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Results: 1-14 |
Results: 14
O[2,3-C]PYRIDIN-5-YL-ETHYL)THIO]-4-PYRIMIDINAMINE, PNU-142721, A NEW BROAD-SPECTRUM HIV-1 NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITOR
Authors: WISHKA DG GRABER DR KOPTA LA OLMSTED RA FRIIS JM HOSLEY JD ADAMS WJ SEEST EP CASTLE TM DOLAK LA KEISER BJ YAGI Y JEGANATHAN A SCHLACHTER ST MURPHY MJ CLEEK GJ NUGENT RA POPPE SM SWANEY SM HAN FS WATT W WHITE WL POEL TJ THOMAS RC VOORMAN RL STEFANSKI KJ STEHLE RG TARPLEY WG MORRIS J
Citation: Dg. Wishka et al., O[2,3-C]PYRIDIN-5-YL-ETHYL)THIO]-4-PYRIMIDINAMINE, PNU-142721, A NEW BROAD-SPECTRUM HIV-1 NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITOR, Journal of medicinal chemistry, 41(9), 1998, pp. 1357-1360
PYRIMIDINE THIOETHERS - A NOVEL CLASS OF HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS WITH ACTIVITY AGAINST BHAP-RESISTANT HIV
Authors: NUGENT RA SCHLACHTER ST MURPHY MJ CLEEK GJ POEL TJ WISHKA DG GRABER DR YAGI Y KEISER BJ OLMSTED RA KOPTA LA SWANEY SM POPPE SM MORRIS J TARPLEY WG THOMAS RC
Citation: Ra. Nugent et al., PYRIMIDINE THIOETHERS - A NOVEL CLASS OF HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS WITH ACTIVITY AGAINST BHAP-RESISTANT HIV, Journal of medicinal chemistry, 41(20), 1998, pp. 3793-3803
ANTIVIRAL ACTIVITY OF THE DIHYDROPYRONE PNU-140690, A NEW NONPEPTIDICHUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE INHIBITOR
Authors: POPPE SM SLADE DE CHONG KT HINSHAW RR PAGANO PJ MARKOWITZ M HO DD MO H GORMAN RR DUEWEKE TJ THAISRIVONGS S TARPLEY WG
Citation: Sm. Poppe et al., ANTIVIRAL ACTIVITY OF THE DIHYDROPYRONE PNU-140690, A NEW NONPEPTIDICHUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE INHIBITOR, Antimicrobial agents and chemotherapy, 41(5), 1997, pp. 1058-1063
VALIDATION OF A QUANTITATIVE RNA PCR ASSAY FOR HIV-1 IN HUMAN PLASMA
Authors: WATHEN LK CRAMPTON DJ PATEL RK NUORALA KW POPPE SM DUEWEKE TJ RE KA KRIEGER KS TARPLEY WG
Citation: Lk. Wathen et al., VALIDATION OF A QUANTITATIVE RNA PCR ASSAY FOR HIV-1 IN HUMAN PLASMA, Journal of clinical laboratory analysis, 10(5), 1996, pp. 262-268
(ALKYLAMINO)PIPERIDINE BIS(HETEROARYL)PIPERIZINE ANALOGS ARE POTENT, BROAD-SPECTRUM NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITORS OF DRUG-RESISTANT ISOLATES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) AND SELECT FOR DRUG-RESISTANT VARIANTS OF HIV-1(IIIB) WITH REDUCED REPLICATION PHENOTYPES
Authors: OLMSTED RA SLADE DE KOPTA LA POPPE SM POEL TJ NEWPORT SW RANK KB BILES C MORGE RA DUEWEKE TJ YAGI Y ROMERO DL THOMAS RC SHARMA SK TARPLEY WG
Citation: Ra. Olmsted et al., (ALKYLAMINO)PIPERIDINE BIS(HETEROARYL)PIPERIZINE ANALOGS ARE POTENT, BROAD-SPECTRUM NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITORS OF DRUG-RESISTANT ISOLATES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) AND SELECT FOR DRUG-RESISTANT VARIANTS OF HIV-1(IIIB) WITH REDUCED REPLICATION PHENOTYPES, Journal of virology, 70(6), 1996, pp. 3698-3705
STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - SULFONAMIDE-CONTAINING 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS
Authors: THAISRIVONGS S SKULNICK HI TURNER SR STROHBACH JW TOMMASI RA JOHNSON PD ARISTOFF PA JUDGE TM GAMMILL RB MORRIS JK ROMINES KR CHRUSCIEL RA HINSHAW RR CHONG KT TARPLEY WG POPPE SM SLADE DE LYNN JC HORNG MM TOMICH PK SEEST EP DOLAK LA HOWE WJ HOWARD GM SCHWENDE FJ TOTH LN PADBURY GE WILSON GJ SHIOU LH ZIPP GL WILKINSON KF RUSH BD RUWART MJ KOEPLINGER KA ZHAO ZY COLE S ZAYA RM KAKUK TJ JANAKIRAMAN MN WATENPAUGH KD
Citation: S. Thaisrivongs et al., STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - SULFONAMIDE-CONTAINING 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS, Journal of medicinal chemistry, 39(22), 1996, pp. 4349-4353
CHARACTERIZATION OF THE P68 P58 HETERODIMER OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 REVERSE-TRANSCRIPTASE/
Authors: FAN NS RANK KB POPPE SM TARPLEY WG SHARMA SK
Citation: Ns. Fan et al., CHARACTERIZATION OF THE P68 P58 HETERODIMER OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 REVERSE-TRANSCRIPTASE/, Biochemistry, 35(6), 1996, pp. 1911-1917
A DRUG-RESISTANCE MUTATION IN THE INHIBITOR BINDING POCKET OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE IMPAIRS DNA-SYNTHESIS AND RNA DEGRADATION
Authors: FAN NS RANK KB SLADE DE POPPE SM EVANS DB KOPTA LA OLMSTED RA THOMAS RC TARPLEY WG SHARMA SK
Citation: Ns. Fan et al., A DRUG-RESISTANCE MUTATION IN THE INHIBITOR BINDING POCKET OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE IMPAIRS DNA-SYNTHESIS AND RNA DEGRADATION, Biochemistry, 35(30), 1996, pp. 9737-9745
A DRUG-RESISTANCE MUTATION (G190E) IN THE INHIBITOR BINDING POCKET IMPAIRS BOTH RNA-DEPENDENT DNA-POLYMERASE AND RIBONUCLEASE-H ACTIVITIES OF HIV-1 REVERSE-TRANSCRIPTASE
Authors: SHARMA SK FAN N RANK KB KOPTA LA OLMSTED RA POPPE SM SLADE DE THOMAS RC TARPLEY WG
Citation: Sk. Sharma et al., A DRUG-RESISTANCE MUTATION (G190E) IN THE INHIBITOR BINDING POCKET IMPAIRS BOTH RNA-DEPENDENT DNA-POLYMERASE AND RIBONUCLEASE-H ACTIVITIES OF HIV-1 REVERSE-TRANSCRIPTASE, Journal of acquired immune deficiency syndromes and human retrovirology, 10, 1995, pp. 2-2
THE DIFFERENTIAL PROCESSING OF HOMODIMERS OF REVERSE TRANSCRIPTASES FROM HUMAN IMMUNODEFICIENCY VIRUSES TYPE-1 AND TYPE-2 IS A CONSEQUENCE OF THE DISTINCT SPECIFICITIES OF THE VIRAL PROTEASES
Authors: FAN NS RANK KB LEONE JW HEINRIKSON RL BANNOW CA SMITH CW EVANS DB POPPE SM TARPLEY WG ROTHROCK DJ TOMASSELLI AG SHARMA SK
Citation: Ns. Fan et al., THE DIFFERENTIAL PROCESSING OF HOMODIMERS OF REVERSE TRANSCRIPTASES FROM HUMAN IMMUNODEFICIENCY VIRUSES TYPE-1 AND TYPE-2 IS A CONSEQUENCE OF THE DISTINCT SPECIFICITIES OF THE VIRAL PROTEASES, The Journal of biological chemistry, 270(22), 1995, pp. 13573-13579
INVITRO CHARACTERIZATION OF BISHETEROARYLPIPERAZINE-RESISTANT RECOMBINANT HIV-1 RT
Authors: DUEWEKE TJ POPPE SM SWANEY SM TARPLEY WG
Citation: Tj. Dueweke et al., INVITRO CHARACTERIZATION OF BISHETEROARYLPIPERAZINE-RESISTANT RECOMBINANT HIV-1 RT, Journal of cellular biochemistry, 1993, pp. 77-77
DEVELOPMENT OF RESISTANCE TO THE BHAP NONNUCLEOSIDE HIV-1 RT INHIBITORS
Authors: POPPE SM DUEWEKE TJ PUSHKARSKAYA T STEVENSON M CHEN ISY TARPLEY WG
Citation: Sm. Poppe et al., DEVELOPMENT OF RESISTANCE TO THE BHAP NONNUCLEOSIDE HIV-1 RT INHIBITORS, Journal of cellular biochemistry, 1993, pp. 84-84
U-90152, A POTENT INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION
Authors: DUEWEKE TJ POPPE SM ROMERO DL SWANEY SM SO AG DOWNEY KM ALTHAUS IW REUSSER F BUSSO M RESNICK L MAYERS DI LANE J ARISTOFF PA THOMAS RC TARPLEY WG
Citation: Tj. Dueweke et al., U-90152, A POTENT INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION, Antimicrobial agents and chemotherapy, 37(5), 1993, pp. 1127-1131
A MUTATION IN REVERSE-TRANSCRIPTASE OF BIS(HETEROARYL)PIPERAZINE-RESISTANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 THAT CONFERS INCREASED SENSITIVITY TO OTHER NONNUCLEOSIDE INHIBITORS
Authors: DUEWEKE TJ PUSHKARSKAYA T POPPE SM SWANEY SM ZHAO JQ CHEN ISY STEVENSON M TARPLEY WG
Citation: Tj. Dueweke et al., A MUTATION IN REVERSE-TRANSCRIPTASE OF BIS(HETEROARYL)PIPERAZINE-RESISTANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 THAT CONFERS INCREASED SENSITIVITY TO OTHER NONNUCLEOSIDE INHIBITORS, Proceedings of the National Academy of Sciences of the United Statesof America, 90(10), 1993, pp. 4713-4717
Risultati: 1-14 |