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Results: 1-25 | 26-50 | 51-61
Results: 1-25/61
Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair
Authors: Takebayashi, Y Pourquier, P Zimonjic, DB Nakayama, K Emmert, S Ueda, T Urasaki, Y Kanzaki, A Akiyama, S Popescu, N Kraemer, KH Pommier, Y
Citation: Y. Takebayashi et al., Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair, NAT MED, 7(8), 2001, pp. 961-966
Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression
Authors: Takebayashi, Y Goldwasser, F Urasaki, Y Kohlhagen, G Pommier, Y
Citation: Y. Takebayashi et al., Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression, CLIN CANC R, 7(1), 2001, pp. 185-191
Structure-activity of inhibition of HIV-1 integrase and virus replication by G-quartet oligonucleotides
Authors: Jing, NJ Marchand, C Guan, YL Liu, J Pallansch, L Lackman-Smith, C De Clercq, E Pommier, Y
Citation: Nj. Jing et al., Structure-activity of inhibition of HIV-1 integrase and virus replication by G-quartet oligonucleotides, DNA CELL B, 20(8), 2001, pp. 499-508
Arylisothiocyanate-containing esters of caffeic acid designed as affinity ligands for HIV-1 integrase
Authors: Zhang, XC Neamati, N Lee, YK Orr, A Brown, RD Whitaker, N Pommier, Y Burke, TR
Citation: Xc. Zhang et al., Arylisothiocyanate-containing esters of caffeic acid designed as affinity ligands for HIV-1 integrase, BIO MED CH, 9(7), 2001, pp. 1649-1657
Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV-1 integrase
Authors: Taktakishvili, M Neamati, N Pommier, Y Nair, V
Citation: M. Taktakishvili et al., Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV-1 integrase, BIOORG MED, 11(11), 2001, pp. 1433-1435
Activation of the Fas pathway independently of Fas ligand during apoptosisinduced by camptothecin in p53 mutant human colon carcinoma cells
Authors: Shao, RG Cao, CX Nieves-Neira, W Dimanche-Boitrel, MT Solary, E Pommier, Y
Citation: Rg. Shao et al., Activation of the Fas pathway independently of Fas ligand during apoptosisinduced by camptothecin in p53 mutant human colon carcinoma cells, ONCOGENE, 20(15), 2001, pp. 1852-1859
Loss of heterozygosity of nucleotide excision repair factors in sporadic ovarian, colon and lung carcinomas: implication for their roles of carcinogenesis in human solid tumors
Authors: Takebayashi, Y Nakayama, K Kanzaki, A Miyashita, H Ogura, O Mori, S Mutoh, M Miyazaki, K Fukumoto, M Pommier, Y
Citation: Y. Takebayashi et al., Loss of heterozygosity of nucleotide excision repair factors in sporadic ovarian, colon and lung carcinomas: implication for their roles of carcinogenesis in human solid tumors, CANCER LETT, 174(2), 2001, pp. 115-125
In vitro human immunodeficiency virus type 1 integrase assays
Authors: Marchand, C Neamati, N Pommier, Y
Citation: C. Marchand et al., In vitro human immunodeficiency virus type 1 integrase assays, METH ENZYM, 340, 2001, pp. 624-633
Topoisomerase I-mediated DNA damage
Authors: Pourquier, P Pommier, Y
Citation: P. Pourquier et Y. Pommier, Topoisomerase I-mediated DNA damage, ADV CANC R, 80, 2001, pp. 189-216
Human mitochondrial topoisomerase I
Authors: Zhang, HL Barcelo, JM Lee, B Kohlhagen, G Zimonjic, DB Popescu, NC Pommier, Y
Citation: Hl. Zhang et al., Human mitochondrial topoisomerase I, P NAS US, 98(19), 2001, pp. 10608-10613
Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters (vol 58, pg 641, 2000)
Authors: Pluymers, W Neamati, N Pannecouque, C Fikkert, V Marchand, C Burke, TR Pommier, Y Schols, D De Clercq, E Debyser, Z Witvrouw, M
Citation: W. Pluymers et al., Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters (vol 58, pg 641, 2000), MOLEC PHARM, 59(2), 2001, pp. 403-403
Quantitative structure-antitumor activity relationships of camptothecin analogues: Cluster analysis and genetic algorithm-based studies
Authors: Fan, Y Shi, LM Kohn, KW Pommier, Y Weinstein, JN
Citation: Y. Fan et al., Quantitative structure-antitumor activity relationships of camptothecin analogues: Cluster analysis and genetic algorithm-based studies, J MED CHEM, 44(20), 2001, pp. 3254-3263
Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells
Authors: Yu, Q La Rose, JH Zhang, HL Pommier, Y
Citation: Q. Yu et al., Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells, FEBS LETTER, 505(1), 2001, pp. 7-12
Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line
Authors: Urasaki, Y Laco, GS Pourquier, P Takebayashi, Y Kohlhagen, G Gioffre, C Zhang, HL Chatterjee, D Pantazis, P Pommier, Y
Citation: Y. Urasaki et al., Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line, CANCER RES, 61(5), 2001, pp. 1964-1969
Use of camptothecin-resistant mammalian cell lines to evaluate the role oftopoisomerase I in the antiproliferative activity of the indolocarbazole, NB-506, and its topoisomerase I binding site
Authors: Urasaki, Y Laco, G Takebayashi, Y Bailly, C Kohlhagen, G Pommier, Y
Citation: Y. Urasaki et al., Use of camptothecin-resistant mammalian cell lines to evaluate the role oftopoisomerase I in the antiproliferative activity of the indolocarbazole, NB-506, and its topoisomerase I binding site, CANCER RES, 61(2), 2001, pp. 504-508
Topoisomerase I-mediated cytotoxicity of N-methyl-N '-nitro-N-nitrosoguanidine: Trapping of topoisomerase I by the O-6-methylguanine
Authors: Pourquier, P Waltman, JL Urasaki, Y Loktionova, NA Pegg, AE Nitiss, JL Pommier, Y
Citation: P. Pourquier et al., Topoisomerase I-mediated cytotoxicity of N-methyl-N '-nitro-N-nitrosoguanidine: Trapping of topoisomerase I by the O-6-methylguanine, CANCER RES, 61(1), 2001, pp. 53-58
Human immunodeficiency virus type 1 integrase-targeted inhibitor design
Authors: Neamati, N Marchand, C Winslow, HE Pommier, Y
Citation: N. Neamati et al., Human immunodeficiency virus type 1 integrase-targeted inhibitor design, ANTIRETROVIRAL THERAPY, 2001, pp. 87-104
A gene expression database for the molecular pharmacology of cancer
Authors: Scherf, U Ross, DT Waltham, M Smith, LH Lee, JK Tanabe, L Kohn, KW Reinhold, WC Myers, TG Andrews, DT Scudiero, DA Eisen, MB Sausville, EA Pommier, Y Botstein, D Brown, PO Weinstein, JN
Citation: U. Scherf et al., A gene expression database for the molecular pharmacology of cancer, NAT GENET, 24(3), 2000, pp. 236-244
Bay-region diol epoxides of benzo[a]pyrene are stealth poisons of topoisomerase I
Authors: Jerina, DM Sayer, JM Kroth, H Kohlhagen, G Laco, GS Pommier, Y
Citation: Dm. Jerina et al., Bay-region diol epoxides of benzo[a]pyrene are stealth poisons of topoisomerase I, POLYCYCL AR, 21(1-4), 2000, pp. 53-62
Identification of HIV-1 integrase inhibitors via three-dimensional database searching using ASV and HIV-1 integrases as targets
Authors: Chen, IJ Neamati, N Nicklaus, MC Orr, A Anderson, L Barchi, JJ Kelley, JA Pommier, Y MacKerell, AD
Citation: Ij. Chen et al., Identification of HIV-1 integrase inhibitors via three-dimensional database searching using ASV and HIV-1 integrases as targets, BIO MED CH, 8(10), 2000, pp. 2385-2398
Recognition and inhibition of HIV integrase by a novel dinucleotide
Authors: Taktakishvili, M Neamati, N Pommier, Y Nair, V
Citation: M. Taktakishvili et al., Recognition and inhibition of HIV integrase by a novel dinucleotide, BIOORG MED, 10(3), 2000, pp. 249-251
Mutations in the HIV type 1 integrase of patients receiving long-term dideoxynucleoside therapy do not confer resistance to zidovudine
Authors: Pilon, AA Marchand, C Kavlick, MF Bajaj, K Owen, J Mitsuya, H Pommier, Y
Citation: Aa. Pilon et al., Mutations in the HIV type 1 integrase of patients receiving long-term dideoxynucleoside therapy do not confer resistance to zidovudine, AIDS RES H, 16(14), 2000, pp. 1417-1422
Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs
Authors: Voeller, DM Grem, JL Pommier, Y Paull, K Allegra, CJ
Citation: Dm. Voeller et al., Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs, CANC CHEMOT, 45(5), 2000, pp. 409-416
Conversion of topoisomerase 1 cleavage complexes on the leading strand of ribosomal DNA into 5 '-phosphorylated DNA double-strand breaks by replication runoff
Authors: Strumberg, D Pilon, AA Smith, M Hickey, R Malkas, L Pommier, Y
Citation: D. Strumberg et al., Conversion of topoisomerase 1 cleavage complexes on the leading strand of ribosomal DNA into 5 '-phosphorylated DNA double-strand breaks by replication runoff, MOL CELL B, 20(11), 2000, pp. 3977-3987
Retroviral integrase inhibitors year 2000: update and perspectives
Authors: Pommier, Y Marchand, C Neamati, N
Citation: Y. Pommier et al., Retroviral integrase inhibitors year 2000: update and perspectives, ANTIVIR RES, 47(3), 2000, pp. 139-148
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