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RATIONALE FOR TREATMENT DESIGN - BIOCHEMICAL MODULATION OF 5-FLUOROURACIL BY LEUCOVORIN
Authors: RUSTUM YM CAO SS ZHANG ZG
Citation: Ym. Rustum et al., RATIONALE FOR TREATMENT DESIGN - BIOCHEMICAL MODULATION OF 5-FLUOROURACIL BY LEUCOVORIN, The cancer journal from Scientific American, 4(1), 1998, pp. 12-18
EXPRESSION OF THE MRP AND MDR1 MULTIDRUG-RESISTANCE GENE-PRODUCTS IN 160 UNTREATED HUMAN CARCINOMAS STUDIED BY IMMUNOHISTOCHEMICAL METHODS IN FORMALIN-PARAFFIN SECTIONS
Authors: TOTH K VAUGHAN MM SCHWARTZ G WINSTON JS SKENDERIS BS SLOCUM HK RUSTUM YM
Citation: K. Toth et al., EXPRESSION OF THE MRP AND MDR1 MULTIDRUG-RESISTANCE GENE-PRODUCTS IN 160 UNTREATED HUMAN CARCINOMAS STUDIED BY IMMUNOHISTOCHEMICAL METHODS IN FORMALIN-PARAFFIN SECTIONS, International journal of surgical pathology, 6(3), 1998, pp. 145-154
COMPARISON OF 5-FLUORO-2'-DEOXYURIDINE WITH 5-FLUOROURACIL AND THEIR ROLE IN THE TREATMENT OF COLORECTAL-CANCER
Authors: VANLAAR JAM RUSTUM YM ACKLAND SP VANGROENINGEN CJ PETERS GJ
Citation: Jam. Vanlaar et al., COMPARISON OF 5-FLUORO-2'-DEOXYURIDINE WITH 5-FLUOROURACIL AND THEIR ROLE IN THE TREATMENT OF COLORECTAL-CANCER, European journal of cancer, 34(3), 1998, pp. 296-306
SCHEDULE-DEPENDENT ANTITUMOR EFFICACY OF IRINOTECAN (CPT-11) AND 5-FLUOROURACIL (5-FU) IN NUDE-MICE BEARING COLON-TUMOR XENOGRAFTS THAT ARERESISTANT TO 5-FU
Authors: VANHOEFER U HAPKE G HARSTRICK A ACHTERRATH W RUSTUM YM SEEBER S
Citation: U. Vanhoefer et al., SCHEDULE-DEPENDENT ANTITUMOR EFFICACY OF IRINOTECAN (CPT-11) AND 5-FLUOROURACIL (5-FU) IN NUDE-MICE BEARING COLON-TUMOR XENOGRAFTS THAT ARERESISTANT TO 5-FU, Annals of oncology, 9, 1998, pp. 634-634
S-1, A NEW ORAL 5-FLUOROURACIL PRODRUG, WITH HIGH THERAPEUTIC INDEX IN RODENTS AND IN PHASE-II CLINICAL-TRIALS
Authors: SHIRASAKA T RUSTUM YM TAGUCHI T
Citation: T. Shirasaka et al., S-1, A NEW ORAL 5-FLUOROURACIL PRODRUG, WITH HIGH THERAPEUTIC INDEX IN RODENTS AND IN PHASE-II CLINICAL-TRIALS, Annals of oncology, 9, 1998, pp. 637-637
RATIONAL DESIGN OF IRINOTECAN ADMINISTRATION BASED ON PRECLINICAL MODELS
Authors: MINDERMAN H CAO SS RUSTUM YM
Citation: H. Minderman et al., RATIONAL DESIGN OF IRINOTECAN ADMINISTRATION BASED ON PRECLINICAL MODELS, Oncology, 12(8), 1998, pp. 22-30
CELL-CYCLE - MOLECULAR TARGETS FOR DIAGNOSIS AND THERAPY - TUMOR-SUPPRESSOR GENES AND CELL-CYCLE PROGRESSION IN CANCER
Authors: GIORDANO A RUSTUM YM WENNER CE
Citation: A. Giordano et al., CELL-CYCLE - MOLECULAR TARGETS FOR DIAGNOSIS AND THERAPY - TUMOR-SUPPRESSOR GENES AND CELL-CYCLE PROGRESSION IN CANCER, Journal of cellular biochemistry, 70(1), 1998, pp. 1-7
NOVEL CELLULAR DETERMINANTS FOR REVERSAL OF MULTIDRUG-RESISTANCE IN CELLS EXPRESSING P170-GLYCOPROTEIN
Authors: YIN MB GUO B VOIGT W VANHOEFER U GIBBS JF SKENDERIS BS FRANK C WRZOSEK C RUSTUM YM
Citation: Mb. Yin et al., NOVEL CELLULAR DETERMINANTS FOR REVERSAL OF MULTIDRUG-RESISTANCE IN CELLS EXPRESSING P170-GLYCOPROTEIN, Biochimica et biophysica acta. Molecular cell research, 1401(3), 1998, pp. 265-276
MODULATION OF PLATINUM-INDUCED TOXICITIES AND THERAPEUTIC INDEX - MECHANISTIC INSIGHTS AND FIRST-GENERATION AND 2ND-GENERATION PROTECTING AGENTS
Authors: HAUSHEER FH KANTER P CAO S HARIDAS K SEETHARAMULU P REDDY D PETLURU P ZHAO M MURALI D SAXE JD YAO S MARTINEZ N ZUKOWSKI A RUSTUM YM
Citation: Fh. Hausheer et al., MODULATION OF PLATINUM-INDUCED TOXICITIES AND THERAPEUTIC INDEX - MECHANISTIC INSIGHTS AND FIRST-GENERATION AND 2ND-GENERATION PROTECTING AGENTS, Seminars in oncology, 25(5), 1998, pp. 584-599
INTERLEUKIN-15 PROTECTS AGAINST TOXICITY AND POTENTIATES ANTITUMOR-ACTIVITY OF 5-FLUOROURACIL ALONE AND IN COMBINATION WITH LEUCOVORIN IN RATS BEARING COLORECTAL-CANCER
Authors: CAO SS TROUTT AB RUSTUM YM
Citation: Ss. Cao et al., INTERLEUKIN-15 PROTECTS AGAINST TOXICITY AND POTENTIATES ANTITUMOR-ACTIVITY OF 5-FLUOROURACIL ALONE AND IN COMBINATION WITH LEUCOVORIN IN RATS BEARING COLORECTAL-CANCER, Cancer research, 58(8), 1998, pp. 1695-1699
INTERLEUKIN-15 OFFERS SELECTIVE PROTECTION FROM IRINOTECAN-INDUCED INTESTINAL TOXICITY IN A PRECLINICAL ANIMAL-MODEL
Authors: CAO SS BLACK JD TROUTT AB RUSTUM YM
Citation: Ss. Cao et al., INTERLEUKIN-15 OFFERS SELECTIVE PROTECTION FROM IRINOTECAN-INDUCED INTESTINAL TOXICITY IN A PRECLINICAL ANIMAL-MODEL, Cancer research, 58(15), 1998, pp. 3270-3274
SUPER IN-VITRO SYNERGY BETWEEN INHIBITORS OF DIHYDROFOLATE-REDUCTASE AND INHIBITORS OF OTHER FOLATE-REQUIRING ENZYMES - THE CRITICAL ROLE OF POLYGLUTAMYLATION
Authors: FAESSEL HM SLOCUM HK JACKSON RC BORITZKI TJ RUSTUM YM NAIR MG GRECO WR
Citation: Hm. Faessel et al., SUPER IN-VITRO SYNERGY BETWEEN INHIBITORS OF DIHYDROFOLATE-REDUCTASE AND INHIBITORS OF OTHER FOLATE-REQUIRING ENZYMES - THE CRITICAL ROLE OF POLYGLUTAMYLATION, Cancer research, 58(14), 1998, pp. 3036-3050
CELLULAR DETERMINANTS OF RESISTANCE TO INDOLOCARBAZOLE ANALOG LO[2,3-ALPHA]PYRROLO[3,4-C]CARBAZOLE-5,7(6H)-DIONE (NB-506), A NOVEL POTENT TOPOISOMERASE-I INHIBITOR, IN MULTIDRUG-RESISTANT HUMAN TUMOR-CELLS
Authors: VANHOEFER U VOIGT W HILGER RA YIN MB HARSTRICK A SEEBER S RUSTUM YM
Citation: U. Vanhoefer et al., CELLULAR DETERMINANTS OF RESISTANCE TO INDOLOCARBAZOLE ANALOG LO[2,3-ALPHA]PYRROLO[3,4-C]CARBAZOLE-5,7(6H)-DIONE (NB-506), A NOVEL POTENT TOPOISOMERASE-I INHIBITOR, IN MULTIDRUG-RESISTANT HUMAN TUMOR-CELLS, Oncology research, 9(9), 1997, pp. 485-494
COMPARATIVE ANTITUMOR EFFICACY OF DOCETAXEL AND PACLITAXEL IN NUDE-MICE BEARING HUMAN TUMOR XENOGRAFTS THAT OVEREXPRESS THE MULTIDRUG-RESISTANCE PROTEIN (MRP)
Authors: VANHOEFER U CAO S HARSTRICK A SEEBER S RUSTUM YM
Citation: U. Vanhoefer et al., COMPARATIVE ANTITUMOR EFFICACY OF DOCETAXEL AND PACLITAXEL IN NUDE-MICE BEARING HUMAN TUMOR XENOGRAFTS THAT OVEREXPRESS THE MULTIDRUG-RESISTANCE PROTEIN (MRP), Annals of oncology, 8(12), 1997, pp. 1221-1228
THYMIDYLATE SYNTHASE INHIBITORS IN CANCER-THERAPY - DIRECT AND INDIRECT INHIBITORS
Authors: RUSTUM YM HARSTRICK A CAO SS VANHOEFER U YIN MB WILKE H SEEBER S
Citation: Ym. Rustum et al., THYMIDYLATE SYNTHASE INHIBITORS IN CANCER-THERAPY - DIRECT AND INDIRECT INHIBITORS, Journal of clinical oncology, 15(1), 1997, pp. 389-400
COMBINED ACTION OF PACLITAXEL AND CISPLATIN AGAINST WILDTYPE AND RESISTANT HUMAN OVARIAN-CARCINOMA CELLS
Authors: LEVASSEUR LM GRECO WR RUSTUM YM SLOCUM HK
Citation: Lm. Levasseur et al., COMBINED ACTION OF PACLITAXEL AND CISPLATIN AGAINST WILDTYPE AND RESISTANT HUMAN OVARIAN-CARCINOMA CELLS, Cancer chemotherapy and pharmacology, 40(6), 1997, pp. 495-505
EVALUATION OF TOPOISOMERASE-I CATALYTIC ACTIVITY AS DETERMINANT OF DRUG RESPONSE IN HUMAN CANCER CELL-LINES
Authors: VOIGT W VANHOEFER U YIN MB MINDERMAN H SCHMOLL HJ RUSTUM YM
Citation: W. Voigt et al., EVALUATION OF TOPOISOMERASE-I CATALYTIC ACTIVITY AS DETERMINANT OF DRUG RESPONSE IN HUMAN CANCER CELL-LINES, Anticancer research, 17(5A), 1997, pp. 3707-3711
MECHANISM-BASED IMPROVEMENT IN THE THERAPEUTIC SELECTIVITY OF 5-FU PRODRUG ALONE AND UNDER CONDITIONS OF METABOLIC MODULATION
Authors: RUSTUM YM
Citation: Ym. Rustum, MECHANISM-BASED IMPROVEMENT IN THE THERAPEUTIC SELECTIVITY OF 5-FU PRODRUG ALONE AND UNDER CONDITIONS OF METABOLIC MODULATION, Oncology, 54, 1997, pp. 7-11
BIOCHEMICAL MODULATION - ITS PHARMACOLOGICAL BASIS AND CLINICAL-APPLICATIONS - QUESTION AND ANSWER SESSION
Authors: PAZDUR R RUSTUM YM VILLALON AH GONZALEZBARON M
Citation: R. Pazdur et al., BIOCHEMICAL MODULATION - ITS PHARMACOLOGICAL BASIS AND CLINICAL-APPLICATIONS - QUESTION AND ANSWER SESSION, Oncology, 54, 1997, pp. 38-39
P53 AND WAF1 ARE INDUCED AND RB PROTEIN IS HYPOPHOSPHORYLATED DURING CELL-GROWTH INHIBITION BY THE THYMIDYLATE SYNTHASE INHIBITOR ZD1694 (TOMUDEX)
Authors: YIN MB VOIGT W PANADERO A VANHOEFER U FRANK C PAJOVIC S AZIZKHAN J RUSTUM YM
Citation: Mb. Yin et al., P53 AND WAF1 ARE INDUCED AND RB PROTEIN IS HYPOPHOSPHORYLATED DURING CELL-GROWTH INHIBITION BY THE THYMIDYLATE SYNTHASE INHIBITOR ZD1694 (TOMUDEX), Molecular pharmacology, 51(4), 1997, pp. 630-636
CARBAMOYLATION OF GLUTATHIONE-REDUCTASE BY N,N-BIS(2-CHLOROETHYL)-N-NITROSOUREA ASSOCIATED WITH INHIBITION OF MULTIDRUG-RESISTANCE PROTEIN (MRP) FUNCTION
Authors: VANHOEFER U YIN MB HARSTRICK A SEEBER S RUSTUM YM
Citation: U. Vanhoefer et al., CARBAMOYLATION OF GLUTATHIONE-REDUCTASE BY N,N-BIS(2-CHLOROETHYL)-N-NITROSOUREA ASSOCIATED WITH INHIBITION OF MULTIDRUG-RESISTANCE PROTEIN (MRP) FUNCTION, Biochemical pharmacology, 53(6), 1997, pp. 801-809
MECHANISMS OF ACQUIRED-RESISTANCE TO MODULATION OF 5-FLUOROURACIL BY LEUCOVORIN IN HCT-8 HUMAN ILEOCECAL CARCINOMA-CELLS
Authors: LU K MCGUIRE JJ SLOCUM HK RUSTUM YM
Citation: K. Lu et al., MECHANISMS OF ACQUIRED-RESISTANCE TO MODULATION OF 5-FLUOROURACIL BY LEUCOVORIN IN HCT-8 HUMAN ILEOCECAL CARCINOMA-CELLS, Biochemical pharmacology, 53(5), 1997, pp. 689-696
ROLE OF FLUOROPYRIMIDINE SCHEDULE AND (6R,S)LEUCOVORIN DOSE IN A PRECLINICAL ANIMAL-MODEL OF COLORECTAL-CARCINOMA
Authors: CAO SS FRANK C RUSTUM YM
Citation: Ss. Cao et al., ROLE OF FLUOROPYRIMIDINE SCHEDULE AND (6R,S)LEUCOVORIN DOSE IN A PRECLINICAL ANIMAL-MODEL OF COLORECTAL-CARCINOMA, Journal of the National Cancer Institute, 88(7), 1996, pp. 430-436
THERAPEUTIC EFFICACY OF FLUOROPYRIMIDINES DEPENDS ON THE DURATION OF THYMIDYLATE SYNTHASE INHIBITION IN THE MURINE COLON 26-B CARCINOMA TUMOR-MODEL
Authors: VANLAAR JAM VANDERWILT CL RUSTUM YM NOORDHUIS P SMID K PINEDO HM PETERS GJ
Citation: Jam. Vanlaar et al., THERAPEUTIC EFFICACY OF FLUOROPYRIMIDINES DEPENDS ON THE DURATION OF THYMIDYLATE SYNTHASE INHIBITION IN THE MURINE COLON 26-B CARCINOMA TUMOR-MODEL, Clinical cancer research, 2(8), 1996, pp. 1327-1333
POLYGLUTAMYLATION OF THE DIHYDROFOLATE-REDUCTASE INHIBITOR GAMMA-METHYLENE-10-DEAZAAMINOPTERIN IS NOT ESSENTIAL FOR ANTITUMOR-ACTIVITY
Authors: CAO S ABRAHAM A NAIR MG PATI R GALIVAN JH HAUSHEER FH RUSTUM YM
Citation: S. Cao et al., POLYGLUTAMYLATION OF THE DIHYDROFOLATE-REDUCTASE INHIBITOR GAMMA-METHYLENE-10-DEAZAAMINOPTERIN IS NOT ESSENTIAL FOR ANTITUMOR-ACTIVITY, Clinical cancer research, 2(4), 1996, pp. 707-712
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