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Results: 1-19 |
Results: 19
VALIDATION OF A RAPID MICROTITER PLATE ASSAY TO CONDUCT CYTOCHROME-P450 2D6 ENZYME-INHIBITION STUDIES
Authors: PALAMANDA JR FAVREAU L LIN CC NOMEIR AA
Citation: Jr. Palamanda et al., VALIDATION OF A RAPID MICROTITER PLATE ASSAY TO CONDUCT CYTOCHROME-P450 2D6 ENZYME-INHIBITION STUDIES, Drug discovery today, 3(10), 1998, pp. 466-470
LIQUID-CHROMATOGRAPHIC ANALYSIS IN MOUSE, DOG AND HUMAN PLASMA - STABILITY, ABSORPTION, METABOLISM AND PHARMACOKINETICS OF THE ANTI-HIV AGENT 2-CHLORO-5-(2-METHYL-5,6-DIHYDRO-1,4-OXATHIIN-3-YL CARBOXAMIDO)ISOPROPYLBENZOATE (NSC-615985, UC84)
Authors: NOMEIR AA MCCOMISH MF FERRALA NF SILVEIRA D COVEY JM CHADWICK M
Citation: Aa. Nomeir et al., LIQUID-CHROMATOGRAPHIC ANALYSIS IN MOUSE, DOG AND HUMAN PLASMA - STABILITY, ABSORPTION, METABOLISM AND PHARMACOKINETICS OF THE ANTI-HIV AGENT 2-CHLORO-5-(2-METHYL-5,6-DIHYDRO-1,4-OXATHIIN-3-YL CARBOXAMIDO)ISOPROPYLBENZOATE (NSC-615985, UC84), Journal of pharmaceutical and biomedical analysis, 17(1), 1998, pp. 27-38
INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE - 4-AMIDO, 4-CARBAMOYL, AND 4-CARBOXAMIDO DERIVATIVES OF ENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERAZINE AND ENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERAZINE
Authors: MALLAMS AK ROSSMAN RR DOLL RJ GIRIJAVALLABHAN VM GANGULY AK PETRIN J WANG L PATTON R BISHOP WR CARR DM KIRSCHMEIER P CATINO JJ BRYANT MS CHEN KJ KORFMACHER WA NARDO C WANG SY NOMEIR AA LIN CC LI ZJ CHEN JP LEE S DELL J LIPARI P MALKOWSKI M YAREMKO B KING I LIU M
Citation: Ak. Mallams et al., INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE - 4-AMIDO, 4-CARBAMOYL, AND 4-CARBOXAMIDO DERIVATIVES OF ENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERAZINE AND ENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERAZINE, Journal of medicinal chemistry, 41(6), 1998, pp. 877-893
-PIPERIDINYL]-2-OXO-ETHYL]-1-PIPERIDINECARBOXAMIDE (SCH-66336) - A VERY POTENT FARNESYL-PROTEIN TRANSFERASE INHIBITOR AS A NOVEL ANTITUMOR AGENT())
Authors: NJOROGE FG TAVERAS AG KELLY J REMISZEWSKI S MALLAMS AK WOLIN R AFONSO A COOPER AB RANE DF LIU YT WONG J VIBULBHAN B PINTO P DESKUS J ALVAREZ CS DELROSARIO J CONNOLLY M WANG J DESAI J ROSSMAN RR BISHOP WR PATTON R WANG L KIRSCHMEIER P BRYANT MS NOMEIR AA LIN CC LIU M MCPHAIL AT DOLL RJ GIRIJAVALLABHAN VM GANGULY AK
Citation: Fg. Njoroge et al., -PIPERIDINYL]-2-OXO-ETHYL]-1-PIPERIDINECARBOXAMIDE (SCH-66336) - A VERY POTENT FARNESYL-PROTEIN TRANSFERASE INHIBITOR AS A NOVEL ANTITUMOR AGENT()), Journal of medicinal chemistry, 41(24), 1998, pp. 4890-4902
POTENT, SELECTIVE, AND ORALLY BIOAVAILABLE TRICYCLIC PYRIDYL ACETAMIDE N-OXIDE INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE WITH ENHANCED IN-VIVO ANTITUMOR-ACTIVITY
Authors: NJOROGE FG VIBULBHAN B PINTO P BISHOP WR BRYANT MS NOMEIR AA LIN CC LIU M DOLL RJ GIRIJAVALLABHAN V GANGULY AK
Citation: Fg. Njoroge et al., POTENT, SELECTIVE, AND ORALLY BIOAVAILABLE TRICYCLIC PYRIDYL ACETAMIDE N-OXIDE INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE WITH ENHANCED IN-VIVO ANTITUMOR-ACTIVITY, Journal of medicinal chemistry, 41(10), 1998, pp. 1561-1567
ANTITUMOR-ACTIVITY OF SCH-66336, AN ORALLY BIOAVAILABLE TRICYCLIC INHIBITOR OF FARNESYL-PROTEIN TRANSFERASE, IN HUMAN TUMOR XENOGRAFT MODELS AND WAP-RAS TRANSGENIC MICE
Authors: LIU M BRYANT MS CHEN JP LEE SN YAREMKO B LIPARI P MALKOWSKI M FERRARI E NIELSEN L PRIOLI N DELL J SINHA D SYED J KORFMACHER WA NOMEIR AA LIN CC WANG L TAVERAS AG DOLL RJ NJOROGE FG MALLAMS AK REMISZEWSKI S CATINO JJ GIRIJAVALLABHAN VM KIRSCHMEIER P BISHOP WR
Citation: M. Liu et al., ANTITUMOR-ACTIVITY OF SCH-66336, AN ORALLY BIOAVAILABLE TRICYCLIC INHIBITOR OF FARNESYL-PROTEIN TRANSFERASE, IN HUMAN TUMOR XENOGRAFT MODELS AND WAP-RAS TRANSGENIC MICE, Cancer research, 58(21), 1998, pp. 4947-4956
PHARMACOKINETIC SCREENING FOR THE SELECTION OF NEW DRUG DISCOVERY CANDIDATES IS GREATLY ENHANCED THROUGH THE USE OF LIQUID-CHROMATOGRAPHY ATMOSPHERIC-PRESSURE IONIZATION TANDEM MASS-SPECTROMETRY
Authors: BRYANT MS KORFMACHER WA WANG SY NARDO C NOMEIR AA LIN CC
Citation: Ms. Bryant et al., PHARMACOKINETIC SCREENING FOR THE SELECTION OF NEW DRUG DISCOVERY CANDIDATES IS GREATLY ENHANCED THROUGH THE USE OF LIQUID-CHROMATOGRAPHY ATMOSPHERIC-PRESSURE IONIZATION TANDEM MASS-SPECTROMETRY, Journal of chromatography, 777(1), 1997, pp. 61-66
HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION AND STABILITY OF 5-(3-METHYLTRIAZEN-1-YL)-IMIDAZO-4-CARBOXIMIDE, THE BIOLOGICALLY-ACTIVE PRODUCT OF THE ANTITUMOR AGENT TEMOZOLOMIDE, IN HUMAN PLASMA
Authors: KIM HK LIN CC PARKER D VEALS J LIM J LIKHARI P STATKEVICH P MARCO A NOMEIR AA
Citation: Hk. Kim et al., HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION AND STABILITY OF 5-(3-METHYLTRIAZEN-1-YL)-IMIDAZO-4-CARBOXIMIDE, THE BIOLOGICALLY-ACTIVE PRODUCT OF THE ANTITUMOR AGENT TEMOZOLOMIDE, IN HUMAN PLASMA, Journal of chromatography B. Biomedical sciences and applications, 703(1-2), 1997, pp. 225-233
METABOLISM AND DISPOSITION OF DIMETHYL HYDROGEN PHOSPHITE IN RATS ANDMICE
Authors: NOMEIR AA MATTHEWS HB
Citation: Aa. Nomeir et Hb. Matthews, METABOLISM AND DISPOSITION OF DIMETHYL HYDROGEN PHOSPHITE IN RATS ANDMICE, Journal of toxicology and environmental health, 51(5), 1997, pp. 489-501
SINGLE-DOSE PHARMACOKINETICS OF ISEPAMICIN IN YOUNG AND GERIATRIC VOLUNTEERS
Authors: NOMEIR AA RADWANSKI E CUTLER D AFFRIME M CHRISTOPHER D KORDUBA C BATRA V LIN CC CAYEN MN
Citation: Aa. Nomeir et al., SINGLE-DOSE PHARMACOKINETICS OF ISEPAMICIN IN YOUNG AND GERIATRIC VOLUNTEERS, Journal of clinical pharmacology, 37(11), 1997, pp. 1021-1030
STRUCTURE-ACTIVITY RELATIONSHIP OF 3-SUBSTITUTED ,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)-PIPERIDINE INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE - DESIGN AND SYNTHESIS OF IN-VIVO ACTIVE ANTITUMOR COMPOUNDS
Authors: NJOROGE FG VIBULBHAN B RANE DF BISHOP WR PETRIN J PATTON R BRYANT MS CHEN KJ NOMEIR AA LIN CC LIU M KING I CHEN JP LEE SN YAREMKO B DELL J LIPARI P MALKOWSKI M LI ZJ CATINO J DOLL RJ GIRIJAVALLABHAN V GANGULY AK
Citation: Fg. Njoroge et al., STRUCTURE-ACTIVITY RELATIONSHIP OF 3-SUBSTITUTED ,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)-PIPERIDINE INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE - DESIGN AND SYNTHESIS OF IN-VIVO ACTIVE ANTITUMOR COMPOUNDS, Journal of medicinal chemistry, 40(26), 1997, pp. 4290-4301
INFLUENCE OF FOOD ON THE ORAL BIOAVAILABILITY OF LORATADINE AND PSEUDOEPHEDRINE FROM EXTENDED-RELEASE TABLETS IN HEALTHY-VOLUNTEERS
Authors: NOMEIR AA MOJAVERIAN P KOSOGLOU T AFFRIME MB NEZAMIS J RADWANSKI E LIN CC CAYEN MN
Citation: Aa. Nomeir et al., INFLUENCE OF FOOD ON THE ORAL BIOAVAILABILITY OF LORATADINE AND PSEUDOEPHEDRINE FROM EXTENDED-RELEASE TABLETS IN HEALTHY-VOLUNTEERS, Journal of clinical pharmacology, 36(10), 1996, pp. 923-930
SPECIES-DIFFERENCES IN THE DISPOSITION AND METABOLISM OF NALIDIXIC-ACID
Authors: NOMEIR AA MARKHAM P BURKA LT GRIFFIN RJ GHANAYEM BI
Citation: Aa. Nomeir et al., SPECIES-DIFFERENCES IN THE DISPOSITION AND METABOLISM OF NALIDIXIC-ACID, The Journal of pharmacology and experimental therapeutics, 279(1), 1996, pp. 222-230
BIOPHARMACEUTIC CHARACTERISTICS OF A NEW EXTENDED-RELEASE THEOPHYLLINE FORMULATION (UNI-DUR)
Authors: OOSTERHUIS B BRANNAN MD GROEN H PEETERS PAM HEMPENIUS J RADWANSKI E NOMEIR AA AFFRIME MB JONKMAN JHG
Citation: B. Oosterhuis et al., BIOPHARMACEUTIC CHARACTERISTICS OF A NEW EXTENDED-RELEASE THEOPHYLLINE FORMULATION (UNI-DUR), Annals of allergy, asthma, & immunology, 75(2), 1995, pp. 157-161
COMPARATIVE DISPOSITION OF 2,3-EPOXY-1-PROPANOL (GLYCIDOL) IN RATS FOLLOWING ORAL AND INTRAVENOUS ADMINISTRATION
Authors: NOMEIR AA SILVEIRA DM FERRALA NF MARKHAM PM MCCOMISH MF GHANAYEM BI CHADWICK M
Citation: Aa. Nomeir et al., COMPARATIVE DISPOSITION OF 2,3-EPOXY-1-PROPANOL (GLYCIDOL) IN RATS FOLLOWING ORAL AND INTRAVENOUS ADMINISTRATION, Journal of toxicology and environmental health, 44(2), 1995, pp. 203-217
DETERMINATION OF 1-METHOXY-2-PROPANOL AND ITS METABOLITE 1,2-PROPANEDIOL IN RAT AND MOUSE PLASMA BY GAS-CHROMATOGRAPHY
Authors: FERRALA NF GHANAYEM BI NOMEIR AA
Citation: Nf. Ferrala et al., DETERMINATION OF 1-METHOXY-2-PROPANOL AND ITS METABOLITE 1,2-PROPANEDIOL IN RAT AND MOUSE PLASMA BY GAS-CHROMATOGRAPHY, Journal of chromatography B. Biomedical applications, 660(2), 1994, pp. 291-296
DETERMINATION OF 1-METHOXY-2-PROPANOL AND ITS METABOLITE 1,2-PROPANEDIOL IN RAT AND MOUSE PLASMA BY GAS-CHROMATOGRAPHY
Authors: FERRALA NF GHANAYEM BI NOMEIR AA
Citation: Nf. Ferrala et al., DETERMINATION OF 1-METHOXY-2-PROPANOL AND ITS METABOLITE 1,2-PROPANEDIOL IN RAT AND MOUSE PLASMA BY GAS-CHROMATOGRAPHY, Journal of chromatography B. Biomedical applications, 660(2), 1994, pp. 291-296
LIQUID-CHROMATOGRAPHIC ANALYSIS, STABILITY AND PROTEIN-BINDING STUDIES OF THE ANTI-HIV AGENT BENZOIC-ACID, [[(1-METHYLETHOXY)THIOXOMETHYL]AMINO]-METHYLETHYL, 1-METHYLETHYL ESTER
Authors: NOMEIR AA MCCOMISH MF MONGAN AL COVEY JM FERRALA NF
Citation: Aa. Nomeir et al., LIQUID-CHROMATOGRAPHIC ANALYSIS, STABILITY AND PROTEIN-BINDING STUDIES OF THE ANTI-HIV AGENT BENZOIC-ACID, [[(1-METHYLETHOXY)THIOXOMETHYL]AMINO]-METHYLETHYL, 1-METHYLETHYL ESTER, Journal of pharmaceutical and biomedical analysis, 12(5), 1994, pp. 693-698
PULMONARY ABSORPTION AND DISPOSITION OF [C-14] THIOPHENE IN RATS FOLLOWING NOSE-ONLY INHALATION EXPOSURE
Authors: NOMEIR AA MARKHAM PM CHADWICK M
Citation: Aa. Nomeir et al., PULMONARY ABSORPTION AND DISPOSITION OF [C-14] THIOPHENE IN RATS FOLLOWING NOSE-ONLY INHALATION EXPOSURE, Journal of toxicology and environmental health, 39(2), 1993, pp. 223-236
Risultati: 1-19 |