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Results: 1-25 | 26-36
Results: 1-25/36
Host determinants of DNA alkylation and DNA repair activity in human colorectal tissue: O-6-methylguanine levels are associated with GSTT1 genotype and O-6-alkylguanine-DNA alkyltransferase activity with CYP2D6 genotype
Authors: Povey, AC Hall, CN Badawi, AF Cooper, DP Guppy, MJ Jackson, PE O'Connor, PJ Margison, GP
Citation: Ac. Povey et al., Host determinants of DNA alkylation and DNA repair activity in human colorectal tissue: O-6-methylguanine levels are associated with GSTT1 genotype and O-6-alkylguanine-DNA alkyltransferase activity with CYP2D6 genotype, MUT RES-GTE, 495(1-2), 2001, pp. 103-115
A rapid receptor-ligand assay determination of estrogens using surface plasmon resonance
Authors: Pearson, J Gill, A Margison, GP Vadgama, P Povey, AC
Citation: J. Pearson et al., A rapid receptor-ligand assay determination of estrogens using surface plasmon resonance, SENS ACTU-B, 76(1-3), 2001, pp. 1-7
Development and application of a sensitive and rapid immunoassay for the quantitation of N7-methyldeoxyguanosine in DNA samples
Authors: Harrison, KL Wood, M Lees, NP Hall, CN Margison, GP Povey, AC
Citation: Kl. Harrison et al., Development and application of a sensitive and rapid immunoassay for the quantitation of N7-methyldeoxyguanosine in DNA samples, CHEM RES T, 14(3), 2001, pp. 295-301
Ethanol modulates rat hepatic DNA repair functions
Authors: Navasumrit, P Margison, GP O'Connor, PJ
Citation: P. Navasumrit et al., Ethanol modulates rat hepatic DNA repair functions, ALC ALCOHOL, 36(5), 2001, pp. 369-376
Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells
Authors: Collis, SJ Tighe, A Scott, SD Roberts, SA Hendry, JH Margison, GP
Citation: Sj. Collis et al., Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells, NUCL ACID R, 29(7), 2001, pp. 1534-1538
O-6-benzylguanine potentiates BCNU but not busulfan toxicity in hematopoietic stem cells
Authors: Westerhof, GR Down, JD Blokland, I Wood, M Boudewijn, A Watson, AJ McGown, AT Ploemacher, RE Margison, GP
Citation: Gr. Westerhof et al., O-6-benzylguanine potentiates BCNU but not busulfan toxicity in hematopoietic stem cells, EXP HEMATOL, 29(5), 2001, pp. 633-638
Increased susceptibility to streptozotocin-induced beta-cell apoptosis anddelayed autoimmune diabetes in alkylpurine-DNA-N-glycosylase-deficient mice
Authors: Cardinal, JW Margison, GP Mynett, KJ Yates, AP Cameron, DP Elder, RH
Citation: Jw. Cardinal et al., Increased susceptibility to streptozotocin-induced beta-cell apoptosis anddelayed autoimmune diabetes in alkylpurine-DNA-N-glycosylase-deficient mice, MOL CELL B, 21(16), 2001, pp. 5605-5613
Immunohistochemical analysis of expression and allelotype of mismatch repair genes (hMLH1 and hMSH2) in bladder cancer
Authors: Kassem, HS Varley, JM Hamam, SM Margison, GP
Citation: Hs. Kassem et al., Immunohistochemical analysis of expression and allelotype of mismatch repair genes (hMLH1 and hMSH2) in bladder cancer, BR J CANC, 84(3), 2001, pp. 321-328
Anti-8-ore-2 '-deoxyguanosine phage antibodies: Isolation, characterization, and relationship to disease states
Authors: Seedhouse, CH Margison, GP Hendry, JH Hajeer, A Embleton, MJ
Citation: Ch. Seedhouse et al., Anti-8-ore-2 '-deoxyguanosine phage antibodies: Isolation, characterization, and relationship to disease states, BIOC BIOP R, 280(3), 2001, pp. 595-604
Development of synthetic promoters for radiation-mediated gene therapy
Authors: Marples, B Scott, SD Hendry, JH Embleton, MJ Lashford, LS Margison, GP
Citation: B. Marples et al., Development of synthetic promoters for radiation-mediated gene therapy, GENE THER, 7(6), 2000, pp. 511-517
A radiation-controlled molecular switch for use in gene therapy of cancer
Authors: Scott, SD Marples, B Hendry, JH Lashford, LS Embleton, MJ Hunter, RD Howell, A Margison, GP
Citation: Sd. Scott et al., A radiation-controlled molecular switch for use in gene therapy of cancer, GENE THER, 7(13), 2000, pp. 1121-1125
Effect of stable integration of the Escherichia coli ada gene on the sensitivity of Saccharomyces cerevisiae to the toxic and mutagenic effects of alkylating agents
Authors: Farkasova, E Chovanec, M Vlasakova, D Vlckova, V Margison, GP Brozmanova, J
Citation: E. Farkasova et al., Effect of stable integration of the Escherichia coli ada gene on the sensitivity of Saccharomyces cerevisiae to the toxic and mutagenic effects of alkylating agents, ENV MOL MUT, 35(1), 2000, pp. 66-69
Formation and persistence of O-6-methylguanine in the mouse colon following treatment with 1, 2-dimethylhydrazine as measured by an O-6-alkylguanine-DNA alkyltransferase inactivation assay
Authors: Jackson, PE Cooper, DP Meyer, TA Wood, M Povey, AC Margison, GP
Citation: Pe. Jackson et al., Formation and persistence of O-6-methylguanine in the mouse colon following treatment with 1, 2-dimethylhydrazine as measured by an O-6-alkylguanine-DNA alkyltransferase inactivation assay, TOX LETT, 115(3), 2000, pp. 205-212
Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts
Authors: Middleton, MR Kelly, J Goodger, S Thatcher, N Margison, GP
Citation: Mr. Middleton et al., Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts, CANC CHEMOT, 45(1), 2000, pp. 15-20
DNA repair: Kinetics and thresholds
Authors: O'Connor, PJ Manning, FCR Gordon, AT Billett, MA Cooper, DP Elder, RH Margison, GP
Citation: Pj. O'Connor et al., DNA repair: Kinetics and thresholds, TOX PATHOL, 28(3), 2000, pp. 375-381
In vivo administration of O-6-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but doesinhibit P450-dependent activation of dacarbazine
Authors: Toft, NJ Sanson, OJ Brookes, RA Arends, MJ Wood, M Margison, GP Winton, DJ Clarke, AR
Citation: Nj. Toft et al., In vivo administration of O-6-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but doesinhibit P450-dependent activation of dacarbazine, CARCINOGENE, 21(4), 2000, pp. 593-598
Role of O-6-alkylguanine-DNA alkyltransferase in the resistance of mouse spermatogenic cells to O-6-alkylating agents
Authors: Thompson, MJ Abdul-Rahman, S Baker, TG Rafferty, JA Margison, GP Bibby, MC
Citation: Mj. Thompson et al., Role of O-6-alkylguanine-DNA alkyltransferase in the resistance of mouse spermatogenic cells to O-6-alkylating agents, J REPR FERT, 119(2), 2000, pp. 339-346
Attenuation of O-6-methylguanine-DNA methyltransferase activity and mRNA levels by cisplatin and temozolomide in Jurkat cells
Authors: D'Atri, S Graziani, G Lacal, PM Nistico, V Gilberti, S Faraoni, I Watson, AJ Bonmassar, E Margison, GP
Citation: S. D'Atri et al., Attenuation of O-6-methylguanine-DNA methyltransferase activity and mRNA levels by cisplatin and temozolomide in Jurkat cells, J PHARM EXP, 294(2), 2000, pp. 664-671
O-6-methylguanine formation, repair protein depletion and clinical outcomewith a 4 hr schedule of temozolomide in the treatment of advanced melanoma: Results of phase II study
Authors: Middleton, MR Lee, SM Arance, A Wood, M Thatcher, N Margison, GP
Citation: Mr. Middleton et al., O-6-methylguanine formation, repair protein depletion and clinical outcomewith a 4 hr schedule of temozolomide in the treatment of advanced melanoma: Results of phase II study, INT J CANC, 88(3), 2000, pp. 469-473
O-6-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts
Authors: Middleton, MR Kelly, J Thatcher, N Donnelly, DJ McElhinney, RS McMurry, TBH McCormick, JE Margison, GP
Citation: Mr. Middleton et al., O-6-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts, INT J CANC, 85(2), 2000, pp. 248-252
Determinants of O-6-alkylguanine-DNA alkyltransferase activity in normal and tumour tissue from human colon and rectum
Authors: Povey, AC Hall, CN Cooper, DP O'Connor, PJ Margison, GP
Citation: Ac. Povey et al., Determinants of O-6-alkylguanine-DNA alkyltransferase activity in normal and tumour tissue from human colon and rectum, INT J CANC, 85(1), 2000, pp. 68-72
Expression of Ku70 correlates with survival in carcinoma of the cervix
Authors: Wilson, CR Davidson, SE Margison, GP Jackson, SP Hendry, JH West, CML
Citation: Cr. Wilson et al., Expression of Ku70 correlates with survival in carcinoma of the cervix, BR J CANC, 83(12), 2000, pp. 1702-1706
Fern spore extracts can damage DNA
Authors: Siman, SE Povey, AC Ward, TH Margison, GP Sheffield, E
Citation: Se. Siman et al., Fern spore extracts can damage DNA, BR J CANC, 83(1), 2000, pp. 69-73
Assays for the repair of oxidative damage by formamidopyrimidine glycosylase (Fpg) and 8-oxoguanine DNA glycosylase (OGG-1)
Authors: Watson, AJ Margison, GP
Citation: Aj. Watson et Gp. Margison, Assays for the repair of oxidative damage by formamidopyrimidine glycosylase (Fpg) and 8-oxoguanine DNA glycosylase (OGG-1), METH MOL B, 152, 2000, pp. 17-32
O-6-alkylguanine-DNA alkyltransferase assay
Authors: Watson, AJ Margison, GP
Citation: Aj. Watson et Gp. Margison, O-6-alkylguanine-DNA alkyltransferase assay, METH MOL B, 152, 2000, pp. 49-61
Risultati: 1-25 | 26-36