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Results: 1-25 | 26-48
Results: 1-25/48
IN-VITRO AND IN-VIVO DRUG-INTERACTIONS INVOLVING HUMAN CYP3A
Authors: THUMMEL KE WILKINSON GR
Citation: Ke. Thummel et Gr. Wilkinson, IN-VITRO AND IN-VIVO DRUG-INTERACTIONS INVOLVING HUMAN CYP3A, Annual review of pharmacology and toxicology, 38, 1998, pp. 389-430
ETHANOL INCREASES RISK OF ACETAMINOPHEN HEPATOTOXICITY IN HEALTHY-ADULTS
Authors: CHIEN JY THUMMEL KE SLATTERY JT RO H NELSON SD LOWN KS WATKINS PB
Citation: Jy. Chien et al., ETHANOL INCREASES RISK OF ACETAMINOPHEN HEPATOTOXICITY IN HEALTHY-ADULTS, Hepatology, 28(4), 1998, pp. 380-380
THE EFFECT OF IRON DEPLETION ON SERUM MARKERS OF LIPID-PEROXIDATION AND FIBROSIS IN CHRONIC HEPATITIS-C
Authors: TUNG BY AFDHAL NH NUNES DP THUMMEL KE KHARASCH ED CROGHAN AM COX PP LIN M KOWDLEY KV
Citation: By. Tung et al., THE EFFECT OF IRON DEPLETION ON SERUM MARKERS OF LIPID-PEROXIDATION AND FIBROSIS IN CHRONIC HEPATITIS-C, Hepatology, 28(4), 1998, pp. 1622-1622
SINGLE-DOSE DISULFIRAM DOES NOT INHIBIT CYP2A6 ACTIVITY
Authors: KHARASCH ED HANKINS DC BAXTER PJ THUMMEL KE
Citation: Ed. Kharasch et al., SINGLE-DOSE DISULFIRAM DOES NOT INHIBIT CYP2A6 ACTIVITY, Clinical pharmacology and therapeutics, 64(1), 1998, pp. 39-45
FIRST-PASS DRUG-METABOLISM AND ITS IMPACT ON ORAL-DRUG DELIVERY - PREFACE
Authors: THUMMEL KE
Citation: Ke. Thummel, FIRST-PASS DRUG-METABOLISM AND ITS IMPACT ON ORAL-DRUG DELIVERY - PREFACE, Advanced drug delivery reviews, 27(2-3), 1997, pp. 97-98
ENZYME-CATALYZED PROCESSES OF FIRST-PASS HEPATIC AND INTESTINAL DRUG EXTRACTION
Authors: THUMMEL KE KUNZE KL SHEN DD
Citation: Ke. Thummel et al., ENZYME-CATALYZED PROCESSES OF FIRST-PASS HEPATIC AND INTESTINAL DRUG EXTRACTION, Advanced drug delivery reviews, 27(2-3), 1997, pp. 99-127
FENTANYL METABOLISM BY HUMAN HEPATIC AND INTESTINAL CYTOCHROME-P450 3A4 - IMPLICATIONS FOR INTERINDIVIDUAL VARIABILITY IN DISPOSITION, EFFICACY, AND DRUG-INTERACTIONS
Authors: LABROO RB PAINE MF THUMMEL KE KHARASCH ED
Citation: Rb. Labroo et al., FENTANYL METABOLISM BY HUMAN HEPATIC AND INTESTINAL CYTOCHROME-P450 3A4 - IMPLICATIONS FOR INTERINDIVIDUAL VARIABILITY IN DISPOSITION, EFFICACY, AND DRUG-INTERACTIONS, Drug metabolism and disposition, 25(9), 1997, pp. 1072-1080
MECHANISMS OF ENHANCED ORAL AVAILABILITY OF CYP3A4 SUBSTRATES BY GRAPEFRUIT CONSTITUENTS - DECREASED ENTEROCYTE CYP3A4 CONCENTRATION AND MECHANISM-BASED INACTIVATION BY FURANOCOUMARINS
Authors: SCHMIEDLINREN P EDWARDS DJ FITZSIMMONS ME HE K LOWN KS WOSTER PM RAHMAN A THUMMEL KE FISHER JM HOLLENBERG PF WATKINS PB
Citation: P. Schmiedlinren et al., MECHANISMS OF ENHANCED ORAL AVAILABILITY OF CYP3A4 SUBSTRATES BY GRAPEFRUIT CONSTITUENTS - DECREASED ENTEROCYTE CYP3A4 CONCENTRATION AND MECHANISM-BASED INACTIVATION BY FURANOCOUMARINS, Drug metabolism and disposition, 25(11), 1997, pp. 1228-1233
MECHANISM OF CYTOCHROME-P450 ACTIVATION BY CAFFEINE AND 7,8-BENZOFLAVONE IN RAT-LIVER MICROSOMES
Authors: LEE CA MANYIKE PT THUMMEL KE NELSON SD SLATTERY JT
Citation: Ca. Lee et al., MECHANISM OF CYTOCHROME-P450 ACTIVATION BY CAFFEINE AND 7,8-BENZOFLAVONE IN RAT-LIVER MICROSOMES, Drug metabolism and disposition, 25(10), 1997, pp. 1150-1156
PHARMACOKINETIC CONSEQUENCES OF INDUCTION OF CYP2E1 BY LIGAND STABILIZATION
Authors: CHEN JY THUMMEL KE SLATTERY JT
Citation: Jy. Chen et al., PHARMACOKINETIC CONSEQUENCES OF INDUCTION OF CYP2E1 BY LIGAND STABILIZATION, Drug metabolism and disposition, 25(10), 1997, pp. 1165-1175
EXPRESSION OF ENZYMATICALLY ACTIVE CYP3A4 BY CACO-2 CELLS GROWN ON EXTRACELLULAR MATRIX-COATED PERMEABLE SUPPORTS IN THE PRESENCE OF 1-ALPHA,25-DIHYDROXYVITAMIN D-3
Authors: SCHMIEDLINREN P THUMMEL KE FISHER JM PAINE MF LOWN KS WATKINS PB
Citation: P. Schmiedlinren et al., EXPRESSION OF ENZYMATICALLY ACTIVE CYP3A4 BY CACO-2 CELLS GROWN ON EXTRACELLULAR MATRIX-COATED PERMEABLE SUPPORTS IN THE PRESENCE OF 1-ALPHA,25-DIHYDROXYVITAMIN D-3, Molecular pharmacology, 51(5), 1997, pp. 741-754
CHARACTERIZATION OF INTERINTESTINAL AND INTRAINTESTINAL VARIATIONS INHUMAN CYP3A-DEPENDENT METABOLISM
Authors: PAINE MF KHALIGHI M FISHER JM SHEN DD KUNZE KL MARSH CL PERKINS JD THUMMEL KE
Citation: Mf. Paine et al., CHARACTERIZATION OF INTERINTESTINAL AND INTRAINTESTINAL VARIATIONS INHUMAN CYP3A-DEPENDENT METABOLISM, The Journal of pharmacology and experimental therapeutics, 283(3), 1997, pp. 1552-1562
CYTOCHROME-P450 2E1 IS THE PRINCIPAL CATALYST OF HUMAN OXIDATIVE HALOTHANE METABOLISM IN-VITRO
Authors: SPRACKLIN DK HANKINS DC FISHER JM THUMMEL KE KHARASCH ED
Citation: Dk. Spracklin et al., CYTOCHROME-P450 2E1 IS THE PRINCIPAL CATALYST OF HUMAN OXIDATIVE HALOTHANE METABOLISM IN-VITRO, The Journal of pharmacology and experimental therapeutics, 281(1), 1997, pp. 400-411
INFLUENCE OF STIRIPENTOL ON CYTOCHROME P450-MEDIATED METABOLIC PATHWAYS IN HUMANS - IN-VITRO AND IN-VIVO COMPARISON AND CALCULATION OF IN-VIVO INHIBITION CONSTANTS
Authors: TRAN A REY E PONS G ROUSSEAU M DATHIS P OLIVE G MATHER GG BISHOP FE WURDEN CJ LABROO R TRAGER WF KUNZE KL THUMMEL KE VINCENT JC GILLARDIN JM LEPAGE F LEVY RH
Citation: A. Tran et al., INFLUENCE OF STIRIPENTOL ON CYTOCHROME P450-MEDIATED METABOLIC PATHWAYS IN HUMANS - IN-VITRO AND IN-VIVO COMPARISON AND CALCULATION OF IN-VIVO INHIBITION CONSTANTS, Clinical pharmacology and therapeutics, 62(5), 1997, pp. 490-504
INFLUENCE OF POLYMORPHIC N-ACETYLTRANSFERASE PHENOTYPE ON THE INHIBITION AND INDUCTION OF ACETAMINOPHEN BIOACTIVATION WITH LONG-TERM ISONIAZID
Authors: CHIEN JT PETER RM NOLAN CM WARTELL C SLATTERY JT NELSON SD CARITHERS RL THUMMEL KE
Citation: Jt. Chien et al., INFLUENCE OF POLYMORPHIC N-ACETYLTRANSFERASE PHENOTYPE ON THE INHIBITION AND INDUCTION OF ACETAMINOPHEN BIOACTIVATION WITH LONG-TERM ISONIAZID, Clinical pharmacology and therapeutics, 61(1), 1997, pp. 24-34
THE ROLE OF CYTOCHROME-P450 3A4 IN ALFENTANIL CLEARANCE - IMPLICATIONS FOR INTERINDIVIDUAL VARIABILITY IN DISPOSITION AND PERIOPERATIVE DRUG-INTERACTIONS
Authors: KHARASCH ED RUSSELL M MAUTZ D THUMMEL KE KUNZE KL BOWDLE TA COX K
Citation: Ed. Kharasch et al., THE ROLE OF CYTOCHROME-P450 3A4 IN ALFENTANIL CLEARANCE - IMPLICATIONS FOR INTERINDIVIDUAL VARIABILITY IN DISPOSITION AND PERIOPERATIVE DRUG-INTERACTIONS, Anesthesiology, 87(1), 1997, pp. 36-50
SELECTIVE EXPRESSION OF CYP3A5 AND NOT CYP3A4 IN HUMAN BLOOD
Authors: JANARDAN SK LOWN KS SCHMIEDLINREN P THUMMEL KE WATKINS PB
Citation: Sk. Janardan et al., SELECTIVE EXPRESSION OF CYP3A5 AND NOT CYP3A4 IN HUMAN BLOOD, Pharmacogenetics, 6(5), 1996, pp. 379-385
IDENTIFICATION OF THE ENZYME RESPONSIBLE FOR OXIDATIVE HALOTHANE METABOLISM - IMPLICATIONS FOR PREVENTION OF HALOTHANE HEPATITIS
Authors: KHARASCH ED HANKINS D MAUTZ D THUMMEL KE
Citation: Ed. Kharasch et al., IDENTIFICATION OF THE ENZYME RESPONSIBLE FOR OXIDATIVE HALOTHANE METABOLISM - IMPLICATIONS FOR PREVENTION OF HALOTHANE HEPATITIS, Lancet, 347(9012), 1996, pp. 1367-1371
HUMAN REDUCTIVE HALOTHANE METABOLISM IN-VITRO IS CATALYZED BY CYTOCHROME-P450 2A6 AND 3A4
Authors: SPRACKLIN DK THUMMEL KE KHARASCH ED
Citation: Dk. Spracklin et al., HUMAN REDUCTIVE HALOTHANE METABOLISM IN-VITRO IS CATALYZED BY CYTOCHROME-P450 2A6 AND 3A4, Drug metabolism and disposition, 24(9), 1996, pp. 976-983
WARFARIN-FLUCONAZOLE .1. INHIBITION OF THE HUMAN CYTOCHROME-P450-DEPENDENT METABOLISM OF WARFARIN BY FLUCONAZOLE - IN-VITRO STUDIES
Authors: KUNZE KL WIENKERS LC THUMMEL KE TRAGER WF
Citation: Kl. Kunze et al., WARFARIN-FLUCONAZOLE .1. INHIBITION OF THE HUMAN CYTOCHROME-P450-DEPENDENT METABOLISM OF WARFARIN BY FLUCONAZOLE - IN-VITRO STUDIES, Drug metabolism and disposition, 24(4), 1996, pp. 414-421
THE COMPLEX INTERACTION BETWEEN ETHANOL AND ACETAMINOPHEN
Authors: SLATTERY JT NELSON SD THUMMEL KE
Citation: Jt. Slattery et al., THE COMPLEX INTERACTION BETWEEN ETHANOL AND ACETAMINOPHEN, Clinical pharmacology and therapeutics, 60(3), 1996, pp. 241-246
FIRST-PASS METABOLISM OF MIDAZOLAM BY THE HUMAN INTESTINE
Authors: PAINE MF SHEN DD KUNZE KL PERKINS JD MARSH CL MCVICAR JP BARR DM GILLIES BS THUMMEL KE
Citation: Mf. Paine et al., FIRST-PASS METABOLISM OF MIDAZOLAM BY THE HUMAN INTESTINE, Clinical pharmacology and therapeutics, 60(1), 1996, pp. 14-24
ORAL FIRST-PASS ELIMINATION OF MIDAZOLAM INVOLVES BOTH GASTROINTESTINAL AND HEPATIC CYP3A-MEDIATED METABOLISM
Authors: THUMMEL KE OSHEA D PAINE MF SHEN DD KUNZE KL PERKINS JD WILKINSON GR
Citation: Ke. Thummel et al., ORAL FIRST-PASS ELIMINATION OF MIDAZOLAM INVOLVES BOTH GASTROINTESTINAL AND HEPATIC CYP3A-MEDIATED METABOLISM, Clinical pharmacology and therapeutics, 59(5), 1996, pp. 491-502
INHIBITION OF SULFAMETHOXAZOLE HYDROXYLAMINE FORMATION BY FLUCONAZOLEIN HUMAN LIVER-MICROSOMES AND HEALTHY-VOLUNTEERS
Authors: MITRA AK THUMMEL KE KALHORN TF KHARASCH ED UNADKAT JD SLATTERY JT
Citation: Ak. Mitra et al., INHIBITION OF SULFAMETHOXAZOLE HYDROXYLAMINE FORMATION BY FLUCONAZOLEIN HUMAN LIVER-MICROSOMES AND HEALTHY-VOLUNTEERS, Clinical pharmacology and therapeutics, 59(3), 1996, pp. 332-340
BACULOVIRUS EXPRESSION AND PURIFICATION OF HUMAN AND RAT CYTOCHROME-P450 2E1
Authors: CHEN WQ PETER RM MCARDLE S THUMMEL KE SIGLE RO NELSON SD
Citation: Wq. Chen et al., BACULOVIRUS EXPRESSION AND PURIFICATION OF HUMAN AND RAT CYTOCHROME-P450 2E1, Archives of biochemistry and biophysics, 335(1), 1996, pp. 123-130
Risultati: 1-25 | 26-48