG K NAYLOROLSEN AM VACCA JP
Citation: Sf. Brady et al., DISCOVERY AND DEVELOPMENT OF THE NOVEL POTENT ORALLY-ACTIVE THROMBIN INHIBITOR N-(9-HYDROXY-9-FLUORENECARBOXY)PROLYL TRANS-4-AMINOCYCLOHEXYLMETHYL AMIDE (L-372,460) - COAPPLICATION OF STRUCTURE-BASED DESIGN AND RAPID MULTIPLE ANALOG SYNTHESIS ON SOLID SUPPORT, Journal of medicinal chemistry, 41(3), 1998, pp. 401-406
EFFICACIOUS, ORALLY BIOAVAILABLE THROMBIN INHIBITORS BASED ON 3-AMINOPYRIDINONE OR 3-AMINOPYRAZINONE ACETAMIDE PEPTIDOMIMETIC TEMPLATES
Authors: SANDERSON PEJ LYLE TA CUTRONA KJ DYER DL DORSEY BD MCDONOUGH CM NAYLOROLSEN AM CHEN IW CHEN ZG COOK JJ COOPER CM GARDELL SJ HARE TR KRUEGER JA LEWIS SD LIN JH LUCAS BJ LYLE EA LYNCH JJ STRANIERI MT VASTAG K YAN YW SHAFER JA VACCA JP
Citation: Pej. Sanderson et al., EFFICACIOUS, ORALLY BIOAVAILABLE THROMBIN INHIBITORS BASED ON 3-AMINOPYRIDINONE OR 3-AMINOPYRAZINONE ACETAMIDE PEPTIDOMIMETIC TEMPLATES, Journal of medicinal chemistry, 41(23), 1998, pp. 4466-4474
DESIGN AND SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE NONBASIC GROUPS IN THE P1 POSITION
Authors: TUCKER TJ BRADY SF LUMMA WC LEWIS SD GARDELL SJ NAYLOROLSEN AM YAN YW SISKO JT STAUFFER KJ LUCAS BJ LYNCH JJ COOK JJ STRANIERI MT HOLAHAN MA LYLE EA BASKIN EP CHEN IW DANCHECK KB KRUEGER JA COOPER CM VACCA JP
Citation: Tj. Tucker et al., DESIGN AND SYNTHESIS OF A SERIES OF POTENT AND ORALLY BIOAVAILABLE NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE NONBASIC GROUPS IN THE P1 POSITION, Journal of medicinal chemistry, 41(17), 1998, pp. 3210-3219
SELECTIVE I-KS, BUT NOT I-KR, BLOCKADE PROTECTS AGAINST VENTRICULAR-FIBRILLATION INDUCED BY MYOCARDIAL-ISCHEMIA
Authors: BILLMAN GE HOULE MS LYNCH JJ
Citation: Ge. Billman et al., SELECTIVE I-KS, BUT NOT I-KR, BLOCKADE PROTECTS AGAINST VENTRICULAR-FIBRILLATION INDUCED BY MYOCARDIAL-ISCHEMIA, Circulation, 98(17), 1998, pp. 257-257
INHIBITION OF SYMPATHETIC-NERVE ACTIVITY PARTIALLY PRESERVES LV CONTRACTILE FUNCTION EARLY IN DEVELOPMENT OF HEART-FAILURE IN CONSCIOUS PIGS
Authors: SHEN YT ENG WS BOLDUC D LYNCH JJ
Citation: Yt. Shen et al., INHIBITION OF SYMPATHETIC-NERVE ACTIVITY PARTIALLY PRESERVES LV CONTRACTILE FUNCTION EARLY IN DEVELOPMENT OF HEART-FAILURE IN CONSCIOUS PIGS, Circulation, 98(17), 1998, pp. 822-822
CHRONIC THERAPY WITH L-753,037, AN ETA B RECEPTOR ANTAGONIST, IN CONSCIOUS DOGS DURING DEVELOPMENT OF HEART-FAILURE/
Authors: SHEN YT BUIE P MOUSSA T LYNCH JJ MA XL
Citation: Yt. Shen et al., CHRONIC THERAPY WITH L-753,037, AN ETA B RECEPTOR ANTAGONIST, IN CONSCIOUS DOGS DURING DEVELOPMENT OF HEART-FAILURE/, Circulation, 98(17), 1998, pp. 3045-3045
ADDITIVE EFFECTS OF ACE-INHIBITION AND ENDOTHELIN RECEPTOR ANTAGONISMIN CONSCIOUS PIGS WITH CONGESTIVE-HEART-FAILURE
Authors: SHEN YT LYNCH JJ
Citation: Yt. Shen et Jj. Lynch, ADDITIVE EFFECTS OF ACE-INHIBITION AND ENDOTHELIN RECEPTOR ANTAGONISMIN CONSCIOUS PIGS WITH CONGESTIVE-HEART-FAILURE, Circulation, 98(17), 1998, pp. 4094-4094
COMBINED EFFECTS OF ANGIOTENSIN-CONVERTING ENZYME-INHIBITION AND ANGIOTENSIN-II RECEPTOR ANTAGONISM IN CONSCIOUS PIGS WITH CONGESTIVE-HEART-FAILURE
Authors: SHEN YT WIEDMANN RT GREENLAND BD LYNCH JJ GROSSMAN W
Citation: Yt. Shen et al., COMBINED EFFECTS OF ANGIOTENSIN-CONVERTING ENZYME-INHIBITION AND ANGIOTENSIN-II RECEPTOR ANTAGONISM IN CONSCIOUS PIGS WITH CONGESTIVE-HEART-FAILURE, Cardiovascular Research, 39(2), 1998, pp. 413-422
TRANSESOPHAGEAL ECHOCARDIOGRAPHIC CORRELATES OF THROMBOEMBOLISM IN HIGH-RISK PATIENTS WITH NONVALVULAR ATRIAL-FIBRILLATION
Authors: ZABALGOITIA M LEONARD A BLACKSHEAR JL SAFFORD R BAKER VS FENSTER P PENNOCK GD OHM J HUERTA BJ STRAUSS R MCKENZIE M HARTMCARTHUR P GRAMBERG M HOUSTON H CHAN KL BIGGS J IVES A ROTHBART R MURRAY D LOUTFI H LYNCH JJ CARLSON L LABOVITZ AJ VIGIL A ASINGER RW DICK CD NEWBURG SM FIFIELD J KHANDHERIA BK HOLLAND AE TUCKER KR GOLDMAN ME ROTHLAUF EB HESS D YOUNG L MEGO DM BOYD S WILSON D NOLTE B EDWARDS C MEZEI L RIGGIO S GIRAUD G MARCHANT C TIMBERG J DITTRICH HC KEEN W KERRIDGE C BERNARD S BATTINELLI N ATWOOD JE QUAGLIETTI S ALPERT MA MASSEY CV HUPP C KOEHLER J PEARCE LA HALPERIN JL HART RG MARLER JR DEMARIA AN TAJIK AJ WEYMAN A
Citation: M. Zabalgoitia et al., TRANSESOPHAGEAL ECHOCARDIOGRAPHIC CORRELATES OF THROMBOEMBOLISM IN HIGH-RISK PATIENTS WITH NONVALVULAR ATRIAL-FIBRILLATION, Annals of internal medicine, 128(8), 1998, pp. 639
L-373,890, AN ACHIRAL, NONCOVALENT, SUBNANOMOLAR THROMBIN INHIBITOR
Authors: SANDERSON PEJ DYER DL NAYLOROLSEN AM VACCA JP GARDELL SJ LEWIS SD LUCAS BJ LYLE EA LYNCH JJ MULICHAK AM
Citation: Pej. Sanderson et al., L-373,890, AN ACHIRAL, NONCOVALENT, SUBNANOMOLAR THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1497-1500
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .13. DESIGN AND SYNTHESISOF AN ORALLY-ACTIVE PYRAZOLOPIPERAZINONE NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONIST/
Authors: ASKEW BC MCINTYRE CJ HUNT CA CLAREMON DA BALDWIN JJ ANDERSON PS GOULD RJ LYNCH RJ CHANG CCT COOK JJ LYNCH JJ HOLAHAN MA SITKO GR STRANIERI MT
Citation: Bc. Askew et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .13. DESIGN AND SYNTHESISOF AN ORALLY-ACTIVE PYRAZOLOPIPERAZINONE NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONIST/, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1531-1536
SYNTHESIS, EVALUATION, AND CRYSTALLOGRAPHIC ANALYSIS OF L-371,912 - APOTENT AND SELECTIVE ACTIVE-SITE THROMBIN INHIBITOR
Authors: LYLE TA CHEN ZG APPLEBY SD FREIDINGER RM GARDELL SJ LEWIS SD LI Y LYLE EA LYNCH JJ MULICHAK AM NG AS NAYLOROLSEN AM SANDERS WM
Citation: Ta. Lyle et al., SYNTHESIS, EVALUATION, AND CRYSTALLOGRAPHIC ANALYSIS OF L-371,912 - APOTENT AND SELECTIVE ACTIVE-SITE THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 7(1), 1997, pp. 67-72
ANGIOTENSIN-II RECEPTOR ANTAGONIST ENHANCES THE EFFECTS OF ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR IN CONSCIOUS PIGS WITH CONGESTIVE-HEART-FAILURE
Authors: SHEN YT LYNCH JJ WIEDMANN RT GREENLAND BD GROSSMAN W
Citation: Yt. Shen et al., ANGIOTENSIN-II RECEPTOR ANTAGONIST ENHANCES THE EFFECTS OF ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR IN CONSCIOUS PIGS WITH CONGESTIVE-HEART-FAILURE, Journal of the American College of Cardiology, 29(2), 1997, pp. 76149-76149
THE EFFECT OF DEXAMETHASONE ON IMMUNOLOGICAL MEMORY TO TETANUS TOXOIDIN SHEEP
Authors: ADAMS DB ANDERSON BH LYNCH JJ MUNRO RK
Citation: Db. Adams et al., THE EFFECT OF DEXAMETHASONE ON IMMUNOLOGICAL MEMORY TO TETANUS TOXOIDIN SHEEP, Veterinary immunology and immunopathology, 60(1-2), 1997, pp. 89-95
EFFECTS OF ANESTHESIA AND OPEN-THORAX SURGERY ON CORONARY VASCULAR RESERVE IN SWINE
Authors: ROGERS IT ACKER WR LODGE KE HOLDER DJ KLEIN HJ LYNCH JJ SHEN YT
Citation: It. Rogers et al., EFFECTS OF ANESTHESIA AND OPEN-THORAX SURGERY ON CORONARY VASCULAR RESERVE IN SWINE, Laboratory animal science, 47(4), 1997, pp. 396-400
BIOLOGICAL PROFILE OF L-745,870, A SELECTIVE ANTAGONIST WITH HIGH-AFFINITY FOR THE DOPAMINE-D4 RECEPTOR
Authors: PATEL S FREEDMAN S CHAPMAN KL EMMS F FLETCHER AE KNOWLES M MARWOOD R MCALLISTER G MYERS J PATEL S CURTIS N KULAGOWSKI JJ LEESON PD RIDGILL M GRAHAM M MATHESON S RATHBONE D WATT AP BRISTOW LJ RUPNIAK NMJ BASKIN E LYNCH JJ RAGAN CI
Citation: S. Patel et al., BIOLOGICAL PROFILE OF L-745,870, A SELECTIVE ANTAGONIST WITH HIGH-AFFINITY FOR THE DOPAMINE-D4 RECEPTOR, The Journal of pharmacology and experimental therapeutics, 283(2), 1997, pp. 636-647
NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .15. ANTITHROMBOTIC EFFICACY OF L-738,167, A LONG-ACTING GPIIB/IIIA ANTAGONIST, CORRELATES WITHINHIBITION OF ADENOSINE DIPHOSPHATE-INDUCED PLATELET-AGGREGATION BUT NOT WITH BLEEDING-TIME PROLONGATION/
Authors: COOK JJ SITKO GR HOLAHAN MA STRANIERI MT GLASS JD ASKEW BC MCINTYRE CJ CLAREMON DA BALDWIN JJ HARTMAN GD GOULD RJ LYNCH JJ
Citation: Jj. Cook et al., NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .15. ANTITHROMBOTIC EFFICACY OF L-738,167, A LONG-ACTING GPIIB/IIIA ANTAGONIST, CORRELATES WITHINHIBITION OF ADENOSINE DIPHOSPHATE-INDUCED PLATELET-AGGREGATION BUT NOT WITH BLEEDING-TIME PROLONGATION/, The Journal of pharmacology and experimental therapeutics, 281(2), 1997, pp. 677-689
ATTACHMENT THEORY - SOCIAL, DEVELOPMENTAL AND CLINICAL PERSPECTIVES -GOLDBERG,S, MUIR,R, KERR,J
Authors: LYNCH JJ
Citation: Jj. Lynch, ATTACHMENT THEORY - SOCIAL, DEVELOPMENTAL AND CLINICAL PERSPECTIVES -GOLDBERG,S, MUIR,R, KERR,J, The Journal of nervous and mental disease, 185(12), 1997, pp. 768-769
Risultati: 1-25 | 26-50 | 51-75 | 76-83