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Results: 1-25 | 26-50 | 51-75 | 76-82
Results: 1-25/82
ADDITIVE EFFECTS OF PS1 AND APP MUTATIONS ON SECRETION OF THE 42-RESIDUE AMYLOID BETA-PROTEIN
Authors: CITRON M ECKMAN CB DIEHL TS CORCORAN C OSTASZEWSKI BL XIA WM LEVESQUE G HYSLOP PS YOUNKIN SG SELKOE DJ
Citation: M. Citron et al., ADDITIVE EFFECTS OF PS1 AND APP MUTATIONS ON SECRETION OF THE 42-RESIDUE AMYLOID BETA-PROTEIN, Neurobiology of disease, 5(2), 1998, pp. 107-116
ALZHEIMERS-DISEASE - A TECHNICAL KO OF AMYLOID-BETA PEPTIDE
Authors: HAASS C SELKOE DJ
Citation: C. Haass et Dj. Selkoe, ALZHEIMERS-DISEASE - A TECHNICAL KO OF AMYLOID-BETA PEPTIDE, Nature, 391(6665), 1998, pp. 339-340
A SUBSTRATE-BASED DIFLUORO KETONE SELECTIVELY INHIBITS ALZHEIMERS GAMMA-SECRETASE ACTIVITY
Authors: WOLFE MS CITRON M DIEHL TS XIA WM DONKOR IO SELKOE DJ
Citation: Ms. Wolfe et al., A SUBSTRATE-BASED DIFLUORO KETONE SELECTIVELY INHIBITS ALZHEIMERS GAMMA-SECRETASE ACTIVITY, Journal of medicinal chemistry, 41(1), 1998, pp. 6-9
THE PROTEOLYTIC FRAGMENTS OF THE ALZHEIMERS-DISEASE-ASSOCIATED PRESENILIN-1 FORM HETERODIMERS AND OCCUR AS A 100-150-KDA MOLECULAR-MASS COMPLEX
Authors: CAPELL A GRUNBERG J PESOLD B DIEHLMANN A CITRON M NIXON R BEYREUTHER K SELKOE DJ HAASS C
Citation: A. Capell et al., THE PROTEOLYTIC FRAGMENTS OF THE ALZHEIMERS-DISEASE-ASSOCIATED PRESENILIN-1 FORM HETERODIMERS AND OCCUR AS A 100-150-KDA MOLECULAR-MASS COMPLEX, The Journal of biological chemistry, 273(6), 1998, pp. 3205-3211
EXPRESSION OF ALZHEIMERS-DISEASE-ASSOCIATED PRESENILIN-1 IS CONTROLLED BY PROTEOLYTIC DEGRADATION AND COMPLEX-FORMATION
Authors: STEINER H CAPELL A PESOLD B CITRON M KLOETZEL PM SELKOE DJ ROMIG H MENDLA K HAASS C
Citation: H. Steiner et al., EXPRESSION OF ALZHEIMERS-DISEASE-ASSOCIATED PRESENILIN-1 IS CONTROLLED BY PROTEOLYTIC DEGRADATION AND COMPLEX-FORMATION, The Journal of biological chemistry, 273(48), 1998, pp. 32322-32331
SUBCELLULAR-DISTRIBUTION AND TURNOVER OF PRESENILINS IN TRANSFECTED CELLS
Authors: ZHANG JM KANG DE XIA WM OKOCHI M MORI H SELKOE DJ KOO EH
Citation: Jm. Zhang et al., SUBCELLULAR-DISTRIBUTION AND TURNOVER OF PRESENILINS IN TRANSFECTED CELLS, The Journal of biological chemistry, 273(20), 1998, pp. 12436-12442
OLIGOMERIZATION OF ENDOGENOUS AND SYNTHETIC AMYLOID BETA-PROTEIN AT NANOMOLAR LEVELS IN CELL-CULTURE AND STABILIZATION OF MONOMER BY CONGO RED
Authors: PODLISNY MB WALSH DM AMARANTE P OSTASZEWSKI BL STIMSON ER MAGGIO JE TEPLOW DB SELKOE DJ
Citation: Mb. Podlisny et al., OLIGOMERIZATION OF ENDOGENOUS AND SYNTHETIC AMYLOID BETA-PROTEIN AT NANOMOLAR LEVELS IN CELL-CULTURE AND STABILIZATION OF MONOMER BY CONGO RED, Biochemistry, 37(11), 1998, pp. 3602-3611
MUTANT PRESENILINS OF ALZHEIMERS-DISEASE INCREASE PRODUCTION OF 42-RESIDUE AMYLOID BETA-PROTEIN IN BOTH TRANSFECTED CELLS AND TRANSGENIC MICE
Authors: CITRON M WESTAWAY D XIA WM CARLSON G DIEHL T LEVESQUE G JOHNSONWOOD K LEE M SEUBERT P DAVIS A KHOLODENKO D MOTTER R SHERRINGTON R PERRY B YAO H STROME R LIEBERBURG I ROMMENS J KIM S SCHENK D FRASER P HYSLOP PS SELKOE DJ
Citation: M. Citron et al., MUTANT PRESENILINS OF ALZHEIMERS-DISEASE INCREASE PRODUCTION OF 42-RESIDUE AMYLOID BETA-PROTEIN IN BOTH TRANSFECTED CELLS AND TRANSGENIC MICE, Nature medicine, 3(1), 1997, pp. 67-72
TRAFFICKING AND PROCESSING OF BETA-AMYLOID PRECURSOR PROTEIN AND THE MECHANISM OF FAMILIAL ALZHEIMERS-DISEASE
Authors: SELKOE DJ
Citation: Dj. Selkoe, TRAFFICKING AND PROCESSING OF BETA-AMYLOID PRECURSOR PROTEIN AND THE MECHANISM OF FAMILIAL ALZHEIMERS-DISEASE, Molecular biology of the cell, 8, 1997, pp. 713-713
PERMEABILITY AND RESIDUAL PLASMA-VOLUME OF HUMAN, DUTCH VARIANT, AND RAT AMYLOID BETA-PROTEIN-1-40 AT THE BLOOD-BRAIN-BARRIER
Authors: PODUSLO JF CURRAN GL HAGGARD JJ BIERE AL SELKOE DJ
Citation: Jf. Poduslo et al., PERMEABILITY AND RESIDUAL PLASMA-VOLUME OF HUMAN, DUTCH VARIANT, AND RAT AMYLOID BETA-PROTEIN-1-40 AT THE BLOOD-BRAIN-BARRIER, Neurobiology of disease, 4(1), 1997, pp. 27-34
PRESENILIN PROTEINS UNDERGO HETEROGENEOUS ENDOPROTEOLYSIS BETWEEN THR(291) AND ALA(299) AND OCCUR AS STABLE N-TERMINAL AND C-TERMINAL FRAGMENTS IN NORMAL AND ALZHEIMER BRAIN-TISSUE
Authors: PODLISNY MB CITRON M AMARANTE P SHERRINGTON R XIA WM ZHANG JM DIEHL T LEVESQUE G FRASER P HAASS C KOO EHM SEUBERT P STGEORGEHYSLOP P TEPLOW DB SELKOE DJ
Citation: Mb. Podlisny et al., PRESENILIN PROTEINS UNDERGO HETEROGENEOUS ENDOPROTEOLYSIS BETWEEN THR(291) AND ALA(299) AND OCCUR AS STABLE N-TERMINAL AND C-TERMINAL FRAGMENTS IN NORMAL AND ALZHEIMER BRAIN-TISSUE, Neurobiology of disease, 3(4), 1997, pp. 325-337
CELL-SURFACE AMYLOID BETA-PROTEIN PRECURSOR COLOCALIZES WITH BETA-1 INTEGRINS AT SUBSTRATE CONTACT SITES IN NEURAL CELLS
Authors: YAMAZAKI T KOO EH SELKOE DJ
Citation: T. Yamazaki et al., CELL-SURFACE AMYLOID BETA-PROTEIN PRECURSOR COLOCALIZES WITH BETA-1 INTEGRINS AT SUBSTRATE CONTACT SITES IN NEURAL CELLS, The Journal of neuroscience, 17(3), 1997, pp. 1004-1010
SKELETAL AND CNS DEFECTS IN PRESENILIN-1-DEFICIENT MICE
Authors: SHEN J BRONSON RT CHEN DF XIA WM SELKOE DJ TONEGAWA S
Citation: J. Shen et al., SKELETAL AND CNS DEFECTS IN PRESENILIN-1-DEFICIENT MICE, Cell, 89(4), 1997, pp. 629-639
NEUROSCIENCE - ALZHEIMERS-DISEASE - GENOTYPES, PHENOTYPE, AND TREATMENTS
Authors: SELKOE DJ
Citation: Dj. Selkoe, NEUROSCIENCE - ALZHEIMERS-DISEASE - GENOTYPES, PHENOTYPE, AND TREATMENTS, Science, 275(5300), 1997, pp. 630-631
INTERACTION BETWEEN AMYLOID PRECURSOR PROTEIN AND PRESENILINS IN MAMMALIAN-CELLS - IMPLICATIONS FOR THE PATHOGENESIS OF ALZHEIMER-DISEASE
Authors: XIA WM ZHANG JM PEREZ R KOO EH SELKOE DJ
Citation: Wm. Xia et al., INTERACTION BETWEEN AMYLOID PRECURSOR PROTEIN AND PRESENILINS IN MAMMALIAN-CELLS - IMPLICATIONS FOR THE PATHOGENESIS OF ALZHEIMER-DISEASE, Proceedings of the National Academy of Sciences of the United Statesof America, 94(15), 1997, pp. 8208-8213
PROTEOLYTIC PROCESSING OF THE ALZHEIMER DISEASE-ASSOCIATED PRESENILIN-1 GENERATES AN IN-VIVO SUBSTRATE FOR PROTEIN-KINASE
Authors: WALTER J GRUNBERG J CAPELL A PESOLD B SCHINDZIELORZ A CITRON M MENDLA K STGEORGEHYSLOP P MULTHAUP G SELKOE DJ HAASS C
Citation: J. Walter et al., PROTEOLYTIC PROCESSING OF THE ALZHEIMER DISEASE-ASSOCIATED PRESENILIN-1 GENERATES AN IN-VIVO SUBSTRATE FOR PROTEIN-KINASE, Proceedings of the National Academy of Sciences of the United Statesof America, 94(10), 1997, pp. 5349-5354
CAFFEINE STIMULATES AMYLOID BETA-PEPTIDE RELEASE FROM BETA-AMYLOID PRECURSOR PROTEIN-TRANSFECTED HEK293 CELLS
Authors: QUERFURTH HW JIANG JW GEIGER JD SELKOE DJ
Citation: Hw. Querfurth et al., CAFFEINE STIMULATES AMYLOID BETA-PEPTIDE RELEASE FROM BETA-AMYLOID PRECURSOR PROTEIN-TRANSFECTED HEK293 CELLS, Journal of neurochemistry, 69(4), 1997, pp. 1580-1591
HEPARIN-BINDING PROPERTIES OF THE AMYLOIDOGENIC PEPTIDES A-BETA AND AMYLIN - DEPENDENCE ON AGGREGATION STATE AND INHIBITION BY CONGO RED
Authors: WATSON DJ LANDER AD SELKOE DJ
Citation: Dj. Watson et al., HEPARIN-BINDING PROPERTIES OF THE AMYLOIDOGENIC PEPTIDES A-BETA AND AMYLIN - DEPENDENCE ON AGGREGATION STATE AND INHIBITION BY CONGO RED, The Journal of biological chemistry, 272(50), 1997, pp. 31617-31624
ECTODOMAIN PHOSPHORYLATION OF BETA-AMYLOID PRECURSOR PROTEIN AT 2 DISTINCT CELLULAR LOCATIONS
Authors: WALTER J CAPELL A HUNG AY LANGEN H SCHNOLZER M THINAKARAN G SISODIA SS SELKOE DJ HAASS C
Citation: J. Walter et al., ECTODOMAIN PHOSPHORYLATION OF BETA-AMYLOID PRECURSOR PROTEIN AT 2 DISTINCT CELLULAR LOCATIONS, The Journal of biological chemistry, 272(3), 1997, pp. 1896-1903
ENHANCED PRODUCTION AND OLIGOMERIZATION OF THE 42-RESIDUE AMYLOID BETA-PROTEIN BY CHINESE-HAMSTER OVARY CELLS STABLY EXPRESSING MUTANT PRESENILINS
Authors: XIA WM ZHANG JM KHOLODENKO D CITRON M PODLISNY MB TEPLOW DB HAASS C SEUBERT P KOO EH SELKOE DJ
Citation: Wm. Xia et al., ENHANCED PRODUCTION AND OLIGOMERIZATION OF THE 42-RESIDUE AMYLOID BETA-PROTEIN BY CHINESE-HAMSTER OVARY CELLS STABLY EXPRESSING MUTANT PRESENILINS, The Journal of biological chemistry, 272(12), 1997, pp. 7977-7982
DEGRADATION OF AMYLOID BETA-PROTEIN BY A METALLOPROTEASE SECRETED BY MICROGLIA AND OTHER NEURAL AND NONNEURAL CELLS
Authors: QIU WQ YE Z KHOLODENKO D SEUBERT P SELKOE DJ
Citation: Wq. Qiu et al., DEGRADATION OF AMYLOID BETA-PROTEIN BY A METALLOPROTEASE SECRETED BY MICROGLIA AND OTHER NEURAL AND NONNEURAL CELLS, The Journal of biological chemistry, 272(10), 1997, pp. 6641-6646
CLINICAL GENETICS .3. ALZHEIMERS-DISEASE - FROM GENES TO PATHOGENESIS
Authors: SELKOE DJ
Citation: Dj. Selkoe, CLINICAL GENETICS .3. ALZHEIMERS-DISEASE - FROM GENES TO PATHOGENESIS, The American journal of psychiatry, 154(9), 1997, pp. 1198-1198
SUBSTITUTION OF PHENYLALANINE BY PROLINE AT POSITION-19 OF AMYLOID-BETA PEPTIDE RESULTS IN AN INCREASED PRODUCTION OF AMYLOID-BETA PEPTIDESWITH ALTERNATIVE N-TERMINI AFTER PROTEIN-KINASE-C STIMULATION
Authors: CAPELL A TEPLOW DB CITRON M SELKOE DJ HAASS C
Citation: A. Capell et al., SUBSTITUTION OF PHENYLALANINE BY PROLINE AT POSITION-19 OF AMYLOID-BETA PEPTIDE RESULTS IN AN INCREASED PRODUCTION OF AMYLOID-BETA PEPTIDESWITH ALTERNATIVE N-TERMINI AFTER PROTEIN-KINASE-C STIMULATION, AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION, 3(3), 1996, pp. 150-155
THE E280A PRESENILIN-1 ALZHEIMER MUTATION PRODUCES INCREASED A-BETA-42 DEPOSITION AND SEVERE CEREBELLAR PATHOLOGY
Authors: LEMERE CA LOPERA F KOSIK KS LENDON CL OSSA J SAIDO TC YAMAGUCHI H RUIZ A MARTINEZ A MADRIGAL L HINCAPIE L ARANGO JCL ANTHONY DC KOO EH GOATE AM SELKOE DJ ARANGO JCV
Citation: Ca. Lemere et al., THE E280A PRESENILIN-1 ALZHEIMER MUTATION PRODUCES INCREASED A-BETA-42 DEPOSITION AND SEVERE CEREBELLAR PATHOLOGY, Nature medicine, 2(10), 1996, pp. 1146-1150
THE ALZHEIMERS-DISEASE-ASSOCIATED PRESENILINS ARE DIFFERENTIALLY PHOSPHORYLATED PROTEINS LOCATED PREDOMINANTLY WITHIN THE ENDOPLASMIC-RETICULUM
Authors: WALTER J CAPELL A GRUNBERG J PESOLD B SCHINDZIELORZ A PRIOR R PODLISNY MB FRASER P HYSLOP PS SELKOE DJ HAASS C
Citation: J. Walter et al., THE ALZHEIMERS-DISEASE-ASSOCIATED PRESENILINS ARE DIFFERENTIALLY PHOSPHORYLATED PROTEINS LOCATED PREDOMINANTLY WITHIN THE ENDOPLASMIC-RETICULUM, Molecular medicine, 2(6), 1996, pp. 673-691
Risultati: 1-25 | 26-50 | 51-75 | 76-82