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Results: 1-11 |
Results: 11
THE STRUCTURE OF MAMMALIAN HEXOKINASE-1
Authors: MULICHAK AM WILSON JE PADMANABHAN K GARAVITO RM
Citation: Am. Mulichak et al., THE STRUCTURE OF MAMMALIAN HEXOKINASE-1, Nature structural biology, 5(7), 1998, pp. 555-560
IDENTIFICATION AND SAR FOR A SELECTIVE, NONPEPTIDYL THROMBIN INHIBITOR
Authors: NAYLOROLSEN AM PONTICELLO GS LEWIS SD MULICHAK AM CHEN ZG HABECKER CN PHILLIPS BT SANDERS WM TUCKER TJ SHAFER JA VACCA JP
Citation: Am. Naylorolsen et al., IDENTIFICATION AND SAR FOR A SELECTIVE, NONPEPTIDYL THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 8(13), 1998, pp. 1697-1702
L-373,890, AN ACHIRAL, NONCOVALENT, SUBNANOMOLAR THROMBIN INHIBITOR
Authors: SANDERSON PEJ DYER DL NAYLOROLSEN AM VACCA JP GARDELL SJ LEWIS SD LUCAS BJ LYLE EA LYNCH JJ MULICHAK AM
Citation: Pej. Sanderson et al., L-373,890, AN ACHIRAL, NONCOVALENT, SUBNANOMOLAR THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 7(12), 1997, pp. 1497-1500
SYNTHESIS, EVALUATION, AND CRYSTALLOGRAPHIC ANALYSIS OF L-371,912 - APOTENT AND SELECTIVE ACTIVE-SITE THROMBIN INHIBITOR
Authors: LYLE TA CHEN ZG APPLEBY SD FREIDINGER RM GARDELL SJ LEWIS SD LI Y LYLE EA LYNCH JJ MULICHAK AM NG AS NAYLOROLSEN AM SANDERS WM
Citation: Ta. Lyle et al., SYNTHESIS, EVALUATION, AND CRYSTALLOGRAPHIC ANALYSIS OF L-371,912 - APOTENT AND SELECTIVE ACTIVE-SITE THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 7(1), 1997, pp. 67-72
DESIGN OF HIGHLY POTENT NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE A NOVEL LIPOPHILIC BINDING POCKET IN THE THROMBIN ACTIVE-SITE
Authors: TUCKER TJ LUMMA WC MULICHAK AM CHEN ZG NAYLOROLSEN AM LEWIS SD LUCAS R FREIDINGER RM KUO LC
Citation: Tj. Tucker et al., DESIGN OF HIGHLY POTENT NONCOVALENT THROMBIN INHIBITORS THAT UTILIZE A NOVEL LIPOPHILIC BINDING POCKET IN THE THROMBIN ACTIVE-SITE, Journal of medicinal chemistry, 40(6), 1997, pp. 830-832
DISCOVERY OF A NOVEL, SELECTIVE, AND ORALLY BIOAVAILABLE CLASS OF THROMBIN INHIBITORS INCORPORATING AMINOPYRIDYL MOIETIES AT THE P1 POSITION
Authors: FENG DM GARDELL SJ LEWIS SD BOCK MG CHEN ZG FREIDINGER RM NAYLOROLSEN AM RAMJIT HG WOLTMANN R BASKIN EP LYNCH JJ LUCAS R SHAFER JA DANCHECK KB CHEN IW MAO SS KRUEGER JA HARE TR MULICHAK AM VACCA JP
Citation: Dm. Feng et al., DISCOVERY OF A NOVEL, SELECTIVE, AND ORALLY BIOAVAILABLE CLASS OF THROMBIN INHIBITORS INCORPORATING AMINOPYRIDYL MOIETIES AT THE P1 POSITION, Journal of medicinal chemistry, 40(23), 1997, pp. 3726-3733
STRUCTURE-BASED DESIGN OF NOVEL HIV PROTEASE INHIBITORS - CARBOXAMIDE-CONTAINING 4-HYDROXYCOUMARINS AND 4-HYDROXY-2-PYRONES AS POTENT NONPEPTIDIC INHIBITORS
Authors: THAISRIVONGS S WATENPAUGH KD HOWE WJ TOMICH PK DOLAK LA CHONG KT TOMICH CSC TOMASSELLI AG TURNER SR STROHBACH JW MULICHAK AM JANAKIRAMAN MN MOON JB LYNN JC HORNG MM HINSHAW RR CURRY KA ROTHROCK DJ
Citation: S. Thaisrivongs et al., STRUCTURE-BASED DESIGN OF NOVEL HIV PROTEASE INHIBITORS - CARBOXAMIDE-CONTAINING 4-HYDROXYCOUMARINS AND 4-HYDROXY-2-PYRONES AS POTENT NONPEPTIDIC INHIBITORS, Journal of medicinal chemistry, 38(18), 1995, pp. 3624-3637
USE OF MEDIUM-SIZED CYCLOALKYL RINGS TO ENHANCE SECONDARY BINDING - DISCOVERY OF A NEW CLASS OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) PROTEASEINHIBITORS
Authors: ROMINES KR WATENPAUGH KD TOMICH PK HOWE WJ MORRIS JK LOVASZ KD MULICHAK AM FINZEL BC LYNN JC HORNG MM SCHWENDE FJ RUWART MJ ZIPP GL CHONG KT DOLAK LA TOTH LN HOWARD GM RUSH BD WILKINSON KF POSSERT PL DALGA RJ HINSHAW RR
Citation: Kr. Romines et al., USE OF MEDIUM-SIZED CYCLOALKYL RINGS TO ENHANCE SECONDARY BINDING - DISCOVERY OF A NEW CLASS OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) PROTEASEINHIBITORS, Journal of medicinal chemistry, 38(11), 1995, pp. 1884-1891
CRYSTAL-STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND P-AMIDINOPHENYLPYRUVATE AT 1.6 ANGSTROM RESOLUTION
Authors: CHEN ZG LI Y MULICHAK AM LEWIS SD SHAFER JA
Citation: Zg. Chen et al., CRYSTAL-STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND P-AMIDINOPHENYLPYRUVATE AT 1.6 ANGSTROM RESOLUTION, Archives of biochemistry and biophysics, 322(1), 1995, pp. 198-203
STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - 4-HYDROXYCOUMARINS AND 4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS
Authors: THAISRIVONGS S TOMICH PK WATENPAUGH KD CHONG KT HOWE WJ YANG CP STROHBACH JW TURNER SR MCGRATH JP BOHANON MJ LYNN JC MULICHAK AM SPINELLI PA HINSHAW RR PAGANO PJ MOON JB RUWART MJ WILKINSON KF RUSH BD ZIPP GL DALGA RJ SCHWENDE FJ HOWARD GM PADBURY GE TOTH LN ZHAO ZY KOEPLINGER KA KAKUK TJ COLE SL ZAYA RM PIPER RC JEFFREY P
Citation: S. Thaisrivongs et al., STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - 4-HYDROXYCOUMARINS AND 4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS, Journal of medicinal chemistry, 37(20), 1994, pp. 3200-3204
THE CRYSTALLOGRAPHIC STRUCTURE OF THE PROTEASE FROM HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 WITH 2 SYNTHETIC PEPTIDIC TRANSITION-STATE ANALOG INHIBITORS
Authors: MULICHAK AM HUI JO TOMASSELLI AG HEINRIKSON RL CURRY KA TOMICH CS THAISRIVONGS S SAWYER TK WATENPAUGH KD
Citation: Am. Mulichak et al., THE CRYSTALLOGRAPHIC STRUCTURE OF THE PROTEASE FROM HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 WITH 2 SYNTHETIC PEPTIDIC TRANSITION-STATE ANALOG INHIBITORS, The Journal of biological chemistry, 268(18), 1993, pp. 3103-3109
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