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Results: 1-25 | 26-26
Results: 1-25/26
Lack of effect of furfural on unscheduled DNA synthesis in the in vivo ratand mouse hepatocyte DNA repair assays and in precision-cut human liver slices
Authors: Lake, BG Edwards, AJ Price, RJ Phillips, BJ Renwick, AB Beamand, JA Adams, TB
Citation: Bg. Lake et al., Lack of effect of furfural on unscheduled DNA synthesis in the in vivo ratand mouse hepatocyte DNA repair assays and in precision-cut human liver slices, FOOD CHEM T, 39(10), 2001, pp. 999-1011
Effect of cruciferous vegetable consumption on heterocyclic aromatic aminemetabolism in man
Authors: Murray, S Lake, BG Gray, S Edwards, AJ Springall, C Bowey, EA Williamson, G Boobis, AR Gooderham, NJ
Citation: S. Murray et al., Effect of cruciferous vegetable consumption on heterocyclic aromatic aminemetabolism in man, CARCINOGENE, 22(9), 2001, pp. 1413-1420
Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes
Authors: Subrahmanyam, V Renwick, AB Walters, DG Young, PJ Price, RJ Tonelli, AP Lake, BG
Citation: V. Subrahmanyam et al., Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes, DRUG META D, 29(8), 2001, pp. 1146-1155
An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant
Authors: Andersson, TB Sjoberg, H Hoffmann, KJ Boobis, AR Watts, P Edwards, RJ Lake, BG Price, RJ Renwick, AB Gomez-Lechon, MJ Castell, JV Ingelman-Sundberg, M Hidestrand, M Goldfarb, PS Lewis, DFV Corcos, L Guillouzo, A Taavitsainen, P Pelkonen, O
Citation: Tb. Andersson et al., An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant, DRUG META D, 29(5), 2001, pp. 712-720
Carbamazepine: a 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems
Authors: Pelkonen, O Myllynen, P Taavitsainen, P Boobis, AR Watts, P Lake, BG Price, RJ Renwick, AB Gomez-Lechon, MJ Castell, JV Ingelman-Sundberg, M Hidestrand, M Guillouzo, A Corcos, L Goldfarb, PS Lewis, DFV
Citation: O. Pelkonen et al., Carbamazepine: a 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems, XENOBIOTICA, 31(6), 2001, pp. 321-343
Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4
Authors: Renwick, AB Lewis, DFV Fulford, S Surry, D Williams, B Worboys, PD Cai, X Wang, RW Price, RJ Lake, BG Evans, DC
Citation: Ab. Renwick et al., Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4, XENOBIOTICA, 31(4), 2001, pp. 187-204
Species differences in hepatic peroxisome proliferation, cell replication and transforming growth factor-beta 1 gene expression in the rat, Syrian hamster and guinea pig
Authors: Lake, BG Rumsby, PC Price, RJ Cunninghame, ME
Citation: Bg. Lake et al., Species differences in hepatic peroxisome proliferation, cell replication and transforming growth factor-beta 1 gene expression in the rat, Syrian hamster and guinea pig, MUT RES-F M, 448(2), 2000, pp. 213-225
Lack of effect of coumarin on unscheduled DNA synthesis in the in vivo rathepatocyte DNA repair assay
Authors: Edwards, AJ Price, RJ Benwick, AB Lake, BG
Citation: Aj. Edwards et al., Lack of effect of coumarin on unscheduled DNA synthesis in the in vivo rathepatocyte DNA repair assay, FOOD CHEM T, 38(5), 2000, pp. 403-409
Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices
Authors: Renwick, AB Watts, PS Edwards, RJ Barton, PT Guyonnet, I Price, RJ Tredger, JM Pelkonen, O Boobis, AR Lake, BG
Citation: Ab. Renwick et al., Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices, DRUG META D, 28(10), 2000, pp. 1202-1209
CYP isoform induction screening in 96-well plates: use of 7-benzyloxy-4-trifluoromethylcoumarin as a substrate for studies with rat hepatocytes
Authors: Price, RJ Surry, D Renwick, AB Meneses-Lorente, G Lake, BG Evans, DC
Citation: Rj. Price et al., CYP isoform induction screening in 96-well plates: use of 7-benzyloxy-4-trifluoromethylcoumarin as a substrate for studies with rat hepatocytes, XENOBIOTICA, 30(8), 2000, pp. 781-795
Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms
Authors: Renwick, AB Surry, D Price, RJ Lake, BG Evans, DC
Citation: Ab. Renwick et al., Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms, XENOBIOTICA, 30(10), 2000, pp. 955-969
Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform
Authors: Lewis, DFV Bird, MG Dickins, M Lake, BG Eddershaw, PJ Tarbit, MH Goldfarb, PS
Citation: Dfv. Lewis et al., Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform, XENOBIOTICA, 30(1), 2000, pp. 1-25
Inhibition of xenobiotic-induced genotoxicity in cultured precision-cut human and rat liver slices
Authors: Lake, BG Beamand, JA Tredger, JM Barton, PT Renwick, AB Price, RJ
Citation: Bg. Lake et al., Inhibition of xenobiotic-induced genotoxicity in cultured precision-cut human and rat liver slices, MUT RES-GTE, 440(1), 1999, pp. 91-100
Genetic variation in the metabolism of coumarin in mouse liver
Authors: Lovell, DP van Iersel, M Walters, DG Price, RJ Lake, BG
Citation: Dp. Lovell et al., Genetic variation in the metabolism of coumarin in mouse liver, PHARMACOGEN, 9(2), 1999, pp. 239-250
Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102
Authors: Lewis, DFV Lake, BG George, SG Dickins, M Eddershaw, PJ Tarbit, MH Beresford, AP Goldfarb, PS Guengerich, FP
Citation: Dfv. Lewis et al., Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102, TOXICOLOGY, 139(1-2), 1999, pp. 53-79
Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity
Authors: Lewis, DFV Dickens, M Lake, BG Eddershaw, PJ Tarbit, MH Goldfarb, PS
Citation: Dfv. Lewis et al., Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity, TOXICOLOGY, 133(1), 1999, pp. 1-33
Effect of some indole derivatives on xenobiotic metabolism and xenobiotic-induced toxicity in cultured rat liver slices
Authors: Renwick, AB Mistry, H Barton, PT Mallet, F Price, RJ Beamand, JA Lake, BG
Citation: Ab. Renwick et al., Effect of some indole derivatives on xenobiotic metabolism and xenobiotic-induced toxicity in cultured rat liver slices, FOOD CHEM T, 37(6), 1999, pp. 609-618
Coumarin metabolism, toxicity and carcinogenicity: Relevance for human risk assessment
Authors: Lake, BG
Citation: Bg. Lake, Coumarin metabolism, toxicity and carcinogenicity: Relevance for human risk assessment, FOOD CHEM T, 37(4), 1999, pp. 423-453
A cancer risk assessment of di(2-ethylhexyl)phthalate: Application of the new US EPA risk assessment guidelines
Authors: Doull, J Cattley, R Elcombe, C Lake, BG Swenberg, J Wilkinson, C Williams, G van Gemert, M
Citation: J. Doull et al., A cancer risk assessment of di(2-ethylhexyl)phthalate: Application of the new US EPA risk assessment guidelines, REGUL TOX P, 29(3), 1999, pp. 327-357
Dose-response relationships for hepatic aflatoxin B1-DNA adduct formation in the rat in vivo and in vitro: The use of immunoslot blotting for adduct quantitation
Authors: Phillips, JC Davies, S Lake, BG
Citation: Jc. Phillips et al., Dose-response relationships for hepatic aflatoxin B1-DNA adduct formation in the rat in vivo and in vitro: The use of immunoslot blotting for adduct quantitation, TER CAR MUT, 19(2), 1999, pp. 157-170
Molecular modelling of CYP4A subfamily members based on sequence homology with CYP102
Authors: Lewis, DFV Lake, BG
Citation: Dfv. Lewis et Bg. Lake, Molecular modelling of CYP4A subfamily members based on sequence homology with CYP102, XENOBIOTICA, 29(8), 1999, pp. 763-781
beta(2)-agonist abuse in food producing animals: use of in vitro liver preparations to assess biotransformation and potential target residues for surveillance
Authors: Sauer, MJ Dave, M Lake, BG Manchee, GR Howells, LC Coldham, NG
Citation: Mj. Sauer et al., beta(2)-agonist abuse in food producing animals: use of in vitro liver preparations to assess biotransformation and potential target residues for surveillance, XENOBIOTICA, 29(5), 1999, pp. 483-497
Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substratecharacteristics, the cytochrome b(5) binding site and comparisons with CYP2B1 and CYP2B4
Authors: Lewis, DFV Lake, BG Dickins, M Eddershaw, PJ Tarbit, MH Goldfarb, PS
Citation: Dfv. Lewis et al., Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substratecharacteristics, the cytochrome b(5) binding site and comparisons with CYP2B1 and CYP2B4, XENOBIOTICA, 29(4), 1999, pp. 361-393
Characterization of olanzapine (LY170053) in human liver slices by liquid chromatography tandem mass spectrometry
Authors: Murphy, AT Lake, BG Bernstein, JR Franklin, RB Gillespie, TA
Citation: At. Murphy et al., Characterization of olanzapine (LY170053) in human liver slices by liquid chromatography tandem mass spectrometry, J MASS SPEC, 33(12), 1998, pp. 1237-1245
Molecular modelling of the rat peroxisome proliferator-activated receptor-alpha (rPPAR alpha) by homology with the human retinoic acid X receptor alpha (hRXR alpha) and investigation of ligand binding interactions I: QSARs
Authors: Lewis, DFV Lake, BG
Citation: Dfv. Lewis et Bg. Lake, Molecular modelling of the rat peroxisome proliferator-activated receptor-alpha (rPPAR alpha) by homology with the human retinoic acid X receptor alpha (hRXR alpha) and investigation of ligand binding interactions I: QSARs, TOX VITRO, 12(6), 1998, pp. 619-632
Risultati: 1-25 | 26-26