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Results: 1-20 |
Results: 20
Induction of CYP3A4 by 1 alpha,25-dihydroxyvitamin D-3 is human cell line-specific and is unlikely to involve pregnane X receptor
Authors: Schmiedlin-Ren, P Thummel, KE Fisher, JM Paine, MF Watkins, PB
Citation: P. Schmiedlin-ren et al., Induction of CYP3A4 by 1 alpha,25-dihydroxyvitamin D-3 is human cell line-specific and is unlikely to involve pregnane X receptor, DRUG META D, 29(11), 2001, pp. 1446-1453
Transcriptional control of intestinal cytochrome P-4503A by 1 alpha,25-dihydroxy vitamin D-3
Authors: Thummel, KE Brimer, C Yasuda, K Thottassery, J Senn, T Lin, Y Ishizuka, H Kharasch, E Schuetz, J Schuetz, E
Citation: Ke. Thummel et al., Transcriptional control of intestinal cytochrome P-4503A by 1 alpha,25-dihydroxy vitamin D-3, MOLEC PHARM, 60(6), 2001, pp. 1399-1406
CYP3A activity in European American and Japanese men using midazolam as anin vivo probe
Authors: Tateishi, T Watanabe, M Nakura, H Asoh, M Shirai, H Mizorogi, Y Kobayashi, S Thummel, KE Wilkinson, GR
Citation: T. Tateishi et al., CYP3A activity in European American and Japanese men using midazolam as anin vivo probe, CLIN PHARM, 69(5), 2001, pp. 333-339
Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: relationship between UGT1A1 promoter genotype and variability in a liver bank
Authors: Fisher, MB VandenBranden, M Findlay, K Burchell, B Thummel, KE Hall, SD Wrighton, SA
Citation: Mb. Fisher et al., Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: relationship between UGT1A1 promoter genotype and variability in a liver bank, PHARMACOGEN, 10(8), 2000, pp. 727-739
Can oral midazolam predict oral cyclosporine disposition?
Authors: Paine, MF Davis, CL Shen, DD Marsh, CL Raisys, VA Thummel, KE
Citation: Mf. Paine et al., Can oral midazolam predict oral cyclosporine disposition?, EUR J PH SC, 12(1), 2000, pp. 51-62
Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells
Authors: Gibbs, MA Baillie, MT Shen, DD Kunze, KL Thummel, KE
Citation: Ma. Gibbs et al., Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells, PHARM RES, 17(3), 2000, pp. 299-305
The human CYP3A subfamily: Practical considerations
Authors: Wrighton, SA Schuetz, EG Thummel, KE Shen, DD Korzekwa, KR Watkins, PB
Citation: Sa. Wrighton et al., The human CYP3A subfamily: Practical considerations, DRUG METAB, 32(3-4), 2000, pp. 339-361
Immunoquantitation of FMO1 in human liver, kidney, and intestine
Authors: Yeung, CK Lang, DH Thummel, KE Rettie, AE
Citation: Ck. Yeung et al., Immunoquantitation of FMO1 in human liver, kidney, and intestine, DRUG META D, 28(9), 2000, pp. 1107-1111
Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen
Authors: Dong, HJ Haining, RL Thummel, KE Rettie, AE Nelson, SD
Citation: Hj. Dong et al., Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen, DRUG META D, 28(12), 2000, pp. 1397-1400
Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults
Authors: Thummel, KE Slattery, JT Ro, H Chien, JY Nelson, SD Lown, KE Watkins, PB
Citation: Ke. Thummel et al., Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults, CLIN PHARM, 67(6), 2000, pp. 591-599
Comparison of CYP2D6 content and metoprolol oxidation between microsomes isolated from human livers and small intestines
Authors: Madani, S Paine, MF Lewis, L Thummel, KE Shen, DD
Citation: S. Madani et al., Comparison of CYP2D6 content and metoprolol oxidation between microsomes isolated from human livers and small intestines, PHARM RES, 16(8), 1999, pp. 1199-1205
Intraindividual variability in male hepatic CYP3A4 activity assessed by alfentanil and midazolam clearance
Authors: Kharasch, ED Jubert, C Senn, T Bowdle, TA Thummel, KE
Citation: Ed. Kharasch et al., Intraindividual variability in male hepatic CYP3A4 activity assessed by alfentanil and midazolam clearance, J CLIN PHAR, 39(7), 1999, pp. 664-669
Lack of single-dose disulfiram effects on cytochrome P-4502C9, 2C19, 2D6, and 3A4 activities: Evidence for specificity toward P-450 2E1
Authors: Kharasch, ED Hankins, DC Jubert, C Thummel, KE Taraday, JK
Citation: Ed. Kharasch et al., Lack of single-dose disulfiram effects on cytochrome P-4502C9, 2C19, 2D6, and 3A4 activities: Evidence for specificity toward P-450 2E1, DRUG META D, 27(6), 1999, pp. 717-723
Effect of inhibitor depletion on inhibitory potency: Tight binding inhibition of CYP3A by clotrimazole
Authors: Gibbs, MA Kunze, KL Howald, WN Thummel, KE
Citation: Ma. Gibbs et al., Effect of inhibitor depletion on inhibitory potency: Tight binding inhibition of CYP3A by clotrimazole, DRUG META D, 27(5), 1999, pp. 596-599
Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: Comparison of K-I values and impact of CYP3A5 expression
Authors: Gibbs, MA Thummel, KE Shen, DD Kunze, KL
Citation: Ma. Gibbs et al., Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: Comparison of K-I values and impact of CYP3A5 expression, DRUG META D, 27(2), 1999, pp. 180-187
Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administrationin humans
Authors: Emery, MG Jubert, C Thummel, KE Kharasch, ED
Citation: Mg. Emery et al., Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administrationin humans, J PHARM EXP, 291(1), 1999, pp. 213-219
Inhibition of human liver cytochrome P-450 1A2 by the class IB antiarrhythmics mexiletine, lidocaine, and tocainide
Authors: Wei, XX Dai, RK Zhai, SP Thummel, KE Friedman, FK Vestal, RE
Citation: Xx. Wei et al., Inhibition of human liver cytochrome P-450 1A2 by the class IB antiarrhythmics mexiletine, lidocaine, and tocainide, J PHARM EXP, 289(2), 1999, pp. 853-858
First-pass midazolam metabolism catalyzed by 1 alpha,25-dihydroxy vitamin D-3-modified Caco-2 cell monolayers
Authors: Fisher, JM Wrighton, SA Watkins, PB Schmiedlin-Ren, P Calamia, JC Shen, DD Kunze, KL Thummel, KE
Citation: Jm. Fisher et al., First-pass midazolam metabolism catalyzed by 1 alpha,25-dihydroxy vitamin D-3-modified Caco-2 cell monolayers, J PHARM EXP, 289(2), 1999, pp. 1134-1142
Midazolam metabolism by modified Caco-2 monolayers: Effects of extracellular protein binding
Authors: Fisher, JM Wrighton, SA Calamia, JC Shen, DD Kunze, KL Thummel, KE
Citation: Jm. Fisher et al., Midazolam metabolism by modified Caco-2 monolayers: Effects of extracellular protein binding, J PHARM EXP, 289(2), 1999, pp. 1143-1150
Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A
Authors: Kinirons, MT O'Shea, D Kim, RB Groopman, JD Thummel, KE Wood, JJ Wilkinson, GR
Citation: Mt. Kinirons et al., Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A, CLIN PHARM, 66(3), 1999, pp. 224-231
Risultati: 1-20 |