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Results: 1-25/47
Authors:
Selkoe, DJ
Citation: Dj. Selkoe, Clearing the brain's amyloid cobwebs, NEURON, 32(2), 2001, pp. 177-180
Authors:
Walsh, DM
Hartley, DM
Condron, MM
Selkoe, DJ
Teplow, DB
Citation: Dm. Walsh et al., In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala(692) -> Gly) Alzheimer'sdisease, BIOCHEM J, 355, 2001, pp. 869-877
Authors:
Shimura, H
Schlossmacher, MC
Hattori, N
Frosch, MP
Trockenbacher, A
Schneider, R
Mizuno, Y
Kosik, KS
Selkoe, DJ
Citation: H. Shimura et al., Ubiquitination of a new form of alpha-synuclein by parkin from human brain: Implications for Parkinson's disease, SCIENCE, 293(5528), 2001, pp. 263-269
Authors:
Selkoe, DJ
Citation: Dj. Selkoe, Alzheimer's disease: Genes, proteins, and therapy, PHYSIOL REV, 81(2), 2001, pp. 741-766
Authors:
Selkoe, DJ
Citation: Dj. Selkoe, Presenilin, Notch, and the genesis and treatment of Alzheimer's disease, P NAS US, 98(20), 2001, pp. 11039-11041
Authors:
Monsonego, A
Maron, R
Zota, V
Selkoe, DJ
Weiner, HL
Citation: A. Monsonego et al., Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease, P NAS US, 98(18), 2001, pp. 10273-10278
Authors:
Sharon, R
Goldberg, MS
Bar-Josef, I
Betensky, RA
Shen, J
Selkoe, DJ
Citation: R. Sharon et al., alpha-synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins, P NAS US, 98(16), 2001, pp. 9110-9115
Authors:
Kimberly, WT
Zheng, JB
Guenette, SY
Selkoe, DJ
Citation: Wt. Kimberly et al., The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a Notch-like manner, J BIOL CHEM, 276(43), 2001, pp. 40288-40292
Authors:
Selkoe, DJ
Xia, W
Kimberly, WT
Vekrellis, K
Walsh, D
Esler, WP
Wolfe, MS
Citation: Dj. Selkoe et al., Mechanisms of A beta production and A beta degradation: Routes to the treatment of Alzheimer's disease, ALZHEIMER'S DISEASE, 2001, pp. 421-432
Authors:
Esler, WP
Kimberly, WT
Ostaszewski, BL
Xia, WM
Selkoe, DJ
Wolfe, MS
Citation: Wp. Esler et al., Toward the identification of gamma-secretase: Using transition state analog inhibitors, ALZHEIMER'S DISEASE, 2001, pp. 777-788
Authors:
Esler, WP
Kimberly, WT
Ostaszewski, BL
Diehl, TS
Moore, CL
Tsai, JY
Rahmati, T
Xia, WM
Selkoe, DJ
Wolfe, MS
Citation: Wp. Esler et al., Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1, NAT CELL BI, 2(7), 2000, pp. 428-434
Authors:
Fezoui, Y
Hartley, DM
Harper, JD
Khurana, R
Walsh, DM
Condron, MM
Selkoe, DJ
Lansbury, PT
Fink, AL
Teplow, DB
Citation: Y. Fezoui et al., An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments, AMYLOID, 7(3), 2000, pp. 166-178
Authors:
Selkoe, DJ
Citation: Dj. Selkoe, Imaging Alzheimer's amyloid, NAT BIOTECH, 18(8), 2000, pp. 823-824
Authors:
Fezoui, Y
Hartley, DM
Walsh, DM
Selkoe, DJ
Osterhout, JJ
Teplow, DB
Citation: Y. Fezoui et al., A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils, NAT ST BIOL, 7(12), 2000, pp. 1095-1099
Authors:
Xia, WM
Ostaszewski, BL
Kimberly, WT
Rahmati, T
Moore, CL
Wolfe, MS
Selkoe, DJ
Citation: Wm. Xia et al., FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: Evidence for direct involvement of PS1 in the gamma-secretase cleavage complex, NEUROBIOL D, 7(6), 2000, pp. 673-681
Authors:
Selkoe, DJ
Citation: Dj. Selkoe, Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration, CUR OP NEUR, 10(1), 2000, pp. 50-57
Authors:
Selkoe, DJ
Citation: Dj. Selkoe, The genetics and molecular pathology of Alzheimer's disease - Roles of amyloid and the presenilins, NEUROL CLIN, 18(4), 2000, pp. 903
Authors:
Weiner, HL
Lemere, CA
Maron, R
Spooner, ET
Grenfell, TJ
Mori, C
Issazdeh, S
Hancock, WW
Selkoe, DJ
Citation: Hl. Weiner et al., Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease, ANN NEUROL, 48(4), 2000, pp. 567-579
Authors:
Vekrellis, K
Ye, Z
Qiu, WQ
Walsh, D
Hartley, D
Chesneau, V
Rosner, MR
Selkoe, DJ
Citation: K. Vekrellis et al., Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme, J NEUROSC, 20(5), 2000, pp. 1657-1665
Authors:
Chesneau, V
Vekrellis, K
Rosner, MR
Selkoe, DJ
Citation: V. Chesneau et al., Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization, BIOCHEM J, 351, 2000, pp. 509-516
Authors:
Selkoe, DJ
Citation: Dj. Selkoe, The origins of Alzheimer disease - A is for amyloid, J AM MED A, 283(12), 2000, pp. 1615-1617
Authors:
Bertram, L
Blacker, D
Mullin, K
Keeney, D
Jones, J
Basu, S
Yhu, S
McInnis, MG
Go, RCP
Vekrellis, K
Selkoe, DJ
Saunders, AJ
Tanzi, RE
Citation: L. Bertram et al., Evidence for genetic linkage of Alzheimer's disease to chromosome 10q, SCIENCE, 290(5500), 2000, pp. 2302
Authors:
Xia, WM
Ray, WJ
Ostaszewski, BL
Rahmati, T
Kimberly, WT
Wolfe, MS
Zhang, JM
Goate, AM
Selkoe, DJ
Citation: Wm. Xia et al., Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation, P NAS US, 97(16), 2000, pp. 9299-9304
Authors:
Selkoe, DJ
Wolfe, MS
Citation: Dj. Selkoe et Ms. Wolfe, In search of gamma-secretase: Presenilin at the cutting edge, P NAS US, 97(11), 2000, pp. 5690-5692
Authors:
Berezovska, O
Jack, C
McLean, P
Aster, JC
Hicks, C
Xia, WM
Wolfe, MS
Kimberly, WT
Weinmaster, G
Selkoe, DJ
Hyman, BT
Citation: O. Berezovska et al., Aspartate mutations in presenilin and gamma-secretase inhibitors both impair Notch1 proteolysis and nuclear translocation with relative preservation of Notch1 signaling, J NEUROCHEM, 75(2), 2000, pp. 583-593