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Results: 1-14 |
Results: 14
Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram
Authors: Von Moltke, LL Greenblatt, DJ Giancarlo, GM Granda, BW Harmatz, JS Shader, RI
Citation: Ll. Von Moltke et al., Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram, DRUG META D, 29(8), 2001, pp. 1102-1109
Methadone inhibits rhodamine123 transport in Caco-2 cells
Authors: Stormer, E Perloff, MD Von Moltke, LL Greenblatt, DJ
Citation: E. Stormer et al., Methadone inhibits rhodamine123 transport in Caco-2 cells, DRUG META D, 29(7), 2001, pp. 954-956
CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam
Authors: Hesse, LM Venkatakrishnan, K Von Moltke, LL Shader, RI Greenblatt, DJ
Citation: Lm. Hesse et al., CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam, DRUG META D, 29(2), 2001, pp. 133-140
Interindividual variability in acetaminophen glucuronidation by human liver microsomes: Identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms
Authors: Court, MH Duan, SX Von Moltke, LL Greenblatt, DJ Patten, CJ Miners, JO Mackenzie, PI
Citation: Mh. Court et al., Interindividual variability in acetaminophen glucuronidation by human liver microsomes: Identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms, J PHARM EXP, 299(3), 2001, pp. 998-1006
Application of the relative activity factor approach in scaling from heterologously expressed cytochromes P450 to human liver microsomes: Studies on amitriptyline as a model substrate
Authors: Venkatakrishnan, K Von Moltke, LL Greenblatt, DJ
Citation: K. Venkatakrishnan et al., Application of the relative activity factor approach in scaling from heterologously expressed cytochromes P450 to human liver microsomes: Studies on amitriptyline as a model substrate, J PHARM EXP, 297(1), 2001, pp. 326-337
Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: Ratios of accessory proteins as sources of discrepancies between the approaches
Authors: Venkatakrishnan, K Von Moltke, LL Court, MH Harmatz, JS Crespi, CL Greenblatt, DJ
Citation: K. Venkatakrishnan et al., Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: Ratios of accessory proteins as sources of discrepancies between the approaches, DRUG META D, 28(12), 2000, pp. 1493-1504
Metabolism of the antidepressant mirtazapine in vitro: Contribution of cytochromes P-450 1A2, 2D6, and 3A4
Authors: Stormer, E Von Moltke, LL Shader, RI Greenblatt, DJ
Citation: E. Stormer et al., Metabolism of the antidepressant mirtazapine in vitro: Contribution of cytochromes P-450 1A2, 2D6, and 3A4, DRUG META D, 28(10), 2000, pp. 1168-1175
CYP2B6 mediates the in vitro hydroxylation of bupropion: Potential drug interactions with other antidepressants
Authors: Hesse, LM Venkatakrishnan, K Court, MH Von Moltke, LL Duan, SX Shader, RI Greenblatt, DJ
Citation: Lm. Hesse et al., CYP2B6 mediates the in vitro hydroxylation of bupropion: Potential drug interactions with other antidepressants, DRUG META D, 28(10), 2000, pp. 1176-1183
Effects of age on in vitro midazolam biotransformation in male CD-1 mouse liver microsomes
Authors: Warrington, JS Poku, JW Von Moltke, LL Shader, RI Harmatz, JS Greenblatt, DJ
Citation: Js. Warrington et al., Effects of age on in vitro midazolam biotransformation in male CD-1 mouse liver microsomes, J PHARM EXP, 292(3), 2000, pp. 1024-1031
Extrapolating in vitro data on drug metabolism to in vivo pharmacokinetics: Evaluation of the pharmacokinetic interaction between amitriptyline and fluoxetine
Authors: Schmider, J Von Moltke, LL Shader, RI Harmatz, JS Greenblatt, DJ
Citation: J. Schmider et al., Extrapolating in vitro data on drug metabolism to in vivo pharmacokinetics: Evaluation of the pharmacokinetic interaction between amitriptyline and fluoxetine, DRUG METAB, 31(2), 1999, pp. 545-600
Human cytochromes and some newer antidepressants: Kinetics, metabolism, and drug interactions
Authors: Greenblatt, DJ Von Moltke, LL Harmatz, JS Shader, RI
Citation: Dj. Greenblatt et al., Human cytochromes and some newer antidepressants: Kinetics, metabolism, and drug interactions, J CL PSYCH, 19(5), 1999, pp. 23S-35S
Pharmacokinetics of protease inhibitors and drug interactions with psychoactive drugs
Authors: Chuck, SK Rodvold, KA Von Moltke, LL Greenblatt, DJ Shader, RI
Citation: Sk. Chuck et al., Pharmacokinetics of protease inhibitors and drug interactions with psychoactive drugs, AIDS PREV M, 1999, pp. 33-60
Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: Role of CYP2C9, CYP2C19, CYP2D6, and CYP3A
Authors: Von Moltke, LL Greenblatt, DJ Grassi, JM Granda, BW Venkatakrishnan, K Schmider, J Harmatz, JS Shader, RI
Citation: Ll. Von Moltke et al., Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: Role of CYP2C9, CYP2C19, CYP2D6, and CYP3A, J PHARM PHA, 50(9), 1998, pp. 997-1004
Kinetic characterization and identification of the enzymes responsible forthe hepatic biotransformation of adinazolam and N-desmethyladinazolam in man
Authors: Venkatakrishnan, K Von Moltke, LL Duan, SX Fleishaker, JC Shader, RI Greenblatt, DJ
Citation: K. Venkatakrishnan et al., Kinetic characterization and identification of the enzymes responsible forthe hepatic biotransformation of adinazolam and N-desmethyladinazolam in man, J PHARM PHA, 50(3), 1998, pp. 265-274
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