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Results: 1-14 |
Results: 14
Influence of beta-adrenoceptor antagonists on the pharmacokinetics of rizatriptan, a 5-HT1B/1D agonist: differential effects of propranolol, nadolol and metoprolol
Authors: Goldberg, MR Sciberras, D De Smet, M Lowry, R Tomasko, L Lee, Y Olah, TV Zhao, J Vyas, KP Halpin, R Kari, PH James, I
Citation: Mr. Goldberg et al., Influence of beta-adrenoceptor antagonists on the pharmacokinetics of rizatriptan, a 5-HT1B/1D agonist: differential effects of propranolol, nadolol and metoprolol, BR J CL PH, 52(1), 2001, pp. 69-76
Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: Evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques.
Authors: Baillie, TA Halpin, RA Matuszewski, BK Geer, LA Chavez-Eng, CM Dean, D Braun, M Doss, G Jones, A Marks, T Melillo, D Vyas, KP
Citation: Ta. Baillie et al., Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: Evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques., DRUG META D, 29(12), 2001, pp. 1614-1628
Synthesis and evaluation of furo[3,4-d]pyrimidinones as selective alpha(1a)-adrenergic receptor antagonists
Authors: Lagu, B Tian, D Chiu, G Nagarathnam, D Fang, J Shen, QR Forray, C Ransom, RW Chang, RSL Vyas, KP Zhang, KY Gluchowski, C
Citation: B. Lagu et al., Synthesis and evaluation of furo[3,4-d]pyrimidinones as selective alpha(1a)-adrenergic receptor antagonists, BIOORG MED, 10(2), 2000, pp. 175-178
Rizatriptan, a novel 5-HT1B/1D agonist for migraine: Single- and multiple-dose tolerability and pharmacokinetics in healthy subjects
Authors: Goldberg, MR Lee, Y Vyas, KP Slaughter, DE Panebianco, D Ermlich, SJ Shadle, CR Brucker, MJ McLoughlin, DA Olah, TV
Citation: Mr. Goldberg et al., Rizatriptan, a novel 5-HT1B/1D agonist for migraine: Single- and multiple-dose tolerability and pharmacokinetics in healthy subjects, J CLIN PHAR, 40(1), 2000, pp. 74-83
Metabolism of a dopamine D-4-selective antagonist in rat, monkey, and humans: Formation of a novel mercapturic acid adduct
Authors: Zhang, KE Kari, PH Davis, MR Doss, G Baillie, TA Vyas, KP
Citation: Ke. Zhang et al., Metabolism of a dopamine D-4-selective antagonist in rat, monkey, and humans: Formation of a novel mercapturic acid adduct, DRUG META D, 28(6), 2000, pp. 633-642
The absorption, distribution, metabolism and excretion of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in rats and dogs
Authors: Halpin, RA Geer, LA Zhang, KE Marks, TM Dean, DC Jones, AN Melillo, D Doss, G Vyas, KP
Citation: Ra. Halpin et al., The absorption, distribution, metabolism and excretion of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in rats and dogs, DRUG META D, 28(10), 2000, pp. 1244-1254
Disposition and pharmacokinetics of the antimigraine drug, rizatriptan, inhumans
Authors: Vyas, KP Halpin, RA Geer, LA Ellis, JD Liu, LD Cheng, HY Chavez-Eng, C Matuszewski, BK Varga, SL Guiblin, AR Rogers, JD
Citation: Kp. Vyas et al., Disposition and pharmacokinetics of the antimigraine drug, rizatriptan, inhumans, DRUG META D, 28(1), 2000, pp. 89-95
Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of IL-775,606, a potent 5-HT1D receptor agonist
Authors: Prueksaritanont, T Lu, P Gorham, L Sternfeld, F Vyas, KP
Citation: T. Prueksaritanont et al., Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of IL-775,606, a potent 5-HT1D receptor agonist, XENOBIOTICA, 30(1), 2000, pp. 47-59
Pharmacokinetics of intravenous alendronate
Authors: Cocquyt, V Kline, WF Gertz, BJ Van Belle, SJP Holland, SD DeSmet, M Quan, H Vyas, KP Zhang, KYE De Greve, J Porras, AG
Citation: V. Cocquyt et al., Pharmacokinetics of intravenous alendronate, J CLIN PHAR, 39(4), 1999, pp. 385-393
In vitro and in vivo studies on the metabolism of tirofiban
Authors: Vickers, S Theoharides, AD Arison, B Balani, SK Cui, D Duncan, CA Ellis, JD Gorham, LM Polsky, SL Prueksaritanont, T Ramjit, HG Slaughter, DE Vyas, KP
Citation: S. Vickers et al., In vitro and in vivo studies on the metabolism of tirofiban, DRUG META D, 27(11), 1999, pp. 1360-1366
Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones
Authors: Nagarathnam, D Miao, SW Lagu, B Chiu, G Fang, J Dhar, TGM Zhang, J Tyagarajan, S Marzabadi, MR Zhang, FQ Wong, WC Sun, WY Tian, D Wetzel, JM Forray, C Chang, RSL Broten, TP Ransom, RW Schorn, TW Chen, TB O'Malley, S Kling, P Schneck, K Bendesky, R Harrell, CM Vyas, KP Gluchowski, C
Citation: D. Nagarathnam et al., Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones, J MED CHEM, 42(23), 1999, pp. 4764-4777
Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification oflinker and 4-methoxycarbonyl-4-phenylpiperidine moiety
Authors: Dhar, TGM Nagarathnam, D Marzabadi, MR Lagu, B Wong, WC Chiu, G Tyagarajan, S Miao, SW Zhang, FQ Sun, WY Tian, D Shen, QR Zhang, J Wetzel, JM Forray, C Chang, RSL Broten, TP Schorn, TW Chen, TB O'Malley, S Ransom, R Schneck, K Bendesky, R Harrell, CM Vyas, KP Zhang, KY Gilbert, J Pettibone, DJ Patane, MA Bock, MG Freidinger, RM Gluchowski, C
Citation: Tgm. Dhar et al., Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification oflinker and 4-methoxycarbonyl-4-phenylpiperidine moiety, J MED CHEM, 42(23), 1999, pp. 4778-4793
Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains
Authors: Lagu, B Tian, D Nagarathnam, D Marzabadi, MR Wong, WC Miao, SW Zhang, FQ Sun, WY Chiu, G Fang, J Forray, C Chang, RSL Ransom, RW Chen, TB O'Malley, S Zhang, KY Vyas, KP Gluchowski, C
Citation: B. Lagu et al., Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains, J MED CHEM, 42(23), 1999, pp. 4794-4803
Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series
Authors: Wong, WC Sun, WY Lagu, B Tian, D Marzabadi, MR Zhang, FQ Nagarathnam, D Miao, SW Wetzel, JM Peng, J Forray, C Chang, RSL Chen, TB Ransom, R O'Malley, S Broten, TP Kling, P Vyas, KP Zhang, KY Gluchowski, C
Citation: Wc. Wong et al., Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series, J MED CHEM, 42(23), 1999, pp. 4804-4813
Risultati: 1-14 |