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Results: 26-50/51
Authors:
Kiefer, JR
Pawlitz, JL
Moreland, KT
Stegeman, RA
Hood, WF
Gierse, JK
Stevens, AM
Goodwin, DC
Rowlinson, SW
Marnett, LJ
Stallings, WC
Kurumbail, RG
Citation: Jr. Kiefer et al., Structural insights into the stereochemistry of the cyclooxygenase reaction, NATURE, 405(6782), 2000, pp. 97-101
Authors:
Kalgutkar, AS
Crews, BC
Rowlinson, SW
Marnett, AB
Kozak, KR
Remmel, RP
Marnett, LJ
Citation: As. Kalgutkar et al., Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: Facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors, P NAS US, 97(2), 2000, pp. 925-930
Authors:
Kalgutkar, AS
Marnett, AB
Crews, BC
Remmel, RP
Marnett, LJ
Citation: As. Kalgutkar et al., Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors, J MED CHEM, 43(15), 2000, pp. 2860-2870
Authors:
Rowlinson, SW
Crews, BC
Goodwin, DC
Schneider, C
Gierse, JK
Marnett, LJ
Citation: Sw. Rowlinson et al., Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2 - Why acetylated COX-1 does not synthesize 15-(R)-HETE, J BIOL CHEM, 275(9), 2000, pp. 6586-6591
Authors:
O'Donnell, VB
Coles, B
Lewis, MJ
Crews, BC
Marnett, LJ
Freeman, BA
Citation: Vb. O'Donnell et al., Catalytic consumption of nitric oxide by prostaglandin H synthase-1 regulates platelet function, J BIOL CHEM, 275(49), 2000, pp. 38239-38244
Authors:
Kozak, KR
Rowlinson, SW
Marnett, LJ
Citation: Kr. Kozak et al., Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2, J BIOL CHEM, 275(43), 2000, pp. 33744-33749
Authors:
Marnett, LJ
Wright, TL
Crews, BC
Tannenbaum, SR
Marrow, JD
Citation: Lj. Marnett et al., Regulation of prostaglandin biosynthesis by nitric oxide is revealed by targeted deletion of inducible nitric-oxide synthase, J BIOL CHEM, 275(18), 2000, pp. 13427-13430
Authors:
Plastaras, JP
Guengerich, FP
Nebert, DW
Marnett, LJ
Citation: Jp. Plastaras et al., Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde, J BIOL CHEM, 275(16), 2000, pp. 11784-11790
Authors:
Lanzo, CA
Sutin, J
Rowlinson, S
Talley, J
Marnett, LJ
Citation: Ca. Lanzo et al., Fluorescence quenching analysis of the association and dissociation of a diarylheterocycle to cyclooxygenase-1 and cyclooxygenase-2: Dynamic basis ofcyclooxygenase-2 selectivity, BIOCHEM, 39(20), 2000, pp. 6228-6234
Authors:
Goodwin, DC
Rowlinson, SW
Marnett, LJ
Citation: Dc. Goodwin et al., Substitution of tyrosine for the proximal histidine ligand to the heme of prostaglandin endoperoxide synthase 2: Implications for the mechanism of cyclooxygenase activation and catalysis, BIOCHEM, 39(18), 2000, pp. 5422-5432
Authors:
Hochgesang, GP
Rowlinson, SW
Marnett, LJ
Citation: Gp. Hochgesang et al., Tyrosine-385 is critical for acetylation of cyclooxygenase-2 by aspirin, J AM CHEM S, 122(27), 2000, pp. 6514-6515
Authors:
Marnett, LJ
Kalgutkar, AS
Citation: Lj. Marnett et As. Kalgutkar, Cyclooxygenase 2 inhibitors: discovery, selectivity and the future, TRENDS PHAR, 20(11), 1999, pp. 465-469
Authors:
Marnett, LJ
Citation: Lj. Marnett, Lipid peroxidation - DNA damage by malondialdehyde, MUT RES-F M, 424(1-2), 1999, pp. 83-95
Authors:
Stevens, JL
Marnett, LJ
Citation: Jl. Stevens et Lj. Marnett, Defining molecular toxicology: A perspective, CHEM RES T, 12(9), 1999, pp. 747-748
Authors:
Goodwin, DC
Landino, LM
Marnett, LJ
Citation: Dc. Goodwin et al., Effects of nitric oxide and nitric oxide-derived species on prostaglandin endoperoxide synthase and prostaglandin biosynthesis, FASEB J, 13(10), 1999, pp. 1121-1136
Authors:
Goodwin, DC
Landino, LM
Marnett, LJ
Citation: Dc. Goodwin et al., Reactions of prostaglandin endoperoxide synthase with nitric oxide and peroxynitrite, DRUG METAB, 31(1), 1999, pp. 273-294
Authors:
Li, L
Zhu, ZY
Joshi, B
Zhang, C
Johnson, CR
Marnett, LJ
Honn, KV
Crissman, JD
Porter, AT
Tang, DG
Citation: L. Li et al., A novel hydroxamic acid compound, BMD188, demonstrates anti-prostate cancer effects by inducing apoptosis. II: In vivo efficacy and pharmacokinetic studies, ANTICANC R, 19(1A), 1999, pp. 61-69
Authors:
Montine, TJ
Sidell, KR
Crews, BC
Markesbery, WR
Marnett, LJ
Roberts, LJ
Morrow, JD
Citation: Tj. Montine et al., Elevated CSF prostaglandin E-2 levels in patients with probable AD, NEUROLOGY, 53(7), 1999, pp. 1495-1498
Authors:
Mao, H
Schnetz-Boutaud, NC
Weisenseel, JP
Marnett, LJ
Stone, MP
Citation: H. Mao et al., Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct, P NAS US, 96(12), 1999, pp. 6615-6620
Authors:
Valyi-Nagy, T
Sidell, KR
Marnett, LJ
Roberts, LJ
Dermody, TS
Morrow, JD
Montine, TJ
Citation: T. Valyi-nagy et al., Divergence of brain prostaglandin H synthase activity and oxidative damagein mice with encephalitis, J NE EXP NE, 58(12), 1999, pp. 1269-1275
Authors:
Johnson, KA
Mierzwa, ML
Fink, SP
Marnett, LJ
Citation: Ka. Johnson et al., MutS recognition of exocyclic DNA adducts that are endogenous products of lipid oxidation, J BIOL CHEM, 274(38), 1999, pp. 27112-27118
Authors:
Marnett, LJ
Rowlinson, SW
Goodwin, DC
Kalgutkar, AS
Lanzo, CA
Citation: Lj. Marnett et al., Arachidonic acid oxygenation by COX-1 and COX-2 - Mechanisms of catalysis and inhibition, J BIOL CHEM, 274(33), 1999, pp. 22903-22906
Authors:
Rowlinson, SW
Crews, BC
Lanzo, CA
Marnett, LJ
Citation: Sw. Rowlinson et al., The binding of arachidonic acid in the cyclooxygenase active site of mouseprostaglandin endoperoxide synthase-2 (COX-2) - A putative L-shaped binding conformation utilizing the top channel region, J BIOL CHEM, 274(33), 1999, pp. 23305-23310
Authors:
Daniel, TO
Liu, H
Morrow, JD
Crews, BC
Marnett, LJ
Citation: To. Daniel et al., Thromboxane A(2) is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis, CANCER RES, 59(18), 1999, pp. 4574-4577
Authors:
Richards, KM
Moody, JS
Marnett, LJ
Citation: Km. Richards et al., Mechanism of inhibition of porcine leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acid, BIOCHEM, 38(50), 1999, pp. 16529-16538