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Results: 1-20 |
Results: 20
Insights into the role of the von Hippel-Lindau gene product - A key player in hypoxic regulation
Authors: Maxwell, PH Pugh, CW Ratcliffe, PJ
Citation: Ph. Maxwell et al., Insights into the role of the von Hippel-Lindau gene product - A key player in hypoxic regulation, EXP NEPHROL, 9(4), 2001, pp. 235-240
Contrasting effects on HIF-1 alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease
Authors: Clifford, SC Cockman, ME Smallwood, AC Mole, DR Woodward, ER Maxwell, PH Ratcliffe, PJ Maher, ER
Citation: Sc. Clifford et al., Contrasting effects on HIF-1 alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease, HUM MOL GEN, 10(10), 2001, pp. 1029-1038
Trans-ethnic fine mapping of a quantitative trait locus for circulating angiotensin I-converting enzyme (ACE)
Authors: McKenzie, CA Abecasis, GR Keavney, B Forrester, T Ratcliffe, PJ Julier, C Connell, JMC Bennett, F McFarlane-Anderson, N Lathrop, GM Cardon, LR
Citation: Ca. Mckenzie et al., Trans-ethnic fine mapping of a quantitative trait locus for circulating angiotensin I-converting enzyme (ACE), HUM MOL GEN, 10(10), 2001, pp. 1077-1084
Activation of the HIF pathway in cancer
Authors: Maxwell, PH Pugh, CW Ratcliffe, PJ
Citation: Ph. Maxwell et al., Activation of the HIF pathway in cancer, CUR OP GEN, 11(3), 2001, pp. 293-299
The pVHL-associated SCF ubiquitin ligase complex: Molecular genetic analysis of elongin B and C, Rbx1 and HIF-1 alpha in renal cell carcinoma
Authors: Clifford, SC Astuti, D Hooper, L Maxwell, PH Ratcliffe, PJ Maher, ER
Citation: Sc. Clifford et al., The pVHL-associated SCF ubiquitin ligase complex: Molecular genetic analysis of elongin B and C, Rbx1 and HIF-1 alpha in renal cell carcinoma, ONCOGENE, 20(36), 2001, pp. 5067-5074
Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation
Authors: Masson, N Willam, C Maxwell, PH Pugh, CW Ratcliffe, PJ
Citation: N. Masson et al., Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation, EMBO J, 20(18), 2001, pp. 5197-5206
C-elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
Authors: Epstein, ACR Gleadle, JM McNeill, LA Hewitson, KS O'Rourke, J Mole, DR Mukherji, M Metzen, E Wilson, MI Dhanda, A Tian, YM Masson, N Hamilton, DL Jaakkola, P Barstead, R Hodgkin, J Maxwell, PH Pugh, CW Schofield, CJ Ratcliffe, PJ
Citation: Acr. Epstein et al., C-elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation, CELL, 107(1), 2001, pp. 43-54
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O-2-regulated prolyl hydroxylation
Authors: Jaakkola, P Mole, DR Tian, YM Wilson, MI Gielbert, J Gaskell, SJ von Kriegsheim, A Hebestreit, HF Mukherji, M Schofield, CJ Maxwell, PH Pugh, CW Ratcliffe, PJ
Citation: P. Jaakkola et al., Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O-2-regulated prolyl hydroxylation, SCIENCE, 292(5516), 2001, pp. 468-472
Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor
Authors: Vaux, EC Wood, SM Cockman, ME Nicholls, LG Yeates, KM Pugh, CW Maxwell, PH Ratcliffe, PJ
Citation: Ec. Vaux et al., Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor, J BIOL CHEM, 276(47), 2001, pp. 44323-44330
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
Authors: Sowter, HM Ratcliffe, PJ Watson, P Greenberg, AH Harris, AL
Citation: Hm. Sowter et al., HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors, CANCER RES, 61(18), 2001, pp. 6669-6673
Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker ofhypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
Authors: Loncaster, JA Harris, AL Davidson, SE Logue, JP Hunter, RD Wycoff, CC Pastorek, J Ratcliffe, PJ Stratford, IJ West, CML
Citation: Ja. Loncaster et al., Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker ofhypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix, CANCER RES, 61(17), 2001, pp. 6394-6399
Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain
Authors: Vaux, EC Metzen, E Yeates, KM Ratcliffe, PJ
Citation: Ec. Vaux et al., Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain, BLOOD, 98(2), 2001, pp. 296-302
Targeting tumors through the HIF system
Authors: Ratcliffe, PJ Pugh, CW Maxwell, PH
Citation: Pj. Ratcliffe et al., Targeting tumors through the HIF system, NAT MED, 6(12), 2000, pp. 1315-1316
Screening for the GRA mutation in Jamaica
Authors: McKenzie, CA Keavney, B Forrester, T Julier, C Ratcliffe, PJ
Citation: Ca. Mckenzie et al., Screening for the GRA mutation in Jamaica, J HUM HYPER, 14(2), 2000, pp. 157-158
Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling
Authors: Wykoff, CC Pugh, CW Maxwell, PH Harris, AL Ratcliffe, PJ
Citation: Cc. Wykoff et al., Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling, ONCOGENE, 19(54), 2000, pp. 6297-6305
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
Authors: Cockman, ME Masson, N Mole, DR Jaakkola, P Chang, GW Clifford, SC Maher, ER Pugh, CW Ratcliffe, PJ Maxwell, PH
Citation: Me. Cockman et al., Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein, J BIOL CHEM, 275(33), 2000, pp. 25733-25741
Hypoxia-inducible expression of tumor-associated carbonic anhydrases
Authors: Wykoff, CC Beasley, NJP Watson, PH Turner, KJ Pastorek, J Sibtain, A Wilson, GD Turley, H Talks, KL Maxwell, PH Pugh, CW Ratcliffe, PJ Harris, AL
Citation: Cc. Wykoff et al., Hypoxia-inducible expression of tumor-associated carbonic anhydrases, CANCER RES, 60(24), 2000, pp. 7075-7083
The expression and distribution of the hypoxia-inducible factors HIF-1 alpha and HIF-2 alpha in normal human tissues, cancers, and tumor-associated macrophages
Authors: Talks, KL Turley, H Gatter, KC Maxwell, PH Pugh, CW Ratcliffe, PJ Harris, AL
Citation: Kl. Talks et al., The expression and distribution of the hypoxia-inducible factors HIF-1 alpha and HIF-2 alpha in normal human tissues, cancers, and tumor-associated macrophages, AM J PATH, 157(2), 2000, pp. 411-421
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Authors: Maxwell, PH Wiesener, MS Chang, GW Clifford, SC Vaux, EC Cockman, ME Wykoff, CC Pugh, CW Maher, ER Ratcliffe, PJ
Citation: Ph. Maxwell et al., The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis, NATURE, 399(6733), 1999, pp. 271-275
Oxygen-regulated and transactivating domains in endothelial PAS protein 1:Comparison with hypoxia-inducible factor-1 alpha
Authors: O'Rourke, JF Tian, YM Ratcliffe, PJ Pugh, CW
Citation: Jf. O'Rourke et al., Oxygen-regulated and transactivating domains in endothelial PAS protein 1:Comparison with hypoxia-inducible factor-1 alpha, J BIOL CHEM, 274(4), 1999, pp. 2060-2071
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