Citation: M. Shimabukuro et al., FATTY ACID-INDUCED BETA-CELL APOPTOSIS - A LINK BETWEEN OBESITY AND DIABETES, Proceedings of the National Academy of Sciences of the United Statesof America, 95(5), 1998, pp. 2498-2502
Authors:
WANG MY
KOYAMA K
SHIMABUKURO M
MANGELSDORF D
NEWGARD CB
UNGER RH
Citation: My. Wang et al., OVEREXPRESSION OF LEPTIN RECEPTORS IN PANCREATIC-ISLETS OF ZUCKER DIABETIC FATTY RATS RESTORES GLUT-2, GLUCOKINASE, AND GLUCOSE-STIMULATED INSULIN-SECRETION, Proceedings of the National Academy of Sciences of the United Statesof America, 95(20), 1998, pp. 11921-11926
Authors:
WANG MY
KOYAMA K
SHIMABUKURO M
NEWGARD CB
UNGER RH
Citation: My. Wang et al., OB-RB GENE-TRANSFER TO LEPTIN-RESISTANT ISLETS REVERSES DIABETOGENIC PHENOTYPE, Proceedings of the National Academy of Sciences of the United Statesof America, 95(2), 1998, pp. 714-718
Authors:
SHIMABUKURO M
WANG MY
ZHOU YT
NEWGARD CB
UNGER RH
Citation: M. Shimabukuro et al., PROTECTION AGAINST LIPOAPOPTOSIS OF BETA-CELLS THROUGH LEPTIN-DEPENDENT MAINTENANCE OF BCL-2 EXPRESSION, Proceedings of the National Academy of Sciences of the United Statesof America, 95(16), 1998, pp. 9558-9561
Authors:
ZHOU YT
SHIMABUKURO M
WANG MY
LEE Y
HIGA M
MILBURN JL
NEWGARD CB
UNGER RH
Citation: Yt. Zhou et al., ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-ALPHA IN DISEASE OF PANCREATIC BETA-CELLS, Proceedings of the National Academy of Sciences of the United Statesof America, 95(15), 1998, pp. 8898-8903
Authors:
KOYAMA K
SHIMABUKURO M
CHEN GX
WANG MY
LEE Y
KALRA PS
DUBE MG
KALRA SP
NEWGARD CB
UNGER RH
Citation: K. Koyama et al., RESISTANCE TO ADENOVIRALLY INDUCED HYPERLEPTINEMIA IN RATS - COMPARISON OF VENTROMEDIAL HYPOTHALAMIC-LESIONS AND MUTATED LEPTIN RECEPTORS, The Journal of clinical investigation, 102(4), 1998, pp. 728-733
Citation: M. Shimabukuro et al., TROGLITAZONE LOWERS ISLET FAT AND RESTORES BETA-CELL FUNCTION OF ZUCKER DIABETIC FATTY RATS, The Journal of biological chemistry, 273(6), 1998, pp. 3547-3550
Authors:
ZHOU YT
SHIMABUKURO M
LEE Y
KOYAMA K
HIGA M
FERGUSON T
UNGER RH
Citation: Yt. Zhou et al., ENHANCED DE-NOVO LIPOGENESIS IN THE LEPTIN-UNRESPONSIVE PANCREATIC-ISLETS OF PREDIABETIC ZUCKER DIABETIC FATTY RATS - ROLE IN THE PATHOGENESIS OF LIPOTOXIC DIABETES, Diabetes, 47(12), 1998, pp. 1904-1908
Citation: K. Koyama et al., TISSUE TRIGLYCERIDES, INSULIN-RESISTANCE, AND INSULIN PRODUCTION - IMPLICATIONS FOR HYPERINSULINEMIA OF OBESITY, American journal of physiology: endocrinology and metabolism, 36(4), 1997, pp. 708-713
Authors:
SHIMABUKURO M
KOYAMA K
CHEN GX
WANG MY
TRIEU F
LEE Y
NEWGARD CB
UNGER RH
Citation: M. Shimabukuro et al., DIRECT ANTIDIABETIC EFFECT OF LEPTIN THROUGH TRIGLYCERIDE DEPLETION OF TISSUES, Proceedings of the National Academy of Sciences of the United Statesof America, 94(9), 1997, pp. 4637-4641
Authors:
ZHOU YT
SHIMABUKURO M
KOYAMA K
LEE Y
WANG MY
TRIEU F
NEWGARD CB
UNGER RH
Citation: Yt. Zhou et al., INDUCTION BY LEPTIN OF UNCOUPLING PROTEIN-2 AND ENZYMES OF FATTY-ACIDOXIDATION, Proceedings of the National Academy of Sciences of the United Statesof America, 94(12), 1997, pp. 6386-6390
Citation: M. Shimabukuro et al., LEPTIN-INDUCED OR TROGLITAZONE-INDUCED LIPOPENIA PROTECTS ISLETS FROMINTERLEUKIN-1-BETA CYTOXICITY, The Journal of clinical investigation, 100(7), 1997, pp. 1750-1754
Citation: M. Shimabukuro et al., ROLE OF NITRIC-OXIDE IN OBESITY-INDUCED BETA-CELL DISEASE, The Journal of clinical investigation, 100(2), 1997, pp. 290-295
Authors:
ZHOU YT
SHIMABUKURO M
LEE Y
KOYAMA K
TRIEU F
UNGER RH
Citation: Yt. Zhou et al., LEPTIN NORMALIZES THE IMPAIRED RESPONSE OF PROINSULIN MESSENGER-RNA TO LONG-CHAIN FATTY-ACIDS IN HETEROZYGOUS ZUCKER DIABETIC FATTY RATS, The Journal of biological chemistry, 272(41), 1997, pp. 25648-25651
Authors:
KOYAMA K
CHEN GX
WANG MY
LEE Y
SHIMABUKURO M
NEWGARD CB
UNGER RH
Citation: K. Koyama et al., BETA-CELL FUNCTION IN NORMAL RATS MADE CHRONICALLY HYPERLEPTINEMIC BYADENOVIRUS-LEPTIN GENE-THERAPY, Diabetes, 46(8), 1997, pp. 1276-1280
Authors:
LEE Y
HIROSE H
ZHOU YT
ESSER V
MCGARRY JD
UNGER RH
Citation: Y. Lee et al., INCREASED LIPOGENIC CAPACITY OF THE ISLETS OF OBESE RATS - A ROLE IN THE PATHOGENESIS OF NIDDM, Diabetes, 46(3), 1997, pp. 408-413
Citation: M. Shimabukuro et al., INDUCTION OF UNCOUPLING PROTEIN-2 MESSENGER-RNA BY TROGLITAZONE IN THE PANCREATIC-ISLETS OF ZUCKER DIABETIC FATTY RATS, Biochemical and biophysical research communications, 237(2), 1997, pp. 359-361
Authors:
CHEN GX
KOYAMA K
YUAN X
LEE Y
ZHOU YT
ODOHERTY R
NEWGARD CB
UNGER RH
Citation: Gx. Chen et al., DISAPPEARANCE OF BODY-FAT IN NORMAL RATS INDUCED BY ADENOVIRUS-MEDIATED LEPTIN GENE-THERAPY, Proceedings of the National Academy of Sciences of the United Statesof America, 93(25), 1996, pp. 14795-14799
Authors:
HIROSE H
LEE YH
INMAN LR
NAGASAWA Y
JOHNSON JH
UNGER RH
Citation: H. Hirose et al., DEFECTIVE FATTY ACID-MEDIATED BETA-CELL COMPENSATION IN ZUCKER DIABETIC FATTY RATS - PATHOGENIC IMPLICATIONS FOR OBESITY-DEPENDENT DIABETES, The Journal of biological chemistry, 271(10), 1996, pp. 5633-5637
Authors:
MILBURN JL
HIROSE H
LEE YH
NAGASAWA Y
OGAWA A
OHNEDA M
BELTRANDELRIO H
NEWGARD CB
JOHNSON JH
UNGER RH
Citation: Jl. Milburn et al., PANCREATIC BETA-CELLS IN OBESITY - EVIDENCE FOR INDUCTION OF FUNCTIONAL, MORPHOLOGIC, AND METABOLIC ABNORMALITIES BY INCREASED LONG-CHAIN FATTY-ACIDS, The Journal of biological chemistry, 270(3), 1995, pp. 1295-1299
Citation: M. Ohneda et al., CALORIC RESTRICTION IN OBESE PREDIABETIC RATS PREVENTS BETA-CELL DEPLETION, LOSS OF BETA-CELL GLUT-2 AND GLUCOSE INCOMPETENCE, Diabetologia, 38(2), 1995, pp. 173-179
Citation: Rh. Unger, LIPOTOXICITY IN THE PATHOGENESIS OF OBESITY-DEPENDENT NIDDM - GENETICAND CLINICAL IMPLICATIONS, Diabetes, 44(8), 1995, pp. 863-870