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Results: 1-10 |
Results: 10
Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins
Authors: Steiner, H Winkler, E Shearman, MS Prywes, R Haass, C
Citation: H. Steiner et al., Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins, NEUROBIOL D, 8(4), 2001, pp. 717-722
Presenilin-dependent gamma-secretase activity modulates thymocyte development
Authors: Doerfler, P Shearman, MS Perlmutter, RM
Citation: P. Doerfler et al., Presenilin-dependent gamma-secretase activity modulates thymocyte development, P NAS US, 98(16), 2001, pp. 9312-9317
Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma-secretase inhibitor - Implications for presenilin biology
Authors: Beher, D Wrigley, JDJ Nadin, A Evin, G Masters, CL Harrison, T Castro, JL Shearman, MS
Citation: D. Beher et al., Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma-secretase inhibitor - Implications for presenilin biology, J BIOL CHEM, 276(48), 2001, pp. 45394-45402
The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase
Authors: Nunan, J Shearman, MS Checler, F Cappai, R Evin, G Beyreuther, K Masters, CL Small, DH
Citation: J. Nunan et al., The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase, EUR J BIOCH, 268(20), 2001, pp. 5329-5336
Photoactivated, active-site-directed gamma-secretase inhibitors covalentlylabel presenilin 1
Authors: Gardell, SJ Li, YM Xu, M Lai, MT Huang, Q Castro, JL DiMuzio-Mower, J Harrison, T Lellis, C Nadin, A Neduvelil, JG Register, RB Sardana, MK Shearman, MS Shi, XP Smith, AL Yin, KC Shafer, JA
Citation: Sj. Gardell et al., Photoactivated, active-site-directed gamma-secretase inhibitors covalentlylabel presenilin 1, ALZHEIMER'S DISEASE, 2001, pp. 789-798
Quantitation of amyloid-beta peptides in biological milieu using a novel homogeneous time-resolved fluorescence (HTRF) assay
Authors: Clarke, EE Shearman, MS
Citation: Ee. Clarke et Ms. Shearman, Quantitation of amyloid-beta peptides in biological milieu using a novel homogeneous time-resolved fluorescence (HTRF) assay, J NEUROSC M, 102(1), 2000, pp. 61-68
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
Authors: Li, YM Xu, M Lai, MT Huang, Q Castro, JL DiMuzio-Mower, J Harrison, T Lellis, C Nadin, JL Neduvelil, JG Register, RB Sardana, MK Shearman, MS Smith, AL Shi, XP Yin, KC Shafer, JA Gardell, SJ
Citation: Ym. Li et al., Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1, NATURE, 405(6787), 2000, pp. 689-694
L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity
Authors: Shearman, MS Beher, D Clarke, EE Lewis, HD Harrison, T Hunt, P Nadin, A Smith, AL Stevenson, G Castro, JL
Citation: Ms. Shearman et al., L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity, BIOCHEM, 39(30), 2000, pp. 8698-8704
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation
Authors: Gervais, FG Xu, DG Robertson, GS Vaillancourt, JP Zhu, YX Huang, JQ LeBlanc, A Smith, D Rigby, M Shearman, MS Clarke, FE Zheng, H Van Der Ploeg, LHT Ruffolo, SC Thornberry, NA Xanthoudakis, S Zamboni, RJ Roy, S Nicholson, DW
Citation: Fg. Gervais et al., Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation, CELL, 97(3), 1999, pp. 395-406
Toxicity of protein aggregates in PC 12 cells: 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay
Authors: Shearman, MS
Citation: Ms. Shearman, Toxicity of protein aggregates in PC 12 cells: 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, METH ENZYM, 309, 1999, pp. 716-723
Risultati: 1-10 |