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Results: 1-9 |
Results: 9
L-374,087, AN EFFICACIOUS, ORALLY BIOAVAILABLE, PYRIDINONE ACETAMIDE THROMBIN INHIBITOR
Authors: SANDERSON PEJ CUTRONA KJ DORSEY BD DYER DL MCDONOUGH CM NAYLOROLSEN AM CHEN IW CHEN ZG COOK JJ GARDELL SJ KRUEGER JA LEWIS SD LIN JH LUCAS BJ LYLE EA LYNCH JJ STRANIERI MT VASTAG K SHAFER JA VACCA JP
Citation: Pej. Sanderson et al., L-374,087, AN EFFICACIOUS, ORALLY BIOAVAILABLE, PYRIDINONE ACETAMIDE THROMBIN INHIBITOR, Bioorganic & medicinal chemistry letters, 8(7), 1998, pp. 817-822
C6 MODIFICATION OF THE PYRIDINONE CORE OF THROMBIN INHIBITOR L-374,087 AS A MEANS OF ENHANCING ITS ORAL ABSORPTION
Authors: ISAACS RCA CUTRONA KJ NEWTON CL SANDERSON PEJ SOLINSKY MG BASKIN EP CHEN IW COOPER CM COOK JJ GARDELL SJ LEWIS SD LUCAS RJ LYLE EA LYNCH JJ NAYLOROLSEN AM STRANIERI MT VASTAG K VACCA JP
Citation: Rca. Isaacs et al., C6 MODIFICATION OF THE PYRIDINONE CORE OF THROMBIN INHIBITOR L-374,087 AS A MEANS OF ENHANCING ITS ORAL ABSORPTION, Bioorganic & medicinal chemistry letters, 8(13), 1998, pp. 1719-1724
DISCOVERY AND DEVELOPMENT OF THE NOVEL POTENT ORALLY-ACTIVE THROMBIN INHIBITOR N-(9-HYDROXY-9-FLUORENECARBOXY)PROLYL TRANS-4-AMINOCYCLOHEXYLMETHYL AMIDE (L-372,460) - COAPPLICATION OF STRUCTURE-BASED DESIGN AND RAPID MULTIPLE ANALOG SYNTHESIS ON SOLID SUPPORT
Authors: BRADY SF STAUFFER KJ LUMMA WC SMITH GM RAMJIT HG LEWIS SD LUCAS BJ GARDELL SJ LYLE EA APPLEBY SD COOK JJ HOLAHAN MA STRANIERI MT LYNCH JJ LIN JH CHEN IW VASTAG K NAYLOROLSEN AM VACCA JP
Citation: Sf. Brady et al., DISCOVERY AND DEVELOPMENT OF THE NOVEL POTENT ORALLY-ACTIVE THROMBIN INHIBITOR N-(9-HYDROXY-9-FLUORENECARBOXY)PROLYL TRANS-4-AMINOCYCLOHEXYLMETHYL AMIDE (L-372,460) - COAPPLICATION OF STRUCTURE-BASED DESIGN AND RAPID MULTIPLE ANALOG SYNTHESIS ON SOLID SUPPORT, Journal of medicinal chemistry, 41(3), 1998, pp. 401-406
EFFICACIOUS, ORALLY BIOAVAILABLE THROMBIN INHIBITORS BASED ON 3-AMINOPYRIDINONE OR 3-AMINOPYRAZINONE ACETAMIDE PEPTIDOMIMETIC TEMPLATES
Authors: SANDERSON PEJ LYLE TA CUTRONA KJ DYER DL DORSEY BD MCDONOUGH CM NAYLOROLSEN AM CHEN IW CHEN ZG COOK JJ COOPER CM GARDELL SJ HARE TR KRUEGER JA LEWIS SD LIN JH LUCAS BJ LYLE EA LYNCH JJ STRANIERI MT VASTAG K YAN YW SHAFER JA VACCA JP
Citation: Pej. Sanderson et al., EFFICACIOUS, ORALLY BIOAVAILABLE THROMBIN INHIBITORS BASED ON 3-AMINOPYRIDINONE OR 3-AMINOPYRAZINONE ACETAMIDE PEPTIDOMIMETIC TEMPLATES, Journal of medicinal chemistry, 41(23), 1998, pp. 4466-4474
CYCLOALKYLPIPERAZINES AS HIV-1 PROTEASE INHIBITORS - ENHANCED ORAL ABSORPTION
Authors: KIM BM EVANS BE GILBERT KF HANIFIN CM VACCA JP MICHELSON SR DARKE PL ZUGAY JA EMINI EA SCHLEIF W LIN JH CHEN IW VASTAG K ANDERSON PS HUFF JR
Citation: Bm. Kim et al., CYCLOALKYLPIPERAZINES AS HIV-1 PROTEASE INHIBITORS - ENHANCED ORAL ABSORPTION, Bioorganic & medicinal chemistry letters, 5(22), 1995, pp. 2707-2712
THIOPHENE DERIVATIVES AS EXTREMELY HIGH-AFFINITY P-3' LIGANDS FOR THEHYDROXYETHYLPIPERAZINE CLASS OF HIV-1 PROTEASE INHIBITORS
Authors: KIM BM GUARE JP VACCA JP MICHELSON SR DARKE PL ZUGAY JA EMINI EA SCHLEIF W LIN JH CHEN IW VASTAG K ANDERSON PS HUFF JR
Citation: Bm. Kim et al., THIOPHENE DERIVATIVES AS EXTREMELY HIGH-AFFINITY P-3' LIGANDS FOR THEHYDROXYETHYLPIPERAZINE CLASS OF HIV-1 PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 5(2), 1995, pp. 185-190
SUBSTITUTED ALKYLPYRIDINES AS P-3' LIGANDS FOR THE HYDROXYETHYLPIPERAZINE CLASS OF HIV-1 PROTEASE INHIBITORS - IMPROVED PHARMACOKINETIC PROFILES
Authors: KIM BM HANIFIN CM ZARTMAN CB VACCA JP MICHELSON SR LIN JH CHEN IW VASTAG K DARKE PL ZUGAY JA EMINI EA SCHLEIF W ANDERSON PS HUFF JR
Citation: Bm. Kim et al., SUBSTITUTED ALKYLPYRIDINES AS P-3' LIGANDS FOR THE HYDROXYETHYLPIPERAZINE CLASS OF HIV-1 PROTEASE INHIBITORS - IMPROVED PHARMACOKINETIC PROFILES, Bioorganic & medicinal chemistry letters, 5(19), 1995, pp. 2239-2244
A NEW HYDROXYETHYLAMINE CLASS OF HIV-1 PROTEASE INHIBITORS WITH HIGH ANTIVIRAL POTENCY AND ORAL BIOAVAILABILITY
Authors: KIM BM VACCA JP GUARE JP HANIFIN CM MICHELSON SR DARKE PL ZUGAY JA EMINI EA SCHLEIF W LIN JH CHEN IW VASTAG K OSTOVIC D ANDERSON PS HUFF JR
Citation: Bm. Kim et al., A NEW HYDROXYETHYLAMINE CLASS OF HIV-1 PROTEASE INHIBITORS WITH HIGH ANTIVIRAL POTENCY AND ORAL BIOAVAILABILITY, Bioorganic & medicinal chemistry letters, 4(19), 1994, pp. 2273-2278
L-735,524 - AN ORALLY BIOAVAILABLE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE INHIBITOR
Authors: VACCA JP DORSEY BD SCHLEIF WA LEVIN RB MCDANIEL SL DARKE PL ZUGAY J QUINTERO JC BLAHY OM ROTH E SARDANA VV SCHLABACH AJ GRAHAM PI CONDRA JH GOTLIB L HOLLOWAY MK LIN J CHEN IW VASTAG K OSTOVIC D ANDERSON PS EMINI EA HUFF JR
Citation: Jp. Vacca et al., L-735,524 - AN ORALLY BIOAVAILABLE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE INHIBITOR, Proceedings of the National Academy of Sciences of the United Statesof America, 91(9), 1994, pp. 4096-4100
Risultati: 1-9 |