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Results: 1-25/40
Authors:
TORPHY TJ
Citation: Tj. Torphy, PHOSPHODIESTERASE ISOZYMES - MOLECULAR TARGETS FOR NOVEL ANTIASTHMA AGENTS, American journal of respiratory and critical care medicine, 157(2), 1998, pp. 351-370
CRITICAL ROLE OF CONSERVED HISTIDINE PAIRS HNXXH AND HDXXH IN RECOMBINANT HUMAN PHOSPHODIESTERASE 4A
Authors:
OMBURO GA
JACOBITZ S
TORPHY TJ
COLMAN RW
Citation: Ga. Omburo et al., CRITICAL ROLE OF CONSERVED HISTIDINE PAIRS HNXXH AND HDXXH IN RECOMBINANT HUMAN PHOSPHODIESTERASE 4A, Cellular signalling, 10(7), 1998, pp. 491-497
Authors:
TORPHY TJ
Citation: Tj. Torphy, ISOENZYMES OF CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES - THEIR PHYSIOLOGICAL ROLES AND PHARMACOLOGICAL MODULATION, Naunyn-Schmiedeberg's archives of pharmacology, 358(1), 1998, pp. 33-33
Authors:
GRISWOLD DE
WEBB EF
BADGER AM
GORYCKI PD
LEVANDOSKI PA
BARNETTE MA
GROUS M
CHRISTENSEN S
TORPHY TJ
Citation: De. Griswold et al., SE-207499 (ARIFLO), A 2ND-GENERATION PHOSPHODIESTERASE-4 INHIBITOR, REDUCES TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-4 PRODUCTION IN-VIVO, The Journal of pharmacology and experimental therapeutics, 287(2), 1998, pp. 705-711
Authors:
BARNETTE MS
CHRISTENSEN SB
ESSAYAN DM
GROUS M
PRABHAKAR U
RUSH JA
KAGEYSOBOTKA A
TORPHY TJ
Citation: Ms. Barnette et al., SE-207499 (ARIFLO), A POTENT AND SELECTIVE 2ND-GENERATION PHOSPHODIESTERASE-4 INHIBITOR - IN-VITRO ANTIINFLAMMATORY ACTIONS, The Journal of pharmacology and experimental therapeutics, 284(1), 1998, pp. 420-426
Authors:
CHRISTENSEN SB
GUIDER A
FORSTER CJ
GLEASON JG
BENDER PE
KARPINSKI JM
DEWOLF WE
BARNETTE MS
UNDERWOOD DC
GRISWOLD DE
CIESLINSKI LB
BURMAN M
BOCHNOWICZ S
OSBORN RR
MANNING CD
GROUS M
HILLEGAS LM
BARTUS JO
RYAN MD
EGGLESTON DS
HALTIWANGER RC
TORPHY TJ
Citation: Sb. Christensen et al., 1,4-CYCLOHEXANECARBOXYLATES - POTENT AND SELECTIVE INHIBITORS OF PHOSPHODIESTERASE-4 FOR THE TREATMENT OF ASTHMA, Journal of medicinal chemistry, 41(6), 1998, pp. 821-835
Authors:
GRISWOLD DE
RUFFOLO RR
POSTE G
TORPHY TJ
Citation: De. Griswold et al., RE-CLASSIFICATION OF NSAIDS, Trends in pharmacological sciences, 18(9), 1997, pp. 311-311
Authors:
OMBURO GA
JACOBITZ S
TORPHY TJ
COLMAN RW
Citation: Ga. Omburo et al., CRITICAL ROLE OF CONSERVED HISTIDINE PAIRS HNXXH AND HDXXH IN CAMP-SPECIFIC PDE, The FASEB journal, 11(9), 1997, pp. 194-194
Authors:
WILLETTE RN
SHILOH AO
SAUERMELCH CF
SULPIZIO A
MICHELL MP
CIESLINSKI LB
TORPHY TJ
OHLSTEIN EH
Citation: Rn. Willette et al., IDENTIFICATION, CHARACTERIZATION, AND FUNCTIONAL-ROLE OF PHOSPHODIESTERASE TYPE-IV IN CEREBRAL VESSELS - EFFECTS OF SELECTIVE PHOSPHODIESTERASE INHIBITORS, Journal of cerebral blood flow and metabolism, 17(2), 1997, pp. 210-219
Authors:
JACOBITZ S
RYAN MD
MCLAUGHLIN MM
LIVI GP
DEWOLF WE
TORPHY TJ
Citation: S. Jacobitz et al., ROLE OF CONSERVED HISTIDINES IN CATALYTIC ACTIVITY AND INHIBITOR BINDING OF HUMAN RECOMBINANT PHOSPHODIESTERASE 4A, Molecular pharmacology, 51(6), 1997, pp. 999-1006
Authors:
UNDERWOOD DC
MATTHEWS JK
OSBORN RR
BOCHNOWICZ S
TORPHY TJ
Citation: Dc. Underwood et al., THE INFLUENCE OF ENDOGENOUS CATECHOLAMINES ON THE INHIBITORY EFFECTS OF ROLIPRAM AGAINST EARLY-PHASE AND LATE-PHASE RESPONSE TO ANTIGEN IN THE GUINEA-PIG, The Journal of pharmacology and experimental therapeutics, 280(1), 1997, pp. 210-219
Authors:
OMBURO GA
TORPHY TJ
SCOTT G
JACOBITZ S
COLMAN RF
COLMAN RW
Citation: Ga. Omburo et al., INACTIVATION OF RECOMBINANT MONOCYTE CAMP-SPECIFIC PHOSPHODIESTERASE BY CAMP ANALOG, 8-[(4-BROMO-2,3-DIOXOBUTYL)THIO]ADENOSINE 3',5'-CYCLIC-MONOPHOSPHATE, Blood, 89(3), 1997, pp. 1019-1026
Authors:
ROBERTS MI
STADEL JM
TORPHY TJ
FLEMING WW
TAYLOR DA
Citation: Mi. Roberts et al., MECHANISMS OF ADAPTIVE SUPERSENSITIVITY - CORRELATION OF GUINEA-PIG ATRIAL SUPERSENSITIVITY WITH MODIFICATIONS IN ADENYLYL-CYCLASE ACTIVITY, Biochemical pharmacology, 53(3), 1997, pp. 347-356
Authors:
UNDERWOOD DC
OSBORN RR
NEWSHOLME SJ
TORPHY TJ
HAY DWP
Citation: Dc. Underwood et al., PERSISTENT AIRWAY EOSINOPHILIA AFTER LEUKOTRIENE (LT) D-4 ADMINISTRATION IN THE GUINEA-PIG - MODULATION BY THE LTD(4) RECEPTOR ANTAGONIST, PRANLUKAST, OR AN INTERLEUKIN-5 MONOCLONAL-ANTIBODY, American journal of respiratory and critical care medicine, 154(4), 1996, pp. 850-857
Authors:
UNDERWOOD DC
BOCHNOWICZ S
OSBORN RR
NEWSHOLME SJ
TORPHY TJ
HAY DWP
Citation: Dc. Underwood et al., THE CYSTEINYL-LEUKOTRIENE (CYSLT) RECEPTOR ANTAGONIST, PRANLUKAST, ATTENUATES AIRWAY INFLAMMATION, Journal of allergy and clinical immunology, 97(1), 1996, pp. 426-426
Authors:
JACOBITZ S
MCLAUGHLIN MM
LIVI GP
BURMAN M
TORPHY TJ
Citation: S. Jacobitz et al., MAPPING THE FUNCTIONAL DOMAINS OF HUMAN RECOMBINANT PHOSPHODIESTERASE4A - STRUCTURAL REQUIREMENTS FOR CATALYTIC ACTIVITY AND ROLIPRAM BINDING, Molecular pharmacology, 50(4), 1996, pp. 891-899
Authors:
MANNING CD
MCLAUGHLIN MM
LIVI GP
CIESLINSKI LB
TORPHY TJ
BARNETTE MS
Citation: Cd. Manning et al., PROLONGED BETA-ADRENOCEPTOR STIMULATION UP-REGULATES CAMP-PHOSPHODIESTERASE ACTIVITY IN HUMAN MONOCYTES BY INCREASING MESSENGER-RNA AND PROTEIN FOR PHOSPHODIESTERASES 4A AND 4B, The Journal of pharmacology and experimental therapeutics, 276(2), 1996, pp. 810-818
Authors:
GRISWOLD DE
HILLEGAS LM
OLEARYBARTUS J
LEE JC
LAYDON JT
TORPHY TJ
Citation: De. Griswold et al., EVALUATION OF HUMAN CYTOKINE PRODUCTION AND EFFECTS OF PHARMACOLOGICAL AGENTS IN A HETEROLOGOUS SYSTEM IN-VIVO, Journal of immunological methods, 195(1-2), 1996, pp. 1-5
Authors:
BARNETTE MS
BARTUS JOL
BURMAN M
CHRISTENSEN SB
CIESLINSKI LB
ESSER KM
PRABHAKAR US
RUSH JA
TORPHY TJ
Citation: Ms. Barnette et al., ASSOCIATION OF THE ANTIINFLAMMATORY ACTIVITY OF PHOSPHODIESTERASE-4 (PDE4) INHIBITORS WITH EITHER INHIBITION OF PDE4 CATALYTIC ACTIVITY OR COMPETITION FOR [H-3] ROLIPRAM BINDING, Biochemical pharmacology, 51(7), 1996, pp. 949-956
Authors:
HAY DWP
TORPHY TJ
UNDEM BJ
Citation: Dwp. Hay et al., CYSTEINYL LEUKOTRIENES IN ASTHMA - OLD MEDIATORS UP TO NEW TRICKS, Trends in pharmacological sciences, 16(9), 1995, pp. 304-309
Authors:
AMEGADZIE BY
HANNING CR
MCLAUGHLIN MM
BURMAN M
CIESLINSKI LB
LIVI GP
TORPHY TJ
Citation: By. Amegadzie et al., CHARACTERIZATION OF 2 HUMAN CAMP-SPECIFIC PHOSPHODIESTERASE SUBTYPES EXPRESSED IN BACULOVIRUS-INFECTED INSECT CELLS, Cell biology international, 19(6), 1995, pp. 477-484
Authors:
BARNETTE MS
GROUS M
CIESLINSKI LB
BURMAN M
CHRISTENSEN SB
TORPHY TJ
Citation: Ms. Barnette et al., INHIBITORS OF PHOSPHODIESTERASE-IV (PDE-IV) INCREASE ACID-SECRETION IN RABBIT ISOLATED GASTRIC GLANDS - CORRELATION BETWEEN FUNCTION AND INTERACTION WITH A HIGH-AFFINITY ROLIPRAM BINDING-SITE, The Journal of pharmacology and experimental therapeutics, 273(3), 1995, pp. 1396-1402
Authors:
BARNETTE MS
MANNING CD
CIESLINSKI LB
BURMAN M
CHRISTENSEN SB
TORPHY TJ
Citation: Ms. Barnette et al., THE ABILITY OF PHOSPHODIESTERASE-IV INHIBITORS TO SUPPRESS SUPEROXIDEPRODUCTION IN GUINEA-PIG EOSINOPHILS IS CORRELATED WITH INHIBITION OFPHOSPHODIESTERASE-IV CATALYTIC ACTIVITY, The Journal of pharmacology and experimental therapeutics, 273(2), 1995, pp. 674-679
Authors:
TORPHY TJ
ZHOU HL
FOLEY JJ
SARAU HM
MANNING CD
BARNETTE MS
Citation: Tj. Torphy et al., SALBUTAMOL UP-REGULATES PDE4 ACTIVITY AND INDUCES A HETEROLOGOUS DESENSITIZATION OF U937 CELLS TO PROSTAGLANDIN E(2) - IMPLICATIONS FOR THETHERAPEUTIC USE OF BETA-ADRENOCEPTOR AGONISTS, The Journal of biological chemistry, 270(40), 1995, pp. 23598-23604
Authors:
CHILTON FH
FONTEH AN
SUNG CM
HICKEY DMB
TORPHY TJ
MAYER RJ
MARSHALL LA
HERAVI JD
WINKLER JD
Citation: Fh. Chilton et al., INHIBITORS OF COA-INDEPENDENT TRANSACYLASE BLOCK THE MOVEMENT OF ARACHIDONATE INTO 1-ETHER-LINKED PHOSPHOLIPIDS OF HUMAN NEUTROPHILS, Biochemistry, 34(16), 1995, pp. 5403-5410