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Results: 1-25 | 26-37 |
Results: 26-37/37
Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice
Authors: Chen, Z Sun, JZ Pradines, A Favre, G Adnane, J Sebti, SM
Citation: Z. Chen et al., Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice, J BIOL CHEM, 275(24), 2000, pp. 17974-17978
Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I
Authors: Rosenbloom, J Saitta, B Gaidarova, S Sandorfi, N Rosenbloom, JC Abrams, WR Hamilton, AD Sebti, SM Kucich, U Jimenez, SA
Citation: J. Rosenbloom et al., Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I, ARTH RHEUM, 43(7), 2000, pp. 1624-1632
TGF-beta 1 stimulation of fibronectin transcription in cultured human lungfibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-delta, and p38, but not erk1/erk2
Authors: Kucich, U Rosenbloom, JC Shen, G Abrams, WR Hamilton, AD Sebti, SM Rosenbloom, J
Citation: U. Kucich et al., TGF-beta 1 stimulation of fibronectin transcription in cultured human lungfibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-delta, and p38, but not erk1/erk2, ARCH BIOCH, 374(2), 2000, pp. 313-324
Probing the hydrophobic pocket of farnesyltransferase: Aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors
Authors: Qian, YM Marugan, JJ Fossum, RD Vogt, A Sebti, SM Hamilton, AD
Citation: Ym. Qian et al., Probing the hydrophobic pocket of farnesyltransferase: Aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors, BIO MED CH, 7(12), 1999, pp. 3011-3024
Inhibition of Ras and related guanosine triphosphate-dependent proteins asa therapeutic strategy for blocking malignant glioma growth: II - Preclinical studies in a nude mouse model
Authors: Pollack, IF Bredel, M Erff, M Hamilton, AD Sebti, SM
Citation: If. Pollack et al., Inhibition of Ras and related guanosine triphosphate-dependent proteins asa therapeutic strategy for blocking malignant glioma growth: II - Preclinical studies in a nude mouse model, NEUROSURGER, 45(5), 1999, pp. 1208-1214
The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS
Authors: Cohen-Jonathan, E Toulas, C Ader, I Monteil, S Allal, C Bonnet, J Hamilton, AD Sebti, SM Daly-Schveitzer, N Favre, G
Citation: E. Cohen-jonathan et al., The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS, RADIAT RES, 152(4), 1999, pp. 404-411
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I
Authors: Vasudevan, A Qian, YM Vogt, A Blaskovich, MA Ohkanda, J Sebti, SM Hamilton, AD
Citation: A. Vasudevan et al., Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I, J MED CHEM, 42(8), 1999, pp. 1333-1340
Second-generation peptidomimetic inhibitors of protein farnesyltransferasedemonstrating improved cellular potency and significant in vivo efficacy
Authors: O'Connor, SJ Barr, KJ Wang, L Sorensen, BK Tasker, AS Sham, H Ng, SC Cohen, J Devine, E Cherian, S Saeed, B Zhang, HC Lee, JY Warner, R Tahir, S Kovar, P Ewing, P Alder, J Mitten, M Leal, J Marsh, K Bauch, J Hoffman, DJ Sebti, SM Rosenberg, SH
Citation: Sj. O'Connor et al., Second-generation peptidomimetic inhibitors of protein farnesyltransferasedemonstrating improved cellular potency and significant in vivo efficacy, J MED CHEM, 42(18), 1999, pp. 3701-3710
Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s)
Authors: Liu, L Moesner, P Kovach, NL Bailey, R Hamilton, AD Sebti, SM Harlan, JM
Citation: L. Liu et al., Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s), J BIOL CHEM, 274(47), 1999, pp. 33334-33340
The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors - A potential mechanism for GGTI-298 antitumor activity
Authors: Sung, JZ Qian, YM Chen, Z Marfurt, J Hamilton, AD Sebti, SM
Citation: Jz. Sung et al., The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors - A potential mechanism for GGTI-298 antitumor activity, J BIOL CHEM, 274(11), 1999, pp. 6930-6934
`Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells
Authors: Mazet, JL Padieu, M Osman, H Maume, G Mailliet, P Dereu, N Hamilton, AD Lavelle, F Sebti, SM Maume, BF
Citation: Jl. Mazet et al., `Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells, FEBS LETTER, 460(2), 1999, pp. 235-240
Antitumor efficacy of a novel class of non-thiol-containing peptidomimeticinhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine
Authors: Sun, JZ Blaskovich, MA Knowles, D Qian, YM Ohkanda, J Bailey, RD Hamilton, AD Sebti, SM
Citation: Jz. Sun et al., Antitumor efficacy of a novel class of non-thiol-containing peptidomimeticinhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine, CANCER RES, 59(19), 1999, pp. 4919-4926
Risultati: 1-25 | 26-37 |