AAAAAA

   
Results: 1-25 | 26-29
Results: 1-25/29
Engineering the active site of ascorbate peroxidase
Authors: Raven, EL Celik, A Cullis, PM Sangar, R Sutcliffe, MJ
Citation: El. Raven et al., Engineering the active site of ascorbate peroxidase, BIOCH SOC T, 29, 2001, pp. 105-111
Three cell line mosaicism involving structural and numerical abnormalitiesof chromosome 18 in a 3.5-year-old girl: 47,XX,+18/47,XX,+del(18)(q22)/46,XX
Authors: Sutcliffe, MJ Mueller, OT Kousseff, BG Dumont, DP McFarland, JA Mawani, F Conforto, D Ranells, JD
Citation: Mj. Sutcliffe et al., Three cell line mosaicism involving structural and numerical abnormalitiesof chromosome 18 in a 3.5-year-old girl: 47,XX,+18/47,XX,+del(18)(q22)/46,XX, AM J MED G, 102(2), 2001, pp. 192-199
The K+ channel signature sequence of murine Kir2.l: mutations that affect microscopic gating but not ionic selectivity
Authors: So, I Ashmole, I Davies, NW Sutcliffe, MJ Stanfield, PR
Citation: I. So et al., The K+ channel signature sequence of murine Kir2.l: mutations that affect microscopic gating but not ionic selectivity, J PHYSL LON, 531(1), 2001, pp. 37-50
Importance of barrier shape in enzyme-catalyzed reactions - Vibrationally assisted hydrogen tunneling in tryptophan tryptophylquinone-dependent aminedehydrogenases
Authors: Basran, J Patel, S Sutcliffe, MJ Scrutton, NS
Citation: J. Basran et al., Importance of barrier shape in enzyme-catalyzed reactions - Vibrationally assisted hydrogen tunneling in tryptophan tryptophylquinone-dependent aminedehydrogenases, J BIOL CHEM, 276(9), 2001, pp. 6234-6242
Optimizing the Michaelis complex of trimethylamine dehydrogenase - Identification of interactions that perturb the ionization of substrate and facilitate catalysis with trimethylamine base
Authors: Basran, J Sutcliffe, MJ Scrutton, NS
Citation: J. Basran et al., Optimizing the Michaelis complex of trimethylamine dehydrogenase - Identification of interactions that perturb the ionization of substrate and facilitate catalysis with trimethylamine base, J BIOL CHEM, 276(46), 2001, pp. 42887-42892
Protein dynamics enhance electronic coupling in electron transfer complexes
Authors: Chohan, KK Jones, M Grossmann, JG Frerman, FE Scrutton, NS Sutcliffe, MJ
Citation: Kk. Chohan et al., Protein dynamics enhance electronic coupling in electron transfer complexes, J BIOL CHEM, 276(36), 2001, pp. 34142-34147
Deuterium isotope effects during carbon-hydrogen bond cleavage by trimethylamine dehydrogenase - Implications for mechanism and vibrationally assisted hydrogen tunneling in wild-type and mutant enzymes
Authors: Basran, J Sutcliffe, MJ Scrutton, NS
Citation: J. Basran et al., Deuterium isotope effects during carbon-hydrogen bond cleavage by trimethylamine dehydrogenase - Implications for mechanism and vibrationally assisted hydrogen tunneling in wild-type and mutant enzymes, J BIOL CHEM, 276(27), 2001, pp. 24581-24587
alpha Arg-237 in Methylophilus methylotrophus (sp W3A1) electron-transferring flavoprotein affords similar to 200-millivolt stabilization of the FAD anionic semiquinone and a kinetic block on full reduction to the dihydroquinone
Authors: Talfournier, F Munro, AW Basran, J Sutcliffe, MJ Daff, S Chapman, SK Scrutton, NS
Citation: F. Talfournier et al., alpha Arg-237 in Methylophilus methylotrophus (sp W3A1) electron-transferring flavoprotein affords similar to 200-millivolt stabilization of the FAD anionic semiquinone and a kinetic block on full reduction to the dihydroquinone, J BIOL CHEM, 276(23), 2001, pp. 20190-20196
Engineering the active site of ascorbate peroxidase
Authors: Celik, A Cullis, PM Sutcliffe, MJ Sangar, R Raven, EL
Citation: A. Celik et al., Engineering the active site of ascorbate peroxidase, EUR J BIOCH, 268(1), 2001, pp. 78-85
QM/MM studies show substantial tunneling for the hydrogen-transfer reaction in methylamine dehydrogenase
Authors: Faulder, PF Tresadern, G Chohan, KK Scrutton, NS Sutcliffe, MJ Hillier, IH Burton, NA
Citation: Pf. Faulder et al., QM/MM studies show substantial tunneling for the hydrogen-transfer reaction in methylamine dehydrogenase, J AM CHEM S, 123(35), 2001, pp. 8604-8605
Structural insights into NMDA ionotropic glutamate receptors via molecularmodelling
Authors: Chohan, KK Wo, ZG Oswald, RE Sutcliffe, MJ
Citation: Kk. Chohan et al., Structural insights into NMDA ionotropic glutamate receptors via molecularmodelling, J MOL MODEL, 6(1), 2000, pp. 16-25
Enzymology takes a quantum leap forward
Authors: Sutcliffe, MJ Scrutton, MS
Citation: Mj. Sutcliffe et Ms. Scrutton, Enzymology takes a quantum leap forward, PHI T ROY A, 358(1766), 2000, pp. 367-386
Enzyme catalysis: over-the-barrier or through-the-barrier?
Authors: Sutcliffe, MJ Scrutton, NS
Citation: Mj. Sutcliffe et Ns. Scrutton, Enzyme catalysis: over-the-barrier or through-the-barrier?, TRENDS BIOC, 25(9), 2000, pp. 405-408
Residues beyond the selectivity filter of the K+ channel Kir2.1 regulate permeation and block by external Rb+ and Cs+
Authors: Thompson, GA Leyland, ML Ashmole, I Sutcliffe, MJ Stanfield, PR
Citation: Ga. Thompson et al., Residues beyond the selectivity filter of the K+ channel Kir2.1 regulate permeation and block by external Rb+ and Cs+, J PHYSL LON, 526(2), 2000, pp. 231-240
X-ray scattering studies of Methylophilus methylotrophus (sp W(3)A(1)) electron-transferring flavoprotein - Evidence for multiple conformational states and an induced fit mechanism for assembly with trimethylamine dehydrogenase
Authors: Jones, M Basran, J Sutcliffe, MJ Grossmann, JG Scrutton, NS
Citation: M. Jones et al., X-ray scattering studies of Methylophilus methylotrophus (sp W(3)A(1)) electron-transferring flavoprotein - Evidence for multiple conformational states and an induced fit mechanism for assembly with trimethylamine dehydrogenase, J BIOL CHEM, 275(28), 2000, pp. 21349-21354
Kinetic studies of the mechanism of carbon-hydrogen bond breakage by the heterotetrameric sarcosine oxidase of Arthrobacter sp 1-IN
Authors: Harris, RJ Meskys, R Sutcliffe, MJ Scrutton, NS
Citation: Rj. Harris et al., Kinetic studies of the mechanism of carbon-hydrogen bond breakage by the heterotetrameric sarcosine oxidase of Arthrobacter sp 1-IN, BIOCHEM, 39(6), 2000, pp. 1189-1198
Differential coupling through Val-344 and Tyr-442 of trimethylamine dehydrogenase in electron transfer reactions with ferricenium ions and electron transferring flavoprotein
Authors: Basran, J Chohan, KK Sutcliffe, MJ Scrutton, NS
Citation: J. Basran et al., Differential coupling through Val-344 and Tyr-442 of trimethylamine dehydrogenase in electron transfer reactions with ferricenium ions and electron transferring flavoprotein, BIOCHEM, 39(31), 2000, pp. 9188-9200
Structural and biochemical characterization of recombinant wild type and aC30A mutant of trimethylamine dehydrogenase from Methylphilus methylotrophus (sp W(3)A(1))
Authors: Trickey, P Basran, J Lian, LY Chen, ZW Barton, JD Sutcliffe, MJ Scrutton, NS Mathews, FS
Citation: P. Trickey et al., Structural and biochemical characterization of recombinant wild type and aC30A mutant of trimethylamine dehydrogenase from Methylphilus methylotrophus (sp W(3)A(1)), BIOCHEM, 39(26), 2000, pp. 7678-7688
Amino acid 305 determines catalytic center accessibility in CYP3A4
Authors: Fowler, SM Riley, RJ Pritchard, MP Sutcliffe, MJ Friedberg, T Wolf, CR
Citation: Sm. Fowler et al., Amino acid 305 determines catalytic center accessibility in CYP3A4, BIOCHEM, 39(15), 2000, pp. 4406-4414
Structure of the complex of Cdc42Hs with a peptide derived from p-21 activated kinase
Authors: Gizachew, D Guo, W Chohan, KK Sutcliffe, MJ Oswald, RE
Citation: D. Gizachew et al., Structure of the complex of Cdc42Hs with a peptide derived from p-21 activated kinase, BIOCHEM, 39(14), 2000, pp. 3963-3971
Electron transfer in trimethylamine dehydrogenase and electron-transferring flavoprotein
Authors: Scrutton, NS Basran, J Wilson, EK Chohan, KK Jang, MH Sutcliffe, MJ Hille, R
Citation: Ns. Scrutton et al., Electron transfer in trimethylamine dehydrogenase and electron-transferring flavoprotein, BIOCH SOC T, 27(2), 1999, pp. 196-201
Reductive half-reaction of the H172Q mutant of trimethylamine dehydrogenase: evidence against a carbanion mechanism and assignment of kinetically influential ionizations in the enzyme-substrate complex
Authors: Basran, J Sutcliffe, MJ Hille, R Scrutton, NS
Citation: J. Basran et al., Reductive half-reaction of the H172Q mutant of trimethylamine dehydrogenase: evidence against a carbanion mechanism and assignment of kinetically influential ionizations in the enzyme-substrate complex, BIOCHEM J, 341, 1999, pp. 307-314
The possible role of a disulphide bond in forming functional Kir2.1 potassium channels
Authors: Leyland, ML Dart, C Spencer, PJ Sutcliffe, MJ Stanfield, PR
Citation: Ml. Leyland et al., The possible role of a disulphide bond in forming functional Kir2.1 potassium channels, PFLUG ARCH, 438(6), 1999, pp. 778-781
Cysteine mutagenesis and homology modeling of the ligand-binding site of akainate-binding protein
Authors: Wo, ZG Chohan, KK Chen, HY Sutcliffe, MJ Oswald, RE
Citation: Zg. Wo et al., Cysteine mutagenesis and homology modeling of the ligand-binding site of akainate-binding protein, J BIOL CHEM, 274(52), 1999, pp. 37210-37218
The role of Tyr-169 of trimethylamine dehydrogenase in substrate oxidationand magnetic interaction between FMN cofactor and the 4Fe/4S center
Authors: Basran, J Jang, MH Sutcliffe, MJ Hille, R Scrutton, NS
Citation: J. Basran et al., The role of Tyr-169 of trimethylamine dehydrogenase in substrate oxidationand magnetic interaction between FMN cofactor and the 4Fe/4S center, J BIOL CHEM, 274(19), 1999, pp. 13155-13161
Risultati: 1-25 | 26-29