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Results: 1-25 | 26-45
Results: 1-25/45
Anti-HBV specific beta-L-2 '-deoxynucleosides
Authors: Bryant, ML Bridges, EG Placidi, L Faraj, A Loi, AG Pierra, C Dukhan, D Gosselin, G Imbach, JL Hernandez, B Juodawlkis, A Tennant, B Korba, B Cote, P Cretton-Scott, E Schinazi, RF Sommadossi, JP
Citation: Ml. Bryant et al., Anti-HBV specific beta-L-2 '-deoxynucleosides, NUCLEOS NUC, 20(4-7), 2001, pp. 597-607
Symptomatic lactic acidosis in hospitalized antiretroviral-treated patients with human immunodeficiency virus infection: A report of 12 cases
Authors: Coghlan, ME Sommadossi, JP Jhala, NC Many, WJ Saag, MS Johnson, VA
Citation: Me. Coghlan et al., Symptomatic lactic acidosis in hospitalized antiretroviral-treated patients with human immunodeficiency virus infection: A report of 12 cases, CLIN INF D, 33(11), 2001, pp. 1914-1921
5-(trifluoromethyl)-beta-L-2 '-deoxyuridine, the L-enantiomer of trifluorothymidine: Stereospecific synthesis and antiherpetic evaluations
Authors: Salvetti, R Marchand, A Pregnolato, M Verri, A Spadari, S Focher, F Briant, M Sommadossi, JP Mathe, C Gosselin, G
Citation: R. Salvetti et al., 5-(trifluoromethyl)-beta-L-2 '-deoxyuridine, the L-enantiomer of trifluorothymidine: Stereospecific synthesis and antiherpetic evaluations, BIO MED CH, 9(7), 2001, pp. 1731-1738
Prototype trial design for rapid dose selection of antiretroviral drugs: an example using emtricitabine (Coviracil)
Authors: Rousseau, FS Kahn, JO Thompson, M Mildvan, D Shepp, D Sommadossi, JP Delehanty, J Simpson, JN Wang, LH Quinn, JB Wakeford, C van der Horst, C
Citation: Fs. Rousseau et al., Prototype trial design for rapid dose selection of antiretroviral drugs: an example using emtricitabine (Coviracil), J ANTIMICRO, 48(4), 2001, pp. 507-513
Stereospecific synthesis and biological evaluations of beta-L-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine
Authors: Griffon, JF Mathe, C Faraj, A Aubertin, AM De Clercq, E Balzarini, J Sommadossi, JP Gosselin, G
Citation: Jf. Griffon et al., Stereospecific synthesis and biological evaluations of beta-L-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine, EUR J MED C, 36(5), 2001, pp. 447-460
Evaluation of the mutagenic and genotoxic activities of anti-hepatitis B analogs of beta-L-adenosine by the Ames test and the Comet assay
Authors: Placidi, L De Meo, M Gosselin, G Imbach, JL Bryant, ML Dumenil, G Sommadossi, JP
Citation: L. Placidi et al., Evaluation of the mutagenic and genotoxic activities of anti-hepatitis B analogs of beta-L-adenosine by the Ames test and the Comet assay, ANTIVIR RES, 50(2), 2001, pp. 139-145
NDP kinase reactivity towards 3TC nucleotides
Authors: Kreimeyer, A Schneider, B Sarfati, R Faraj, A Sommadossi, JP Veron, M Deville-Bonne, D
Citation: A. Kreimeyer et al., NDP kinase reactivity towards 3TC nucleotides, ANTIVIR RES, 50(2), 2001, pp. 147-156
Intravenous infusion of Cereport increases uptake and efficacy of acyclovir in herpes simplex virus-infected rat brains
Authors: Bidanset, DJ Placidi, L Rybak, R Palmer, J Sommadossi, JP Kern, ER
Citation: Dj. Bidanset et al., Intravenous infusion of Cereport increases uptake and efficacy of acyclovir in herpes simplex virus-infected rat brains, ANTIM AG CH, 45(8), 2001, pp. 2316-2323
Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine
Authors: Furman, PA Jeffrey, J Keifer, LL Feng, JY Anderson, KS Borroto-Esoda, K Hill, E Copeland, WC Chu, CK Sommadossi, JP Liberman, I Schinazi, RF Painter, GR
Citation: Pa. Furman et al., Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine, ANTIM AG CH, 45(1), 2001, pp. 158-165
Antiviral L-nucleosides specific for hepatitis B virus infection
Authors: Bryant, ML Bridges, EG Placidi, L Faraj, A Loi, AG Pierra, C Dukhan, D Gosselin, G Imbach, JL Hernandez, B Juodawlkis, A Tennant, B Korba, B Cote, P Marion, P Cretton-Scott, E Schinazi, RF Sommadossi, JP
Citation: Ml. Bryant et al., Antiviral L-nucleosides specific for hepatitis B virus infection, ANTIM AG CH, 45(1), 2001, pp. 229-235
Indinavir, nevirapine, stavudine, and lamivudine for human immunodeficiency virus-infected, amprenavir- experienced subjects: AIDS Clinical Trials Group protocol 373
Authors: Gulick, RM Smeaton, LM D'Aquila, RT Eron, JJ Currier, JS Gerber, JG Acosta, E Sommadossi, JP Tung, R Snyder, S Kuritzkes, DR Murphy, RL
Citation: Rm. Gulick et al., Indinavir, nevirapine, stavudine, and lamivudine for human immunodeficiency virus-infected, amprenavir- experienced subjects: AIDS Clinical Trials Group protocol 373, J INFEC DIS, 183(5), 2001, pp. 715-721
In vitro and in vivo metabolism and pharmacokinetics of bis [(T-butyl)-S-acyl-2-thioethyl]-beta-1-2 ',3 '-dideoxy-5-fluorocytidine monophosphate
Authors: Martin, LT Cretton-Scott, E Placidi, L Faraj, A Loi, AG Schinazi, RF McClure, HM Gosselin, G Imbach, JL Sommadossi, JP
Citation: Lt. Martin et al., In vitro and in vivo metabolism and pharmacokinetics of bis [(T-butyl)-S-acyl-2-thioethyl]-beta-1-2 ',3 '-dideoxy-5-fluorocytidine monophosphate, NUCLEOS NUC, 19(1-2), 2000, pp. 481-499
Simultaneous quantitation of the 5 '-triphosphate metabolites of zidovudine, lamivudine, and stavudine in peripheral mononuclear blood cells of HIV infected patients by high-performance liquid chromatography tandem mass spectrometry
Authors: Moore, JD Valette, G Darque, A Zhou, XJ Sommadossi, JP
Citation: Jd. Moore et al., Simultaneous quantitation of the 5 '-triphosphate metabolites of zidovudine, lamivudine, and stavudine in peripheral mononuclear blood cells of HIV infected patients by high-performance liquid chromatography tandem mass spectrometry, J AM SOC M, 11(12), 2000, pp. 1134-1143
Phase I dose escalation pharmacokinetics of O-(chloroacetylcarbamoyl) fumagillol (TNP-470) and its metabolites in AIDS patients with Kaposi's sarcoma
Authors: Moore, JD Dezube, BJ Gill, P Zhou, XJ Acosta, EP Sommadossi, JP
Citation: Jd. Moore et al., Phase I dose escalation pharmacokinetics of O-(chloroacetylcarbamoyl) fumagillol (TNP-470) and its metabolites in AIDS patients with Kaposi's sarcoma, CANC CHEMOT, 46(3), 2000, pp. 173-179
Enhanced penetration of indinavir in cerebrospinal fluid and semen after the addition of low-dose ritonavir
Authors: van Praag, RME Weverling, GJ Portegies, P Jurriaans, S Zhou, XJ Turner-Foisy, ML Sommadossi, JP Burger, DM Lange, JMA Hoetelmans, RMW Prins, JM
Citation: Rme. Van Praag et al., Enhanced penetration of indinavir in cerebrospinal fluid and semen after the addition of low-dose ritonavir, AIDS, 14(9), 2000, pp. 1187-1194
Plasma population pharmacokinetics and penetration into cerebrospinal fluid of indinavir in combination with zidovudine and lamivudine in HIV-1-infected patients
Authors: Zhou, XJ Havlir, DV Richman, DD Acosta, EP Hirsch, M Collier, AC Tebas, P Sommadossi, JP
Citation: Xj. Zhou et al., Plasma population pharmacokinetics and penetration into cerebrospinal fluid of indinavir in combination with zidovudine and lamivudine in HIV-1-infected patients, AIDS, 14(18), 2000, pp. 2869-2876
Continued lamivudine versus delavirdine in combination with indinavir and zidovudine or stavudine in lamivudine-experienced patients: results of Adult AIDS Clinical Trials Group protocol 370
Authors: Kuritzkes, DR Bassett, RL Johnson, VA Marschner, IC Eron, JJ Sommadossi, JP Acosta, EP Murphy, RL Fife, K Wood, K Bell, D Martinez, A Pettinelli, CB
Citation: Dr. Kuritzkes et al., Continued lamivudine versus delavirdine in combination with indinavir and zidovudine or stavudine in lamivudine-experienced patients: results of Adult AIDS Clinical Trials Group protocol 370, AIDS, 14(11), 2000, pp. 1553-1561
Effects of beta-L-3 '-azido-3 '-deoxythymidine 5 '-triphosphate on host and viral DNA polymerases
Authors: Faraj, A El Alaoui, AM Gosselin, G Imbach, JL Morrow, C Sommadossi, JP
Citation: A. Faraj et al., Effects of beta-L-3 '-azido-3 '-deoxythymidine 5 '-triphosphate on host and viral DNA polymerases, ANTIVIR RES, 47(2), 2000, pp. 97-102
Synthesis and antiviral evaluation of some beta-L-2 ',3 '-dideoxy-5-chloropyrimidine nucleosides and pronucleotides
Authors: Pierra, C Imbach, JL De Clercq, E Balzarini, J Van Aerschot, A Herdewijn, P Faraj, A Loi, AG Sommadossi, JP Gosselin, G
Citation: C. Pierra et al., Synthesis and antiviral evaluation of some beta-L-2 ',3 '-dideoxy-5-chloropyrimidine nucleosides and pronucleotides, ANTIVIR RES, 45(3), 2000, pp. 169-183
Drug susceptibility in HIV infection after viral rebound in patients receiving indinavir-containing regimens
Authors: Havlir, DV Hellmann, NS Petropoulos, CJ Whitcomb, JM Collier, AC Hirsch, MS Tebas, P Sommadossi, JP Richman, DD
Citation: Dv. Havlir et al., Drug susceptibility in HIV infection after viral rebound in patients receiving indinavir-containing regimens, J AM MED A, 283(2), 2000, pp. 229-234
In vitro activities of methylenecyclopropane analogues of nucleosides and their phosphoralaninate prodrugs against cytomegalovirus and other herpesvirus infections
Authors: Rybak, RJ Hartline, CB Qiu, YL Zemlicka, J Harden, E Marshall, G Sommadossi, JP Kern, ER
Citation: Rj. Rybak et al., In vitro activities of methylenecyclopropane analogues of nucleosides and their phosphoralaninate prodrugs against cytomegalovirus and other herpesvirus infections, ANTIM AG CH, 44(6), 2000, pp. 1506-1511
Intracellular metabolism of beta-L-2 ',3 '-dideoxyadenosine: Relevance to its limited antiviral activity
Authors: Placidi, L Cretton-Scott, E Gosselin, G Pierra, C Schinazi, RF Imbach, JL El Kouni, M Sommadossi, JP
Citation: L. Placidi et al., Intracellular metabolism of beta-L-2 ',3 '-dideoxyadenosine: Relevance to its limited antiviral activity, ANTIM AG CH, 44(4), 2000, pp. 853-858
Differential effects of antiretroviral nucleoside analogs on mitochondrialfunction in HepG2 cells
Authors: Pan-Zhou, XR Cui, LX Zhou, XJ Sommadossi, JP Darley-Usmar, VM
Citation: Xr. Pan-zhou et al., Differential effects of antiretroviral nucleoside analogs on mitochondrialfunction in HepG2 cells, ANTIM AG CH, 44(3), 2000, pp. 496-503
Safety assessment, in vitro and in vivo, and pharmacokinetics of emivirine, a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1
Authors: Szczech, GM Furman, P Painter, GR Barry, DW Borroto-Esoda, K Grizzle, TB Blum, MR Sommadossi, JP Endoh, R Niwa, T Yamamoto, M Moxham, C
Citation: Gm. Szczech et al., Safety assessment, in vitro and in vivo, and pharmacokinetics of emivirine, a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1, ANTIM AG CH, 44(1), 2000, pp. 123-130
In vivo antagonism with zidovudine plus stavudine combination therapy
Authors: Havlir, DV Tierney, C Friedland, GH Pollard, RB Smeaton, L Sommadossi, JP Fox, L Kessler, H Fife, KH Richman, DD
Citation: Dv. Havlir et al., In vivo antagonism with zidovudine plus stavudine combination therapy, J INFEC DIS, 182(1), 2000, pp. 321-325
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