Authors:
Rowe, CJ
Bohm, IU
Thomas, IP
Wilkinson, B
Rudd, BAM
Foster, G
Blackaby, AP
Sidebottom, PJ
Roddis, Y
Buss, AD
Staunton, J
Leadlay, PF
Citation: Cj. Rowe et al., Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase, CHEM BIOL, 8(5), 2001, pp. 475-485
Authors:
Holzbaur, IE
Ranganathan, A
Thomas, IP
Kearney, DJA
Reather, JA
Rudd, BAM
Staunton, J
Leadlay, PF
Citation: Ie. Holzbaur et al., Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates, CHEM BIOL, 8(4), 2001, pp. 329-340
Citation: Ml. Heathcole et al., Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units, CHEM BIOL, 8(2), 2001, pp. 207-220
Authors:
Gaisser, S
Lill, R
Wirtz, G
Grolle, F
Staunton, J
Leadlay, PF
Citation: S. Gaisser et al., New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster, MOL MICROB, 41(5), 2001, pp. 1223-1231
Authors:
Wilkinson, B
Foster, G
Rudd, BAM
Taylor, NL
Blackaby, AP
Sidebottom, PJ
Cooper, DJ
Dawson, MJ
Buss, AD
Gaisser, S
Bohm, IU
Rowe, CJ
Cortes, J
Leadlay, PF
Staunton, J
Citation: B. Wilkinson et al., Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase, CHEM BIOL, 7(2), 2000, pp. 111-117
Authors:
Bycroft, M
Weissman, KJ
Staunton, J
Leadlay, PF
Citation: M. Bycroft et al., Efficient purification and kinetic characterization of a bimodular derivative of the erythromycin polyketide synthase, EUR J BIOCH, 267(2), 2000, pp. 520-526
Citation: Nh. Thoma et al., Protection of radical intermediates at the active site of adenosylcobalamin-dependent methylmalonyl-CoA mutase, BIOCHEM, 39(31), 2000, pp. 9213-9221
Authors:
Mirjalili, N
Zormpaidis, V
Leadlay, PF
Ison, AP
Citation: N. Mirjalili et al., The effect of rapeseed oil uptake on the production of erythromycin and triketide lactone by Saccharopolyspora erythraea, BIOTECH PR, 15(5), 1999, pp. 911-918
Authors:
Holzbaur, IE
Harris, RC
Bycroft, M
Cortes, J
Bisang, C
Staunton, J
Rudd, BAM
Leadlay, PF
Citation: Ie. Holzbaur et al., Molecular basis of Celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase, CHEM BIOL, 6(4), 1999, pp. 189-195
Authors:
Ranganathan, A
Timoney, M
Bycroft, M
Cortes, J
Thomas, IP
Wilkinson, B
Kellenberger, L
Hanefeld, U
Galloway, IS
Staunton, J
Leadlay, PF
Citation: A. Ranganathan et al., Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues, CHEM BIOL, 6(10), 1999, pp. 731-741
Citation: Pj. Gates et al., Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry, RAP C MASS, 13(4), 1999, pp. 242-246
Citation: Kj. Weissman et al., Structural elucidation studies of polyketide tetrasubstituted delta-lactones by gas chromatography/tandem mass spectrometry and electrospray mass spectrometry, RAP C MASS, 13(21), 1999, pp. 2103-2108
Citation: Gc. Kearney et al., Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry II, RAP C MASS, 13(16), 1999, pp. 1650-1656
Authors:
Weissman, KJ
Bycroft, M
Cutter, AL
Hanefeld, U
Frost, EJ
Timoney, MC
Harris, R
Handa, S
Roddis, M
Staunton, J
Leadlay, PF
Citation: Kj. Weissman et al., Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitrostudies on a bimodular polyketide synthase, CHEM BIOL, 5(12), 1998, pp. 743-754