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Results: 1-12 |
Results: 12
SPECIES-DEPENDENT ENANTIOSELECTIVE PHARMACOKINETICS OF PNU-103017, A PYRONE HIV PROTEASE INHIBITOR
Authors: ZHONG WZ WILLIAMS MG BORIN MT PADBURY GE
Citation: Wz. Zhong et al., SPECIES-DEPENDENT ENANTIOSELECTIVE PHARMACOKINETICS OF PNU-103017, A PYRONE HIV PROTEASE INHIBITOR, Chirality, 10(3), 1998, pp. 210-216
CONTRIBUTION OF SERUM-PROTEIN ASSOCIATION TO DISCREPANCY BETWEEN THE IN-VIVO AND IN-VITRO UDS RESULTS FOR -2,4-DI-1-PYRROLIDINYL-7H-PYRROLO[2,3-D]PYRIMIDINE (U-89843)
Authors: ZHAO ZY KOEPLINGER KA PADBURY GE AARON CS HARBACH PR MAYO JK MATTES WB BUNDY GL
Citation: Zy. Zhao et al., CONTRIBUTION OF SERUM-PROTEIN ASSOCIATION TO DISCREPANCY BETWEEN THE IN-VIVO AND IN-VITRO UDS RESULTS FOR -2,4-DI-1-PYRROLIDINYL-7H-PYRROLO[2,3-D]PYRIMIDINE (U-89843), Mutation research. Genetic toxicology and environmental mutagenesis, 395(2-3), 1997, pp. 119-126
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SULFONE SUBSTITUTED HIV PROTEASE INHIBITORS
Authors: SCHWARTZ TM BUNDY GL STROHBACH JW THAISRIVONGS S JOHNSON PD SKULNICK HI TOMICH PK LYNN JC CHONG KT HINSHAW RR RAUB TJ PADBURY GE TOTH LN
Citation: Tm. Schwartz et al., SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SULFONE SUBSTITUTED HIV PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 7(4), 1997, pp. 399-402
PYRROLOPYRIMIDINES - NOVEL BRAIN-PENETRATING ANTIOXIDANTS WITH NEUROPROTECTIVE ACTIVITY IN BRAIN INJURY AND ISCHEMIA MODELS
Authors: HALL ED ANDRUS PK SMITH SL FLECK TJ SCHERCH HM LUTZKE BS SAWADA GA ALTHAUS JS VONVOIGTLANDER PF PADBURY GE LARSON PG PALMER JR BUNDY GL
Citation: Ed. Hall et al., PYRROLOPYRIMIDINES - NOVEL BRAIN-PENETRATING ANTIOXIDANTS WITH NEUROPROTECTIVE ACTIVITY IN BRAIN INJURY AND ISCHEMIA MODELS, The Journal of pharmacology and experimental therapeutics, 281(2), 1997, pp. 895-904
BIOACTIVATION OF -2,4-DI-1-PYRROLIDINYL-7H-PYRROLO[2,3-D]PYRIMIDINE (U-89843) TO REACTIVE INTERMEDIATES THAT BIND COVALENTLY TO MACROMOLECULES AND PRODUCE GENOTOXICITY
Authors: ZHAO ZY KOEPLINGER KA PADBURY GE HAUER MJ BUNDY GL BANITT LS SCHWARTZ TM ZIMMERMANN DC HARBACH PR MAYO JK AARON CS
Citation: Zy. Zhao et al., BIOACTIVATION OF -2,4-DI-1-PYRROLIDINYL-7H-PYRROLO[2,3-D]PYRIMIDINE (U-89843) TO REACTIVE INTERMEDIATES THAT BIND COVALENTLY TO MACROMOLECULES AND PRODUCE GENOTOXICITY, Chemical research in toxicology, 9(8), 1996, pp. 1230-1239
EFFECT OF THE PYRROLOPYRIMIDINES U89843D, U94430E, AND U101033E ON ANTIGEN-INDUCED LUNG INFLAMMATION IN SENSITIZED RATS AND MICE
Authors: KOLBASA KP GRIFFIN RL FIDLER SF HATFIELD CA TOTH LN LARSON PG BANITT LS LIN JM BUNDY GL PADBURY GE CHIN JE RICHARDS IM
Citation: Kp. Kolbasa et al., EFFECT OF THE PYRROLOPYRIMIDINES U89843D, U94430E, AND U101033E ON ANTIGEN-INDUCED LUNG INFLAMMATION IN SENSITIZED RATS AND MICE, The FASEB journal, 10(3), 1996, pp. 972-972
IN-VITRO AND IN-VIVO BIOTRANSFORMATION OF -2,4-DI-1-PYRROLIDINYL-7H-PYRROLO[2,3-D]PYRIMIDINE (U-89843) IN THE RAT
Authors: ZHAO ZY KOEPLINGER KA BUNDY GL BANITT LS PADBURY GE HAUER MJ SANDERS PE
Citation: Zy. Zhao et al., IN-VITRO AND IN-VIVO BIOTRANSFORMATION OF -2,4-DI-1-PYRROLIDINYL-7H-PYRROLO[2,3-D]PYRIMIDINE (U-89843) IN THE RAT, Drug metabolism and disposition, 24(2), 1996, pp. 187-198
STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - SULFONAMIDE-CONTAINING 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS
Authors: THAISRIVONGS S SKULNICK HI TURNER SR STROHBACH JW TOMMASI RA JOHNSON PD ARISTOFF PA JUDGE TM GAMMILL RB MORRIS JK ROMINES KR CHRUSCIEL RA HINSHAW RR CHONG KT TARPLEY WG POPPE SM SLADE DE LYNN JC HORNG MM TOMICH PK SEEST EP DOLAK LA HOWE WJ HOWARD GM SCHWENDE FJ TOTH LN PADBURY GE WILSON GJ SHIOU LH ZIPP GL WILKINSON KF RUSH BD RUWART MJ KOEPLINGER KA ZHAO ZY COLE S ZAYA RM KAKUK TJ JANAKIRAMAN MN WATENPAUGH KD
Citation: S. Thaisrivongs et al., STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - SULFONAMIDE-CONTAINING 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS, Journal of medicinal chemistry, 39(22), 1996, pp. 4349-4353
STRUCTURE-BASED DESIGN OF SULFONAMIDE-SUBSTITUTED NONPEPTIDIC HIV PROTEASE INHIBITORS
Authors: SKULNICK HI JOHNSON PD HOWE WJ TOMICH PK CHONG KT WATENPAUGH KD JANAKIRAMAN MN DOLAK LA MCGRATH JP LYNN JC HORNG MM HINSHAW RR ZIPP GL RUWART MJ SCHWENDE FJ ZHONG WZ PADBURY GE DALGA RJ SHIOU LH POSSERT PL RUSH BD WILKINSON KF HOWARD GM TOTH LN WILLIAMS MG KAKUK TJ COLE SL ZAYA RM LOVASZ KD MORRIS JK ROMINES KR THAISRIVONGS S ARISTOFF PA
Citation: Hi. Skulnick et al., STRUCTURE-BASED DESIGN OF SULFONAMIDE-SUBSTITUTED NONPEPTIDIC HIV PROTEASE INHIBITORS, Journal of medicinal chemistry, 38(26), 1995, pp. 4968-4971
SYNTHESIS OF NOVEL 2,4-DIAMINOPYRROLO[2,3-D]PYRIMIDINES WITH ANTIOXIDANT, NEUROPROTECTIVE, AND ANTIASTHMA ACTIVITY
Authors: BUNDY GL AYER DE BANITT LS BELONGA KL MIZSAK SA PALMER JR TUSTIN JM CHIN JE HALL ED LINSEMAN KL RICHARDS IM SCHERCH HM SUN FF YONKERS PA LARSON PG LIN JM PADBURY GE AARON CS MAYO JK
Citation: Gl. Bundy et al., SYNTHESIS OF NOVEL 2,4-DIAMINOPYRROLO[2,3-D]PYRIMIDINES WITH ANTIOXIDANT, NEUROPROTECTIVE, AND ANTIASTHMA ACTIVITY, Journal of medicinal chemistry, 38(21), 1995, pp. 4161-4163
FULLY AUTOMATED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF CARZELESIN (U-80,244) AND METABOLITES (U-76,073 ANDU-76,074) IN HUMAN PLASMA
Authors: VANTELLINGEN O PELS EM HENRAR REC SCHAAF LJ PADBURY GE BEIJNEN JH NOOIJEN WJ
Citation: O. Vantellingen et al., FULLY AUTOMATED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF CARZELESIN (U-80,244) AND METABOLITES (U-76,073 ANDU-76,074) IN HUMAN PLASMA, Journal of chromatography B. Biomedical applications, 652(1), 1994, pp. 51-58
STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - 4-HYDROXYCOUMARINS AND 4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS
Authors: THAISRIVONGS S TOMICH PK WATENPAUGH KD CHONG KT HOWE WJ YANG CP STROHBACH JW TURNER SR MCGRATH JP BOHANON MJ LYNN JC MULICHAK AM SPINELLI PA HINSHAW RR PAGANO PJ MOON JB RUWART MJ WILKINSON KF RUSH BD ZIPP GL DALGA RJ SCHWENDE FJ HOWARD GM PADBURY GE TOTH LN ZHAO ZY KOEPLINGER KA KAKUK TJ COLE SL ZAYA RM PIPER RC JEFFREY P
Citation: S. Thaisrivongs et al., STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - 4-HYDROXYCOUMARINS AND 4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS, Journal of medicinal chemistry, 37(20), 1994, pp. 3200-3204
Risultati: 1-12 |