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Results: 1-25 | 26-35
Results: 1-25/35
IDENTIFICATION OF SIDE-CHAINS ON 1,2,5-THIADIAZOLE-AZACYCLES OPTIMAL FOR MUSCARINIC M1 RECEPTOR ACTIVATION
Authors: SAUERBERG P JEPPESEN L OLESEN PH SHEARDOWN MJ FINKJENSEN A RASMUSSEN T RIMVALL K SHANNON HE BYMASTER FP DELAPP NW CALLIGARO DO WARD JS WHITESITT CA THOMSEN C
Citation: P. Sauerberg et al., IDENTIFICATION OF SIDE-CHAINS ON 1,2,5-THIADIAZOLE-AZACYCLES OPTIMAL FOR MUSCARINIC M1 RECEPTOR ACTIVATION, Bioorganic & medicinal chemistry letters, 8(20), 1998, pp. 2897-2902
MUSCARINIC AGENTS - A NEW APPROACH TO THE TREATMENT OF PSYCHOSIS
Authors: SHANNON HE BYMASTER FP BODICK NW OFFEN WW DELAPP NC PERRY KW RASMUSSEN K WARD JS WHITESITT CA FINKJENSEN A OLESEN P RASMUSSEN T SHEARDOWN M SWEDBERG M SAUERBERG P
Citation: He. Shannon et al., MUSCARINIC AGENTS - A NEW APPROACH TO THE TREATMENT OF PSYCHOSIS, Schizophrenia research, 29(1-2), 1998, pp. 158-159
1,2,5-THIADIAZOLE ANALOGS OF ACECLIDINE AS POTENT M(1) MUSCARINIC AGONISTS
Authors: WARD JS MERRITT L CALLIGARO DO BYMASTER FP SHANNON HE MITCH CH WHITESITT C BRUNSTING D SHEARDOWN MJ OLESEN PH SWEDBERG MDB JEPPESEN L SAUERBERG P
Citation: Js. Ward et al., 1,2,5-THIADIAZOLE ANALOGS OF ACECLIDINE AS POTENT M(1) MUSCARINIC AGONISTS, Journal of medicinal chemistry, 41(3), 1998, pp. 379-392
MUSCARINIC AGONISTS WITH ANTIPSYCHOTIC-LIKE ACTIVITY - STRUCTURE-ACTIVITY-RELATIONSHIPS OF 1,2,5-THIADIAZOLE ANALOGS WITH FUNCTIONAL DOPAMINE ANTAGONIST ACTIVITY
Authors: SAUERBERG P JEPPESEN L OLESEN PH RASMUSSEN T SWEDBERG MDB SHEARDOWN MJ FINKJENSEN A THOMSEN C THOGERSEN H RIMVALL K WARD JS CALLIGARO DO DELAPP NW BYMASTER FP SHANNON HE
Citation: P. Sauerberg et al., MUSCARINIC AGONISTS WITH ANTIPSYCHOTIC-LIKE ACTIVITY - STRUCTURE-ACTIVITY-RELATIONSHIPS OF 1,2,5-THIADIAZOLE ANALOGS WITH FUNCTIONAL DOPAMINE ANTAGONIST ACTIVITY, Journal of medicinal chemistry, 41(22), 1998, pp. 4378-4384
CONFORMATIONALLY CONSTRAINED ANALOGS OF THE MUSCARINIC AGONIST IADIAZOL-3-YL)-1,2,5,6-TETRAHYDRO-1-METHYLPYRIDINE - SYNTHESIS, RECEPTOR AFFINITY, AND ANTINOCICEPTIVE ACTIVITY
Authors: SAUERBERG P OLESEN PH SHEARDOWN MJ RIMVALL K THOGERSEN H SHANNON HE SAWYER BD WARD JS BYMASTER FP DELAPP NW CALLIGARO DO SWEDBERG MDB
Citation: P. Sauerberg et al., CONFORMATIONALLY CONSTRAINED ANALOGS OF THE MUSCARINIC AGONIST IADIAZOL-3-YL)-1,2,5,6-TETRAHYDRO-1-METHYLPYRIDINE - SYNTHESIS, RECEPTOR AFFINITY, AND ANTINOCICEPTIVE ACTIVITY, Journal of medicinal chemistry, 41(1), 1998, pp. 109-116
UNEXPECTED ANTIPSYCHOTIC-LIKE ACTIVITY WITH THE MUSCARINIC RECEPTOR-LIGAND O-1,2,5-THIADIAZOL-4-YL)-1-AZABICYCLO[3.2.1]OCTANE
Authors: BYMASTER FP SHANNON HE RASMUSSEN K DELAPP NW MITCH CH WARD JS CALLIGARO DO LUDVIGSEN TS SHEARDOWN MJ OLESEN PH SWEDBERG MDB SAUERBERG P FINKJENSEN A
Citation: Fp. Bymaster et al., UNEXPECTED ANTIPSYCHOTIC-LIKE ACTIVITY WITH THE MUSCARINIC RECEPTOR-LIGAND O-1,2,5-THIADIAZOL-4-YL)-1-AZABICYCLO[3.2.1]OCTANE, European journal of pharmacology, 356(2-3), 1998, pp. 109-119
XANOMELINE COMPARED TO OTHER MUSCARINIC AGENTS ON STIMULATION OF PHOSPHOINOSITIDE HYDROLYSIS IN-VIVO AND OTHER CHOLINOMIMETIC EFFECTS
Authors: BYMASTER FP CARTER PA PETERS SC ZHANG W WARD JS MITCH CH CALLIGARO DO WHITESITT CA DELAPP N SHANNON HE RIMVALL K JEPPESEN L SHEARDOWN MJ FINKJENSEN A SAUERBERG P
Citation: Fp. Bymaster et al., XANOMELINE COMPARED TO OTHER MUSCARINIC AGENTS ON STIMULATION OF PHOSPHOINOSITIDE HYDROLYSIS IN-VIVO AND OTHER CHOLINOMIMETIC EFFECTS, Brain research, 795(1-2), 1998, pp. 179-190
EFFECTS OF THE M1 AGONIST XANOMELINE ON PROCESSING OF HUMAN BETA-AMYLOID PRECURSOR PROTEIN (FAD, SWEDISH MUTANT) TRANSFECTED INTO CHINESE-HAMSTER OVARY-M1 CELLS
Authors: DELAPP N WU S BELAGAJE R JOHNSTONE E LITTLE S SHANNON H BYMASTER F CALLIGARO D MITCH C WHITESITT C WARD J SHEARDOWN M FINKJENSEN A JEPPESEN L THOMSEN C SAUERBERG P
Citation: N. Delapp et al., EFFECTS OF THE M1 AGONIST XANOMELINE ON PROCESSING OF HUMAN BETA-AMYLOID PRECURSOR PROTEIN (FAD, SWEDISH MUTANT) TRANSFECTED INTO CHINESE-HAMSTER OVARY-M1 CELLS, Biochemical and biophysical research communications, 244(1), 1998, pp. 156-160
SYNTHESIS AND STRUCTURAL DETERMINATION OF STEREOISOMERS OF MUSCARINICLIGANDS OF THE OPYLTHIO-1,2,5-THIADIAZOL-4-YL)-1-AZABICYCLOALKANE TYPE
Authors: OLESEN PH SAUERBERG P PETERSEN TG TREPPENDAHL S BENTZEN B DEETER J WARD JS MITCH CH LEHMANN SNV
Citation: Ph. Olesen et al., SYNTHESIS AND STRUCTURAL DETERMINATION OF STEREOISOMERS OF MUSCARINICLIGANDS OF THE OPYLTHIO-1,2,5-THIADIAZOL-4-YL)-1-AZABICYCLOALKANE TYPE, Chirality, 9(8), 1997, pp. 739-749
XANOMELINE - A SELECTIVE MUSCARINIC AGONIST FOR THE TREATMENT OF ALZHEIMERS-DISEASE
Authors: BYMASTER FP WHITESITT CA SHANNON HE DELAPP N WARD JS CALLIGARO DO SHIPLEY LA BUELKESAM JL BODICK NC FARDE L SHEARDOWN MJ OLESEN PH HANSEN KT SUZDAK PD SWEDBERG MDB SAUERBERG P MITCH CH
Citation: Fp. Bymaster et al., XANOMELINE - A SELECTIVE MUSCARINIC AGONIST FOR THE TREATMENT OF ALZHEIMERS-DISEASE, Drug development research, 40(2), 1997, pp. 158-170
CONFORMATIONALLY CONSTRAINED ANALOGS OF THE MUSCARINIC AGONIST METHYLTHIO-TZTP - SYNTHESIS, RECEPTOR AFFINITY AND ANALGESIC ACTIVITY
Authors: SAUERBERG P OLESEN PH THOGERSEN H NIELSEN S SHEARDOWN MJ RIMVALL K SHANNON HE WARD JS MITCH CH BYMASTER FP SWEDBERG MDB
Citation: P. Sauerberg et al., CONFORMATIONALLY CONSTRAINED ANALOGS OF THE MUSCARINIC AGONIST METHYLTHIO-TZTP - SYNTHESIS, RECEPTOR AFFINITY AND ANALGESIC ACTIVITY, Life sciences, 60(13-14), 1997, pp. 4-4
STIMULATION OF PHOSPHOINOSITIDE HYDROLYSIS IN-VIVO BY XANOMELINE AND OTHER MUSCARINIC AGENTS
Authors: BYMASTER F CARTER P SHANNON H DELAPP N WHITESITT C WARD J CALLIGARO D MITCH C SHEARDOWN M SWEDBERG M RIMVALL K FINKJENSEN A JEPPESEN L SAUERBERG P
Citation: F. Bymaster et al., STIMULATION OF PHOSPHOINOSITIDE HYDROLYSIS IN-VIVO BY XANOMELINE AND OTHER MUSCARINIC AGENTS, Life sciences, 60(13-14), 1997, pp. 5-5
THE TETRAHYDROPYRIDINE RING CONFERS OPTIMAL M(1) SELECTIVITY AND BLOOD-BRAIN-BARRIER PENETRATION AMONG HEXYLOXY-1,2,5-THIADIAZOLE AZACYCLES
Authors: WARD JS MERRITT L STRATFORD R BROWN TJ WIJAYARATNE R SZEWCZYK SP CALLIGARO DO BYMASTER FP SHANNON HE MITCH CH JOHNSON DW WIKEL JH OLESEN MJ SHEARDOWN MJ SWEDBERG MDB SAUERBERG P
Citation: Js. Ward et al., THE TETRAHYDROPYRIDINE RING CONFERS OPTIMAL M(1) SELECTIVITY AND BLOOD-BRAIN-BARRIER PENETRATION AMONG HEXYLOXY-1,2,5-THIADIAZOLE AZACYCLES, Life sciences, 60(13-14), 1997, pp. 6-6
MUSCARINIC AGONISTS PRODUCE ANALGESIA THROUGH PERTUSSIS-TOXIN-SENSITIVE MUSCARINIC RECEPTORS IN THE SPINAL-CORD
Authors: SHANNON HE WOMER DE DELAPP NW BYMASTER FP MITCH CH WARD JS WHITESITT C CALLIGARO D SWEDBERG MDB SHEARDOWN MJ SAUERBERG P RIMVALL K FINKJENSEN A JEPPESEN L
Citation: He. Shannon et al., MUSCARINIC AGONISTS PRODUCE ANALGESIA THROUGH PERTUSSIS-TOXIN-SENSITIVE MUSCARINIC RECEPTORS IN THE SPINAL-CORD, Life sciences, 60(13-14), 1997, pp. 78-78
ANTICONVULSANT EFFECTS OF MUSCARINICS
Authors: SWEDBERG MDB SHANNON HE SHEARDOWN MJ KLITGAARD H BYMASTER FP WARD JS MITCH CH OLESEN PH ESKESEN K SUZDAK PD CALLIGARO DO SAUERBERG P
Citation: Mdb. Swedberg et al., ANTICONVULSANT EFFECTS OF MUSCARINICS, Life sciences, 60(13-14), 1997, pp. 80-80
IN-VIVO PHARMACOLOGY OF BUTYLTHIO[2.2.2] (LY297802 NNC11-1053), AN ORALLY ACTING ANTINOCICEPTIVE MUSCARINIC AGONIST/
Authors: SHANNON HE WOMER DE BYMASTER FP CALLIGARO DO DELAPP NC MITCH CH WARD JS WHITESITT CA SWEDBERG MDB SHEARDOWN MJ FINKJENSEN A OLESEN PH RIMVALL K SAUERBERG P
Citation: He. Shannon et al., IN-VIVO PHARMACOLOGY OF BUTYLTHIO[2.2.2] (LY297802 NNC11-1053), AN ORALLY ACTING ANTINOCICEPTIVE MUSCARINIC AGONIST/, Life sciences, 60(13-14), 1997, pp. 969-976
M-1 RECEPTOR AGONIST ACTIVITY IS NOT A REQUIREMENT FOR MUSCARINIC ANTINOCICEPTION
Authors: SHEARDOWN MJ SHANNON HE SWEDBERG MDB SUZDAK PD BYMASTER FP OLESEN PH MITCH CH WARD JS SAUERBERG P
Citation: Mj. Sheardown et al., M-1 RECEPTOR AGONIST ACTIVITY IS NOT A REQUIREMENT FOR MUSCARINIC ANTINOCICEPTION, The Journal of pharmacology and experimental therapeutics, 281(2), 1997, pp. 868-875
BUTYLTHIO[2.2.2] (NNC 11-1053 LY297802) - AN ORALLY-ACTIVE MUSCARINICAGONIST ANALGESIC/
Authors: SWEDBERG MDB SHEARDOWN MJ SAUERBERG P OLESEN PH SUZDAK PD HANSEN KT BYMASTER FP WARD JS MITCH CH CALLIGARO DO DELAPP NW SHANNON HE
Citation: Mdb. Swedberg et al., BUTYLTHIO[2.2.2] (NNC 11-1053 LY297802) - AN ORALLY-ACTIVE MUSCARINICAGONIST ANALGESIC/, The Journal of pharmacology and experimental therapeutics, 281(2), 1997, pp. 876-883
PHARMACOLOGY OF BUTYLTHIO[2.2.2] (LY297802 NNC11-1053) - A NOVEL ANALGESIC WITH MIXED MUSCARINIC RECEPTOR AGONIST AND ANTAGONIST ACTIVITY/
Authors: SHANNON HE SHEARDOWN MJ BYMASTER FP CALLIGARO DO DELAPP NW GIDDA J MITCH CH SAWYER BD STENGEL PW WARD JS WONG DT OLESEN PH SUZDAK PD SAUERBERG P SWEDBERG MDB
Citation: He. Shannon et al., PHARMACOLOGY OF BUTYLTHIO[2.2.2] (LY297802 NNC11-1053) - A NOVEL ANALGESIC WITH MIXED MUSCARINIC RECEPTOR AGONIST AND ANTAGONIST ACTIVITY/, The Journal of pharmacology and experimental therapeutics, 281(2), 1997, pp. 884-894
MUSCARINIC ANALGESICS WITH POTENT AND SELECTIVE EFFECTS ON THE GASTROINTESTINAL-TRACT - POTENTIAL APPLICATION FOR THE TREATMENT OF IRRITABLE-BOWEL-SYNDROME
Authors: MITCH CH BROWN TJ BYMASTER FP CALLIGARO DO DIECKMAN D MERRIT L PETERS SC QUIMBY SJ SHANNON HE SHIPLEY LA WARD JS HANSEN K OLESEN PH SAUERBERG P SHEARDOWN MJ SWEDBERG MDB SUZDAK P GREENWOOD B
Citation: Ch. Mitch et al., MUSCARINIC ANALGESICS WITH POTENT AND SELECTIVE EFFECTS ON THE GASTROINTESTINAL-TRACT - POTENTIAL APPLICATION FOR THE TREATMENT OF IRRITABLE-BOWEL-SYNDROME, Journal of medicinal chemistry, 40(4), 1997, pp. 538-546
PET STUDY OF THE M(1)-AGONISTS [C-11] XANOMELINE AND [C-11] BUTYLTHIO-TZTP IN MONKEY AND MAN
Authors: FARDE L SUHARA T HALLDIN C NYBACK H NAKASHIMA Y SWAHN CG KARLSSON P GINOVART N BYMASTER FP SHANNON HE FOGED C SUZDAK PD SAUERBERG P
Citation: L. Farde et al., PET STUDY OF THE M(1)-AGONISTS [C-11] XANOMELINE AND [C-11] BUTYLTHIO-TZTP IN MONKEY AND MAN, Dementia, 7(4), 1996, pp. 187-195
3-(3-ALKYLTHIO-1,2,5-THIADIAZOL-4-YL)1-AZABICYCLE - STRUCTURE-ACTIVITY-RELATIONSHIPS FOR ANTINOCICEPTION MEDIATED BY CENTRAL MUSCARINIC RECEPTORS
Authors: OLESEN PH SAUERBERG P TREPPENDAHL S LARSSON O SHEARDOWN MJ SUZDAK PD MITCH CH WARD JS BYMASTER FP SHANNON HE SWEDBERG MDB
Citation: Ph. Olesen et al., 3-(3-ALKYLTHIO-1,2,5-THIADIAZOL-4-YL)1-AZABICYCLE - STRUCTURE-ACTIVITY-RELATIONSHIPS FOR ANTINOCICEPTION MEDIATED BY CENTRAL MUSCARINIC RECEPTORS, European journal of medicinal chemistry, 31(3), 1996, pp. 221-230
MUSCARINIC AGONISTS AS ANALGESICS - ANTINOCICEPTIVE ACTIVITY VERSUS M(1) ACTIVITY - SAR OF ALKYLTHIO-TZTPS AND RELATED 1,2,5-THIADIAZOLE ANALOGS
Authors: SAUERBERG P OLESEN PH SHEARDOWN MJ SUZDAK PD SHANNON HE BYMASTER FP CALLIGARO DO MITCH CH WARD JS SWEDBERG MDB
Citation: P. Sauerberg et al., MUSCARINIC AGONISTS AS ANALGESICS - ANTINOCICEPTIVE ACTIVITY VERSUS M(1) ACTIVITY - SAR OF ALKYLTHIO-TZTPS AND RELATED 1,2,5-THIADIAZOLE ANALOGS, Life sciences, 56(11-12), 1995, pp. 807-814
MUSCARINIC RECEPTOR CHARACTERIZATION AND EVALUATION OF A SERIES OF NOVEL MUSCARINIC LIGANDS IN THE ISOLATED RABBIT THORACIC AORTA
Authors: SAWYER BD SHANNON HE WARD JS MITCH CH SHEARDOWN MJ OLESEN PH SAUERBERG P
Citation: Bd. Sawyer et al., MUSCARINIC RECEPTOR CHARACTERIZATION AND EVALUATION OF A SERIES OF NOVEL MUSCARINIC LIGANDS IN THE ISOLATED RABBIT THORACIC AORTA, Life sciences, 56(11-12), 1995, pp. 1004-1004
SIDE-CHAIN STERIC BULK AND MUSCARINIC AGONIST SAR IN ALKOXY-TZTPS
Authors: MITCH CH BYMASTER FP CALLIGARO DO QUIMBY SJ SAWYER BD WARD JS OLESEN PH SAUERBERG P SHEARDOWN MJ SUZDAK PD SWEDBERG M SHANNON HE
Citation: Ch. Mitch et al., SIDE-CHAIN STERIC BULK AND MUSCARINIC AGONIST SAR IN ALKOXY-TZTPS, Life sciences, 56(11-12), 1995, pp. 1004-1004
Risultati: 1-25 | 26-35