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Results: 1-20 |
Results: 20
Phase I and pharmacokinetic study of 10-propargyl-10-deazaaminopterin, a new antifolate (vol 6, pg 3493, 2000)
Authors: Krug, LM Ng, KK Kris, MG Miller, VA Tong, W Heelan, RT Leon, L Leung, D Kelly, J Sirotnak, FM
Citation: Lm. Krug et al., Phase I and pharmacokinetic study of 10-propargyl-10-deazaaminopterin, a new antifolate (vol 6, pg 3493, 2000), CLIN CANC R, 7(4), 2001, pp. 1102-1102
Phase I and pharmacological study of two schedules of the antifolate edatrexate in combination with cisplatin
Authors: Laurie, SA Pfister, DG Kris, MG Tong, WP Chronowski, G Pisters, KWM Heelan, RT Sirotnak, FM
Citation: Sa. Laurie et al., Phase I and pharmacological study of two schedules of the antifolate edatrexate in combination with cisplatin, CLIN CANC R, 7(3), 2001, pp. 501-509
Experimental therapeutics with a new 10-deazaaminopterin in human mesothelioma: Further improving efficacy through structural design, pharmacologic modulation at the level of MRP ATPases, and combined therapy with platinums
Authors: Khokhar, NZ She, Y Rusch, VW Sirotnak, FM
Citation: Nz. Khokhar et al., Experimental therapeutics with a new 10-deazaaminopterin in human mesothelioma: Further improving efficacy through structural design, pharmacologic modulation at the level of MRP ATPases, and combined therapy with platinums, CLIN CANC R, 7(10), 2001, pp. 3199-3205
Synthesis and antifolate evaluation of the aminopterin analogue with a bicyclo[2.2.2]octane ring in place of the benzene ring
Authors: Reynolds, RC Johnson, CA Piper, JR Sirotnak, FM
Citation: Rc. Reynolds et al., Synthesis and antifolate evaluation of the aminopterin analogue with a bicyclo[2.2.2]octane ring in place of the benzene ring, EUR J MED C, 36(3), 2001, pp. 237-242
Phase I and pharmacokinetic study of 10-propargyl-10-deazaaminopterin, a new antifolate
Authors: Krug, LM Ng, KK Kris, MG Miller, VA Tong, W Heelan, RT Leon, L Leung, D Kelly, J Sirotnak, FM
Citation: Lm. Krug et al., Phase I and pharmacokinetic study of 10-propargyl-10-deazaaminopterin, a new antifolate, CLIN CANC R, 6(9), 2000, pp. 3493-3498
Co-administration of probenecid, an inhibitor of a cMOAT/MRP-like plasma membrane ATPase, greatly enhanced the efficacy of a new 10-deazaaminopterin against human solid tumors in vivo
Authors: Sirotnak, FM Wendel, HG Bornmann, WGB Tong, WP Miller, VA Scher, HI Kris, MG
Citation: Fm. Sirotnak et al., Co-administration of probenecid, an inhibitor of a cMOAT/MRP-like plasma membrane ATPase, greatly enhanced the efficacy of a new 10-deazaaminopterin against human solid tumors in vivo, CLIN CANC R, 6(9), 2000, pp. 3705-3712
Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase
Authors: Sirotnak, FM Zakowski, MF Miller, VA Scher, HI Kris, MG
Citation: Fm. Sirotnak et al., Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase, CLIN CANC R, 6(12), 2000, pp. 4885-4892
Two promoters regulate transcription of the mouse folylpolyglutamate synthetase gene - Three tightly clustered Sp1 sites within the first intron markedly enhance activity of promoter B
Authors: Chen, J Hayes, P Roy, K Sirotnak, FM
Citation: J. Chen et al., Two promoters regulate transcription of the mouse folylpolyglutamate synthetase gene - Three tightly clustered Sp1 sites within the first intron markedly enhance activity of promoter B, GENE, 242(1-2), 2000, pp. 257-264
Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency
Authors: Said, HM Chatterjee, N Haq, RU Subramanian, VS Ortiz, A Matherly, LH Sirotnak, FM Halsted, C Rubin, SA
Citation: Hm. Said et al., Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency, AM J P-CELL, 279(6), 2000, pp. C1889-C1895
A peptidomimetic inhibitor of ras functionality markedly suppresses growthof human prostate tumor xenografts in mice. Prospects for long-term clinical utility
Authors: Sirotnak, FM Sepp-Lorenzino, L Kohl, NE Rosen, N Scher, HI
Citation: Fm. Sirotnak et al., A peptidomimetic inhibitor of ras functionality markedly suppresses growthof human prostate tumor xenografts in mice. Prospects for long-term clinical utility, CANC CHEMOT, 46(1), 2000, pp. 79-83
Molecular cloning of the murine cMOAT ATPase
Authors: Fritz, F Chen, J Hayes, P Sirotnak, FM
Citation: F. Fritz et al., Molecular cloning of the murine cMOAT ATPase, BBA-GENE ST, 1492(2-3), 2000, pp. 531-536
Contrasting effects of oncogene expression on two carrier-mediated systemsinternalizing folate compounds in fisher rat 3T3 cells
Authors: Kuhnel, JM Chiao, JH Sirotnak, FM
Citation: Jm. Kuhnel et al., Contrasting effects of oncogene expression on two carrier-mediated systemsinternalizing folate compounds in fisher rat 3T3 cells, J CELL PHYS, 184(3), 2000, pp. 364-372
Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epitheliu
Authors: Chancy, CD Kekuda, R Huang, W Prasad, PD Kuhnel, JM Sirotnak, FM Roon, P Ganapathy, V Smith, SB
Citation: Cd. Chancy et al., Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epitheliu, J BIOL CHEM, 275(27), 2000, pp. 20676-20684
Markedly decreased binding of vincristine to tubulin in vinca alkaloid-resistant Chinese hamster cells is associated with selective overexpression ofalpha and beta tubulin isoforms
Authors: Sirotnak, FM Danenberg, KD Chen, J Fritz, F Danenberg, PV
Citation: Fm. Sirotnak et al., Markedly decreased binding of vincristine to tubulin in vinca alkaloid-resistant Chinese hamster cells is associated with selective overexpression ofalpha and beta tubulin isoforms, BIOC BIOP R, 269(1), 2000, pp. 21-24
Re: Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo - Response
Authors: Sirotnak, FM
Citation: Fm. Sirotnak, Re: Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo - Response, J NAT CANC, 91(23), 1999, pp. 2049-2050
Enhancing cytotoxic sensitivity of tumor cells to antifolates: Another opportunity for gene therapy?
Authors: Sirotnak, FM
Citation: Fm. Sirotnak, Enhancing cytotoxic sensitivity of tumor cells to antifolates: Another opportunity for gene therapy?, J NAT CANC, 91(14), 1999, pp. 1178-1179
Phase I study of the sequential administration of edatrexate and paclitaxel in patients with advanced solid tumors
Authors: Rigas, JR Kris, MG Miller, VA Pisters, KMW Heelan, RT Grant, SC Fennelly, DW Chou, TC Sirotnak, FM
Citation: Jr. Rigas et al., Phase I study of the sequential administration of edatrexate and paclitaxel in patients with advanced solid tumors, ANN ONCOL, 10(5), 1999, pp. 601-603
Organization and structure of the mouse gamma-glutamyl hydrolase gene and the functional identification of its promoter
Authors: Esaki, T Masumoto, N Hayes, P Chen, J Sirotnak, FM
Citation: T. Esaki et al., Organization and structure of the mouse gamma-glutamyl hydrolase gene and the functional identification of its promoter, GENE, 234(1), 1999, pp. 93-100
Transcription of the mouse RFC-1 gene encoding a folate transporter. Multiplicity and properties of promoters with minimum requirements for their basal activity
Authors: Tolner, B Singh, A Esaki, T Roy, K Sirotnak, FM
Citation: B. Tolner et al., Transcription of the mouse RFC-1 gene encoding a folate transporter. Multiplicity and properties of promoters with minimum requirements for their basal activity, GENE, 231(1-2), 1999, pp. 163-172
Carrier-mediated membrane transport of folates in mammalian cells
Authors: Sirotnak, FM Tolner, B
Citation: Fm. Sirotnak et B. Tolner, Carrier-mediated membrane transport of folates in mammalian cells, ANN R NUTR, 19, 1999, pp. 91-122
Risultati: 1-20 |