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Results: 1-19 |
Results: 19
Origin and true nature of the starter unit for the rapamycin polyketide synthase
Authors: Lowden, PAS Wilkinson, B Bohm, GA Handa, S Floss, HG Leadlay, PF Staunton, J
Citation: Pas. Lowden et al., Origin and true nature of the starter unit for the rapamycin polyketide synthase, ANGEW CHEM, 40(4), 2001, pp. 777-779
Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase
Authors: Rowe, CJ Bohm, IU Thomas, IP Wilkinson, B Rudd, BAM Foster, G Blackaby, AP Sidebottom, PJ Roddis, Y Buss, AD Staunton, J Leadlay, PF
Citation: Cj. Rowe et al., Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase, CHEM BIOL, 8(5), 2001, pp. 475-485
Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates
Authors: Holzbaur, IE Ranganathan, A Thomas, IP Kearney, DJA Reather, JA Rudd, BAM Staunton, J Leadlay, PF
Citation: Ie. Holzbaur et al., Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates, CHEM BIOL, 8(4), 2001, pp. 329-340
Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units
Authors: Heathcole, ML Staunton, J Leadlay, PF
Citation: Ml. Heathcole et al., Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units, CHEM BIOL, 8(2), 2001, pp. 207-220
New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster
Authors: Gaisser, S Lill, R Wirtz, G Grolle, F Staunton, J Leadlay, PF
Citation: S. Gaisser et al., New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster, MOL MICROB, 41(5), 2001, pp. 1223-1231
Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase
Authors: Wilkinson, B Foster, G Rudd, BAM Taylor, NL Blackaby, AP Sidebottom, PJ Cooper, DJ Dawson, MJ Buss, AD Gaisser, S Bohm, IU Rowe, CJ Cortes, J Leadlay, PF Staunton, J
Citation: B. Wilkinson et al., Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase, CHEM BIOL, 7(2), 2000, pp. 111-117
A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea
Authors: Gaisser, S Reather, J Wirtz, G Kellenberger, L Staunton, JU Leadlay, PF
Citation: S. Gaisser et al., A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea, MOL MICROB, 36(2), 2000, pp. 391-401
Efficient purification and kinetic characterization of a bimodular derivative of the erythromycin polyketide synthase
Authors: Bycroft, M Weissman, KJ Staunton, J Leadlay, PF
Citation: M. Bycroft et al., Efficient purification and kinetic characterization of a bimodular derivative of the erythromycin polyketide synthase, EUR J BIOCH, 267(2), 2000, pp. 520-526
Protection of radical intermediates at the active site of adenosylcobalamin-dependent methylmalonyl-CoA mutase
Authors: Thoma, NH Evans, PR Leadlay, PF
Citation: Nh. Thoma et al., Protection of radical intermediates at the active site of adenosylcobalamin-dependent methylmalonyl-CoA mutase, BIOCHEM, 39(31), 2000, pp. 9213-9221
The effect of rapeseed oil uptake on the production of erythromycin and triketide lactone by Saccharopolyspora erythraea
Authors: Mirjalili, N Zormpaidis, V Leadlay, PF Ison, AP
Citation: N. Mirjalili et al., The effect of rapeseed oil uptake on the production of erythromycin and triketide lactone by Saccharopolyspora erythraea, BIOTECH PR, 15(5), 1999, pp. 911-918
Molecular basis of Celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase
Authors: Holzbaur, IE Harris, RC Bycroft, M Cortes, J Bisang, C Staunton, J Rudd, BAM Leadlay, PF
Citation: Ie. Holzbaur et al., Molecular basis of Celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase, CHEM BIOL, 6(4), 1999, pp. 189-195
Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues
Authors: Ranganathan, A Timoney, M Bycroft, M Cortes, J Thomas, IP Wilkinson, B Kellenberger, L Hanefeld, U Galloway, IS Staunton, J Leadlay, PF
Citation: A. Ranganathan et al., Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues, CHEM BIOL, 6(10), 1999, pp. 731-741
Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry
Authors: Gates, PJ Kearney, GC Jones, R Leadlay, PF Staunton, J
Citation: Pj. Gates et al., Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry, RAP C MASS, 13(4), 1999, pp. 242-246
Structural elucidation studies of polyketide tetrasubstituted delta-lactones by gas chromatography/tandem mass spectrometry and electrospray mass spectrometry
Authors: Weissman, KJ Kearney, GC Leadlay, PF Staunton, J
Citation: Kj. Weissman et al., Structural elucidation studies of polyketide tetrasubstituted delta-lactones by gas chromatography/tandem mass spectrometry and electrospray mass spectrometry, RAP C MASS, 13(21), 1999, pp. 2103-2108
Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry II
Authors: Kearney, GC Gates, PJ Leadlay, PF Staunton, J Jones, R
Citation: Gc. Kearney et al., Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry II, RAP C MASS, 13(16), 1999, pp. 1650-1656
Lipase activity in Streptomycetes
Authors: Large, KP Mirjalili, N Osborne, M Peacock, LM Zormpaidis, V Walsh, M Cavanagh, ME Leadlay, PF Ison, AP
Citation: Kp. Large et al., Lipase activity in Streptomycetes, ENZYME MICR, 25(7), 1999, pp. 569-575
A chain initiation factor common to both modular and aromatic polyketide synthases
Authors: Bisang, C Long, PF Cortes, J Westcott, J Crosby, J Matharu, AL Cox, RJ Simpson, TJ Staunton, J Leadlay, PF
Citation: C. Bisang et al., A chain initiation factor common to both modular and aromatic polyketide synthases, NATURE, 401(6752), 1999, pp. 502-505
Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitrostudies on a bimodular polyketide synthase
Authors: Weissman, KJ Bycroft, M Cutter, AL Hanefeld, U Frost, EJ Timoney, MC Harris, R Handa, S Roddis, M Staunton, J Leadlay, PF
Citation: Kj. Weissman et al., Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitrostudies on a bimodular polyketide synthase, CHEM BIOL, 5(12), 1998, pp. 743-754
Enantiospecific synthesis of tetrasubstituted delta-lactones
Authors: Wilkinson, AL Hanefeld, U Wilkinson, B Leadlay, PF Staunton, J
Citation: Al. Wilkinson et al., Enantiospecific synthesis of tetrasubstituted delta-lactones, TETRAHEDR L, 39(52), 1998, pp. 9827-9830
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