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Results: 1-13 |
Results: 13
DISCOVERY OF RITONAVIR, A POTENT INHIBITOR OF HIV PROTEASE WITH HIGH ORAL BIOAVAILABILITY AND CLINICAL EFFICACY
Authors: KEMPF DJ SHAM HL MARSH KC FLENTGE CA BETEBENNER D GREEN BE MCDONALD E VASAVANONDA S SALDIVAR A WIDEBURG NE KATI WM RUIZ L ZHAO C FINO LM PATTERSON J MOLLA A PLATTNER JJ NORBECK DW
Citation: Dj. Kempf et al., DISCOVERY OF RITONAVIR, A POTENT INHIBITOR OF HIV PROTEASE WITH HIGH ORAL BIOAVAILABILITY AND CLINICAL EFFICACY, Journal of medicinal chemistry, 41(4), 1998, pp. 602-617
LACK OF STEREOSPECIFICITY IN THE BINDING OF THE P2 AMINO-ACID OF RITONAVIR TO HIV PROTEASE
Authors: KEMPF DJ MOLLA A MARSH KC PARK C RODRIGUES AD KORNEYEVA M VASAVANONDA S MCDONALD E FLENTGE CA MUCHMORE S WIDEBURG NE SALDIVAR A COOPER A KATI WM STEWART KD NORBECK DW
Citation: Dj. Kempf et al., LACK OF STEREOSPECIFICITY IN THE BINDING OF THE P2 AMINO-ACID OF RITONAVIR TO HIV PROTEASE, Bioorganic & medicinal chemistry letters, 7(6), 1997, pp. 699-704
EVALUATION OF FUROFURAN AS A P-2 LIGAND FOR SYMMETRY-BASED HIV PROTEASE INHIBITORS
Authors: CHEN XQ LI L KEMPF DJ SHAM H WIDEBURG NE SALDIVAR A VASAVANONDA S MARSH KC MCDONALD E NORBECK DW
Citation: Xq. Chen et al., EVALUATION OF FUROFURAN AS A P-2 LIGAND FOR SYMMETRY-BASED HIV PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 6(23), 1996, pp. 2847-2852
A NOVEL, PICOMOLAR INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASES
Authors: SHAM HL ZHAO C STEWART KD BETEBENNER DA LIN SQ PARK CH KONG XP ROSENBROOK W HERRIN T MADIGAN D VASAVANONDA S LYONS N MOLLA A SALDIVAR A MARSH KC MCDONALD E WIDEBURG NE DENISSEN JF ROBINS T KEMPF DJ PLATTNER JJ NORBECK DW
Citation: Hl. Sham et al., A NOVEL, PICOMOLAR INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASES, Journal of medicinal chemistry, 39(2), 1996, pp. 392-397
NOVEL AZACYCLIC UREAS THAT ARE POTENT INHIBITORS OF HIV-1 PROTEASE
Authors: SHAM HL ZHAO C MARSH KC BETEBENNER DA LIN SQ ROSENBROOK W HERRIN T LI LP MADIGAN D VASAVANONDA S MOLLA A SALDIVAR A MCDONALD E WIDEBURG NE KEMPF D NORBECK DW PLATTNER JJ
Citation: Hl. Sham et al., NOVEL AZACYCLIC UREAS THAT ARE POTENT INHIBITORS OF HIV-1 PROTEASE, Biochemical and biophysical research communications, 225(2), 1996, pp. 436-440
EVALUATION OF SUBSTITUTED BENZAMIDES AS P2 LIGANDS FOR SYMMETRY-BASEDINHIBITORS OF HIV PROTEASE
Authors: KEMPF DJ FLENTGE CA WIDEBURG NE SALDIVAR A VASAVANONDA S NORBECK DW
Citation: Dj. Kempf et al., EVALUATION OF SUBSTITUTED BENZAMIDES AS P2 LIGANDS FOR SYMMETRY-BASEDINHIBITORS OF HIV PROTEASE, Bioorganic & medicinal chemistry letters, 5(22), 1995, pp. 2725-2728
POTENT INHIBITOR OF THE HUMAN RHINOVIRUS (HRV) 3C PROTEASE CONTAININGA BACKBONE MODIFIED GLUTAMINE
Authors: SHAM HL ROSENBROOK W KATI W BETEBENNER DA WIDEBURG NE SALDIVAR A PLATTNER JJ NORBECK DW
Citation: Hl. Sham et al., POTENT INHIBITOR OF THE HUMAN RHINOVIRUS (HRV) 3C PROTEASE CONTAININGA BACKBONE MODIFIED GLUTAMINE, Journal of the Chemical Society. Perkin transactions. I, (9), 1995, pp. 1081-1082
ABT-538 IS A POTENT INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE AND HAS HIGH ORAL BIOAVAILABILITY IN HUMANS
Authors: KEMPF DJ MARSH KC DENISSEN JF MCDONALD E VASAVANONDA S FLENTGE CA GREEN BE FINO L PARK CH KONG XP WIDEBURG NE SALDIVAR A RUIZ L KATI WM SHAM HL ROBINS T STEWART KD HSU A PLATTNER JJ LEONARD JM NORBECK DW
Citation: Dj. Kempf et al., ABT-538 IS A POTENT INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE AND HAS HIGH ORAL BIOAVAILABILITY IN HUMANS, Proceedings of the National Academy of Sciences of the United Statesof America, 92(7), 1995, pp. 2484-2488
HIGHLY EFFICIENT SYNTHESIS OF -2-AMINO-4,4-DIFLUORO-1,6-DIPHENYL-3-HYDROXYHEXANE - THE KEY INTERMEDIATE FOR A SERIES OF POTENT HIV PROTEINASE-INHIBITORS
Authors: SHAM HL BETEBENNER DA WIDEBURG NE KEMPF DJ PLATTNER JJ NORBECK DW
Citation: Hl. Sham et al., HIGHLY EFFICIENT SYNTHESIS OF -2-AMINO-4,4-DIFLUORO-1,6-DIPHENYL-3-HYDROXYHEXANE - THE KEY INTERMEDIATE FOR A SERIES OF POTENT HIV PROTEINASE-INHIBITORS, Journal of fluorine chemistry, 73(2), 1995, pp. 221-224
SYMMETRY-BASED INHIBITORS OF HIV PROTEASE - ORAL BIOAVAILABILITY AND RESISTANCE EMERGENCE
Authors: KEMPF DJ FLENTGE C MARSH KC MCDONALD E ROBINS T VASAVANONDA S CHEN CM WIDEBURG NE PARK C KONG XP DENISSEN J HO DD MARKOWITZ M TOYOSHIMA T SINGH MK ERICKSON J SHAM HL STEWART K GREEN BE TURON M SALDIVAR A NORBECK DW
Citation: Dj. Kempf et al., SYMMETRY-BASED INHIBITORS OF HIV PROTEASE - ORAL BIOAVAILABILITY AND RESISTANCE EMERGENCE, Journal of cellular biochemistry, 1994, pp. 130-130
BIOCHEMICAL-CHARACTERIZATION OF HIV-1 PROTEASE MUTANTS RESISTANT TO A-77003, A-80987
Authors: CHEN CM SALDIVAR A TURON M WIDEBURG NE ROBINS T VASAVANONDA S STEWART K PARK C KONG XP KEMPF DJ HO D ERICKSON J NORBECK DW
Citation: Cm. Chen et al., BIOCHEMICAL-CHARACTERIZATION OF HIV-1 PROTEASE MUTANTS RESISTANT TO A-77003, A-80987, Journal of cellular biochemistry, 1994, pp. 166-166
CHARACTERIZATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VARIANTS WITHINCREASED RESISTANCE TO A C-2-SYMMETRICAL PROTEASE INHIBITOR
Authors: HO DD TOYOSHIMA T MO HM KEMPF DJ NORBECK D CHEN CM WIDEBURG NE BURT SK ERICKSON JW SINGH MK
Citation: Dd. Ho et al., CHARACTERIZATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VARIANTS WITHINCREASED RESISTANCE TO A C-2-SYMMETRICAL PROTEASE INHIBITOR, Journal of virology, 68(3), 1994, pp. 2016-2020
INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C(2) SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
Authors: HOSUR MV BHAT TN KEMPF DJ BALDWIN ET LIU BS GULNIK S WIDEBURG NE NORBECK DW APPELT K ERICKSON JW
Citation: Mv. Hosur et al., INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C(2) SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE, Journal of the American Chemical Society, 116(3), 1994, pp. 847-855
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