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Results: 1-20 |
Results: 20
TACE and other ADAM proteases as targets for drug discovery
Authors: Moss, ML White, JM Lambert, MH Andrews, RC
Citation: Ml. Moss et al., TACE and other ADAM proteases as targets for drug discovery, DRUG DISC T, 6(8), 2001, pp. 417-426
Synthesis and biological activity of L-tyrosine-based PPAR gamma agonists with reduced molecular weight
Authors: Liu, KG Lambert, MH Ayscue, AH Henke, BR Leesnitzer, LM Oliver, WR Plunket, KD Xu, HE Sternbach, DD Willson, TM
Citation: Kg. Liu et al., Synthesis and biological activity of L-tyrosine-based PPAR gamma agonists with reduced molecular weight, BIOORG MED, 11(24), 2001, pp. 3111-3113
Identification of a series of PPAR-gamma/delta dual agonists via solid-phase parallel synthesis
Authors: Liu, KG Lambert, MH Leesnitzer, LM Oliver, W Ott, RJ Plunket, KD Stuart, LW Brown, PJ Willson, TM Sternbach, DD
Citation: Kg. Liu et al., Identification of a series of PPAR-gamma/delta dual agonists via solid-phase parallel synthesis, BIOORG MED, 11(22), 2001, pp. 2959-2962
Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPAR alpha, PPAR-gamma, and PPAR delta
Authors: Liu, KG Smith, JS Ayscue, AH Henke, BR Lambert, MH Leesnitzer, LM Plunket, KD Willson, TM Sternbach, DD
Citation: Kg. Liu et al., Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPAR alpha, PPAR-gamma, and PPAR delta, BIOORG MED, 11(17), 2001, pp. 2385-2388
N-hydroxyformamide peptidomimetics as TACE/matrix metalloprotease inhibitors: Oral activity via P1 ' isobutyl substitution
Authors: Musso, DL Andersen, MW Andrews, RC Austin, R Beaudet, EJ Becherer, JD Bubacz, DG Bickett, DM Chan, JH Conway, JG Cowan, DJ Gaul, MD Glennon, KC Hedeen, KM Lambert, MH Leesnitzer, MA McDougald, DL Mitchell, JL Moss, ML Rabinowitz, MH Rizzolio, MC Schaller, LT Stanford, JB Tippin, TK Warner, JR Whitesell, LG Wiethe, RW
Citation: Dl. Musso et al., N-hydroxyformamide peptidomimetics as TACE/matrix metalloprotease inhibitors: Oral activity via P1 ' isobutyl substitution, BIOORG MED, 11(16), 2001, pp. 2147-2151
Peroxisome proliferator-activated receptors: From genes to physiology
Authors: Kliewer, SA Xu, HE Lambert, MH Willson, TM
Citation: Sa. Kliewer et al., Peroxisome proliferator-activated receptors: From genes to physiology, REC PROG H, 56, 2001, pp. 239-263
Peroxisome proliferator-activated receptor gamma and metabolic disease
Authors: Willson, TM Lambert, MH Kliewer, SA
Citation: Tm. Willson et al., Peroxisome proliferator-activated receptor gamma and metabolic disease, ANN R BIOCH, 70, 2001, pp. 341-367
The human nuclear xenobiotic receptor PXR: Structural determinants of directed promiscuity
Authors: Watkins, RE Wisely, GB Moore, LB Collins, JL Lambert, MH Williams, SP Willson, TM Kliewer, SA Redinbo, MR
Citation: Re. Watkins et al., The human nuclear xenobiotic receptor PXR: Structural determinants of directed promiscuity, SCIENCE, 292(5525), 2001, pp. 2329-2333
A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport
Authors: Oliver, WR Shenk, JL Snaith, MR Russell, CS Plunket, KD Bodkin, NL Lewis, MC Winegar, DA Sznaidman, ML Lambert, MH Xu, HE Sternbach, DD Kliewer, SA Hansen, BC Willson, TM
Citation: Wr. Oliver et al., A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport, P NAS US, 98(9), 2001, pp. 5306-5311
Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors
Authors: Xu, HE Lambert, MH Montana, VG Plunket, KD Moore, LB Collins, JB Oplinger, JA Kliewer, SA Gampe, RT McKee, DD Moore, JT Willson, TM
Citation: He. Xu et al., Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors, P NAS US, 98(24), 2001, pp. 13919-13924
Pharmacophore analysis of the nuclear oxysterol receptor LXR alpha
Authors: Spencer, TA Li, DS Russel, JS Collins, JL Bledsoe, RK Consler, TG Moore, LB Galardi, CM McKee, DD Moore, JT Watson, MA Parks, DJ Lambert, MH Willson, TM
Citation: Ta. Spencer et al., Pharmacophore analysis of the nuclear oxysterol receptor LXR alpha, J MED CHEM, 44(6), 2001, pp. 886-897
Design of selective and soluble inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)
Authors: Rabinowitz, MH Andrews, RC Becherer, JD Bickett, DM Bubacz, DG Conway, JG Cowan, DJ Gaul, M Glennon, K Lambert, MH Leesnitzer, MA McDougald, DL Moss, ML Musso, DL Rizzolio, MC
Citation: Mh. Rabinowitz et al., Design of selective and soluble inhibitors of tumor necrosis factor-alpha converting enzyme (TACE), J MED CHEM, 44(24), 2001, pp. 4252-4267
Asymmetry in the PPAR gamma/RXR alpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors
Authors: Gampe, RT Montana, VG Lambert, MH Miller, AB Bledsoe, RK Milburn, MV Kliewer, SA Willson, TM Xu, HE
Citation: Rt. Gampe et al., Asymmetry in the PPAR gamma/RXR alpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors, MOL CELL, 5(3), 2000, pp. 545-555
Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix
Authors: Gampe, RT Montana, VG Lambert, MH Wisely, GB Milburn, MV Xu, HE
Citation: Rt. Gampe et al., Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix, GENE DEV, 14(17), 2000, pp. 2229-2241
Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype
Authors: Takada, I Yu, RT Xu, HE Lambert, MH Montana, VG Kliewer, SA Evans, RM Umesono, K
Citation: I. Takada et al., Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype, MOL ENDOCR, 14(5), 2000, pp. 733-740
The pregnane x receptor: A promiscuous xenobiotic receptor that has diverged during evolution
Authors: Jones, SA Moore, LB Shenk, JL Wisely, GB Hamilton, GA McKee, DD Tomkinson, NCO LeCluyse, EL Lambert, MH Willson, TM Kliewer, SA Moore, JT
Citation: Sa. Jones et al., The pregnane x receptor: A promiscuous xenobiotic receptor that has diverged during evolution, MOL ENDOCR, 14(1), 2000, pp. 27-39
Atomic structure of PDE4: Insights into phosphodiesterase mechanism and specificity
Authors: Xu, RX Hassell, AM Vanderwall, D Lambert, MH Holmes, WD Luther, MA Rocque, WJ Milburn, MV Zhao, YD Ke, HM Nolte, RT
Citation: Rx. Xu et al., Atomic structure of PDE4: Insights into phosphodiesterase mechanism and specificity, SCIENCE, 288(5472), 2000, pp. 1822-1825
Substrate specificity of human collagenase 3 assessed using a phage-displayed peptide library
Authors: Deng, SJ Bickett, DM Mitchell, JL Lambert, MH Blackburn, RK Carter, HL Neugebauer, J Pahel, G Weiner, MP Moss, ML
Citation: Sj. Deng et al., Substrate specificity of human collagenase 3 assessed using a phage-displayed peptide library, J BIOL CHEM, 275(40), 2000, pp. 31422-31427
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
Authors: Xu, HE Lambert, MH Montana, VG Parks, DJ Blanchard, SG Brown, PJ Sternbach, DD Lehmann, JM Wisely, GB Willson, TM Kliewer, SA Milburn, MV
Citation: He. Xu et al., Molecular recognition of fatty acids by peroxisome proliferator-activated receptors, MOL CELL, 3(3), 1999, pp. 397-403
Molecular determinants of nuclear receptor-corepressor interaction
Authors: Perissi, V Staszewski, LM McInerney, EM Kurokawa, R Krones, A Rose, DW Lambert, MH Milburn, MV Glass, CK Rosenfeld, MG
Citation: V. Perissi et al., Molecular determinants of nuclear receptor-corepressor interaction, GENE DEV, 13(24), 1999, pp. 3198-3208
Risultati: 1-20 |