Authors:
WISHKA DG
GRABER DR
KOPTA LA
OLMSTED RA
FRIIS JM
HOSLEY JD
ADAMS WJ
SEEST EP
CASTLE TM
DOLAK LA
KEISER BJ
YAGI Y
JEGANATHAN A
SCHLACHTER ST
MURPHY MJ
CLEEK GJ
NUGENT RA
POPPE SM
SWANEY SM
HAN FS
WATT W
WHITE WL
POEL TJ
THOMAS RC
VOORMAN RL
STEFANSKI KJ
STEHLE RG
TARPLEY WG
MORRIS J
Citation: Dg. Wishka et al., O[2,3-C]PYRIDIN-5-YL-ETHYL)THIO]-4-PYRIMIDINAMINE, PNU-142721, A NEW BROAD-SPECTRUM HIV-1 NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITOR, Journal of medicinal chemistry, 41(9), 1998, pp. 1357-1360
Authors:
NUGENT RA
SCHLACHTER ST
MURPHY MJ
CLEEK GJ
POEL TJ
WISHKA DG
GRABER DR
YAGI Y
KEISER BJ
OLMSTED RA
KOPTA LA
SWANEY SM
POPPE SM
MORRIS J
TARPLEY WG
THOMAS RC
Citation: Ra. Nugent et al., PYRIMIDINE THIOETHERS - A NOVEL CLASS OF HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS WITH ACTIVITY AGAINST BHAP-RESISTANT HIV, Journal of medicinal chemistry, 41(20), 1998, pp. 3793-3803
Authors:
POPPE SM
SLADE DE
CHONG KT
HINSHAW RR
PAGANO PJ
MARKOWITZ M
HO DD
MO H
GORMAN RR
DUEWEKE TJ
THAISRIVONGS S
TARPLEY WG
Citation: Sm. Poppe et al., ANTIVIRAL ACTIVITY OF THE DIHYDROPYRONE PNU-140690, A NEW NONPEPTIDICHUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE INHIBITOR, Antimicrobial agents and chemotherapy, 41(5), 1997, pp. 1058-1063
Authors:
WATHEN LK
CRAMPTON DJ
PATEL RK
NUORALA KW
POPPE SM
DUEWEKE TJ
RE KA
KRIEGER KS
TARPLEY WG
Citation: Lk. Wathen et al., VALIDATION OF A QUANTITATIVE RNA PCR ASSAY FOR HIV-1 IN HUMAN PLASMA, Journal of clinical laboratory analysis, 10(5), 1996, pp. 262-268
Authors:
OLMSTED RA
SLADE DE
KOPTA LA
POPPE SM
POEL TJ
NEWPORT SW
RANK KB
BILES C
MORGE RA
DUEWEKE TJ
YAGI Y
ROMERO DL
THOMAS RC
SHARMA SK
TARPLEY WG
Citation: Ra. Olmsted et al., (ALKYLAMINO)PIPERIDINE BIS(HETEROARYL)PIPERIZINE ANALOGS ARE POTENT, BROAD-SPECTRUM NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITORS OF DRUG-RESISTANT ISOLATES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) AND SELECT FOR DRUG-RESISTANT VARIANTS OF HIV-1(IIIB) WITH REDUCED REPLICATION PHENOTYPES, Journal of virology, 70(6), 1996, pp. 3698-3705
Authors:
THAISRIVONGS S
SKULNICK HI
TURNER SR
STROHBACH JW
TOMMASI RA
JOHNSON PD
ARISTOFF PA
JUDGE TM
GAMMILL RB
MORRIS JK
ROMINES KR
CHRUSCIEL RA
HINSHAW RR
CHONG KT
TARPLEY WG
POPPE SM
SLADE DE
LYNN JC
HORNG MM
TOMICH PK
SEEST EP
DOLAK LA
HOWE WJ
HOWARD GM
SCHWENDE FJ
TOTH LN
PADBURY GE
WILSON GJ
SHIOU LH
ZIPP GL
WILKINSON KF
RUSH BD
RUWART MJ
KOEPLINGER KA
ZHAO ZY
COLE S
ZAYA RM
KAKUK TJ
JANAKIRAMAN MN
WATENPAUGH KD
Citation: S. Thaisrivongs et al., STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - SULFONAMIDE-CONTAINING 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS, Journal of medicinal chemistry, 39(22), 1996, pp. 4349-4353
Authors:
ROMERO DL
OLMSTED RA
POEL TJ
MORGE RA
BILES C
KEISER BJ
KOPTA LA
FRIIS JM
HOSLEY JD
STEFANSKI KJ
WISHKA DG
EVANS DB
MORRIS J
STEHLE RG
SHARMA SK
YAGI Y
VOORMAN RL
ADAMS WJ
TARPLEY WG
THOMAS RC
Citation: Dl. Romero et al., TARGETING DELAVIRDINE ATEVIRDINE RESISTANT HIV-1 - IDENTIFICATION OF (ALKYLAMINO)PIPERIDINE-CONTAINING BIS(HETEROARYL)PIPERAZINES AS BROAD-SPECTRUM HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS/, Journal of medicinal chemistry, 39(19), 1996, pp. 3769-3789
Authors:
FAN NS
RANK KB
POPPE SM
TARPLEY WG
SHARMA SK
Citation: Ns. Fan et al., CHARACTERIZATION OF THE P68 P58 HETERODIMER OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 REVERSE-TRANSCRIPTASE/, Biochemistry, 35(6), 1996, pp. 1911-1917
Authors:
FAN NS
RANK KB
SLADE DE
POPPE SM
EVANS DB
KOPTA LA
OLMSTED RA
THOMAS RC
TARPLEY WG
SHARMA SK
Citation: Ns. Fan et al., A DRUG-RESISTANCE MUTATION IN THE INHIBITOR BINDING POCKET OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE IMPAIRS DNA-SYNTHESIS AND RNA DEGRADATION, Biochemistry, 35(30), 1996, pp. 9737-9745
Authors:
ALTHAUS IW
CHOU KC
LEMAY RJ
FRANKS KM
DEIBEL MR
KEZDY FJ
RESNICK L
BUSSO ME
SO AG
DOWNEY KM
ROMERO DL
THOMAS RC
ARISTOFF PA
TARPLEY WG
REUSSER F
Citation: Iw. Althaus et al., THE BENZYLTHIO-PYRIMIDINE U-31,355, A POTENT INHIBITOR OF HIV-1 REVERSE-TRANSCRIPTASE, Biochemical pharmacology, 51(6), 1996, pp. 743-750
Authors:
SHARMA SK
FAN N
RANK KB
KOPTA LA
OLMSTED RA
POPPE SM
SLADE DE
THOMAS RC
TARPLEY WG
Citation: Sk. Sharma et al., A DRUG-RESISTANCE MUTATION (G190E) IN THE INHIBITOR BINDING POCKET IMPAIRS BOTH RNA-DEPENDENT DNA-POLYMERASE AND RIBONUCLEASE-H ACTIVITIES OF HIV-1 REVERSE-TRANSCRIPTASE, Journal of acquired immune deficiency syndromes and human retrovirology, 10, 1995, pp. 2-2
Authors:
FAN NS
RANK KB
LEONE JW
HEINRIKSON RL
BANNOW CA
SMITH CW
EVANS DB
POPPE SM
TARPLEY WG
ROTHROCK DJ
TOMASSELLI AG
SHARMA SK
Citation: Ns. Fan et al., THE DIFFERENTIAL PROCESSING OF HOMODIMERS OF REVERSE TRANSCRIPTASES FROM HUMAN IMMUNODEFICIENCY VIRUSES TYPE-1 AND TYPE-2 IS A CONSEQUENCE OF THE DISTINCT SPECIFICITIES OF THE VIRAL PROTEASES, The Journal of biological chemistry, 270(22), 1995, pp. 13573-13579
Authors:
FAN NS
RANK KB
EVANS DB
THOMAS RC
TARPLEY WG
SHARMA SK
Citation: Ns. Fan et al., SIMULTANEOUS MUTATIONS AT TYR-181 AND TYR-188 IN HIV-1 REVERSE-TRANSCRIPTASE PREVENTS INHIBITION OF RNA-DEPENDENT DNA-POLYMERASE-ACTIVITY BY THE BISHETEROARYLPIPERAZINE (BHAP) U-90152S, FEBS letters, 370(1-2), 1995, pp. 59-62
Authors:
FAN NS
EVANS DB
RANK KB
THOMAS RC
TARPLEY WG
SHARMA SK
Citation: Ns. Fan et al., MECHANISM OF RESISTANCE TO U-90152S AND SENSITIZATION TO L-697,661 BYA PROLINE TO LEUCINE CHANGE AT RESIDUE-236 OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) REVERSE-TRANSCRIPTASE, FEBS letters, 359(2-3), 1995, pp. 233-238
Authors:
MARTIN LN
SOIKE KF
MURPHEYCORB M
BOHM RP
ROBERTS ED
KAKUK TJ
THAISRIVONGS S
VIDMAR TJ
RUWART MJ
DAVIO SR
TARPLEY WG
Citation: Ln. Martin et al., EFFECTS OF U-75875, A PEPTIDOMIMETIC INHIBITOR OF RETROVIRAL PROTEASES, ON SIMIAN IMMUNODEFICIENCY VIRUS-INFECTION IN RHESUS-MONKEYS, Antimicrobial agents and chemotherapy, 38(6), 1994, pp. 1277-1283
Authors:
ROMERO DL
MORGE RA
BILES C
BERRIOSPENA TN
MAY PD
PALMER JR
JOHNSON PD
SMITH HW
BUSSO M
TAN CK
VOORMAN RL
REUSSER F
ALTHAUS IW
DOWNEY KM
SO AG
RESNICK L
TARPLEY WG
ARISTOFF PA
Citation: Dl. Romero et al., DISCOVERY, SYNTHESIS, AND BIOACTIVITY OF BIS(HETEROARYL)PIPERAZINES .1. A NOVEL CLASS OF NONNUCLEOSIDE HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS, Journal of medicinal chemistry, 37(7), 1994, pp. 999-1014
Authors:
EVANS DB
FAN NS
SWANEY SM
TARPLEY WG
SHARMA SK
Citation: Db. Evans et al., AN ACTIVE RECOMBINANT P15 RNASE-H DOMAIN IS FUNCTIONALLY DISTINCT FROM THE RNASE-H DOMAIN ASSOCIATED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE, The Journal of biological chemistry, 269(34), 1994, pp. 21741-21747
Authors:
ALTHAUS IW
CHOU JJ
GONZALES AJ
LEMAY RJ
DEIBEL MR
CHOU KC
KEZDY FJ
ROMERO DL
THOMAS RC
ARISTOFF PA
TARPLEY WG
REUSSER F
Citation: Iw. Althaus et al., STEADY-STATE KINETIC-STUDIES WITH THE POLYSULFONATE U-9843, AN HIV REVERSE-TRANSCRIPTASE INHIBITOR, Experientia, 50(1), 1994, pp. 23-28
Authors:
ALTHAUS IW
CHOU JJ
GONZALES AJ
DEIBEL MR
CHOU KC
KEZDY FJ
ROMERO DL
THOMAS RC
ARISTOFF PA
TARPLEY WG
REUSSER F
Citation: Iw. Althaus et al., KINETIC-STUDIES WITH THE NONNUCLEOSIDE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE INHIBITOR U-90152E, Biochemical pharmacology, 47(11), 1994, pp. 2017-2028
Authors:
SAWYER TK
FISHER JF
HESTER JB
SMITH CW
TOMASSELLI AG
TARPLEY WG
BURTON PS
HUI JO
MCQUADE TJ
CONRADI RA
BRADFORD VS
LIU L
KINNER JH
TUSTIN J
ALEXANDER DL
HARRISON AW
EMMERT DE
STAPLES DJ
MAGGIORA LL
ZHANG YZ
POORMAN RA
DUNN BM
RAO C
SCARBOROUGH PE
LOWTHER WT
CRAIK C
DECAMP D
MOON J
HOWE WJ
HEINRIKSON RL
Citation: Tk. Sawyer et al., PEPTIDOMIMETIC INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE (HIV-PR) - DESIGN, ENZYME BINDING AND SELECTIVITY, ANTIVIRAL EFFICACY, AND CELL-PERMEABILITY PROPERTIES, Bioorganic & medicinal chemistry letters, 3(5), 1993, pp. 819-824
Citation: Tj. Dueweke et al., INVITRO CHARACTERIZATION OF BISHETEROARYLPIPERAZINE-RESISTANT RECOMBINANT HIV-1 RT, Journal of cellular biochemistry, 1993, pp. 77-77
Authors:
DUEWEKE TJ
POPPE SM
ROMERO DL
SWANEY SM
SO AG
DOWNEY KM
ALTHAUS IW
REUSSER F
BUSSO M
RESNICK L
MAYERS DI
LANE J
ARISTOFF PA
THOMAS RC
TARPLEY WG
Citation: Tj. Dueweke et al., U-90152, A POTENT INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION, Antimicrobial agents and chemotherapy, 37(5), 1993, pp. 1127-1131
Authors:
BUKRINSKY MI
SHAROVA N
MCDONALD TL
PUSHKARSKAYA T
TARPLEY WG
STEVENSON M
Citation: Mi. Bukrinsky et al., ASSOCIATION OF INTEGRASE, MATRIX, AND REVERSE-TRANSCRIPTASE ANTIGENS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 WITH VIRAL NUCLEIC-ACIDS FOLLOWING ACUTE INFECTION, Proceedings of the National Academy of Sciences of the United Statesof America, 90(13), 1993, pp. 6125-6129
Authors:
DUEWEKE TJ
PUSHKARSKAYA T
POPPE SM
SWANEY SM
ZHAO JQ
CHEN ISY
STEVENSON M
TARPLEY WG
Citation: Tj. Dueweke et al., A MUTATION IN REVERSE-TRANSCRIPTASE OF BIS(HETEROARYL)PIPERAZINE-RESISTANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 THAT CONFERS INCREASED SENSITIVITY TO OTHER NONNUCLEOSIDE INHIBITORS, Proceedings of the National Academy of Sciences of the United Statesof America, 90(10), 1993, pp. 4713-4717