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Results: 1-17 |
Results: 17
Pyrrolidine-3-carboxylic acids as endothelin antagonists. 5. Highly selective, potent, and orally active ETA antagonists
Authors: Jae, HS Winn, M von Geldern, TW Sorensen, BK Chiou, WJ Nguyen, B Marsh, KC Opgenorth, TJ
Citation: Hs. Jae et al., Pyrrolidine-3-carboxylic acids as endothelin antagonists. 5. Highly selective, potent, and orally active ETA antagonists, J MED CHEM, 44(23), 2001, pp. 3978-3984
Endothelin and ETA receptors in long-term arterial pressure homeostasis inconscious nonhuman primates
Authors: Reinhart, GA Preusser, LC Opgenorth, TJ Wegner, CD Cox, BF
Citation: Ga. Reinhart et al., Endothelin and ETA receptors in long-term arterial pressure homeostasis inconscious nonhuman primates, AM J P-REG, 279(5), 2000, pp. R1701-R1706
'Irreversible' endothelin-1 binding does not prohibit ABT-627 from reversing endothelin-1-induced effects
Authors: Chiou, WJ Wessale, JL von Geldern, T Opgenorth, TJ Wu-Wong, JR
Citation: Wj. Chiou et al., 'Irreversible' endothelin-1 binding does not prohibit ABT-627 from reversing endothelin-1-induced effects, J CARDIO PH, 36, 2000, pp. S48-S52
Increased susceptibility to deoxycorticosterone acetate-salt-induced hyper-tension in endothelin-B-receptor-deficient rats
Authors: Matsumura, Y Kuro, T Kobayashi, Y Konishi, F Takaoka, M Wessale, JL Opgenorth, TJ Gariepy, CE Yanagisawa, M
Citation: Y. Matsumura et al., Increased susceptibility to deoxycorticosterone acetate-salt-induced hyper-tension in endothelin-B-receptor-deficient rats, J CARDIO PH, 36, 2000, pp. S86-S89
Effects of endothelin receptor antagonists on the plasma immunoreactive endothelin-1 level
Authors: Opgenorth, TJ Wessale, JL Dixon, DB Adler, AL Calzadilla, SV Padley, RJ Wu-Wong, JR
Citation: Tj. Opgenorth et al., Effects of endothelin receptor antagonists on the plasma immunoreactive endothelin-1 level, J CARDIO PH, 36, 2000, pp. S292-S296
Plasma endothelin-1 levels neither increase nor correlate with neurological scores, stroke risk factors, or outcome in patients with ischemic stroke
Authors: Haapaniemi, E Tatlisumak, T Hamel, K Soinne, L Lanni, C Opgenorth, TJ Kaste, M
Citation: E. Haapaniemi et al., Plasma endothelin-1 levels neither increase nor correlate with neurological scores, stroke risk factors, or outcome in patients with ischemic stroke, STROKE, 31(3), 2000, pp. 720-725
Direct determination of endothelin receptor antagonist levels in plasma using a scintillation proximity assay
Authors: Dayton, BD Chiou, WJ Opgenorth, TJ Wu-Wong, JR
Citation: Bd. Dayton et al., Direct determination of endothelin receptor antagonist levels in plasma using a scintillation proximity assay, LIFE SCI, 66(10), 2000, pp. 937-945
Selective antagonism of the ETA receptor, but not the ETB receptor, is protective against ischemic acute renal failure in rats
Authors: Kuro, T Kohnou, K Kobayashi, Y Takaoka, M Opgenorth, TJ Wessale, JL Matsumura, Y
Citation: T. Kuro et al., Selective antagonism of the ETA receptor, but not the ETB receptor, is protective against ischemic acute renal failure in rats, JPN J PHARM, 82(4), 2000, pp. 307-316
ABT-627, an endothelin ETA receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain
Authors: Jarvis, MF Wessale, JL Zhu, CZ Lynch, JJ Dayton, BD Calzadilla, SV Padley, RJ Opgenorth, TJ Kowaluk, EA
Citation: Mf. Jarvis et al., ABT-627, an endothelin ETA receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain, EUR J PHARM, 388(1), 2000, pp. 29-35
Exaggerated vascular and renal pathology in endothelin-B receptor-deficient rats with deoxycorticosterone acetate-salt hypertension
Authors: Matsumura, Y Kuro, T Kobayashi, Y Konishi, F Takaoka, M Wessale, JL Opgenorth, TJ Gariepy, CE Yanagisawa, M
Citation: Y. Matsumura et al., Exaggerated vascular and renal pathology in endothelin-B receptor-deficient rats with deoxycorticosterone acetate-salt hypertension, CIRCULATION, 102(22), 2000, pp. 2765-2773
Discovery of a series of pyrrolidine-based endothelin receptor antagonistswith enhanced ETA receptor selectivity
Authors: Boyd, SA Mantei, RA Tasker, AS Liu, G Sorensen, BK Henry, KJ von Geldern, TW Winn, M Wu-Wong, JSR Chiou, WJ Dixon, DB Hutchins, CW Marsh, KC Nguyen, E Opgenorth, TJ
Citation: Sa. Boyd et al., Discovery of a series of pyrrolidine-based endothelin receptor antagonistswith enhanced ETA receptor selectivity, BIO MED CH, 7(6), 1999, pp. 991-1002
Different contributions of endothelin-A and endothelin-B receptors in the pathogenesis of deoxycorticosterone acetate-salt-induced hypertension in rats
Authors: Matsumura, Y Hashimoto, N Taira, S Kuro, T Kitano, R Ohkita, M Opgenorth, TJ Takaoka, M
Citation: Y. Matsumura et al., Different contributions of endothelin-A and endothelin-B receptors in the pathogenesis of deoxycorticosterone acetate-salt-induced hypertension in rats, HYPERTENSIO, 33(2), 1999, pp. 759-765
New bone formation in an osteoblastic tumor model is increased by endothelin-1 overexpression and decreased by endothelin A receptor blockade
Authors: Nelson, JB Nguyen, SH Wu-Wong, JR Opgenorth, TJ Dixon, DB Chung, LWK Inoue, N
Citation: Jb. Nelson et al., New bone formation in an osteoblastic tumor model is increased by endothelin-1 overexpression and decreased by endothelin A receptor blockade, UROLOGY, 53(5), 1999, pp. 1063-1069
Pyrrolidine-3-carboxylic acids as endothelin antagonists. 4. Side chain conformational restriction leads to ETB selectivity
Authors: von Geldern, TW Tasker, AS Sorensen, BK Winn, M Szczepankiewicz, BG Dixon, DB Chiou, WJ Wang, LM Wessale, JL Adler, A Marsh, KC Nguyen, E Opgenorth, TJ
Citation: Tw. Von Geldern et al., Pyrrolidine-3-carboxylic acids as endothelin antagonists. 4. Side chain conformational restriction leads to ETB selectivity, J MED CHEM, 42(18), 1999, pp. 3668-3678
Design, synthesis, and activity of a series of pyrrolidine-3-carboxylic acid-based, highly specific, orally active ETB antagonists containing a diphenylmethylamine acetamide side chain
Authors: Liu, G Kozmina, NS Winn, M von Geldern, TW Chiou, WJ Dixon, DB Nguyen, E Marsh, KC Opgenorth, TJ
Citation: G. Liu et al., Design, synthesis, and activity of a series of pyrrolidine-3-carboxylic acid-based, highly specific, orally active ETB antagonists containing a diphenylmethylamine acetamide side chain, J MED CHEM, 42(18), 1999, pp. 3679-3689
Pharmacology of A-216546: a highly selective antagonist for endothelin ETAreceptor
Authors: Wu-Wong, JSR Dixon, DB Chiou, WJ Dayton, BD Novosad, EI Adler, AL Wessale, JL Calzadilla, SV Hernandez, L Marsh, KC Liu, G Szczepankiewicz, B von Geldern, TW Opgenorth, TJ
Citation: Jsr. Wu-wong et al., Pharmacology of A-216546: a highly selective antagonist for endothelin ETAreceptor, EUR J PHARM, 366(2-3), 1999, pp. 189-201
Perioperative plasma endothelin-1 and big endothelin-1 concentrations in elderly patients undergoing major surgical procedures
Authors: Nelson, JB Opgenorth, TJ Fleisher, LA Frank, SM
Citation: Jb. Nelson et al., Perioperative plasma endothelin-1 and big endothelin-1 concentrations in elderly patients undergoing major surgical procedures, ANESTH ANAL, 88(4), 1999, pp. 898-903
Risultati: 1-17 |