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Results: 1-17 |
Results: 17
Effects of the (-)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene on DNA adduct formation and cell cycle arrest in human diploid fibroblasts
Authors: Mahadevan, B Luch, A Seidel, A Pelling, JC Baird, WM
Citation: B. Mahadevan et al., Effects of the (-)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene on DNA adduct formation and cell cycle arrest in human diploid fibroblasts, CARCINOGENE, 22(1), 2001, pp. 161-169
Chemically induced cancers and genetic differences in sensitivity
Authors: Luch, A
Citation: A. Luch, Chemically induced cancers and genetic differences in sensitivity, CHEM UNSER, 35(5), 2001, pp. 294-305
Metabolic activation of dibenzo[a,l]pyrene by cytochrome P450 enzymes to stable DNA adducts occurs exclusively through the formation of the (-)-trans-(11R,12R)-diol
Authors: Luch, A Schober, W Greim, H Doehmer, J Jacob, J Seidel, A Baird, WM
Citation: A. Luch et al., Metabolic activation of dibenzo[a,l]pyrene by cytochrome P450 enzymes to stable DNA adducts occurs exclusively through the formation of the (-)-trans-(11R,12R)-diol, POLYCYCL AR, 21(1-4), 2000, pp. 87-98
Species-dependent metabolism of benzo[c]chrysene mediated by C-DNA-expressed human, rodent and fish cytochrome P450 enzymes
Authors: Jacob, J Raab, G Schober, W Frank, H Luch, A Doehmer, J Seidel, A
Citation: J. Jacob et al., Species-dependent metabolism of benzo[c]chrysene mediated by C-DNA-expressed human, rodent and fish cytochrome P450 enzymes, POLYCYCL AR, 21(1-4), 2000, pp. 109-121
Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures
Authors: Melendez-Colon, VJ Luch, A Seidel, A Baird, WM
Citation: Vj. Melendez-colon et al., Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures, CHEM RES T, 13(1), 2000, pp. 10-17
DNA modification induced after metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in V79 Chinese hamster cells stably expressing singlecytochromes P450
Authors: Luch, A Coffing, SL Seidel, A Greim, H Baird, WM Doehmer, J
Citation: A. Luch et al., DNA modification induced after metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in V79 Chinese hamster cells stably expressing singlecytochromes P450, POLYCYCL AR, 16(1-4), 1999, pp. 71-78
Relationship of dibenzo[a,l]pyrene-DNA binding to the induction of p53, p21(WAF1) and cell cycle arrest in human cells in culture
Authors: Baird, WM Kaspin, LC Kudla, K Seidel, A Greim, H Luch, A
Citation: Wm. Baird et al., Relationship of dibenzo[a,l]pyrene-DNA binding to the induction of p53, p21(WAF1) and cell cycle arrest in human cells in culture, POLYCYCL AR, 16(1-4), 1999, pp. 119-129
Species-dependent metabolism of benzo[c]phenanthrene and dibenzo[a,l]pyrene by various CYP450 isoforms
Authors: Jacob, J Raab, G Soballa, VJ Luch, A Grimmer, G Greim, H Doehmer, J Morrison, HG Stegeman, JJ Seidel, A
Citation: J. Jacob et al., Species-dependent metabolism of benzo[c]phenanthrene and dibenzo[a,l]pyrene by various CYP450 isoforms, POLYCYCL AR, 16(1-4), 1999, pp. 191-203
The establishment of the V79 cell battery and its application in toxicology and pharmacology
Authors: Doehmer, J Krebsfanger, N Schober, W Luch, A Buters, JTM
Citation: J. Doehmer et al., The establishment of the V79 cell battery and its application in toxicology and pharmacology, ALTEX-AL TI, 16(3), 1999, pp. 180-181
Structure elucidation of the adducts formed by fjord-region dibenzo[a,l]pyrene 11,12-dihydrodiol 13,14-epoxides and deoxyadenosine
Authors: Li, KM George, M Gross, ML Seidel, A Luch, A Rogan, EG Cavalieri, EL
Citation: Km. Li et al., Structure elucidation of the adducts formed by fjord-region dibenzo[a,l]pyrene 11,12-dihydrodiol 13,14-epoxides and deoxyadenosine, CHEM RES T, 12(9), 1999, pp. 758-767
Metabolic activation of dibenzo[a,l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells
Authors: Luch, A Schober, W Soballa, VJ Raab, G Greim, H Jacob, J Doehmer, J Seidel, A
Citation: A. Luch et al., Metabolic activation of dibenzo[a,l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells, CHEM RES T, 12(4), 1999, pp. 353-364
Molecular studies on the toxifying effects by genetically engineered cytochromes P450
Authors: Doehmer, J Buters, JTM Luch, A Soballa, V Baird, WM Morisson, H Stegeman, JJ Townsend, AJ Greenlee, WF Glatt, HR Seidel, A Jacob, J Greim, H
Citation: J. Doehmer et al., Molecular studies on the toxifying effects by genetically engineered cytochromes P450, DRUG METAB, 31(2), 1999, pp. 423-435
Tumor-initiating activity of the (+)-(S,S)- and (-)-(R,R)-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene in mouse skin
Authors: Luch, A Friesel, H Seidel, A Platt, KL
Citation: A. Luch et al., Tumor-initiating activity of the (+)-(S,S)- and (-)-(R,R)-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene in mouse skin, CANCER LETT, 136(2), 1999, pp. 119-128
The level of DNA modification by (+)-syn-(11S,12R,13S,14R)- and (-)-anti-(11R,12S,13S,14R)-dihydrodiol epoxides of dibenzo[a,l]pyrene determined the effect on the proteins p53 and p21(WAF1) in the human mammary carcinoma cell line MCF-7
Authors: Luch, A Kudla, K Seidel, A Doehmer, J Greim, H Baird, WM
Citation: A. Luch et al., The level of DNA modification by (+)-syn-(11S,12R,13S,14R)- and (-)-anti-(11R,12S,13S,14R)-dihydrodiol epoxides of dibenzo[a,l]pyrene determined the effect on the proteins p53 and p21(WAF1) in the human mammary carcinoma cell line MCF-7, CARCINOGENE, 20(5), 1999, pp. 859-865
Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites
Authors: Melendez-Colon, VJ Luch, A Seidel, A Baird, WM
Citation: Vj. Melendez-colon et al., Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites, CARCINOGENE, 20(10), 1999, pp. 1885-1891
Comparison of cytochrome P450- and peroxidase-dependent metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in human cell lines: Formation of stable DNA adducts and absence of a detectable increase in apurinic sites
Authors: Melendez-Colon, VJ Luch, A Seidel, A Baird, WM
Citation: Vj. Melendez-colon et al., Comparison of cytochrome P450- and peroxidase-dependent metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in human cell lines: Formation of stable DNA adducts and absence of a detectable increase in apurinic sites, CANCER RES, 59(7), 1999, pp. 1412-1416
The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a,l]pyrene to DNA-binding metabolites by human cytochrome P450 1A1 or 1B1
Authors: Luch, A Kishiyama, S Seidel, A Doehmer, J Greim, H Baird, WM
Citation: A. Luch et al., The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a,l]pyrene to DNA-binding metabolites by human cytochrome P450 1A1 or 1B1, CANCER RES, 59(18), 1999, pp. 4603-4609
Risultati: 1-17 |