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Results: 1-25 | 26-36
Results: 1-25/36
Methods to determine the constitutive activity of histamine H-2 receptors
Authors: Leurs, R Hoffmann, M Alewijnse, AE Smit, MJ Timmerman, H
Citation: R. Leurs et al., Methods to determine the constitutive activity of histamine H-2 receptors, METH ENZYM, 343, 2002, pp. 405-416
Pharmacological analysis of immepip and imetit homologues. Further evidence for histamine H-3 receptor heterogeneity?
Authors: Alves-Rodrigues, A Lemstra, S Vollinga, RC Menge, WMPB Timmerman, H Leurs, R
Citation: A. Alves-rodrigues et al., Pharmacological analysis of immepip and imetit homologues. Further evidence for histamine H-3 receptor heterogeneity?, BEH BRA RES, 124(2), 2001, pp. 121-127
Histamine H-1-receptor activation of nuclear factor-kappa B: Roles for G beta gamma- and G alpha(q/11)-subunits in constitutive and agonist-mediated signaling
Authors: Bakker, RA Schoonus, SBJ Smit, MJ Timmerman, H Leurs, R
Citation: Ra. Bakker et al., Histamine H-1-receptor activation of nuclear factor-kappa B: Roles for G beta gamma- and G alpha(q/11)-subunits in constitutive and agonist-mediated signaling, MOLEC PHARM, 60(5), 2001, pp. 1133-1142
Identification of rat H-3 receptor isoforms with different brain expression and signaling properties
Authors: Drutel, G Peitsaro, N Karlstedt, K Wieland, K Smit, MJ Timmerman, H Panula, P Leurs, R
Citation: G. Drutel et al., Identification of rat H-3 receptor isoforms with different brain expression and signaling properties, MOLEC PHARM, 59(1), 2001, pp. 1-8
Significance of GABAergic systems in the action of improgan, a non-opioid analgesic
Authors: Hough, LB Nalwalk, JW Leurs, R Menge, WMPB Timmerman, H
Citation: Lb. Hough et al., Significance of GABAergic systems in the action of improgan, a non-opioid analgesic, LIFE SCI, 68(24), 2001, pp. 2751-2757
Constitutive activity of histamine H-3 receptors stably expressed in SK-N-MC cells: Display of agonism and inverse agonism by H-3 antagonists
Authors: Wieland, K Bongers, G Yamamoto, Y Hashimoto, T Yamatodani, A Menge, WMBP Timmerman, H Lovenberg, TW Leurs, R
Citation: K. Wieland et al., Constitutive activity of histamine H-3 receptors stably expressed in SK-N-MC cells: Display of agonism and inverse agonism by H-3 antagonists, J PHARM EXP, 299(3), 2001, pp. 908-914
Development of a pharmacophore model for histamine H-3 receptor antagonists, using the newly developed molecular modeling program SLATE
Authors: De Esch, IJP Mills, JEJ Perkins, TDJ Romeo, G Hoffmann, M Wieland, K Leurs, R Menge, WMPB Nederkoorn, PHJ Dean, PM Timmerman, H
Citation: Ijp. De Esch et al., Development of a pharmacophore model for histamine H-3 receptor antagonists, using the newly developed molecular modeling program SLATE, J MED CHEM, 44(11), 2001, pp. 1666-1674
Constitutive signaling of the human cytomegalovirus-encoded chemokine receptor US28
Authors: Casarosa, P Bakker, RA Verzijl, D Navis, M Timmerman, H Leurs, R Smit, MJ
Citation: P. Casarosa et al., Constitutive signaling of the human cytomegalovirus-encoded chemokine receptor US28, J BIOL CHEM, 276(2), 2001, pp. 1133-1137
Proper receptor signalling in a mutant catfish gonadotropin-releasing hormone receptor lacking the highly conserved Asp(90) residue
Authors: Blomenrohr, M Kuhne, R Hund, E Leurs, R Bogerd, J ter Laak, T
Citation: M. Blomenrohr et al., Proper receptor signalling in a mutant catfish gonadotropin-releasing hormone receptor lacking the highly conserved Asp(90) residue, FEBS LETTER, 501(2-3), 2001, pp. 131-134
Recombinant Semliki Forest virus for over-expression and pharmacological characterisation of the histamine H-2 receptor in mammalian cells
Authors: Hoffmann, M Verzijl, D Lundstrom, K Simmen, U Alewijnse, AE Timmerman, H Leurs, R
Citation: M. Hoffmann et al., Recombinant Semliki Forest virus for over-expression and pharmacological characterisation of the histamine H-2 receptor in mammalian cells, EUR J PHARM, 427(2), 2001, pp. 105-114
H-3 receptor gene is cloned at last
Authors: Leurs, R Hoffmann, M Wieland, K Timmerman, H
Citation: R. Leurs et al., H-3 receptor gene is cloned at last, TRENDS PHAR, 21(1), 2000, pp. 11-12
The role of the state in enabling private sector development: An assessment methodology
Authors: Leurs, R
Citation: R. Leurs, The role of the state in enabling private sector development: An assessment methodology, PUBL ADM D, 20(1), 2000, pp. 43-59
Antinociceptive activity of derivatives of improgran and burimamide
Authors: Hough, LB Nalwalk, JW Leurs, R Menge, WMPB Timmerman, H
Citation: Lb. Hough et al., Antinociceptive activity of derivatives of improgran and burimamide, PHARM BIO B, 65(1), 2000, pp. 61-66
Characterization of histamine H-3 receptors in mouse brain using the H-3 antagonist [I-125]iodophenpropit
Authors: Jansen, FP Mochizuki, T Maeyama, K Leurs, R Timmerman, H
Citation: Fp. Jansen et al., Characterization of histamine H-3 receptors in mouse brain using the H-3 antagonist [I-125]iodophenpropit, N-S ARCH PH, 362(1), 2000, pp. 60-67
The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H-2 receptor
Authors: Alewijnse, AE Timmerman, H Jacobs, EH Smit, MJ Roovers, E Cotecchia, S Leurs, R
Citation: Ae. Alewijnse et al., The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H-2 receptor, MOLEC PHARM, 57(5), 2000, pp. 890-898
Pivotal role for the cytoplasmic carboxyl-terminal tail of a nonmammalian gonadotropin-releasing hormone receptor in cell surface expression, ligand binding, and receptor phosphorylation and internalization. (vol 56, pg 1229, 1999)
Authors: Blomenrohr, M Heding, A Sellar, R Leurs, R Bogerd, J Eidne, KA Willars, GB
Citation: M. Blomenrohr et al., Pivotal role for the cytoplasmic carboxyl-terminal tail of a nonmammalian gonadotropin-releasing hormone receptor in cell surface expression, ligand binding, and receptor phosphorylation and internalization. (vol 56, pg 1229, 1999), MOLEC PHARM, 57(1), 2000, pp. 211-211
Characterization of the binding site of the histamine H-3 receptor. 2. Synthesis, in vitro pharmacology, and QSAR of a series of monosubstituted benzyl analogues of thioperamide
Authors: Windhorst, AD Timmerman, H Worthington, EA Bijloo, GJ Nederkoorn, PHJ Menge, WMPB Leurs, R Herscheid, JDM
Citation: Ad. Windhorst et al., Characterization of the binding site of the histamine H-3 receptor. 2. Synthesis, in vitro pharmacology, and QSAR of a series of monosubstituted benzyl analogues of thioperamide, J MED CHEM, 43(9), 2000, pp. 1754-1761
Constitutive activity of the histamine H-1 receptor reveals inverse agonism of histamine H-1 receptor antagonists
Authors: Bakker, RA Wieland, K Timmerman, H Leurs, R
Citation: Ra. Bakker et al., Constitutive activity of the histamine H-1 receptor reveals inverse agonism of histamine H-1 receptor antagonists, EUR J PHARM, 387(1), 2000, pp. R5-R7
Modulation of histamine H-2 receptor signalling by G-protein-coupled receptor kinase 2 and 3
Authors: Rodriguez-Pena, MS Timmerman, H Leurs, R
Citation: Ms. Rodriguez-pena et al., Modulation of histamine H-2 receptor signalling by G-protein-coupled receptor kinase 2 and 3, BR J PHARM, 131(8), 2000, pp. 1707-1715
Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice
Authors: Hough, LB Nalwalk, JW Chen, Y Schuller, A Zhu, Y Zhang, J Menge, WMPB Leurs, R Timmerman, H Pintar, JE
Citation: Lb. Hough et al., Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice, BRAIN RES, 880(1-2), 2000, pp. 102-108
Radiosynthesis and biodistribution of I-123-labeled antagonists of the histamine H-3 receptor as potential SPECT ligands
Authors: Windhorst, AD Timmerman, H Klok, RP Custers, FGJ Menge, WMPB Leurs, R Stark, H Schunack, W Gielen, EGJ van Kroonenburgh, MJPG Herscheid, JDM
Citation: Ad. Windhorst et al., Radiosynthesis and biodistribution of I-123-labeled antagonists of the histamine H-3 receptor as potential SPECT ligands, NUCL MED BI, 26(6), 1999, pp. 651-659
Evaluation of [F-18]VUF 5000 as a potential PET ligand for brain imaging of the histamine H-3 receptor
Authors: Windhorst, AD Timmerman, H Klok, RP Menge, WMPB Leurs, R Herscheid, JDM
Citation: Ad. Windhorst et al., Evaluation of [F-18]VUF 5000 as a potential PET ligand for brain imaging of the histamine H-3 receptor, BIO MED CH, 7(9), 1999, pp. 1761-1767
Molecular properties and signalling pathways of the histamine H-1 receptor
Authors: Smit, MJ Hoffmann, M Timmerman, H Leurs, R
Citation: Mj. Smit et al., Molecular properties and signalling pathways of the histamine H-1 receptor, CLIN EXP AL, 29, 1999, pp. 19-28
Synthesis, in vitro pharmacology and radiosynthesis of N-(cis-4-fluoromethylcyclohexyl)-4-(1(H)-imidazol-4-yl)piperidine-1-thiocarbonamide (VUF 5000), a potential pet ligand for the histamine H-3 receptor.
Authors: Windhorst, AD Timmerman, H Menge, WMPB Leurs, R Herscheid, JDM
Citation: Ad. Windhorst et al., Synthesis, in vitro pharmacology and radiosynthesis of N-(cis-4-fluoromethylcyclohexyl)-4-(1(H)-imidazol-4-yl)piperidine-1-thiocarbonamide (VUF 5000), a potential pet ligand for the histamine H-3 receptor., J LABEL C R, 42(3), 1999, pp. 293-307
Platelet adenylyl cyclase activity as a biochemical trait marker for predisposition to alcoholism
Authors: Ratsma, JE Gunning, WB Leurs, R Schoffelmeer, ANM
Citation: Je. Ratsma et al., Platelet adenylyl cyclase activity as a biochemical trait marker for predisposition to alcoholism, ALC CLIN EX, 23(4), 1999, pp. 600-604
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