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Results: 1-14 |
Results: 14
Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding
Authors: Arocas, V Bock, SC Raja, S Olson, ST Bjork, I
Citation: V. Arocas et al., Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding, J BIOL CHEM, 276(47), 2001, pp. 43809-43817
The pH dependence of serpin-proteinase complex dissociation reveals a mechanism of complex stabilization involving inactive and active conformationalstates of the proteinase which are perturbable by calcium
Authors: Calugaru, SV Swanson, R Olson, ST
Citation: Sv. Calugaru et al., The pH dependence of serpin-proteinase complex dissociation reveals a mechanism of complex stabilization involving inactive and active conformationalstates of the proteinase which are perturbable by calcium, J BIOL CHEM, 276(35), 2001, pp. 32446-32455
Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence - Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin
Authors: Chuang, YJ Swanson, R Raja, SM Olson, ST
Citation: Yj. Chuang et al., Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence - Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin, J BIOL CHEM, 276(18), 2001, pp. 14961-14971
Resolution of Michaelis complex, acylation, and conformational change steps in the reactions of the serpin, plasminogen activator inhibitor-1, with tissue plasminogen activator and trypsin
Authors: Olson, ST Swanson, R Day, D Verhamme, I Kvassman, J Shore, JD
Citation: St. Olson et al., Resolution of Michaelis complex, acylation, and conformational change steps in the reactions of the serpin, plasminogen activator inhibitor-1, with tissue plasminogen activator and trypsin, BIOCHEM, 40(39), 2001, pp. 11742-11756
The antithrombin P1 residue is important for target proteinase specificitybut not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase specificity but normal heparin activation
Authors: Chuang, YJ Swanson, R Raja, SM Bock, SC Olson, ST
Citation: Yj. Chuang et al., The antithrombin P1 residue is important for target proteinase specificitybut not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase specificity but normal heparin activation, BIOCHEM, 40(22), 2001, pp. 6670-6679
The N-terminal region of cystatin A (stefin A) binds to papain subsequent to the two hairpin loops of the inhibitor. Demonstration of two-step binding by rapid-kinetic studies of cystatin A labeled at the N-terminus with a fluorescent reporter group
Authors: Estrada, S Olson, ST Raub-Segall, E Bjork, I
Citation: S. Estrada et al., The N-terminal region of cystatin A (stefin A) binds to papain subsequent to the two hairpin loops of the inhibitor. Demonstration of two-step binding by rapid-kinetic studies of cystatin A labeled at the N-terminus with a fluorescent reporter group, PROTEIN SCI, 9(11), 2000, pp. 2218-2224
Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A
Authors: Lawrence, DA Olson, ST Muhammad, S Day, DE Kvassman, JO Ginsburg, D Shore, JD
Citation: Da. Lawrence et al., Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A, J BIOL CHEM, 275(8), 2000, pp. 5839-5844
Critical role of the linker region between helix D and strand 2A in heparin activation of antithrombin
Authors: Meagher, JL Olson, ST Gettins, PGW
Citation: Jl. Meagher et al., Critical role of the linker region between helix D and strand 2A in heparin activation of antithrombin, J BIOL CHEM, 275(4), 2000, pp. 2698-2704
Role of arginine 129 in heparin binding and activation of antithrombin
Authors: Desai, U Swanson, R Bock, SC Bjork, I Olson, ST
Citation: U. Desai et al., Role of arginine 129 in heparin binding and activation of antithrombin, J BIOL CHEM, 275(25), 2000, pp. 18976-18984
Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by promoting the assembly of an intermediate heparin-antithrombin-factor Xabridging complex. Demonstration by rapid kinetics studies
Authors: Rezaie, AR Olson, ST
Citation: Ar. Rezaie et St. Olson, Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by promoting the assembly of an intermediate heparin-antithrombin-factor Xabridging complex. Demonstration by rapid kinetics studies, BIOCHEM, 39(39), 2000, pp. 12083-12090
The region of antithrombin interacting with full-length heparin chains outside the high-affinity pentasaccharide sequence extends to Lys136 but not to Lys139
Authors: Arocas, V Turk, B Bock, SC Olson, ST Bjork, I
Citation: V. Arocas et al., The region of antithrombin interacting with full-length heparin chains outside the high-affinity pentasaccharide sequence extends to Lys136 but not to Lys139, BIOCHEM, 39(29), 2000, pp. 8512-8518
Importance of the P2 glycine of antithrombin in target proteinase specificity, heparin activation, and the efficiency of proteinase trapping as revealed by a P2 Gly -> Pro mutation
Authors: Chuang, YJ Gettins, PGW Olson, ST
Citation: Yj. Chuang et al., Importance of the P2 glycine of antithrombin in target proteinase specificity, heparin activation, and the efficiency of proteinase trapping as revealed by a P2 Gly -> Pro mutation, J BIOL CHEM, 274(40), 1999, pp. 28142-28149
Role of regulatory exosite I in binding of thrombin to human factor V, factor Va, factor Va subunits, and activation fragments
Authors: Dharmawardana, KR Olson, ST Bock, PE
Citation: Kr. Dharmawardana et al., Role of regulatory exosite I in binding of thrombin to human factor V, factor Va, factor Va subunits, and activation fragments, J BIOL CHEM, 274(26), 1999, pp. 18635-18643
The role of Arg46 and Arg47 of antithrombin in heparin binding
Authors: Arocas, V Bock, SC Olson, ST Bjork, I
Citation: V. Arocas et al., The role of Arg46 and Arg47 of antithrombin in heparin binding, BIOCHEM, 38(31), 1999, pp. 10196-10204
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