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Results: 1-16 |
Results: 16
USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN-K INHIBITORS - CRYSTAL-STRUCTURES OF 2 PAPAIN-INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES
Authors: LALONDE JM ZHAO BG SMITH WW JANSON CA DESJARLAIS RL TOMASZEK TA CARR TJ THOMPSON SK OH HJ YAMASHITA DS VEBER DF ABDELMEGUID SS
Citation: Jm. Lalonde et al., USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN-K INHIBITORS - CRYSTAL-STRUCTURES OF 2 PAPAIN-INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES, Journal of medicinal chemistry, 41(23), 1998, pp. 4567-4576
STRUCTURE-BASED DESIGN OF CATHEPSIN-K INHIBITORS CONTAINING A BENZYLOXY-SUBSTITUTED BENZOYL PEPTIDOMIMETIC
Authors: THOMPSON SK SMITH WW ZHAO BG HALBERT SM TOMASZEK TA TEW DG LEVY MA JANSON CA DALESSIO KJ MCQUENEY MS KURDYLA J JONES CS DESJARLAIS RL ABDELMEGUID SS VEBER DF
Citation: Sk. Thompson et al., STRUCTURE-BASED DESIGN OF CATHEPSIN-K INHIBITORS CONTAINING A BENZYLOXY-SUBSTITUTED BENZOYL PEPTIDOMIMETIC, Journal of medicinal chemistry, 41(21), 1998, pp. 3923-3927
CONFORMATIONALLY CONSTRAINED 1,3-DIAMINO KETONES - A SERIES OF POTENTINHIBITORS OF THE CYSTEINE PROTEASE CATHEPSIN-K
Authors: MARQUIS RW YAMASHITA DS RU Y LOCASTRO SM OH HJ ERHARD KF DESJARLAIS RL HEAD MS SMITH WW ZHAO BG JANSON CA ABDELMEGUID SS TOMASZEK TA LEVY MA VEBER DF
Citation: Rw. Marquis et al., CONFORMATIONALLY CONSTRAINED 1,3-DIAMINO KETONES - A SERIES OF POTENTINHIBITORS OF THE CYSTEINE PROTEASE CATHEPSIN-K, Journal of medicinal chemistry, 41(19), 1998, pp. 3563-3567
USE OF X-RAY CO-CRYSTAL STRUCTURES AND MOLECULAR MODELING TO DESIGN POTENT AND SELECTIVE NONPEPTIDE INHIBITORS OF CATHEPSIN-K
Authors: DESJARLAIS RL YAMASHITA DS OH HJ UZINSKAS IN ERHARD KF ALLEN AC HALTIWANGER RC ZHAO BG SMITH WW ABDELMEGUID SS DALESSIO K JANSON CA MCQUENEY MS TOMASZEK TA LEVY MA VEBER DF
Citation: Rl. Desjarlais et al., USE OF X-RAY CO-CRYSTAL STRUCTURES AND MOLECULAR MODELING TO DESIGN POTENT AND SELECTIVE NONPEPTIDE INHIBITORS OF CATHEPSIN-K, Journal of the American Chemical Society, 120(35), 1998, pp. 9114-9115
PEPTIDE ALDEHYDE INHIBITORS OF CATHEPSIN-K INHIBIT BONE-RESORPTION BOTH IN-VITRO AND IN-VIVO
Authors: VOTTA BJ LEVY MA BADGER A BRADBEER J DODDS RA JAMES IE THOMPSON S BOSSARD MJ CARR T CONNOR JR TOMASZEK TA SZEWCZUK L DRAKE FH VEBER DF GOWEN M
Citation: Bj. Votta et al., PEPTIDE ALDEHYDE INHIBITORS OF CATHEPSIN-K INHIBIT BONE-RESORPTION BOTH IN-VITRO AND IN-VIVO, Journal of bone and mineral research, 12(9), 1997, pp. 1396-1406
DESIGN OF POTENT AND SELECTIVE HUMAN CATHEPSIN-K INHIBITORS THAT SPANTHE ACTIVE-SITE
Authors: THOMPSON SK HALBERT SM BOSSARD MJ TOMASZEK TA LEVY MA ZHAO BG SMITH WW ABDELMEGUID SS JANSON CA DALESSIO KJ MCQUENEY MS AMEGADZIE BY HANNING CR DESJARLAIS RL BRIAND J SARKAR SK HUDDLESTON MJ IJAMES CF CARR SA GARNES KT SHU A HEYS JR BRADBEER J ZEMBRYKI D LEERYKACZEWSKI L JAMES IE LARK MW DRAKE FH GOWEN M GLEASON JG VEBER DF
Citation: Sk. Thompson et al., DESIGN OF POTENT AND SELECTIVE HUMAN CATHEPSIN-K INHIBITORS THAT SPANTHE ACTIVE-SITE, Proceedings of the National Academy of Sciences of the United Statesof America, 94(26), 1997, pp. 14249-14254
STRUCTURE AND DESIGN OF POTENT AND SELECTIVE CATHEPSIN-K INHIBITORS
Authors: YAMASHITA DS SMITH WW ZHAO BG JANSON CA TOMASZEK TA BOSSARD MJ LEVY MA OH HJ CARR TJ THOMPSON SK IJAMES CF CARR SA MCQUENEY M DALESSIO KJ AMEGADZIE BY HANNING CR ABDELMEGUID S DESJARLAIS RL GLEASON JG VEBER DF
Citation: Ds. Yamashita et al., STRUCTURE AND DESIGN OF POTENT AND SELECTIVE CATHEPSIN-K INHIBITORS, Journal of the American Chemical Society, 119(46), 1997, pp. 11351-11352
PEPTIDE ALDEHYDE INHIBITORS OF CATHEPSIN-K INHIBIT BONE-RESORPTION BOTH IN-VITRO AND IN-VIVO
Authors: DRAKE F VOTTA BJ BADGER A DODDS RA JAMES I LEVY MA THOMPSON S BOSSARD MJ CARR T CONNOR JR TOMASZEK TA SZEWCZUK L VEBER D GOWEN M
Citation: F. Drake et al., PEPTIDE ALDEHYDE INHIBITORS OF CATHEPSIN-K INHIBIT BONE-RESORPTION BOTH IN-VITRO AND IN-VIVO, Journal of bone and mineral research, 11, 1996, pp. 246-246
PROTEOLYTIC ACTIVITY OF HUMAN OSTEOCLAST CATHEPSIN-K - EXPRESSION, PURIFICATION, ACTIVATION, AND SUBSTRATE IDENTIFICATION
Authors: BOSSARD MJ TOMASZEK TA THOMPSON SK AMEGADZIE BY HANNING CR JONES C KURDYLA JT MCNULTY DE DRAKE FH GOWEN M LEVY MA
Citation: Mj. Bossard et al., PROTEOLYTIC ACTIVITY OF HUMAN OSTEOCLAST CATHEPSIN-K - EXPRESSION, PURIFICATION, ACTIVATION, AND SUBSTRATE IDENTIFICATION, The Journal of biological chemistry, 271(21), 1996, pp. 12517-12524
SYNTHESIS AND ACTIVITY OF AN HIV-1 PROTEASE INHIBITOR CONTAINING A CONTIGUOUS (E)-OLEFIN-HYDROXYETHYLENE PEPTIDE MIMETIC
Authors: KEENAN RM EPPLEY DF TOMASZEK TA
Citation: Rm. Keenan et al., SYNTHESIS AND ACTIVITY OF AN HIV-1 PROTEASE INHIBITOR CONTAINING A CONTIGUOUS (E)-OLEFIN-HYDROXYETHYLENE PEPTIDE MIMETIC, Tetrahedron letters, 36(6), 1995, pp. 819-822
SYNTHESIS AND ANTIVIRAL ACTIVITY OF A NOVEL CLASS OF HIV-1 PROTEASE INHIBITORS CONTAINING A HETEROCYCLIC P-1'-P-2' AMIDE BOND ISOSTERE
Authors: THOMPSON SK EPPLEY AM FRAZEE JS DARCY MG LUM RT TOMASZEK TA IVANOFF LA MORRIS JF STERNBERG EJ LAMBERT DM FERNANDEZ AV PETTEWAY SR MEEK TD METCALF BW GLEASON JG
Citation: Sk. Thompson et al., SYNTHESIS AND ANTIVIRAL ACTIVITY OF A NOVEL CLASS OF HIV-1 PROTEASE INHIBITORS CONTAINING A HETEROCYCLIC P-1'-P-2' AMIDE BOND ISOSTERE, Bioorganic & medicinal chemistry letters, 4(20), 1994, pp. 2441-2446
RATIONAL DESIGN, SYNTHESIS, AND CRYSTALLOGRAPHIC ANALYSIS OF A HYDROXYETHYLENE-BASED HIV-1 PROTEASE INHIBITOR CONTAINING A HETEROCYCLIC P-1' P-2' AMIDE BOND ISOSTERE
Authors: THOMPSON SK MURTHY KHM ZHAO B WINBORNE E GREEN DW FISHER SM DESJARLAIS RL TOMASZEK TA MEEK TD GLEASON JG ABDELMEGUID SS
Citation: Sk. Thompson et al., RATIONAL DESIGN, SYNTHESIS, AND CRYSTALLOGRAPHIC ANALYSIS OF A HYDROXYETHYLENE-BASED HIV-1 PROTEASE INHIBITOR CONTAINING A HETEROCYCLIC P-1' P-2' AMIDE BOND ISOSTERE, Journal of medicinal chemistry, 37(19), 1994, pp. 3100-3107
AN ORALLY BIOAVAILABLE HIV-1 PROTEASE INHIBITOR CONTAINING AN IMIDAZOLE-DERIVED PEPTIDE-BOND REPLACEMENT - CRYSTALLOGRAPHIC AND PHARMACOKINETIC ANALYSIS
Authors: ABDELMEGUID SS METCALF BW CARR TJ DEMARSH P DESJARLAIS RL FISHER S GREEN DW IVANOFF L LAMBERT DM MURTHY KHM PETTEWAY SR PITTS WJ TOMASZEK TA WINBORNE E ZHAO BG DREYER GB MEEK TD
Citation: Ss. Abdelmeguid et al., AN ORALLY BIOAVAILABLE HIV-1 PROTEASE INHIBITOR CONTAINING AN IMIDAZOLE-DERIVED PEPTIDE-BOND REPLACEMENT - CRYSTALLOGRAPHIC AND PHARMACOKINETIC ANALYSIS, Biochemistry, 33(39), 1994, pp. 11671-11677
NONPEPTIDE HIV PROTEASE INHIBITORS DESIGNED TO REPLACE A BOUND WATER
Authors: CHENERA B DESJARLAIS RL FINKELSTEIN JA EGGLESTON DS MEEK TD TOMASZEK TA DREYER GB
Citation: B. Chenera et al., NONPEPTIDE HIV PROTEASE INHIBITORS DESIGNED TO REPLACE A BOUND WATER, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2717-2722
A NOVEL CONSTRAINED REDUCED-AMIDE INHIBITOR OF HIV-1 PROTEASE DERIVEDFROM THE SEQUENTIAL INCORPORATION OF GAMMA-TURN MIMETICS INTO A MODELSUBSTRATE
Authors: NEWLANDER KA CALLAHAN JF MOORE ML TOMASZEK TA HUFFMAN WF
Citation: Ka. Newlander et al., A NOVEL CONSTRAINED REDUCED-AMIDE INHIBITOR OF HIV-1 PROTEASE DERIVEDFROM THE SEQUENTIAL INCORPORATION OF GAMMA-TURN MIMETICS INTO A MODELSUBSTRATE, Journal of medicinal chemistry, 36(16), 1993, pp. 2321-2331
INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C2-SYMMETRICAL PHOSPHINATE - SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS
Authors: ABDELMEGUID SS ZHAO BG MURTHY KHM WINBORNE E CHOI JK DESJARLAIS RL MINNICH MD CULP JS DEBOUCK C TOMASZEK TA MEEK TD DREYER GB
Citation: Ss. Abdelmeguid et al., INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C2-SYMMETRICAL PHOSPHINATE - SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS, Biochemistry, 32(31), 1993, pp. 7972-7980
Risultati: 1-16 |