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Results: 1-25 | 26-37
Results: 1-25/37
MODULATION OF O-6-ALKYLATING AGENT INDUCED CLASTOGENICITY BY ENHANCEDDNA-REPAIR CAPACITY OF BONE-MARROW CELLS
Authors: CHINNASAMY N FAIRBAIRN LJ LAHER J WILLINGTON MA RAFFERTY JA
Citation: N. Chinnasamy et al., MODULATION OF O-6-ALKYLATING AGENT INDUCED CLASTOGENICITY BY ENHANCEDDNA-REPAIR CAPACITY OF BONE-MARROW CELLS, Mutation research. Genetic toxicology and environmental mutagenesis, 416(1-2), 1998, pp. 1-10
CD34(-TERM CULTURE-INITIATING CELLS, NOD()AC133(+) CELLS ISOLATED FROM CORD BLOOD ARE HIGHLY ENRICHED IN LONG)SCID-REPOPULATING CELLS AND DENDRITIC CELL PROGENITORS/
Authors: DEWYNTER EA BUCK D HART C HEYWOOD R COUTINHO LH CLAYTON A RAFFERTY JA BURT D GUENECHEA G BUEREN JA GAGEN D FAIRBAIRN LJ LORD BI TESTA NG
Citation: Ea. Dewynter et al., CD34(-TERM CULTURE-INITIATING CELLS, NOD()AC133(+) CELLS ISOLATED FROM CORD BLOOD ARE HIGHLY ENRICHED IN LONG)SCID-REPOPULATING CELLS AND DENDRITIC CELL PROGENITORS/, Stem cells, 16(6), 1998, pp. 387-396
CHEMOPROTECTIVE GENE-TRANSFER - I - TRANSDUCTION OF HUMAN HEMATOPOIETIC PROGENITORS WITH O-6-BENZYLGUANINE-RESISTANT O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE ATTENUATES THE TOXIC EFFECTS OF O-6-ALKYLATING AGENTS IN-VITRO
Authors: HICKSON I FAIRBAIRN LJ CHINNASAMY N LASHFORD LS THATCHER N MARGISON GP DEXTER TM RAFFERTY JA
Citation: I. Hickson et al., CHEMOPROTECTIVE GENE-TRANSFER - I - TRANSDUCTION OF HUMAN HEMATOPOIETIC PROGENITORS WITH O-6-BENZYLGUANINE-RESISTANT O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE ATTENUATES THE TOXIC EFFECTS OF O-6-ALKYLATING AGENTS IN-VITRO, Gene therapy, 5(6), 1998, pp. 835-841
CHEMOPROTECTIVE GENE-TRANSFER-II - MULTILINEAGE IN-VIVO PROTECTION OFHEMATOPOIESIS AGAINST THE EFFECTS OF AN ANTITUMOR AGENT BY EXPRESSIONOF A MUTANT HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE
Authors: CHINNASAMY N RAFFERTY JA HICKSON I LASHFORD LS LONGHURST SJ THATCHER N MARGISON GP DEXTER TM FAIRBAIRN LJ
Citation: N. Chinnasamy et al., CHEMOPROTECTIVE GENE-TRANSFER-II - MULTILINEAGE IN-VIVO PROTECTION OFHEMATOPOIESIS AGAINST THE EFFECTS OF AN ANTITUMOR AGENT BY EXPRESSIONOF A MUTANT HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE, Gene therapy, 5(6), 1998, pp. 842-847
ALKYLPURINE-DNA-N-GLYCOSYLASE KNOCKOUT MICE SHOW INCREASED SUSCEPTIBILITY TO INDUCTION OF MUTATIONS BY METHYL METHANESULFONATE
Authors: ELDER RH JANSEN JG WEEKS RJ WILLINGTON MA DEANS B WATSON PJ MYNETT KJ BAILEY JA COOPER DP RAFFERTY JA HEERAN MC WIJNHOVEN SWP VANZEELAND AA MARGISON GP
Citation: Rh. Elder et al., ALKYLPURINE-DNA-N-GLYCOSYLASE KNOCKOUT MICE SHOW INCREASED SUSCEPTIBILITY TO INDUCTION OF MUTATIONS BY METHYL METHANESULFONATE, Molecular and cellular biology, 18(10), 1998, pp. 5828-5837
LEVELS OF THE DNA-REPAIR ENZYME HUMAN APURINIC APYRIMIDINIC ENDONUCLEASE (APE1, APEX, REF-1) ARE ASSOCIATED WITH THE INTRINSIC RADIOSENSITIVITY OF CERVICAL CANCERS/
Authors: HERRING CJ WEST CML WILKS DP DAVIDSON SE HUNTER RD BERRY P FORSTER G MACKINNON J RAFFERTY JA ELDER RH HENDRY JH MARGISON GP
Citation: Cj. Herring et al., LEVELS OF THE DNA-REPAIR ENZYME HUMAN APURINIC APYRIMIDINIC ENDONUCLEASE (APE1, APEX, REF-1) ARE ASSOCIATED WITH THE INTRINSIC RADIOSENSITIVITY OF CERVICAL CANCERS/, British Journal of Cancer, 78(9), 1998, pp. 1128-1133
INDUCTION OF O-6-ALKYLGUANINE-DNA-ALKYLTRANSFERASE IN THE HEPATOCYTESOF RATS FOLLOWING TREATMENT WITH 2-ACETYLAMINOFLUORENE
Authors: CHINNASAMY N RAFFERTY JA MARGISON GP OCONNOR PJ ELDER RH
Citation: N. Chinnasamy et al., INDUCTION OF O-6-ALKYLGUANINE-DNA-ALKYLTRANSFERASE IN THE HEPATOCYTESOF RATS FOLLOWING TREATMENT WITH 2-ACETYLAMINOFLUORENE, DNA and cell biology, 16(4), 1997, pp. 493-500
GENE-THERAPY FOR CHEMOPROTECTION OF BONE-MARROW FROM THE TOXIC AND CARCINOGENIC EFFECTS OF THE O-6-ALKYLATING AGENTS
Authors: RAFFERTY JA CHINNASAMY N HICKSON I MARGISON GP DEXTER TM FAIRBAIRN LJ
Citation: Ja. Rafferty et al., GENE-THERAPY FOR CHEMOPROTECTION OF BONE-MARROW FROM THE TOXIC AND CARCINOGENIC EFFECTS OF THE O-6-ALKYLATING AGENTS, Cancer gene therapy, 4(6), 1997, pp. 89-89
GENE-THERAPY FOR STEM-CELL PROTECTION USING MUTANT HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE
Authors: CHINNASAMY N HICKSON I DEXTER TM MARGISON GP FAIRBAIRN LJ RAFFERTY JA
Citation: N. Chinnasamy et al., GENE-THERAPY FOR STEM-CELL PROTECTION USING MUTANT HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE, Cancer gene therapy, 4(5), 1997, pp. 303-303
TOWARDS GENE-THERAPY FOR STEM-CELL PROTECTION USING MUTANT HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE
Authors: HICKSON I FAIRBAIRN LJ CHINNASAMY N DEXTER TM MARGISON GP RAFFERTY JA
Citation: I. Hickson et al., TOWARDS GENE-THERAPY FOR STEM-CELL PROTECTION USING MUTANT HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE, Cancer gene therapy, 4(1), 1997, pp. 70-70
APOLIPOPROTEIN-E GENOTYPES AND SERUM-LIPID LEVELS IN ALZHEIMERS-DISEASE AND MULTIINFARCT DEMENTIA
Authors: WIERINGA GE BURLINSON S RAFFERTY JA GOWLAND E BURNS A
Citation: Ge. Wieringa et al., APOLIPOPROTEIN-E GENOTYPES AND SERUM-LIPID LEVELS IN ALZHEIMERS-DISEASE AND MULTIINFARCT DEMENTIA, International journal of geriatric psychiatry, 12(3), 1997, pp. 359-362
THE POTENTIAL ROLE OF GLYCINE-160 OF HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE IN REACTION WITH O-6-BENZYLGUANINE AS DETERMINED BY SITE-DIRECTED MUTAGENESIS AND MOLECULAR MODELING COMPARISONS
Authors: RAFFERTY JA WIBLEY JEA SPEERS P HICKSON I MARGISON GP MOODY PCE DOUGLAS KT
Citation: Ja. Rafferty et al., THE POTENTIAL ROLE OF GLYCINE-160 OF HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE IN REACTION WITH O-6-BENZYLGUANINE AS DETERMINED BY SITE-DIRECTED MUTAGENESIS AND MOLECULAR MODELING COMPARISONS, Biochimica et biophysica acta. Protein structure and molecular enzymology, 1342(1), 1997, pp. 90-102
BACTERIAL AND MAMMALIAN DNA ALKYLTRANSFERASES SENSITIZE ESCHERICHIA-COLI TO THE LETHAL AND MUTAGENIC EFFECTS OF DIBROMOALKANES
Authors: ABRIL N LUQUEROMERO FL PRIETOALAMO MJ RAFFERTY JA MARGISON GP PUEYO C
Citation: N. Abril et al., BACTERIAL AND MAMMALIAN DNA ALKYLTRANSFERASES SENSITIZE ESCHERICHIA-COLI TO THE LETHAL AND MUTAGENIC EFFECTS OF DIBROMOALKANES, Carcinogenesis, 18(10), 1997, pp. 1883-1888
O-6-BENZYLGUANINE POTENTIATES THE IN-VIVO TOXICITY AND CLASTOGENICITYOF TEMOZOLOMIDE AND BCNU IN MOUSE BONE-MARROW
Authors: CHINNASAMY N RAFFERTY JA HICKSON I ASHBY J TINWELL H MARGISON GP DEXTER TM FAIRBAIRN LJ
Citation: N. Chinnasamy et al., O-6-BENZYLGUANINE POTENTIATES THE IN-VIVO TOXICITY AND CLASTOGENICITYOF TEMOZOLOMIDE AND BCNU IN MOUSE BONE-MARROW, Blood, 89(5), 1997, pp. 1566-1573
PROTECTION OF MAMMALIAN-CELLS AGAINST CHLOROETHYLATING AGENT TOXICITYBY AN O-6-BENZYLGUANINE-RESISTANT MUTANT OF HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE
Authors: HICKSON I FAIRBAIRN LJ CHINNASAMY N DEXTER TM MARGISON GP RAFFERTY JA
Citation: I. Hickson et al., PROTECTION OF MAMMALIAN-CELLS AGAINST CHLOROETHYLATING AGENT TOXICITYBY AN O-6-BENZYLGUANINE-RESISTANT MUTANT OF HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE, Gene therapy, 3(10), 1996, pp. 868-877
GENE-TRANSFER TO AUGMENT THE THERAPEUTIC INDEX OF ANTICANCER CHEMOTHERAPY
Authors: BAUM C MARGISON G ECKERT HG FAIRBAIRN LJ OSTERTAG W RAFFERTY JA
Citation: C. Baum et al., GENE-TRANSFER TO AUGMENT THE THERAPEUTIC INDEX OF ANTICANCER CHEMOTHERAPY, Gene therapy, 3(1), 1996, pp. 1-3
INDUCTION OF MURINE O-6-ALKYLGUANINE-DNA-ALKYLTRANSFERASE IN RESPONSETO IONIZING-RADIATION IS P53 GENE DOSE-DEPENDENT
Authors: RAFFERTY JA CLARKE AR SELLAPPAN D KOREF MS FRAYLING IM MARGISON GP
Citation: Ja. Rafferty et al., INDUCTION OF MURINE O-6-ALKYLGUANINE-DNA-ALKYLTRANSFERASE IN RESPONSETO IONIZING-RADIATION IS P53 GENE DOSE-DEPENDENT, Oncogene, 12(3), 1996, pp. 693-697
CHEMOPROTECTION OF NORMAL-TISSUES BY TRANSFER OF DRUG-RESISTANCE GENES
Authors: RAFFERTY JA HICKSON I CHINNASAMY N LASHFORD LS MARGISON GP DEXTER TM FAIRBAIRN LJ
Citation: Ja. Rafferty et al., CHEMOPROTECTION OF NORMAL-TISSUES BY TRANSFER OF DRUG-RESISTANCE GENES, Cancer metastasis reviews, 15(3), 1996, pp. 365-383
CONTRIBUTION OF OGT-ENCODED ALKYLTRANSFERASE TO RESISTANCE TO CHLOROETHYLNITROSOUREAS IN NUCLEOTIDE EXCISION REPAIR-DEFICIENT ESCHERICHIA-COLI
Authors: ABRIL N FERREZUELO F PRIETOALAMO MJ RAFFERTY JA MARGISON GP PUEYO C
Citation: N. Abril et al., CONTRIBUTION OF OGT-ENCODED ALKYLTRANSFERASE TO RESISTANCE TO CHLOROETHYLNITROSOUREAS IN NUCLEOTIDE EXCISION REPAIR-DEFICIENT ESCHERICHIA-COLI, Carcinogenesis, 17(8), 1996, pp. 1609-1614
MODULATING NITROSOUREA RESPONSE IN TUMORS AND NORMAL TISSUE - APPLICATION TO FOTEMUSTINE
Authors: MARGISON GP RAFFERTY JA ELDER RH KELLY J WATSON AJ WILLINGTON MA LEE SM HICKSON I FAIRBAIRN LJ DEXTER TM JELINEK J STOCKING C BAUM C OSTERTAG W EGHYAZI S HANSSON J RINGBORG U DONNELLY D MCMURRY TBH MCCORMICK J MCELHINNEY RS
Citation: Gp. Margison et al., MODULATING NITROSOUREA RESPONSE IN TUMORS AND NORMAL TISSUE - APPLICATION TO FOTEMUSTINE, Medicamentos de actualidad, 32, 1996, pp. 51-59
LONG-TERM PROTECTION OF HEMATOPOIESIS AGAINST THE CYTOTOXIC EFFECTS OF MULTIPLE DOSES OF NITROSOUREA BY RETROVIRUS-MEDIATED EXPRESSION OF HUMAN O-6-ALKYLGUANINE-DNA-ALKYLTRANSFERASE
Authors: JELINEK J FAIRBAIRN LJ DEXTER TM RAFFERTY JA STOCKING C OSTERTAG W MARGISON GP
Citation: J. Jelinek et al., LONG-TERM PROTECTION OF HEMATOPOIESIS AGAINST THE CYTOTOXIC EFFECTS OF MULTIPLE DOSES OF NITROSOUREA BY RETROVIRUS-MEDIATED EXPRESSION OF HUMAN O-6-ALKYLGUANINE-DNA-ALKYLTRANSFERASE, Blood, 87(5), 1996, pp. 1957-1961
DNA-REPAIR DEFICIENCY IN SYSTEMIC LUPUS-ERYTHEMATOSUS - CAUSE OR CONSEQUENCE OF DISEASE AND IMPLICATIONS FOR MANAGEMENT
Authors: HERRICK AL RAFFERTY JA MARGISON GP
Citation: Al. Herrick et al., DNA-REPAIR DEFICIENCY IN SYSTEMIC LUPUS-ERYTHEMATOSUS - CAUSE OR CONSEQUENCE OF DISEASE AND IMPLICATIONS FOR MANAGEMENT, Lupus, 4(6), 1995, pp. 423-424
O-6-BENZYLGUANINE INCREASES THE SENSITIVITY OF HUMAN PRIMARY BONE-MARROW CELLS TO THE CYTOTOXIC EFFECTS OF TEMOZOLOMIDE
Authors: FAIRBAIRN LJ WATSON AJ RAFFERTY JA ELDER RH MARGISON GP
Citation: Lj. Fairbairn et al., O-6-BENZYLGUANINE INCREASES THE SENSITIVITY OF HUMAN PRIMARY BONE-MARROW CELLS TO THE CYTOTOXIC EFFECTS OF TEMOZOLOMIDE, Experimental hematology, 23(2), 1995, pp. 112-116
DNA-REPAIR DEFICIENCY IN SYSTEMIC LUPUS-ERYTHEMATOSUS AND RHEUMATOID-ARTHRITIS - CAUSE OR CONSEQUENCE OF DISEASE
Authors: HERRICK AL GREEN H JAYSON MIV RAFFERTY JA MARGISON GP
Citation: Al. Herrick et al., DNA-REPAIR DEFICIENCY IN SYSTEMIC LUPUS-ERYTHEMATOSUS AND RHEUMATOID-ARTHRITIS - CAUSE OR CONSEQUENCE OF DISEASE, Arthritis and rheumatism, 38(9), 1995, pp. 355-355
BCL-2 DELAY OF ALKYLATING AGENT-INDUCED APOPTOTIC DEATH IN A MURINE HEMATOPOIETIC STEM-CELL LINE
Authors: FAIRBAIRN LJ COWLING GJ DEXTER TM RAFFERTY JA MARGISON GP REIPERT B
Citation: Lj. Fairbairn et al., BCL-2 DELAY OF ALKYLATING AGENT-INDUCED APOPTOTIC DEATH IN A MURINE HEMATOPOIETIC STEM-CELL LINE, Molecular carcinogenesis, 11(1), 1994, pp. 49-55
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