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Results: 1-25/57
Authors:
WORKMAN P
KELLAND L
Citation: P. Workman et L. Kelland, PRECLINICAL ASSESSMENT - SHOULD WE MODIFY OUR PRECLINICAL EVALUATION FOR AGENTS AIMED AT NEW MOLECULAR TARGETS, Annals of oncology, 9, 1998, pp. 18-18
Authors:
WORKMAN P
RAYNAUD F
JUDSON I
KELSON A
TRACY M
LEWIS A
OBAGYE E
Citation: P. Workman et al., OXYGEN-SENSITIVE REDUCTIVE METABOLISM OF THE FLUORINATED 2-NITROIMIDAZOLE SR-4554 (CRC-94 17) - SUPPORT FOR CLINICAL DEVELOPMENT AS A NONINVASIVE HYPOXIA DETECTION PROBE/, Annals of oncology, 9, 1998, pp. 110-110
Authors:
BRUNTON VG
STEELE G
LEWIS AD
WORKMAN P
Citation: Vg. Brunton et al., GELDANAMYCIN-INDUCED CYTOTOXICITY IN HUMAN COLON-CANCER CELL-LINES - EVIDENCE AGAINST THE INVOLVEMENT OF C-SRC OR DT-DIAPHORASE, Cancer chemotherapy and pharmacology, 41(5), 1998, pp. 417-422
Authors:
WORKMAN P
TWENTYMAN P
BALKWILL F
BALMAIN A
CHAPLIN D
DOUBLE J
EMBLETON J
NEWELL D
RAYMOND R
STABLES J
STEPHENS T
WALLACE J
Citation: P. Workman et al., UNITED-KINGDOM COORDINATING COMMITTEE ON CANCER-RESEARCH (UKCCCR) GUIDELINES FOR THE WELFARE OF ANIMALS IN EXPERIMENTAL NEOPLASIA (2ND EDITION), British Journal of Cancer, 77(1), 1998, pp. 1-10
Authors:
ABOAGYE EO
MAXWELL RJ
HORSMAN MR
LEWIS AD
WORKMAN P
TRACY M
GRIFFITHS JR
Citation: Eo. Aboagye et al., THE RELATIONSHIP BETWEEN TUMOR OXYGENATION DETERMINED BY OXYGEN-ELECTRODE MEASUREMENTS AND MAGNETIC-RESONANCE SPECTROSCOPY OF THE FLUORINATED 2-NITROIMIDAZOLE SR-4554, British Journal of Cancer, 77(1), 1998, pp. 65-70
Authors:
BAILEY SM
LEWIS AD
KNOX RJ
PATTERSON LH
FISHER GR
WORKMAN P
Citation: Sm. Bailey et al., REDUCTION OF THE INDOLOQUINONE ANTICANCER DRUG EO9 BY PURIFIED DT-DIAPHORASE - A DETAILED KINETIC-STUDY AND ANALYSIS OF METABOLITES, Biochemical pharmacology, 56(5), 1998, pp. 613-621
Authors:
SENAN S
RAMPLING R
GRAHAN MA
WILSON P
ROBIN H
ECKARDT N
LAWSON N
MCDONALD A
VONROEMELING R
WORKMAN P
KAYE SB
Citation: S. Senan et al., PHASE-1 AND PHARMACOKINETIC STUDY OF TIRAPAZAMINE (SR-4233) ADMINISTERED EVERY 3 WEEKS (VOL 3, PG 31, 1997), Clinical cancer research, 3(9), 1997, pp. 1676-1676
Authors:
SENAN S
RAMPLING R
GRAHAM MA
WILSON P
ROBIN H
ECKARDT N
LAWSON N
MCDONALD A
VONROEMELING R
WORKMAN P
KAYE SB
Citation: S. Senan et al., PHASE-I AND PHARMACOKINETIC STUDY OF TIRAPAZAMINE (SR-4233) ADMINISTERED EVERY 3 WEEKS, Clinical cancer research, 3(1), 1997, pp. 31-38
Authors:
CROSS MJ
HODGKIN MN
PLUMB JA
BRUNTON VG
STEWART A
MACAULLY G
HILL R
KERR DJ
WORKMAN P
WAKELAM MJO
Citation: Mj. Cross et al., INHIBITION OF PHOSPHOLIPID SIGNALING AND PROLIFERATION OF SWISS 3T3 CELLS BY THE WORTMANNIN ANALOG DEMETHOXYVIRIDIN, Biochimica et biophysica acta. Molecular basis of disease, 1362(1), 1997, pp. 29-38
Authors:
GRAHAM MA
SENAN S
ROBIN H
ECKHARDT N
LENDREM D
HINCKS J
GREENSLADE D
RAMPLING R
KAYE SB
VONROEMELING R
WORKMAN P
Citation: Ma. Graham et al., PHARMACOKINETICS OF THE HYPOXIC CELL CYTOTOXIC AGENT TIRAPAZAMINE ANDITS MAJOR BIOREDUCTIVE METABOLITES IN MICE AND HUMANS - RETROSPECTIVEANALYSIS OF A PHARMACOKINETICALLY GUIDED DOSE-ESCALATION STRATEGY IN A PHASE-I TRIAL, Cancer chemotherapy and pharmacology, 40(1), 1997, pp. 1-10
Authors:
WORKMAN P
Citation: P. Workman, TOWARDS INTELLIGENT ANTICANCER DRUG SCREENING IN THE POST-GENOME ERA, Anti-cancer drug design, 12(7), 1997, pp. 525-531
Authors:
ABOAGYE EO
MAXWELL RJ
KELSON AB
TRACY M
LEWIS AD
GRAHAM MA
HORSMAN MR
GRIFFITHS JR
WORKMAN P
Citation: Eo. Aboagye et al., PRECLINICAL EVALUATION OF THE FLUORINATED 2-NITROIMIDAZOLE XY-3,3,3-TRIFLUOROPROPYL)-2-(2-NITRO-1-IMIDAZOLYL) ACETAMIDE (SR-4554) AS A PROBE FOR THE MEASUREMENT OF TUMOR HYPOXIA, Cancer research, 57(15), 1997, pp. 3314-3318
Authors:
BAILEY SM
WYATT MD
FRIEDLOS F
HARTLEY JA
KNOX RJ
LEWIS AD
WORKMAN P
Citation: Sm. Bailey et al., INVOLVEMENT OF DT-DIAPHORASE (EC-1.6.99.2) IN THE DNA CROSS-LINKING AND SEQUENCE SELECTIVITY OF THE BIOREDUCTIVE ANTITUMOR AGENT EO9, British Journal of Cancer, 76(12), 1997, pp. 1596-1603
Authors:
ABOAGYE EO
LEWIS AD
TRACY M
WORKMAN P
Citation: Eo. Aboagye et al., BIOREDUCTIVE METABOLISM OF THE NOVEL FLUORINATED 2-NITROIMIDAZOLE HYPOXIA PROBE DROXY-3,3,3-TRIFLUOROPROPYL)-2-(2-NITROIMIDAZOLYL) ACETAMIDE (SR-4554), Biochemical pharmacology, 54(11), 1997, pp. 1217-1224
Authors:
FITZSIMMONS SA
WORKMAN P
GREVER M
PAULL K
CAMALIER R
LEWIS AD
Citation: Sa. Fitzsimmons et al., REDUCTASE ENZYME EXPRESSION ACROSS THE NATIONAL-CANCER-INSTITUTE TUMOR-CELL LINE PANEL - CORRELATION WITH SENSITIVITY TO MITOMYCIN-C AND E09, Journal of the National Cancer Institute, 88(5), 1996, pp. 259-269
Authors:
WORKMAN P
FITZSIMMONS SA
GREVER M
PAULL K
CAMALIER R
LEWIS AD
Citation: P. Workman et al., REDUCTASE ENZYME EXPRESSION ACROSS THE NATIONAL-CANCER-INSTITUTE TUMOR-CELL LINE PANEL - CORRELATION WITH SENSITIVITY TO MITOMYCIN-C AND EO9 - RESPONSE, Journal of the National Cancer Institute, 88(16), 1996, pp. 1161-1163
Authors:
HENDERSON ND
PLUMB JA
ROBINS DJ
WORKMAN P
Citation: Nd. Henderson et al., SYNTHESIS AND ANTICANCER ACTIVITY OF 2,6-DISUBSTITUTED N-METHYLPIPERIDINE DERIVATIVES AND THEIR N-OXIDES, Anti-cancer drug design, 11(6), 1996, pp. 421-438
Authors:
BRUNTON VG
LEAR MJ
MCKEOWN P
ROBINS DJ
WORKMAN P
Citation: Vg. Brunton et al., SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF TYRPHOSTINS CONTAINING QUINOLINE MOIETIES, Anti-cancer drug design, 11(6), 1996, pp. 463-483
Authors:
BRUNTON VG
KELLAND LR
LEAR MJ
MONTGOMERY GJ
ROBERTSON JH
ROBINS DJ
QUEEN J
WORKMAN P
Citation: Vg. Brunton et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF A SERIES OF TYRPHOSTINS CONTAINING NITROTHIOPHENE MOIETIES AS POSSIBLE EPIDERMAL GROWTH-FACTOR RECEPTOR TYROSINE KINASE INHIBITORS, Anti-cancer drug design, 11(4), 1996, pp. 265-295
Authors:
ABOAGYE EO
LEWIS AD
GRAHAM MA
TRACY M
KELSON AB
RYAN KJ
WORKMAN P
Citation: Eo. Aboagye et al., THE PHARMACOKINETICS, BIOAVAILABILITY AND BIODISTRIBUTION IN MICE OF A RATIONALLY DESIGNED 2-NITROIMIDAZOLE HYPOXIA PROBE SR-4554, Anti-cancer drug design, 11(3), 1996, pp. 231-242
Authors:
STRATFORD I
WORKMAN P
COLEMAN N
Citation: I. Stratford et al., MESSAGE FROM THE CHAIRMEN, British Journal of Cancer, 74, 1996, pp. 4-4
Authors:
MCLEOD HL
BRUNTON VG
ECKARDT N
LEAR MJ
ROBINS DJ
WORKMAN P
GRAHAM MA
Citation: Hl. Mcleod et al., IN-VIVO PHARMACOLOGY AND ANTITUMOR EVALUATION OF THE TYRPHOSTIN TYROSINE KINASE INHIBITOR RG13022, British Journal of Cancer, 74(11), 1996, pp. 1714-1718
Authors:
ABOAGYE EO
GRAHAM MA
LEWIS AD
WORKMAN P
KELSON AB
TRACY M
Citation: Eo. Aboagye et al., DEVELOPMENT AND VALIDATION OF A SOLID-PHASE EXTRACTION AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY FOR A NOVEL FLUORINATED 2-NITROIMIDAZOLE HYPOXIA PROBE (SR-4554) IN BALB C MOUSE PLASMA/, Journal of chromatography B. Biomedical applications, 672(1), 1995, pp. 125-132
Authors:
ROBIN H
SENAN S
WORKMAN P
GRAHAM MA
Citation: H. Robin et al., DEVELOPMENT AND VALIDATION OF A SENSITIVE SOLID-PHASE-EXTRACTION AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ASSAY FOR THE BIOREDUCTIVE AGENT TIRAPAZAMINE AND ITS MAJOR METABOLITES IN MOUSE AND HUMAN PLASMA FORPHARMACOKINETICALLY GUIDED DOSE-ESCALATION, Cancer chemotherapy and pharmacology, 36(3), 1995, pp. 266-270
Authors:
HOULIHAN WJ
LOHMEYER M
WORKMAN P
CHEON SH
Citation: Wj. Houlihan et al., PHOSPHOLIPID ANTITUMOR AGENTS, Medicinal research reviews, 15(3), 1995, pp. 157-223