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Results: 1-10 |
Results: 10
Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol
Authors: Kozak, KR Prusakiewicz, JJ Rowlinson, SW Schneider, C Marnett, LJ
Citation: Kr. Kozak et al., Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol, J BIOL CHEM, 276(32), 2001, pp. 30072-30077
Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid
Authors: Boutaud, O Brame, CJ Chaurand, P Li, JY Rowlinson, SW Crews, BC Ji, C Marnett, LJ Caprioli, RM Roberts, LJ Oates, JA
Citation: O. Boutaud et al., Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid, BIOCHEM, 40(23), 2001, pp. 6948-6955
Structural insights into the stereochemistry of the cyclooxygenase reaction
Authors: Kiefer, JR Pawlitz, JL Moreland, KT Stegeman, RA Hood, WF Gierse, JK Stevens, AM Goodwin, DC Rowlinson, SW Marnett, LJ Stallings, WC Kurumbail, RG
Citation: Jr. Kiefer et al., Structural insights into the stereochemistry of the cyclooxygenase reaction, NATURE, 405(6782), 2000, pp. 97-101
Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: Facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors
Authors: Kalgutkar, AS Crews, BC Rowlinson, SW Marnett, AB Kozak, KR Remmel, RP Marnett, LJ
Citation: As. Kalgutkar et al., Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: Facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors, P NAS US, 97(2), 2000, pp. 925-930
Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2 - Why acetylated COX-1 does not synthesize 15-(R)-HETE
Authors: Rowlinson, SW Crews, BC Goodwin, DC Schneider, C Gierse, JK Marnett, LJ
Citation: Sw. Rowlinson et al., Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2 - Why acetylated COX-1 does not synthesize 15-(R)-HETE, J BIOL CHEM, 275(9), 2000, pp. 6586-6591
Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2
Authors: Kozak, KR Rowlinson, SW Marnett, LJ
Citation: Kr. Kozak et al., Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2, J BIOL CHEM, 275(43), 2000, pp. 33744-33749
Substitution of tyrosine for the proximal histidine ligand to the heme of prostaglandin endoperoxide synthase 2: Implications for the mechanism of cyclooxygenase activation and catalysis
Authors: Goodwin, DC Rowlinson, SW Marnett, LJ
Citation: Dc. Goodwin et al., Substitution of tyrosine for the proximal histidine ligand to the heme of prostaglandin endoperoxide synthase 2: Implications for the mechanism of cyclooxygenase activation and catalysis, BIOCHEM, 39(18), 2000, pp. 5422-5432
Tyrosine-385 is critical for acetylation of cyclooxygenase-2 by aspirin
Authors: Hochgesang, GP Rowlinson, SW Marnett, LJ
Citation: Gp. Hochgesang et al., Tyrosine-385 is critical for acetylation of cyclooxygenase-2 by aspirin, J AM CHEM S, 122(27), 2000, pp. 6514-6515
Arachidonic acid oxygenation by COX-1 and COX-2 - Mechanisms of catalysis and inhibition
Authors: Marnett, LJ Rowlinson, SW Goodwin, DC Kalgutkar, AS Lanzo, CA
Citation: Lj. Marnett et al., Arachidonic acid oxygenation by COX-1 and COX-2 - Mechanisms of catalysis and inhibition, J BIOL CHEM, 274(33), 1999, pp. 22903-22906
The binding of arachidonic acid in the cyclooxygenase active site of mouseprostaglandin endoperoxide synthase-2 (COX-2) - A putative L-shaped binding conformation utilizing the top channel region
Authors: Rowlinson, SW Crews, BC Lanzo, CA Marnett, LJ
Citation: Sw. Rowlinson et al., The binding of arachidonic acid in the cyclooxygenase active site of mouseprostaglandin endoperoxide synthase-2 (COX-2) - A putative L-shaped binding conformation utilizing the top channel region, J BIOL CHEM, 274(33), 1999, pp. 23305-23310
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