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Results: 1-25 | 26-50 | 51-53
Results: 1-25/53
Thresholds of O-6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide
Authors: Kokkinakis, DM Bocangel, DB Schold, SC Moschel, RC Pegg, AE
Citation: Dm. Kokkinakis et al., Thresholds of O-6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide, CLIN CANC R, 7(2), 2001, pp. 421-428
alpha-Difluoromethylornithine induction of apoptosis: A mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats
Authors: Fong, TYY Nguyen, VT Pegg, AE Magee, PN
Citation: Tyy. Fong et al., alpha-Difluoromethylornithine induction of apoptosis: A mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats, CANC EPID B, 10(3), 2001, pp. 191-199
Novel DNA repair alkyltransferase from Caenorhabditis elegans
Authors: Kanugula, S Pegg, AE
Citation: S. Kanugula et Ae. Pegg, Novel DNA repair alkyltransferase from Caenorhabditis elegans, ENV MOL MUT, 38(2-3), 2001, pp. 235-243
Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonist-induced cardiac hypertrophy
Authors: Shantz, LM Feith, DJ Pegg, AE
Citation: Lm. Shantz et al., Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonist-induced cardiac hypertrophy, BIOCHEM J, 358, 2001, pp. 25-32
Polyamine analogues inhibit the ubiquitination of spermidine/spermine N-1-acetyltransferase and prevent its targeting to the proteasome for degradation
Authors: Coleman, CS Pegg, AE
Citation: Cs. Coleman et Ae. Pegg, Polyamine analogues inhibit the ubiquitination of spermidine/spermine N-1-acetyltransferase and prevent its targeting to the proteasome for degradation, BIOCHEM J, 358, 2001, pp. 137-145
Effect of polyamine depletion on caspase activation: a study with sperminesynthase-deficient cells
Authors: Stefanelli, C Pignatti, C Tantini, B Fattori, M Stanic, I Mackintosh, CA Flamigni, F Guarnieri, C Caldarera, CM Pegg, AE
Citation: C. Stefanelli et al., Effect of polyamine depletion on caspase activation: a study with sperminesynthase-deficient cells, BIOCHEM J, 355, 2001, pp. 199-206
Inactivation of human O-6-alkylguanine-DNA alkyltransferase by modified oligodeoxyribonucleotides containing O-6-benzylguanine
Authors: Pegg, AE Goodtzova, K Loktionova, NA Kanugula, S Pauly, GT Moschel, RC
Citation: Ae. Pegg et al., Inactivation of human O-6-alkylguanine-DNA alkyltransferase by modified oligodeoxyribonucleotides containing O-6-benzylguanine, J PHARM EXP, 296(3), 2001, pp. 958-965
Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme
Authors: Bauer, PM Buga, GM Fukuto, JM Pegg, AE Ignarro, LJ
Citation: Pm. Bauer et al., Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme, J BIOL CHEM, 276(37), 2001, pp. 34458-34464
Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis
Authors: Feith, DJ Shantz, LM Pegg, AE
Citation: Dj. Feith et al., Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis, CANCER RES, 61(16), 2001, pp. 6073-6081
Topoisomerase I-mediated cytotoxicity of N-methyl-N '-nitro-N-nitrosoguanidine: Trapping of topoisomerase I by the O-6-methylguanine
Authors: Pourquier, P Waltman, JL Urasaki, Y Loktionova, NA Pegg, AE Nitiss, JL Pommier, Y
Citation: P. Pourquier et al., Topoisomerase I-mediated cytotoxicity of N-methyl-N '-nitro-N-nitrosoguanidine: Trapping of topoisomerase I by the O-6-methylguanine, CANCER RES, 61(1), 2001, pp. 53-58
The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase (vol 40, pg 9484, 2001)
Authors: Tolbert, WD Ekstrom, JL Mathews, II Secrist, JA Kapoor, P Pegg, AE Ealick, SE
Citation: Wd. Tolbert et al., The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase (vol 40, pg 9484, 2001), BIOCHEM, 40(43), 2001, pp. 13124-13124
The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase
Authors: Tolbert, WD Ekstrom, JL Mathews, II Secrist, JA Kapoor, P Pegg, AE Ealick, SE
Citation: Wd. Tolbert et al., The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase, BIOCHEM, 40(32), 2001, pp. 9484-9494
Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant
Authors: Ekstrom, JL Tolbert, WD Xiong, HS Pegg, AE Ealick, SE
Citation: Jl. Ekstrom et al., Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant, BIOCHEM, 40(32), 2001, pp. 9495-9504
The role of human O-6-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli
Authors: Liu, H Xu-Welliver, M Pegg, AE
Citation: H. Liu et al., The role of human O-6-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli, MUT RES-F M, 452(1), 2000, pp. 1-10
Repair of O-6-alkylguanine by alkyltransferases
Authors: Pegg, AE
Citation: Ae. Pegg, Repair of O-6-alkylguanine by alkyltransferases, MUT RES-R M, 462(2-3), 2000, pp. 83-100
Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft
Authors: Patel, VJ Elion, GB Houghton, PJ Keir, S Pegg, AE Johnson, SP Dolan, ME Bigner, DD Friedman, HS
Citation: Vj. Patel et al., Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft, CLIN CANC R, 6(10), 2000, pp. 4154-4157
Phase I trial of carmustine plus O-6-benzylguanine for patients with recurrent or progressive malignant glioma
Authors: Friedman, HS Pluda, J Quinn, JA Ewesuedo, RB Long, L Friedman, AH Cokgor, I Colvin, OM Haglund, MM Ashley, DM Rich, JN Sampson, J Pegg, AE Moschel, RC McLendon, RE Provenzale, JM Stewart, ES Tourt-Uhlig, S Garcia-Turner, AM Herndon, JE Bigner, DD Dolan, ME
Citation: Hs. Friedman et al., Phase I trial of carmustine plus O-6-benzylguanine for patients with recurrent or progressive malignant glioma, J CL ONCOL, 18(20), 2000, pp. 3522-3528
O-6-benzylguanine-mediated enhancement of nitrosourea activity in Mer(-) central nervous system tumor xenografts - implications for clinical trials
Authors: Keir, ST Dolan, ME Pegg, AE Lawless, A Moschel, RC Bigner, DD Friedman, HS
Citation: St. Keir et al., O-6-benzylguanine-mediated enhancement of nitrosourea activity in Mer(-) central nervous system tumor xenografts - implications for clinical trials, CANC CHEMOT, 45(6), 2000, pp. 437-440
Potentiation of BCNU antitumor efficacy by 9-substituted O-6-benzylguanines. Effect of metabolism
Authors: Kokkinakis, DM Moschel, RC Pegg, AE Schold, SC
Citation: Dm. Kokkinakis et al., Potentiation of BCNU antitumor efficacy by 9-substituted O-6-benzylguanines. Effect of metabolism, CANC CHEMOT, 45(1), 2000, pp. 69-77
Crystal structure of the human O-6-alkylguanine-DNA alkyltransferase
Authors: Wibley, JEA Pegg, AE Moody, PCE
Citation: Jea. Wibley et al., Crystal structure of the human O-6-alkylguanine-DNA alkyltransferase, NUCL ACID R, 28(2), 2000, pp. 393-401
Effect of spermine synthase deficiency on polyamine biosynthesis and content in mice and embryonic fibroblasts, and the sensitivity of fibroblasts to1,3-bis-(2-chloroethyl)-N-nitrosourea
Authors: Mackintosh, CA Pegg, AE
Citation: Ca. Mackintosh et Ae. Pegg, Effect of spermine synthase deficiency on polyamine biosynthesis and content in mice and embryonic fibroblasts, and the sensitivity of fibroblasts to1,3-bis-(2-chloroethyl)-N-nitrosourea, BIOCHEM J, 351, 2000, pp. 439-447
Overexpression of antizyme in the hearts of transgenic mice prevents the isoprenaline-induced increase in cardiac ornithine decarboxylase activity and polyamines, but does not prevent cardiac hypertrophy
Authors: Mackintosh, CA Feith, DJ Shantz, LM Pegg, AE
Citation: Ca. Mackintosh et al., Overexpression of antizyme in the hearts of transgenic mice prevents the isoprenaline-induced increase in cardiac ornithine decarboxylase activity and polyamines, but does not prevent cardiac hypertrophy, BIOCHEM J, 350, 2000, pp. 645-653
Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O-6-alkylguanine-DNA alkyltransferase insensitive to O-6-benzylguanine
Authors: Xu-Welliver, M Pegg, AE
Citation: M. Xu-welliver et Ae. Pegg, Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O-6-alkylguanine-DNA alkyltransferase insensitive to O-6-benzylguanine, BIOCHEM J, 347, 2000, pp. 519-526
Conserved residue lysine(165) is essential for the ability of O-6-alkylguanine-DNA alkyltransferase to react with O-6-benzylguanine
Authors: Xu-Welliver, M Kanugula, S Loktionova, NA Crone, TM Pegg, AE
Citation: M. Xu-welliver et al., Conserved residue lysine(165) is essential for the ability of O-6-alkylguanine-DNA alkyltransferase to react with O-6-benzylguanine, BIOCHEM J, 347, 2000, pp. 527-534
Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding
Authors: Daniels, DS Mol, CD Arvai, AS Kanugula, S Pegg, AE Tainer, JA
Citation: Ds. Daniels et al., Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding, EMBO J, 19(7), 2000, pp. 1719-1730
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