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Results: 1-13 |
Results: 13
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA : DNA
Authors: Sarafianos, SG Das, K Tantillo, C Clark, AD Ding, J Whitcomb, JM Boyer, PL Hughes, SH Arnold, E
Citation: Sg. Sarafianos et al., Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA : DNA, EMBO J, 20(6), 2001, pp. 1449-1461
Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase
Authors: Tachedjian, G Orlova, M Sarafianos, SG Arnold, E Goff, SP
Citation: G. Tachedjian et al., Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase, P NAS US, 98(13), 2001, pp. 7188-7193
RNase H cleavage of the 5 ' end of the human immunodeficiency virus type 1genome
Authors: Gao, HQ Sarafianos, SG Arnold, E Hughes, SH
Citation: Hq. Gao et al., RNase H cleavage of the 5 ' end of the human immunodeficiency virus type 1genome, J VIROLOGY, 75(23), 2001, pp. 11874-11880
YADD mutants of human immunodeficiency virus type 1 and Moloney murine leukemia virus reverse transcriptase are resistant to lamivudine triphosphate (3TCTP) in vitro
Authors: Boyer, PL Gao, HQ Clark, PK Sarafianos, SG Arnold, E Hughes, SH
Citation: Pl. Boyer et al., YADD mutants of human immunodeficiency virus type 1 and Moloney murine leukemia virus reverse transcriptase are resistant to lamivudine triphosphate (3TCTP) in vitro, J VIROLOGY, 75(14), 2001, pp. 6321-6328
Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC)
Authors: Das, K Xiong, XF Yang, HL Westland, CE Gibbs, CS Sarafianos, SG Arnold, E
Citation: K. Das et al., Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC), J VIROLOGY, 75(10), 2001, pp. 4771-4779
Selective excision of AZTMP by drug-resistant human immunodeficiency virusreverse transcriptase
Authors: Boyer, PL Sarafianos, SG Arnold, E Hughes, SH
Citation: Pl. Boyer et al., Selective excision of AZTMP by drug-resistant human immunodeficiency virusreverse transcriptase, J VIROLOGY, 75(10), 2001, pp. 4832-4842
Analysis of mutations at positions 115 and 116 in the dNTP binding site ofHIV-1 reverse transcriptase
Authors: Boyer, PL Sarafianos, SG Arnold, E Hughes, SH
Citation: Pl. Boyer et al., Analysis of mutations at positions 115 and 116 in the dNTP binding site ofHIV-1 reverse transcriptase, P NAS US, 97(7), 2000, pp. 3056-3061
The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase
Authors: Gao, HQ Boyer, PL Sarafianos, SG Arnold, E Hughes, SH
Citation: Hq. Gao et al., The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase, J MOL BIOL, 300(2), 2000, pp. 403-418
Interactions of conformationally biased north and south 2 '-fluoro-2 ',3 '-dideoxynucleoside 5 '-triphosphates with the active site of HIV-1 reverse transcriptase
Authors: Mu, L Sarafianos, SG Nicklaus, MC Russ, P Siddiqui, MA Ford, H Mitsuya, H Le, R Kodama, E Meier, C Knispel, T Anderson, L Barchi, JJ Marquez, VE
Citation: L. Mu et al., Interactions of conformationally biased north and south 2 '-fluoro-2 ',3 '-dideoxynucleoside 5 '-triphosphates with the active site of HIV-1 reverse transcriptase, BIOCHEM, 39(37), 2000, pp. 11205-11215
Touching the heart of HIV-1 drug resistance: the fingers close down on thedNTP at the polymerase active site
Authors: Sarafianos, SG Das, K Ding, JP Boyer, PL Hughes, SH Arnold, E
Citation: Sg. Sarafianos et al., Touching the heart of HIV-1 drug resistance: the fingers close down on thedNTP at the polymerase active site, CHEM BIOL, 6(5), 1999, pp. R137-R146
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves sterichindrance with beta-branched amino acids
Authors: Sarafianos, SG Das, K Clark, AD Ding, JP Boyer, PL Hughes, SH Arnold, E
Citation: Sg. Sarafianos et al., Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves sterichindrance with beta-branched amino acids, P NAS US, 96(18), 1999, pp. 10027-10032
Similarities and differences in the RNase H activities of human immunodeficiency virus type 1 reverse transcriptase and moloney murine leukemia virusreverse transcriptase
Authors: Gao, HQ Sarafianos, SG Arnold, E Hughes, SH
Citation: Hq. Gao et al., Similarities and differences in the RNase H activities of human immunodeficiency virus type 1 reverse transcriptase and moloney murine leukemia virusreverse transcriptase, J MOL BIOL, 294(5), 1999, pp. 1097-1113
Structure and functional implications of the polymerase active site regionin a complex of HIV-1 RT with a double-stranded DNA template-primer and anantibody Fab fragment at 2.8 angstrom resolution
Authors: Ding, JP Das, K Hsiou, Y Sarafianos, SG Clark, AD Jacobo-Molina, A Tantillo, C Hughes, SH Arnold, E
Citation: Jp. Ding et al., Structure and functional implications of the polymerase active site regionin a complex of HIV-1 RT with a double-stranded DNA template-primer and anantibody Fab fragment at 2.8 angstrom resolution, J MOL BIOL, 284(4), 1998, pp. 1095-1111
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