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Results: 1-10 |
Results: 10
Metabolism of sulfinpyrazone sulfide and sulfinpyrazone by human liver microsomes and cDNA-expressed cytochrome P450s
Authors: He, MX Rettie, AE Neal, J Trager, WF
Citation: Mx. He et al., Metabolism of sulfinpyrazone sulfide and sulfinpyrazone by human liver microsomes and cDNA-expressed cytochrome P450s, DRUG META D, 29(5), 2001, pp. 701-711
Fluvoxamine-theophylline interaction: Gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2
Authors: Yao, CP Kunze, KL Kharasch, ED Wang, Y Trager, WF Ragueneau, I Levy, RH
Citation: Cp. Yao et al., Fluvoxamine-theophylline interaction: Gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2, CLIN PHARM, 70(5), 2001, pp. 415-424
Active site characteristics of CYP4B1 probed with aromatic ligands
Authors: Henne, KR Fisher, MB Iyer, KR Lang, DH Trager, WF Rettie, AE
Citation: Kr. Henne et al., Active site characteristics of CYP4B1 probed with aromatic ligands, BIOCHEM, 40(29), 2001, pp. 8597-8605
A refined 3-dimensional QSAR of cytochrome P4502C9: Computational predictions of drug interactions
Authors: Rao, S Aoyama, R Schrag, M Trager, WF Rettie, A Jones, JP
Citation: S. Rao et al., A refined 3-dimensional QSAR of cytochrome P4502C9: Computational predictions of drug interactions, J MED CHEM, 43(15), 2000, pp. 2789-2796
Mechanism-based inactivation of cytochrome P450 3A4 by L-754,394
Authors: Lightning, LK Jones, JP Friedberg, T Pritchard, MP Shou, M Rushmore, TH Trager, WF
Citation: Lk. Lightning et al., Mechanism-based inactivation of cytochrome P450 3A4 by L-754,394, BIOCHEM, 39(15), 2000, pp. 4276-4287
Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450
Authors: Erickson, DA Mather, G Trager, WF Levy, RH Keirns, JJ
Citation: Da. Erickson et al., Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450, DRUG META D, 27(12), 1999, pp. 1488-1495
Electrospray ionization mass spectrometric analysis of intact cytochrome P450: Identification of tienilic acid adducts to P450 2C9
Authors: Koenigs, LL Peter, RM Hunter, AP Haining, RL Rettie, AE Friedberg, T Pritchard, MP Shou, M Rushmore, TH Trager, WF
Citation: Ll. Koenigs et al., Electrospray ionization mass spectrometric analysis of intact cytochrome P450: Identification of tienilic acid adducts to P450 2C9, BIOCHEM, 38(8), 1999, pp. 2312-2319
Enzymatic determinants of the substrate specificity of CYP2C9: Role of B '-C loop residues in providing the pi-stacking anchor site for warfarin binding
Authors: Haining, RL Jones, JP Henne, KR Fisher, MB Koop, DR Trager, WF Rettie, AE
Citation: Rl. Haining et al., Enzymatic determinants of the substrate specificity of CYP2C9: Role of B '-C loop residues in providing the pi-stacking anchor site for warfarin binding, BIOCHEM, 38(11), 1999, pp. 3285-3292
Structural forms of phenprocoumon and warfarin that are metabolized at theactive site of CYP2C9
Authors: He, MX Korzekwa, KR Jones, JP Rettie, AE Trager, WF
Citation: Mx. He et al., Structural forms of phenprocoumon and warfarin that are metabolized at theactive site of CYP2C9, ARCH BIOCH, 372(1), 1999, pp. 16-28
Experimental and theoretical study of the effect of active-site constrained substrate motion on the magnitude of the observed intramolecular isotope effect for the P450 101 catalyzed benzylic hydroxylation of isomeric xylenes and 4,4 '-dimethylbiphenyl
Authors: Audergon, C Iyer, KR Jones, JP Darbyshire, JF Trager, WF
Citation: C. Audergon et al., Experimental and theoretical study of the effect of active-site constrained substrate motion on the magnitude of the observed intramolecular isotope effect for the P450 101 catalyzed benzylic hydroxylation of isomeric xylenes and 4,4 '-dimethylbiphenyl, J AM CHEM S, 121(1), 1999, pp. 41-47
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