AAAAAA

   
Results: 1-25 | 26-32
Results: 1-25/32
O[2,3-C]PYRIDIN-5-YL-ETHYL)THIO]-4-PYRIMIDINAMINE, PNU-142721, A NEW BROAD-SPECTRUM HIV-1 NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITOR
Authors: WISHKA DG GRABER DR KOPTA LA OLMSTED RA FRIIS JM HOSLEY JD ADAMS WJ SEEST EP CASTLE TM DOLAK LA KEISER BJ YAGI Y JEGANATHAN A SCHLACHTER ST MURPHY MJ CLEEK GJ NUGENT RA POPPE SM SWANEY SM HAN FS WATT W WHITE WL POEL TJ THOMAS RC VOORMAN RL STEFANSKI KJ STEHLE RG TARPLEY WG MORRIS J
Citation: Dg. Wishka et al., O[2,3-C]PYRIDIN-5-YL-ETHYL)THIO]-4-PYRIMIDINAMINE, PNU-142721, A NEW BROAD-SPECTRUM HIV-1 NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITOR, Journal of medicinal chemistry, 41(9), 1998, pp. 1357-1360
PYRIMIDINE THIOETHERS - A NOVEL CLASS OF HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS WITH ACTIVITY AGAINST BHAP-RESISTANT HIV
Authors: NUGENT RA SCHLACHTER ST MURPHY MJ CLEEK GJ POEL TJ WISHKA DG GRABER DR YAGI Y KEISER BJ OLMSTED RA KOPTA LA SWANEY SM POPPE SM MORRIS J TARPLEY WG THOMAS RC
Citation: Ra. Nugent et al., PYRIMIDINE THIOETHERS - A NOVEL CLASS OF HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS WITH ACTIVITY AGAINST BHAP-RESISTANT HIV, Journal of medicinal chemistry, 41(20), 1998, pp. 3793-3803
ANTIVIRAL ACTIVITY OF THE DIHYDROPYRONE PNU-140690, A NEW NONPEPTIDICHUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE INHIBITOR
Authors: POPPE SM SLADE DE CHONG KT HINSHAW RR PAGANO PJ MARKOWITZ M HO DD MO H GORMAN RR DUEWEKE TJ THAISRIVONGS S TARPLEY WG
Citation: Sm. Poppe et al., ANTIVIRAL ACTIVITY OF THE DIHYDROPYRONE PNU-140690, A NEW NONPEPTIDICHUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE INHIBITOR, Antimicrobial agents and chemotherapy, 41(5), 1997, pp. 1058-1063
VALIDATION OF A QUANTITATIVE RNA PCR ASSAY FOR HIV-1 IN HUMAN PLASMA
Authors: WATHEN LK CRAMPTON DJ PATEL RK NUORALA KW POPPE SM DUEWEKE TJ RE KA KRIEGER KS TARPLEY WG
Citation: Lk. Wathen et al., VALIDATION OF A QUANTITATIVE RNA PCR ASSAY FOR HIV-1 IN HUMAN PLASMA, Journal of clinical laboratory analysis, 10(5), 1996, pp. 262-268
(ALKYLAMINO)PIPERIDINE BIS(HETEROARYL)PIPERIZINE ANALOGS ARE POTENT, BROAD-SPECTRUM NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITORS OF DRUG-RESISTANT ISOLATES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) AND SELECT FOR DRUG-RESISTANT VARIANTS OF HIV-1(IIIB) WITH REDUCED REPLICATION PHENOTYPES
Authors: OLMSTED RA SLADE DE KOPTA LA POPPE SM POEL TJ NEWPORT SW RANK KB BILES C MORGE RA DUEWEKE TJ YAGI Y ROMERO DL THOMAS RC SHARMA SK TARPLEY WG
Citation: Ra. Olmsted et al., (ALKYLAMINO)PIPERIDINE BIS(HETEROARYL)PIPERIZINE ANALOGS ARE POTENT, BROAD-SPECTRUM NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITORS OF DRUG-RESISTANT ISOLATES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) AND SELECT FOR DRUG-RESISTANT VARIANTS OF HIV-1(IIIB) WITH REDUCED REPLICATION PHENOTYPES, Journal of virology, 70(6), 1996, pp. 3698-3705
STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - SULFONAMIDE-CONTAINING 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS
Authors: THAISRIVONGS S SKULNICK HI TURNER SR STROHBACH JW TOMMASI RA JOHNSON PD ARISTOFF PA JUDGE TM GAMMILL RB MORRIS JK ROMINES KR CHRUSCIEL RA HINSHAW RR CHONG KT TARPLEY WG POPPE SM SLADE DE LYNN JC HORNG MM TOMICH PK SEEST EP DOLAK LA HOWE WJ HOWARD GM SCHWENDE FJ TOTH LN PADBURY GE WILSON GJ SHIOU LH ZIPP GL WILKINSON KF RUSH BD RUWART MJ KOEPLINGER KA ZHAO ZY COLE S ZAYA RM KAKUK TJ JANAKIRAMAN MN WATENPAUGH KD
Citation: S. Thaisrivongs et al., STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - SULFONAMIDE-CONTAINING 5,6-DIHYDRO-4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS, Journal of medicinal chemistry, 39(22), 1996, pp. 4349-4353
TARGETING DELAVIRDINE ATEVIRDINE RESISTANT HIV-1 - IDENTIFICATION OF (ALKYLAMINO)PIPERIDINE-CONTAINING BIS(HETEROARYL)PIPERAZINES AS BROAD-SPECTRUM HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS/
Authors: ROMERO DL OLMSTED RA POEL TJ MORGE RA BILES C KEISER BJ KOPTA LA FRIIS JM HOSLEY JD STEFANSKI KJ WISHKA DG EVANS DB MORRIS J STEHLE RG SHARMA SK YAGI Y VOORMAN RL ADAMS WJ TARPLEY WG THOMAS RC
Citation: Dl. Romero et al., TARGETING DELAVIRDINE ATEVIRDINE RESISTANT HIV-1 - IDENTIFICATION OF (ALKYLAMINO)PIPERIDINE-CONTAINING BIS(HETEROARYL)PIPERAZINES AS BROAD-SPECTRUM HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS/, Journal of medicinal chemistry, 39(19), 1996, pp. 3769-3789
CHARACTERIZATION OF THE P68 P58 HETERODIMER OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 REVERSE-TRANSCRIPTASE/
Authors: FAN NS RANK KB POPPE SM TARPLEY WG SHARMA SK
Citation: Ns. Fan et al., CHARACTERIZATION OF THE P68 P58 HETERODIMER OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 REVERSE-TRANSCRIPTASE/, Biochemistry, 35(6), 1996, pp. 1911-1917
A DRUG-RESISTANCE MUTATION IN THE INHIBITOR BINDING POCKET OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE IMPAIRS DNA-SYNTHESIS AND RNA DEGRADATION
Authors: FAN NS RANK KB SLADE DE POPPE SM EVANS DB KOPTA LA OLMSTED RA THOMAS RC TARPLEY WG SHARMA SK
Citation: Ns. Fan et al., A DRUG-RESISTANCE MUTATION IN THE INHIBITOR BINDING POCKET OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE IMPAIRS DNA-SYNTHESIS AND RNA DEGRADATION, Biochemistry, 35(30), 1996, pp. 9737-9745
THE BENZYLTHIO-PYRIMIDINE U-31,355, A POTENT INHIBITOR OF HIV-1 REVERSE-TRANSCRIPTASE
Authors: ALTHAUS IW CHOU KC LEMAY RJ FRANKS KM DEIBEL MR KEZDY FJ RESNICK L BUSSO ME SO AG DOWNEY KM ROMERO DL THOMAS RC ARISTOFF PA TARPLEY WG REUSSER F
Citation: Iw. Althaus et al., THE BENZYLTHIO-PYRIMIDINE U-31,355, A POTENT INHIBITOR OF HIV-1 REVERSE-TRANSCRIPTASE, Biochemical pharmacology, 51(6), 1996, pp. 743-750
A DRUG-RESISTANCE MUTATION (G190E) IN THE INHIBITOR BINDING POCKET IMPAIRS BOTH RNA-DEPENDENT DNA-POLYMERASE AND RIBONUCLEASE-H ACTIVITIES OF HIV-1 REVERSE-TRANSCRIPTASE
Authors: SHARMA SK FAN N RANK KB KOPTA LA OLMSTED RA POPPE SM SLADE DE THOMAS RC TARPLEY WG
Citation: Sk. Sharma et al., A DRUG-RESISTANCE MUTATION (G190E) IN THE INHIBITOR BINDING POCKET IMPAIRS BOTH RNA-DEPENDENT DNA-POLYMERASE AND RIBONUCLEASE-H ACTIVITIES OF HIV-1 REVERSE-TRANSCRIPTASE, Journal of acquired immune deficiency syndromes and human retrovirology, 10, 1995, pp. 2-2
THE DIFFERENTIAL PROCESSING OF HOMODIMERS OF REVERSE TRANSCRIPTASES FROM HUMAN IMMUNODEFICIENCY VIRUSES TYPE-1 AND TYPE-2 IS A CONSEQUENCE OF THE DISTINCT SPECIFICITIES OF THE VIRAL PROTEASES
Authors: FAN NS RANK KB LEONE JW HEINRIKSON RL BANNOW CA SMITH CW EVANS DB POPPE SM TARPLEY WG ROTHROCK DJ TOMASSELLI AG SHARMA SK
Citation: Ns. Fan et al., THE DIFFERENTIAL PROCESSING OF HOMODIMERS OF REVERSE TRANSCRIPTASES FROM HUMAN IMMUNODEFICIENCY VIRUSES TYPE-1 AND TYPE-2 IS A CONSEQUENCE OF THE DISTINCT SPECIFICITIES OF THE VIRAL PROTEASES, The Journal of biological chemistry, 270(22), 1995, pp. 13573-13579
SIMULTANEOUS MUTATIONS AT TYR-181 AND TYR-188 IN HIV-1 REVERSE-TRANSCRIPTASE PREVENTS INHIBITION OF RNA-DEPENDENT DNA-POLYMERASE-ACTIVITY BY THE BISHETEROARYLPIPERAZINE (BHAP) U-90152S
Authors: FAN NS RANK KB EVANS DB THOMAS RC TARPLEY WG SHARMA SK
Citation: Ns. Fan et al., SIMULTANEOUS MUTATIONS AT TYR-181 AND TYR-188 IN HIV-1 REVERSE-TRANSCRIPTASE PREVENTS INHIBITION OF RNA-DEPENDENT DNA-POLYMERASE-ACTIVITY BY THE BISHETEROARYLPIPERAZINE (BHAP) U-90152S, FEBS letters, 370(1-2), 1995, pp. 59-62
MECHANISM OF RESISTANCE TO U-90152S AND SENSITIZATION TO L-697,661 BYA PROLINE TO LEUCINE CHANGE AT RESIDUE-236 OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) REVERSE-TRANSCRIPTASE
Authors: FAN NS EVANS DB RANK KB THOMAS RC TARPLEY WG SHARMA SK
Citation: Ns. Fan et al., MECHANISM OF RESISTANCE TO U-90152S AND SENSITIZATION TO L-697,661 BYA PROLINE TO LEUCINE CHANGE AT RESIDUE-236 OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) REVERSE-TRANSCRIPTASE, FEBS letters, 359(2-3), 1995, pp. 233-238
EFFECTS OF U-75875, A PEPTIDOMIMETIC INHIBITOR OF RETROVIRAL PROTEASES, ON SIMIAN IMMUNODEFICIENCY VIRUS-INFECTION IN RHESUS-MONKEYS
Authors: MARTIN LN SOIKE KF MURPHEYCORB M BOHM RP ROBERTS ED KAKUK TJ THAISRIVONGS S VIDMAR TJ RUWART MJ DAVIO SR TARPLEY WG
Citation: Ln. Martin et al., EFFECTS OF U-75875, A PEPTIDOMIMETIC INHIBITOR OF RETROVIRAL PROTEASES, ON SIMIAN IMMUNODEFICIENCY VIRUS-INFECTION IN RHESUS-MONKEYS, Antimicrobial agents and chemotherapy, 38(6), 1994, pp. 1277-1283
DISCOVERY, SYNTHESIS, AND BIOACTIVITY OF BIS(HETEROARYL)PIPERAZINES .1. A NOVEL CLASS OF NONNUCLEOSIDE HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS
Authors: ROMERO DL MORGE RA BILES C BERRIOSPENA TN MAY PD PALMER JR JOHNSON PD SMITH HW BUSSO M TAN CK VOORMAN RL REUSSER F ALTHAUS IW DOWNEY KM SO AG RESNICK L TARPLEY WG ARISTOFF PA
Citation: Dl. Romero et al., DISCOVERY, SYNTHESIS, AND BIOACTIVITY OF BIS(HETEROARYL)PIPERAZINES .1. A NOVEL CLASS OF NONNUCLEOSIDE HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS, Journal of medicinal chemistry, 37(7), 1994, pp. 999-1014
AN ACTIVE RECOMBINANT P15 RNASE-H DOMAIN IS FUNCTIONALLY DISTINCT FROM THE RNASE-H DOMAIN ASSOCIATED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE
Authors: EVANS DB FAN NS SWANEY SM TARPLEY WG SHARMA SK
Citation: Db. Evans et al., AN ACTIVE RECOMBINANT P15 RNASE-H DOMAIN IS FUNCTIONALLY DISTINCT FROM THE RNASE-H DOMAIN ASSOCIATED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE, The Journal of biological chemistry, 269(34), 1994, pp. 21741-21747
STEADY-STATE KINETIC-STUDIES WITH THE POLYSULFONATE U-9843, AN HIV REVERSE-TRANSCRIPTASE INHIBITOR
Authors: ALTHAUS IW CHOU JJ GONZALES AJ LEMAY RJ DEIBEL MR CHOU KC KEZDY FJ ROMERO DL THOMAS RC ARISTOFF PA TARPLEY WG REUSSER F
Citation: Iw. Althaus et al., STEADY-STATE KINETIC-STUDIES WITH THE POLYSULFONATE U-9843, AN HIV REVERSE-TRANSCRIPTASE INHIBITOR, Experientia, 50(1), 1994, pp. 23-28
KINETIC-STUDIES WITH THE NONNUCLEOSIDE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE INHIBITOR U-90152E
Authors: ALTHAUS IW CHOU JJ GONZALES AJ DEIBEL MR CHOU KC KEZDY FJ ROMERO DL THOMAS RC ARISTOFF PA TARPLEY WG REUSSER F
Citation: Iw. Althaus et al., KINETIC-STUDIES WITH THE NONNUCLEOSIDE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE INHIBITOR U-90152E, Biochemical pharmacology, 47(11), 1994, pp. 2017-2028
PEPTIDOMIMETIC INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE (HIV-PR) - DESIGN, ENZYME BINDING AND SELECTIVITY, ANTIVIRAL EFFICACY, AND CELL-PERMEABILITY PROPERTIES
Authors: SAWYER TK FISHER JF HESTER JB SMITH CW TOMASSELLI AG TARPLEY WG BURTON PS HUI JO MCQUADE TJ CONRADI RA BRADFORD VS LIU L KINNER JH TUSTIN J ALEXANDER DL HARRISON AW EMMERT DE STAPLES DJ MAGGIORA LL ZHANG YZ POORMAN RA DUNN BM RAO C SCARBOROUGH PE LOWTHER WT CRAIK C DECAMP D MOON J HOWE WJ HEINRIKSON RL
Citation: Tk. Sawyer et al., PEPTIDOMIMETIC INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE (HIV-PR) - DESIGN, ENZYME BINDING AND SELECTIVITY, ANTIVIRAL EFFICACY, AND CELL-PERMEABILITY PROPERTIES, Bioorganic & medicinal chemistry letters, 3(5), 1993, pp. 819-824
INVITRO CHARACTERIZATION OF BISHETEROARYLPIPERAZINE-RESISTANT RECOMBINANT HIV-1 RT
Authors: DUEWEKE TJ POPPE SM SWANEY SM TARPLEY WG
Citation: Tj. Dueweke et al., INVITRO CHARACTERIZATION OF BISHETEROARYLPIPERAZINE-RESISTANT RECOMBINANT HIV-1 RT, Journal of cellular biochemistry, 1993, pp. 77-77
DEVELOPMENT OF RESISTANCE TO THE BHAP NONNUCLEOSIDE HIV-1 RT INHIBITORS
Authors: POPPE SM DUEWEKE TJ PUSHKARSKAYA T STEVENSON M CHEN ISY TARPLEY WG
Citation: Sm. Poppe et al., DEVELOPMENT OF RESISTANCE TO THE BHAP NONNUCLEOSIDE HIV-1 RT INHIBITORS, Journal of cellular biochemistry, 1993, pp. 84-84
U-90152, A POTENT INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION
Authors: DUEWEKE TJ POPPE SM ROMERO DL SWANEY SM SO AG DOWNEY KM ALTHAUS IW REUSSER F BUSSO M RESNICK L MAYERS DI LANE J ARISTOFF PA THOMAS RC TARPLEY WG
Citation: Tj. Dueweke et al., U-90152, A POTENT INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION, Antimicrobial agents and chemotherapy, 37(5), 1993, pp. 1127-1131
ASSOCIATION OF INTEGRASE, MATRIX, AND REVERSE-TRANSCRIPTASE ANTIGENS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 WITH VIRAL NUCLEIC-ACIDS FOLLOWING ACUTE INFECTION
Authors: BUKRINSKY MI SHAROVA N MCDONALD TL PUSHKARSKAYA T TARPLEY WG STEVENSON M
Citation: Mi. Bukrinsky et al., ASSOCIATION OF INTEGRASE, MATRIX, AND REVERSE-TRANSCRIPTASE ANTIGENS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 WITH VIRAL NUCLEIC-ACIDS FOLLOWING ACUTE INFECTION, Proceedings of the National Academy of Sciences of the United Statesof America, 90(13), 1993, pp. 6125-6129
A MUTATION IN REVERSE-TRANSCRIPTASE OF BIS(HETEROARYL)PIPERAZINE-RESISTANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 THAT CONFERS INCREASED SENSITIVITY TO OTHER NONNUCLEOSIDE INHIBITORS
Authors: DUEWEKE TJ PUSHKARSKAYA T POPPE SM SWANEY SM ZHAO JQ CHEN ISY STEVENSON M TARPLEY WG
Citation: Tj. Dueweke et al., A MUTATION IN REVERSE-TRANSCRIPTASE OF BIS(HETEROARYL)PIPERAZINE-RESISTANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 THAT CONFERS INCREASED SENSITIVITY TO OTHER NONNUCLEOSIDE INHIBITORS, Proceedings of the National Academy of Sciences of the United Statesof America, 90(10), 1993, pp. 4713-4717
Risultati: 1-25 | 26-32