Authors:
Povey, AC
Hall, CN
Badawi, AF
Cooper, DP
Guppy, MJ
Jackson, PE
O'Connor, PJ
Margison, GP
Citation: Ac. Povey et al., Host determinants of DNA alkylation and DNA repair activity in human colorectal tissue: O-6-methylguanine levels are associated with GSTT1 genotype and O-6-alkylguanine-DNA alkyltransferase activity with CYP2D6 genotype, MUT RES-GTE, 495(1-2), 2001, pp. 103-115
Authors:
Pearson, J
Gill, A
Margison, GP
Vadgama, P
Povey, AC
Citation: J. Pearson et al., A rapid receptor-ligand assay determination of estrogens using surface plasmon resonance, SENS ACTU-B, 76(1-3), 2001, pp. 1-7
Authors:
Harrison, KL
Wood, M
Lees, NP
Hall, CN
Margison, GP
Povey, AC
Citation: Kl. Harrison et al., Development and application of a sensitive and rapid immunoassay for the quantitation of N7-methyldeoxyguanosine in DNA samples, CHEM RES T, 14(3), 2001, pp. 295-301
Authors:
Collis, SJ
Tighe, A
Scott, SD
Roberts, SA
Hendry, JH
Margison, GP
Citation: Sj. Collis et al., Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells, NUCL ACID R, 29(7), 2001, pp. 1534-1538
Authors:
Westerhof, GR
Down, JD
Blokland, I
Wood, M
Boudewijn, A
Watson, AJ
McGown, AT
Ploemacher, RE
Margison, GP
Citation: Gr. Westerhof et al., O-6-benzylguanine potentiates BCNU but not busulfan toxicity in hematopoietic stem cells, EXP HEMATOL, 29(5), 2001, pp. 633-638
Authors:
Kassem, HS
Varley, JM
Hamam, SM
Margison, GP
Citation: Hs. Kassem et al., Immunohistochemical analysis of expression and allelotype of mismatch repair genes (hMLH1 and hMSH2) in bladder cancer, BR J CANC, 84(3), 2001, pp. 321-328
Authors:
Farkasova, E
Chovanec, M
Vlasakova, D
Vlckova, V
Margison, GP
Brozmanova, J
Citation: E. Farkasova et al., Effect of stable integration of the Escherichia coli ada gene on the sensitivity of Saccharomyces cerevisiae to the toxic and mutagenic effects of alkylating agents, ENV MOL MUT, 35(1), 2000, pp. 66-69
Authors:
Jackson, PE
Cooper, DP
Meyer, TA
Wood, M
Povey, AC
Margison, GP
Citation: Pe. Jackson et al., Formation and persistence of O-6-methylguanine in the mouse colon following treatment with 1, 2-dimethylhydrazine as measured by an O-6-alkylguanine-DNA alkyltransferase inactivation assay, TOX LETT, 115(3), 2000, pp. 205-212
Authors:
Middleton, MR
Kelly, J
Goodger, S
Thatcher, N
Margison, GP
Citation: Mr. Middleton et al., Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts, CANC CHEMOT, 45(1), 2000, pp. 15-20
Authors:
Toft, NJ
Sanson, OJ
Brookes, RA
Arends, MJ
Wood, M
Margison, GP
Winton, DJ
Clarke, AR
Citation: Nj. Toft et al., In vivo administration of O-6-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but doesinhibit P450-dependent activation of dacarbazine, CARCINOGENE, 21(4), 2000, pp. 593-598
Authors:
Thompson, MJ
Abdul-Rahman, S
Baker, TG
Rafferty, JA
Margison, GP
Bibby, MC
Citation: Mj. Thompson et al., Role of O-6-alkylguanine-DNA alkyltransferase in the resistance of mouse spermatogenic cells to O-6-alkylating agents, J REPR FERT, 119(2), 2000, pp. 339-346
Authors:
D'Atri, S
Graziani, G
Lacal, PM
Nistico, V
Gilberti, S
Faraoni, I
Watson, AJ
Bonmassar, E
Margison, GP
Citation: S. D'Atri et al., Attenuation of O-6-methylguanine-DNA methyltransferase activity and mRNA levels by cisplatin and temozolomide in Jurkat cells, J PHARM EXP, 294(2), 2000, pp. 664-671
Authors:
Middleton, MR
Lee, SM
Arance, A
Wood, M
Thatcher, N
Margison, GP
Citation: Mr. Middleton et al., O-6-methylguanine formation, repair protein depletion and clinical outcomewith a 4 hr schedule of temozolomide in the treatment of advanced melanoma: Results of phase II study, INT J CANC, 88(3), 2000, pp. 469-473
Authors:
Middleton, MR
Kelly, J
Thatcher, N
Donnelly, DJ
McElhinney, RS
McMurry, TBH
McCormick, JE
Margison, GP
Citation: Mr. Middleton et al., O-6-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts, INT J CANC, 85(2), 2000, pp. 248-252
Authors:
Povey, AC
Hall, CN
Cooper, DP
O'Connor, PJ
Margison, GP
Citation: Ac. Povey et al., Determinants of O-6-alkylguanine-DNA alkyltransferase activity in normal and tumour tissue from human colon and rectum, INT J CANC, 85(1), 2000, pp. 68-72
Citation: Aj. Watson et Gp. Margison, Assays for the repair of oxidative damage by formamidopyrimidine glycosylase (Fpg) and 8-oxoguanine DNA glycosylase (OGG-1), METH MOL B, 152, 2000, pp. 17-32