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Results: 1-21 |
Results: 21
3-PYRIDYLETHANOLAMINES - POTENT AND SELECTIVE HUMAN BETA(3) ADRENERGIC-RECEPTOR AGONISTS
Authors: NAYLOR EM COLANDREA VJ CANDELORE MR CASCIERI MA COLWELL LF DENG LP FEENEY WP FORREST MJ HOM GJ MACINTYRE DE STRADER CD TOTA L WANG PR WYVRATT MJ FISHER MH WEBER AE
Citation: Em. Naylor et al., 3-PYRIDYLETHANOLAMINES - POTENT AND SELECTIVE HUMAN BETA(3) ADRENERGIC-RECEPTOR AGONISTS, Bioorganic & medicinal chemistry letters, 8(21), 1998, pp. 3087-3092
3-PYRIDYLOXYPROPANOLAMINE AGONISTS OF THE BETA(3) ADRENERGIC-RECEPTORWITH IMPROVED PHARMACOKINETIC PROPERTIES
Authors: WEBER AE OK HO ALVARO RF CANDELORE MR CASCIERI MA CHIU SHL DENG LP FORREST MJ HOM GJ HUTCHINS JE KAO J MACINTYRE DE MATHVINK RJ MCLOUGHLIN D MILLER RR NEWBOLD RC OLAH TV PARMEE ER PERKINS L STEARNS RA STRADER CD SZUMILOSKI J TANG YS TOTA L VICARIO PP WYVRATT MJ FISHER MH
Citation: Ae. Weber et al., 3-PYRIDYLOXYPROPANOLAMINE AGONISTS OF THE BETA(3) ADRENERGIC-RECEPTORWITH IMPROVED PHARMACOKINETIC PROPERTIES, Bioorganic & medicinal chemistry letters, 8(16), 1998, pp. 2111-2116
DESENSITIZATION OF BETA(3)-ADRENERGIC RECEPTOR-STIMULATED ADENYLYL-CYCLASE ACTIVITY AND LIPOLYSIS IN RATS
Authors: VICARIO PP CANDELORE MR SCHAEFFER MT KELLY L THOMPSON GM BRADY EJ SAPERSTEIN R MACINTYRE DE TOTA LM CASCIERI MA
Citation: Pp. Vicario et al., DESENSITIZATION OF BETA(3)-ADRENERGIC RECEPTOR-STIMULATED ADENYLYL-CYCLASE ACTIVITY AND LIPOLYSIS IN RATS, Life sciences, 62(7), 1998, pp. 627-638
BETA-3 ADRENERGIC-RECEPTOR AGONISTS CAUSE AN INCREASE IN GASTROINTESTINAL TRANSIT-TIME IN WILD-TYPE MICE, BUT NOT IN MICE LACKING THE BETA-3 ADRENERGIC-RECEPTOR
Authors: FLETCHER DS CANDELORE MR GRUJIC D LOWELL BB LUELL S SUSULIC VS MACINTYRE DE
Citation: Ds. Fletcher et al., BETA-3 ADRENERGIC-RECEPTOR AGONISTS CAUSE AN INCREASE IN GASTROINTESTINAL TRANSIT-TIME IN WILD-TYPE MICE, BUT NOT IN MICE LACKING THE BETA-3 ADRENERGIC-RECEPTOR, The Journal of pharmacology and experimental therapeutics, 287(2), 1998, pp. 720-724
STRUCTURAL OPTIMIZATION AFFORDING ENYL-4-(3-OXO-1,2,4-TRIAZOL-5-YL)METHYLMORPHOLINE, A POTENT, ORALLY-ACTIVE, LONG-ACTING MORPHOLINE ACETALHUMAN NK-1 RECEPTOR ANTAGONIST
Authors: HALE JJ MILLS SG MACCOSS M FINKE PE CASCIERI MA SADOWSKI S BER E CHICCHI GG KURTZ M METZGER J EIERMANN G TSOU NN TATTERSALL FD RUPNIAK NMJ WILLIAMS AR RYCROFT W HARGREAVES R MACINTYRE DE
Citation: Jj. Hale et al., STRUCTURAL OPTIMIZATION AFFORDING ENYL-4-(3-OXO-1,2,4-TRIAZOL-5-YL)METHYLMORPHOLINE, A POTENT, ORALLY-ACTIVE, LONG-ACTING MORPHOLINE ACETALHUMAN NK-1 RECEPTOR ANTAGONIST, Journal of medicinal chemistry, 41(23), 1998, pp. 4607-4614
4,4-DISUBSTITUTED PIPERIDINE HIGH-AFFINITY NK1 ANTAGONISTS - STRUCTURE-ACTIVITY-RELATIONSHIPS AND IN-VIVO ACTIVITY
Authors: STEVENSON GI HUSCROFT I MACLEOD AM SWAIN CJ CASCIERI MA CHICCHI GG GRAHAM MI HARRISON T KELLEHER FJ KURTZ M LADDUWAHETTY T MERCHANT KJ METZGER JM MACINTYRE DE SADOWSKI S SOHAL B OWENS AP
Citation: Gi. Stevenson et al., 4,4-DISUBSTITUTED PIPERIDINE HIGH-AFFINITY NK1 ANTAGONISTS - STRUCTURE-ACTIVITY-RELATIONSHIPS AND IN-VIVO ACTIVITY, Journal of medicinal chemistry, 41(23), 1998, pp. 4623-4635
A SELECTIVE HUMAN BETA(3) ADRENERGIC-RECEPTOR AGONIST INCREASES METABOLIC-RATE IN RHESUS-MONKEYS
Authors: FISHER MH AMEND AM BACH TJ BARKER JM BRADY EJ CANDELORE MR CARROLL D CASCIERI MA CHIU SHL DENG LP FORREST MJ HEGARTYFRISCINO B GUAN XM HOM GJ HUTCHINS JE KELLY LJ MATHVINK RJ METZGER JM MILLER RR OK HO PARMEE ER SAPERSTEIN R STRADER CD STEARNS RA THOMPSON GM TOTA L VICARIO PP WEBER AE WOODS JW WYVRATT MJ ZAFIAN PT MACINTYRE DE
Citation: Mh. Fisher et al., A SELECTIVE HUMAN BETA(3) ADRENERGIC-RECEPTOR AGONIST INCREASES METABOLIC-RATE IN RHESUS-MONKEYS, The Journal of clinical investigation, 101(11), 1998, pp. 2387-2393
AN NK1 RECEPTOR ANTAGONIST AFFECTS THE CIRCADIAN REGULATION OF LOCOMOTOR-ACTIVITY IN GOLDEN-HAMSTERS
Authors: CHALLET E NAYLOR E METZGER JM MACINTYRE DE TUREK FW
Citation: E. Challet et al., AN NK1 RECEPTOR ANTAGONIST AFFECTS THE CIRCADIAN REGULATION OF LOCOMOTOR-ACTIVITY IN GOLDEN-HAMSTERS, Brain research, 800(1), 1998, pp. 32-39
MOLECULAR APPROACHES TO THE DISCOVERY OF NEW TREATMENTS FOR OBESITY
Authors: STRADER CD MACINTYRE DE CANDELORE MR PARKER EM
Citation: Cd. Strader et al., MOLECULAR APPROACHES TO THE DISCOVERY OF NEW TREATMENTS FOR OBESITY, CURRENT OPINION IN CHEMICAL BIOLOGY, 1(2), 1997, pp. 204-209
3-BENZYLOXY-2-PHENYLPIPERIDINE NK1 ANTAGONISTS - THE INFLUENCE OF ALPHA-METHYL SUBSTITUTION
Authors: SWAIN CJ WILLIAMS BJ BAKER R CASCIERI MA CHICCHI G FORREST M HERBERT R KEOWN L LADDUWAHETTY T LUELL S MACINTYRE DE METZGER J MORTON S OWENS AP SADOWSKI S WATT AP
Citation: Cj. Swain et al., 3-BENZYLOXY-2-PHENYLPIPERIDINE NK1 ANTAGONISTS - THE INFLUENCE OF ALPHA-METHYL SUBSTITUTION, Bioorganic & medicinal chemistry letters, 7(23), 1997, pp. 2959-2962
TACHYKININ NK1 RECEPTOR ANTAGONISTS ACT CENTRALLY TO INHIBIT EMESIS INDUCED BY THE CHEMOTHERAPEUTIC AGENT CISPLATIN IN FERRETS
Authors: TATTERSALL FD RYCROFT W FRANCIS B PEARCE D MERCHANT K MACLEOD AM LADDUWAHETTY T KEOWN L SWAIN C BAKER R CASCIERI M BER E METZGER J MACINTYRE DE HILL RG HARGREAVES RJ
Citation: Fd. Tattersall et al., TACHYKININ NK1 RECEPTOR ANTAGONISTS ACT CENTRALLY TO INHIBIT EMESIS INDUCED BY THE CHEMOTHERAPEUTIC AGENT CISPLATIN IN FERRETS, Neuropharmacology, 35(8), 1996, pp. 1121-1129
NYL-4-((3-OXO-1,2,4-TRIAZOL-5-YL)METHYL)MORPHOLINE .1. A POTENT, ORALLY-ACTIVE, MORPHOLINE-BASED HUMAN NEUROKININ-1 RECEPTOR ANTAGONIST
Authors: HALE JJ MILLS SG MACCOSS M SHAH SK QI HB MATHRE DJ CASCIERI MA SADOWSKI S STRADER CD MACINTYRE DE METZGER JM
Citation: Jj. Hale et al., NYL-4-((3-OXO-1,2,4-TRIAZOL-5-YL)METHYL)MORPHOLINE .1. A POTENT, ORALLY-ACTIVE, MORPHOLINE-BASED HUMAN NEUROKININ-1 RECEPTOR ANTAGONIST, Journal of medicinal chemistry, 39(9), 1996, pp. 1760-1762
N-HETEROARYL-2-PHENYL-3-(BENZYLOXY)PIPERIDINES - A NOVEL CLASS OF POTENT ORALLY-ACTIVE HUMAN NK1 ANTAGONISTS
Authors: LADDUWAHETTY T BAKER R CASCIERI MA CHAMBERS MS HAWORTH K KEOWN LE MACINTYRE DE METZGER JM OWEN S RYCROFT W SADOWSKI S SEWARD EM SHEPHEARD SL SWAIN CJ TATTERSALL FD WATT AP WILLIAMSON DW HARGREAVES RJ
Citation: T. Ladduwahetty et al., N-HETEROARYL-2-PHENYL-3-(BENZYLOXY)PIPERIDINES - A NOVEL CLASS OF POTENT ORALLY-ACTIVE HUMAN NK1 ANTAGONISTS, Journal of medicinal chemistry, 39(15), 1996, pp. 2907-2914
A SYNTHETIC INHIBITOR OF INTERLEUKIN-1-BETA CONVERTING-ENZYME PREVENTS ENDOTOXIN-INDUCED INTERLEUKIN-1-BETA PRODUCTION IN-VITRO AND IN-VIVO
Authors: FLETCHER DS AGARWAL L CHAPMAN KT CHIN J EGGER LA LIMJUCO G LUELL S MACINTYRE DE PETERSON EP THORNBERRY NA KOSTURA MJ
Citation: Ds. Fletcher et al., A SYNTHETIC INHIBITOR OF INTERLEUKIN-1-BETA CONVERTING-ENZYME PREVENTS ENDOTOXIN-INDUCED INTERLEUKIN-1-BETA PRODUCTION IN-VITRO AND IN-VIVO, Journal of interferon & cytokine research, 15(3), 1995, pp. 243-248
LIPOPOLYSACCHARIDE-INDUCED HYPOTENSION AND VASCULAR HYPOREACTIVITY INTHE RAT - TISSUE-ANALYSIS OF NITRIC-OXIDE SYNTHASE MESSENGER-RNA AND PROTEIN EXPRESSION IN THE PRESENCE AND ABSENCE OF DEXAMETHASONE, N-G-MONOMETHYL-L-ARGININE OR INDOMETHACIN
Authors: HOM GJ GRANT SK WOLFE G BACH TJ MACINTYRE DE HUTCHINSON NI
Citation: Gj. Hom et al., LIPOPOLYSACCHARIDE-INDUCED HYPOTENSION AND VASCULAR HYPOREACTIVITY INTHE RAT - TISSUE-ANALYSIS OF NITRIC-OXIDE SYNTHASE MESSENGER-RNA AND PROTEIN EXPRESSION IN THE PRESENCE AND ABSENCE OF DEXAMETHASONE, N-G-MONOMETHYL-L-ARGININE OR INDOMETHACIN, The Journal of pharmacology and experimental therapeutics, 272(1), 1995, pp. 452-459
SYNTHESIS AND BIOLOGICAL EVALUATION OF NK1 ANTAGONISTS DERIVED FROM L-TRYPTOPHAN
Authors: MACLEOD AM CASCIERI MA MERCHANT KJ SADOWSKI S HARDWICKE S LEWIS RT MACINTYRE DE METZGER JM FONG TM SHEPHEARD S TATTERSALL FD HARGREAVES R BAKER R
Citation: Am. Macleod et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF NK1 ANTAGONISTS DERIVED FROM L-TRYPTOPHAN, Journal of medicinal chemistry, 38(6), 1995, pp. 934-941
IDENTIFICATION OF A SERIES OF 3-(BENZYLOXY)-1-AZABICYCLO[2.2.2]OCTANEHUMAN NK1 ANTAGONISTS
Authors: SWAIN CJ SEWARD EM CASCIERI MA FONG TM HERBERT R MACINTYRE DE MERCHANT KJ OWEN SN OWENS AP SABIN V TEALL M VANNIEL MB WILLIAMS BJ SADOWSKI S STRADER C BALL RG BAKER R
Citation: Cj. Swain et al., IDENTIFICATION OF A SERIES OF 3-(BENZYLOXY)-1-AZABICYCLO[2.2.2]OCTANEHUMAN NK1 ANTAGONISTS, Journal of medicinal chemistry, 38(24), 1995, pp. 4793-4805
IDENTIFICATION OF L-TRYPTOPHAN DERIVATIVES WITH POTENT AND SELECTIVE ANTAGONIST ACTIVITY AT THE NK1 RECEPTOR
Authors: MACLEOD M MERCHANT KJ BROOKFIELD F KELLEHER F STEVENSON G OWENS AP SWAIN CJ BAKER R CASCIERI MA SADOWSKI S BER E STRADER CD MACINTYRE DE METZGER JM BALL RG
Citation: M. Macleod et al., IDENTIFICATION OF L-TRYPTOPHAN DERIVATIVES WITH POTENT AND SELECTIVE ANTAGONIST ACTIVITY AT THE NK1 RECEPTOR, Journal of medicinal chemistry, 37(9), 1994, pp. 1269-1274
MK 287 - A POTENT, SPECIFIC, AND ORALLY-ACTIVE RECEPTOR ANTAGONIST OFPLATELET-ACTIVATING-FACTOR
Authors: HWANG SB LAM MH SZALKOWSKI DM MACINTYRE DE BACH TJ LUELL S MEUER R SAHOO SP ALBERTS AW CHABALA JC
Citation: Sb. Hwang et al., MK 287 - A POTENT, SPECIFIC, AND ORALLY-ACTIVE RECEPTOR ANTAGONIST OFPLATELET-ACTIVATING-FACTOR, Journal of lipid mediators, 7(2), 1993, pp. 115-134
FORMATION OF EOSINOPHILIC AND MONOCYTIC INTRADERMAL INFLAMMATORY SITES IN THE DOG BY INJECTION OF HUMAN RANTES BUT NOT HUMAN MONOCYTE CHEMOATTRACTANT PROTEIN-1, HUMAN MACROPHAGE INFLAMMATORY PROTEIN 1-ALPHA, OR HUMAN INTERLEUKIN-8
Authors: MEURER R VANRIPER G FEENEY W CUNNINGHAM P HORA D SPRINGER MS MACINTYRE DE ROSEN H
Citation: R. Meurer et al., FORMATION OF EOSINOPHILIC AND MONOCYTIC INTRADERMAL INFLAMMATORY SITES IN THE DOG BY INJECTION OF HUMAN RANTES BUT NOT HUMAN MONOCYTE CHEMOATTRACTANT PROTEIN-1, HUMAN MACROPHAGE INFLAMMATORY PROTEIN 1-ALPHA, OR HUMAN INTERLEUKIN-8, The Journal of experimental medicine, 178(6), 1993, pp. 1913-1921
THE USE OF ENZYME-COATED BEADS TO MONITOR INHIBITION OF HUMAN-LEUKOCYTE ELASTASE IN THE LARGE AIRWAYS OF THE RAT BY ORALLY-ADMINISTERED MONOCYCLIC BETA-LACTAMS
Authors: PETERSON LB WILLIAMS D METZGER J GREEN B KNIGHT WB MACINTYRE DE
Citation: Lb. Peterson et al., THE USE OF ENZYME-COATED BEADS TO MONITOR INHIBITION OF HUMAN-LEUKOCYTE ELASTASE IN THE LARGE AIRWAYS OF THE RAT BY ORALLY-ADMINISTERED MONOCYCLIC BETA-LACTAMS, The American review of respiratory disease, 147(4), 1993, pp. 75-75
Risultati: 1-21 |