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Results: 1-25 | 26-33
Results: 1-25/33
PREPARATION OF 9-DEOXO-4''-DEOXY-6,9-EPOXYERYTHROMYCIN LACTAMS MOTILACTIDES - POTENT AND ORALLY-ACTIVE PROKINETIC AGENTS
Authors: FAGHIH R NELLANS HN LARTEY PA PETERSEN A MARSH K BENNANI YL PLATTNER JJ
Citation: R. Faghih et al., PREPARATION OF 9-DEOXO-4''-DEOXY-6,9-EPOXYERYTHROMYCIN LACTAMS MOTILACTIDES - POTENT AND ORALLY-ACTIVE PROKINETIC AGENTS, Bioorganic & medicinal chemistry letters, 8(7), 1998, pp. 805-810
SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-PYRIDONES - II - 8-(FLUORO-SUBSTITUTED PYRROLIDINYL)-2-PYRIDONES AS ANTIBACTERIAL AGENTS
Authors: LI Q WANG WB BERST KB CLAIBORNE A HASVOLD L RAYE K TUFANO M NILIUS A SHEN LL FLAMM R ALDER J MARSH K CROWELL D CHU DTW PLATTNER JJ
Citation: Q. Li et al., SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-PYRIDONES - II - 8-(FLUORO-SUBSTITUTED PYRROLIDINYL)-2-PYRIDONES AS ANTIBACTERIAL AGENTS, Bioorganic & medicinal chemistry letters, 8(15), 1998, pp. 1953-1958
HUMAN SERUM ATTENUATES THE ACTIVITY OF PROTEASE INHIBITORS TOWARD WILD-TYPE AND MUTANT HUMAN-IMMUNODEFICIENCY-VIRUS
Authors: MOLLA A VASAVANONDA S KUMAR G SHAM HL JOHNSON M GRABOWSKI B DENISSEN JF KOHLBRENNER W PLATTNER JJ LEONARD JM NORBECK DW KEMPF DJ
Citation: A. Molla et al., HUMAN SERUM ATTENUATES THE ACTIVITY OF PROTEASE INHIBITORS TOWARD WILD-TYPE AND MUTANT HUMAN-IMMUNODEFICIENCY-VIRUS, Virology (New York, N.Y. Print), 250(2), 1998, pp. 255-262
DISCOVERY OF RITONAVIR, A POTENT INHIBITOR OF HIV PROTEASE WITH HIGH ORAL BIOAVAILABILITY AND CLINICAL EFFICACY
Authors: KEMPF DJ SHAM HL MARSH KC FLENTGE CA BETEBENNER D GREEN BE MCDONALD E VASAVANONDA S SALDIVAR A WIDEBURG NE KATI WM RUIZ L ZHAO C FINO LM PATTERSON J MOLLA A PLATTNER JJ NORBECK DW
Citation: Dj. Kempf et al., DISCOVERY OF RITONAVIR, A POTENT INHIBITOR OF HIV PROTEASE WITH HIGH ORAL BIOAVAILABILITY AND CLINICAL EFFICACY, Journal of medicinal chemistry, 41(4), 1998, pp. 602-617
SYNTHESIS OF 9-DEOXO-4''-DEOXY-6,9-EPOXYERYTHROMYCIN DERIVATIVES - NOVEL AND ACID-STABLE MOTILIDES
Authors: FAGHIH R LARTEY PA NELLANS HN SEIF L BURNELLCURTY C KLEIN LL THOMAS P PETERSEN A BORRE A PAGANO T KIM KH HEINDEL M BENNANI YL PLATTNER JJ
Citation: R. Faghih et al., SYNTHESIS OF 9-DEOXO-4''-DEOXY-6,9-EPOXYERYTHROMYCIN DERIVATIVES - NOVEL AND ACID-STABLE MOTILIDES, Journal of medicinal chemistry, 41(18), 1998, pp. 3402-3408
ANHYDROLIDE MACROLIDES - 1 - SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 2,3-ANHYDRO-6-O-METHYL 11,12-CARBAMATE ERYTHROMYCIN-A ANALOGS
Authors: ELLIOTT RL PIREH D GRIESGRABER G NILIUS AM EWING PJ BUI MH RANEY PM FLAMM RK KIM K HENRY RF CHU DTW PLATTNER JJ OR YS
Citation: Rl. Elliott et al., ANHYDROLIDE MACROLIDES - 1 - SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 2,3-ANHYDRO-6-O-METHYL 11,12-CARBAMATE ERYTHROMYCIN-A ANALOGS, Journal of medicinal chemistry, 41(10), 1998, pp. 1651-1659
ANHYDROLIDE MACROLIDES - 2 - SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 2,3-ANHYDRO-6-O-METHYL 11,12-CARBAZATE ERYTHROMYCIN-A ANALOGS
Authors: GRIESGRABER G KRAMER MJ ELLIOTT RL NILIUS AM EWING PJ RANEY PM BUI MH FLAMM RK CHU DTW PLATTNER JJ OR YS
Citation: G. Griesgraber et al., ANHYDROLIDE MACROLIDES - 2 - SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 2,3-ANHYDRO-6-O-METHYL 11,12-CARBAZATE ERYTHROMYCIN-A ANALOGS, Journal of medicinal chemistry, 41(10), 1998, pp. 1660-1670
NOVEL 3-DEOXY-3-DESCLADINOSYL-6-O-METHYL ERYTHROMYCIN-A ANALOGS - SYNTHESIS AND IN-VITRO ACTIVITY
Authors: ELLIOTT RL PIREH D NILIUS AM JOHNSON PM FLAMM RK CHU DTW PLATTNER JJ OR YS
Citation: Rl. Elliott et al., NOVEL 3-DEOXY-3-DESCLADINOSYL-6-O-METHYL ERYTHROMYCIN-A ANALOGS - SYNTHESIS AND IN-VITRO ACTIVITY, Bioorganic & medicinal chemistry letters, 7(5), 1997, pp. 641-646
PHARMACOKINETIC ENHANCEMENT OF INHIBITORS OF THE HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE BY COADMINISTRATION WITH RITONAVIR
Authors: KEMPF DJ MARSH KC KUMAR G RODRIGUES AD DENISSEN JF MCDONALD E KUKULKA MJ HSU A GRANNEMAN GR BAROLDI PA SUN E PIZZUTI D PLATTNER JJ NORBECK DW LEONARD JM
Citation: Dj. Kempf et al., PHARMACOKINETIC ENHANCEMENT OF INHIBITORS OF THE HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE BY COADMINISTRATION WITH RITONAVIR, Antimicrobial agents and chemotherapy, 41(3), 1997, pp. 654-660
NEW DIRECTIONS IN ANTIBACTERIAL RESEARCH
Authors: CHU DTW PLATTNER JJ KATZ L
Citation: Dtw. Chu et al., NEW DIRECTIONS IN ANTIBACTERIAL RESEARCH, Journal of medicinal chemistry, 39(20), 1996, pp. 3853-3874
A NOVEL, PICOMOLAR INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASES
Authors: SHAM HL ZHAO C STEWART KD BETEBENNER DA LIN SQ PARK CH KONG XP ROSENBROOK W HERRIN T MADIGAN D VASAVANONDA S LYONS N MOLLA A SALDIVAR A MARSH KC MCDONALD E WIDEBURG NE DENISSEN JF ROBINS T KEMPF DJ PLATTNER JJ NORBECK DW
Citation: Hl. Sham et al., A NOVEL, PICOMOLAR INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASES, Journal of medicinal chemistry, 39(2), 1996, pp. 392-397
SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-PYRIDONES - A NOVEL SERIES OF POTENT DNA GYRASE INHIBITORS AS ANTIBACTERIAL AGENTS
Authors: LI Q CHU DTW CLAIBORNE A COOPER CS LEE CM RAYE K BERST KB DONNER P WANG WB HASVOLD L FUNG A MA ZK TUFANO M FLAMM R SHEN LL BARANOWSKI J NILIUS A ALDER J MEULBROEK J MARSH K CROWELL D HUI YH SEIF L MELCHER LM HENRY R SPANTON S FAGHIH R KLEIN LL TANAKA SK PLATTNER JJ
Citation: Q. Li et al., SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-PYRIDONES - A NOVEL SERIES OF POTENT DNA GYRASE INHIBITORS AS ANTIBACTERIAL AGENTS, Journal of medicinal chemistry, 39(16), 1996, pp. 3070-3088
3-KETO-11,12-CARBAZATE DERIVATIVES OF 6-O-METHYLERYTHROMYCIN-A SYNTHESIS AND IN-VITRO ACTIVITY
Authors: GRIESGRABER G OR YS CHU DTW NILIUS AM JOHNSON PM FLAMM RK HENRY RF PLATTNER JJ
Citation: G. Griesgraber et al., 3-KETO-11,12-CARBAZATE DERIVATIVES OF 6-O-METHYLERYTHROMYCIN-A SYNTHESIS AND IN-VITRO ACTIVITY, Journal of antibiotics, 49(5), 1996, pp. 465-477
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 6-DEOXYSPOREAMICIN-A
Authors: FAGHIH R FREIBERG L LEONARD J PLATTNER JJ LARTEY PA
Citation: R. Faghih et al., SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 6-DEOXYSPOREAMICIN-A, Journal of antibiotics, 49(5), 1996, pp. 493-495
NOVEL AZACYCLIC UREAS THAT ARE POTENT INHIBITORS OF HIV-1 PROTEASE
Authors: SHAM HL ZHAO C MARSH KC BETEBENNER DA LIN SQ ROSENBROOK W HERRIN T LI LP MADIGAN D VASAVANONDA S MOLLA A SALDIVAR A MCDONALD E WIDEBURG NE KEMPF D NORBECK DW PLATTNER JJ
Citation: Hl. Sham et al., NOVEL AZACYCLIC UREAS THAT ARE POTENT INHIBITORS OF HIV-1 PROTEASE, Biochemical and biophysical research communications, 225(2), 1996, pp. 436-440
POTENT INHIBITOR OF THE HUMAN RHINOVIRUS (HRV) 3C PROTEASE CONTAININGA BACKBONE MODIFIED GLUTAMINE
Authors: SHAM HL ROSENBROOK W KATI W BETEBENNER DA WIDEBURG NE SALDIVAR A PLATTNER JJ NORBECK DW
Citation: Hl. Sham et al., POTENT INHIBITOR OF THE HUMAN RHINOVIRUS (HRV) 3C PROTEASE CONTAININGA BACKBONE MODIFIED GLUTAMINE, Journal of the Chemical Society. Perkin transactions. I, (9), 1995, pp. 1081-1082
A PRACTICAL STEREOSELECTIVE SYNTHESIS OF ,4S)4-TERT-BUTOXYCARBONYLAMINO-2-METHYLPYRROLIDINE
Authors: LI Q CHU DTW RAYE K CLAIBORNE A SEIF L MACRI B PLATTNER JJ
Citation: Q. Li et al., A PRACTICAL STEREOSELECTIVE SYNTHESIS OF ,4S)4-TERT-BUTOXYCARBONYLAMINO-2-METHYLPYRROLIDINE, Tetrahedron letters, 36(46), 1995, pp. 8391-8394
ABT-538 IS A POTENT INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE AND HAS HIGH ORAL BIOAVAILABILITY IN HUMANS
Authors: KEMPF DJ MARSH KC DENISSEN JF MCDONALD E VASAVANONDA S FLENTGE CA GREEN BE FINO L PARK CH KONG XP WIDEBURG NE SALDIVAR A RUIZ L KATI WM SHAM HL ROBINS T STEWART KD HSU A PLATTNER JJ LEONARD JM NORBECK DW
Citation: Dj. Kempf et al., ABT-538 IS A POTENT INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE AND HAS HIGH ORAL BIOAVAILABILITY IN HUMANS, Proceedings of the National Academy of Sciences of the United Statesof America, 92(7), 1995, pp. 2484-2488
ANTITUMOR-ACTIVITY OF 9(R)-DIHYDROTAXANE ANALOGS
Authors: KLEIN LL LI LP MARING CJ YEUNG CM THOMAS SA GRAMPOVNIK DJ PLATTNER JJ
Citation: Ll. Klein et al., ANTITUMOR-ACTIVITY OF 9(R)-DIHYDROTAXANE ANALOGS, Journal of medicinal chemistry, 38(9), 1995, pp. 1482-1492
SYNTHESIS OF 4''-DEOXY MOTILIDES - IDENTIFICATION OF A POTENT AND ORALLY-ACTIVE PROKINETIC DRUG CANDIDATE
Authors: LARTEY PA NELLANS HN FAGHIH R PETERSEN A EDWARDS CM FREIBERG L QUIGLEY S MARSH K KLEIN LL PLATTNER JJ
Citation: Pa. Lartey et al., SYNTHESIS OF 4''-DEOXY MOTILIDES - IDENTIFICATION OF A POTENT AND ORALLY-ACTIVE PROKINETIC DRUG CANDIDATE, Journal of medicinal chemistry, 38(10), 1995, pp. 1793-1798
HIGHLY EFFICIENT SYNTHESIS OF -2-AMINO-4,4-DIFLUORO-1,6-DIPHENYL-3-HYDROXYHEXANE - THE KEY INTERMEDIATE FOR A SERIES OF POTENT HIV PROTEINASE-INHIBITORS
Authors: SHAM HL BETEBENNER DA WIDEBURG NE KEMPF DJ PLATTNER JJ NORBECK DW
Citation: Hl. Sham et al., HIGHLY EFFICIENT SYNTHESIS OF -2-AMINO-4,4-DIFLUORO-1,6-DIPHENYL-3-HYDROXYHEXANE - THE KEY INTERMEDIATE FOR A SERIES OF POTENT HIV PROTEINASE-INHIBITORS, Journal of fluorine chemistry, 73(2), 1995, pp. 221-224
STEREOSELECTIVE DEOXYGENATION OF ERYTHROMYCIN AT C-12 - EFFECT OF STRUCTURE AND CONFORMATION ON PROKINETIC ACTIVITY
Authors: LARTEY PA FAGHIH R PAGANO T NELLANS HN PETERSEN A PLATTNER JJ
Citation: Pa. Lartey et al., STEREOSELECTIVE DEOXYGENATION OF ERYTHROMYCIN AT C-12 - EFFECT OF STRUCTURE AND CONFORMATION ON PROKINETIC ACTIVITY, Journal of antibiotics, 48(7), 1995, pp. 730-732
POTENT INHIBITORS OF THE HIV-1 PROTEASE WITH GOOD ORAL BIOAVAILABILITIES
Authors: SHAM HL ZHAO C MARSH KC BETEBENNER DA LIN SQ MCDONALD E VASAVANONDA S WIDEBURG N SALDIVAR A ROBINS T KEMPF DJ PLATTNER JJ NORBECK DW
Citation: Hl. Sham et al., POTENT INHIBITORS OF THE HIV-1 PROTEASE WITH GOOD ORAL BIOAVAILABILITIES, Biochemical and biophysical research communications, 211(1), 1995, pp. 159-165
C-3'-N-ACYL ANALOGS OF 9(R)-DIHYDROTAXOL - SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS
Authors: MARING CJ GRAMPOVNIK DJ YEUNG CM KLEIN LL LI LP THOMAS SA PLATTNER JJ
Citation: Cj. Maring et al., C-3'-N-ACYL ANALOGS OF 9(R)-DIHYDROTAXOL - SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS, Bioorganic & medicinal chemistry letters, 4(12), 1994, pp. 1429-1432
SYNTHESIS AND ANTITUMOR ACTIVITIES OF TETRACYCLIC QUINOLONE ANTINEOPLASTIC AGENTS
Authors: CHU DTW HALLAS R TANAKA SK ALDER J BALLI D PLATTNER JJ
Citation: Dtw. Chu et al., SYNTHESIS AND ANTITUMOR ACTIVITIES OF TETRACYCLIC QUINOLONE ANTINEOPLASTIC AGENTS, Drugs under experimental and clinical research, 20(5), 1994, pp. 177-183
Risultati: 1-25 | 26-33