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Results: 1-13 |
Results: 13
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity
Authors: Ohkanda, J Lockman, JW Yokoyama, K Gelb, MH Croft, SL Kendrick, H Harrell, MI Feagin, JE Blaskovich, MA Sebti, SM Hamilton, AD
Citation: J. Ohkanda et al., Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity, BIOORG MED, 11(6), 2001, pp. 761-764
3-hydroxy-4(1H)-pyridinone-containing linear and cyclic hexapeptides and their iron(III) complexes - Synthesis, property, and the growth-promotion activity-
Authors: Katoh, A Hikita, Y Harata, M Ohkanda, J Tsubomura, T Higuchi, A Saito, R Harada, K
Citation: A. Katoh et al., 3-hydroxy-4(1H)-pyridinone-containing linear and cyclic hexapeptides and their iron(III) complexes - Synthesis, property, and the growth-promotion activity-, HETEROCYCLE, 55(11), 2001, pp. 2171-2187
The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells
Authors: Crespo, NC Ohkanda, J Yen, TJ Hamilton, AD Sebti, SM
Citation: Nc. Crespo et al., The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells, J BIOL CHEM, 276(19), 2001, pp. 16161-16167
Protein prenylation in trypanosomatids - A new piggy-back medicinal chemistry target for the development of agents against tropical diseases
Authors: Gelb, MH Buckner, FS Yokoyama, K Ohkanda, J Hamilton, AD Nguyen, L Rossi-Bergmann, B Stuart, KD Sebti, SM Van Voorhis, WC
Citation: Mh. Gelb et al., Protein prenylation in trypanosomatids - A new piggy-back medicinal chemistry target for the development of agents against tropical diseases, CANC DRUG, 8, 2001, pp. 221-232
Inhibition of farnesyltransferase increases TGF beta type II receptor expression and enhances the responsiveness of human cancer cells to TGF beta
Authors: Adnane, J Bizouarn, FA Chen, Z Ohkanda, J Hamilton, AD Munoz-Antonia, T Sebti, SM
Citation: J. Adnane et al., Inhibition of farnesyltransferase increases TGF beta type II receptor expression and enhances the responsiveness of human cancer cells to TGF beta, ONCOGENE, 19(48), 2000, pp. 5525-5533
Synthesis of quinoxaline derivatives bearing the styryl and phenylethynyl groups and application to a fluorescence derivatization reagent
Authors: Katoh, A Yoshida, T Ohkanda, J
Citation: A. Katoh et al., Synthesis of quinoxaline derivatives bearing the styryl and phenylethynyl groups and application to a fluorescence derivatization reagent, HETEROCYCLE, 52(2), 2000, pp. 911-920
Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
Authors: Lantry, LE Zhang, ZQ Yao, RS Crist, KA Wang, Y Ohkanda, J Hamilton, AD Sebti, SM Lubet, RA You, M
Citation: Le. Lantry et al., Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, CARCINOGENE, 21(1), 2000, pp. 113-116
Development of a tripeptide mimetic strategy for the inhibition of proteinfarnesyltransferase
Authors: Kothare, MA Ohkanda, J Lockman, JW Qian, YM Blaskovich, MA Sebti, SM Hamilton, AD
Citation: Ma. Kothare et al., Development of a tripeptide mimetic strategy for the inhibition of proteinfarnesyltransferase, TETRAHEDRON, 56(50), 2000, pp. 9833-9841
Synthesis of 6-(bromoacetyl)amino-2,3-dimorpholinoquinoxaline and application to a new fluorescence derivatization reagent of fatty acids for the high-performance liquid chromatographic analysis
Authors: Katoh, A Fujimoto, T Takahashi, M Ohkanda, J
Citation: A. Katoh et al., Synthesis of 6-(bromoacetyl)amino-2,3-dimorpholinoquinoxaline and application to a new fluorescence derivatization reagent of fatty acids for the high-performance liquid chromatographic analysis, HETEROCYCLE, 50(1), 1999, pp. 299-308
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I
Authors: Vasudevan, A Qian, YM Vogt, A Blaskovich, MA Ohkanda, J Sebti, SM Hamilton, AD
Citation: A. Vasudevan et al., Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I, J MED CHEM, 42(8), 1999, pp. 1333-1340
Antitumor efficacy of a novel class of non-thiol-containing peptidomimeticinhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine
Authors: Sun, JZ Blaskovich, MA Knowles, D Qian, YM Ohkanda, J Bailey, RD Hamilton, AD Sebti, SM
Citation: Jz. Sun et al., Antitumor efficacy of a novel class of non-thiol-containing peptidomimeticinhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine, CANCER RES, 59(19), 1999, pp. 4919-4926
Synthesis of 2,2 '-bipyridines bearing amino or carboxyl group at the sidechain and physical properties of their ruthenium(II) complexes
Authors: Katoh, A Kitamura, Y Fujii, H Horie, Y Satoh, T Ohkanda, J Yokomori, Y
Citation: A. Katoh et al., Synthesis of 2,2 '-bipyridines bearing amino or carboxyl group at the sidechain and physical properties of their ruthenium(II) complexes, HETEROCYCLE, 49, 1998, pp. 281-296
New hexadentate ligands composed of 1-hydroxy-2(1H)-pyrimidinone, alpha,omega-diamine and 1,1,1-tris(carboxyethoxymethyl)-ethane or tri(carboxybutyl)isocyanurate. Synthesis and characterization of their iron(III) complexes
Authors: Katoh, A Hida, Y Kamitani, J Ohkanda, J
Citation: A. Katoh et al., New hexadentate ligands composed of 1-hydroxy-2(1H)-pyrimidinone, alpha,omega-diamine and 1,1,1-tris(carboxyethoxymethyl)-ethane or tri(carboxybutyl)isocyanurate. Synthesis and characterization of their iron(III) complexes, J CHEM S DA, (22), 1998, pp. 3859-3864
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