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Results: 1-22 |
Results: 22
Assembly of Alzheimer's amyloid-beta fibrils and approaches for therapeutic intervention
Authors: Yang, DS Serpell, LC Yip, CM McLaurin, J Chrishti, MA Horne, P Boudreau, L Kisilevsky, R Westaway, D Fraser, PE
Citation: Ds. Yang et al., Assembly of Alzheimer's amyloid-beta fibrils and approaches for therapeutic intervention, AMYLOID, 8, 2001, pp. 10-19
Biology of the prion gene complex
Authors: Mastrangelo, P Westaway, D
Citation: P. Mastrangelo et D. Westaway, Biology of the prion gene complex, BIOC CELL B, 79(5), 2001, pp. 613-628
The prion gene complex encoding PrPC and Doppel: insights from mutational analysis
Authors: Mastrangelo, P Westaway, D
Citation: P. Mastrangelo et D. Westaway, The prion gene complex encoding PrPC and Doppel: insights from mutational analysis, GENE, 275(1), 2001, pp. 1-18
Transgenic mouse models of Alzheimer's disease
Authors: Janus, C Westaway, D
Citation: C. Janus et D. Westaway, Transgenic mouse models of Alzheimer's disease, PHYSL BEHAV, 73(5), 2001, pp. 873-886
Two different neurodegenerative diseases caused by proteins with similar structures
Authors: Mo, HP Moore, RC Cohen, FE Westaway, D Prusiner, SB Wright, PE Dyson, HJ
Citation: Hp. Mo et al., Two different neurodegenerative diseases caused by proteins with similar structures, P NAS US, 98(5), 2001, pp. 2352-2357
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
Authors: Chishti, MA Yang, DS Janus, C Phinney, AL Horne, P Pearson, J Strome, R Zuker, N Loukides, J French, J Turner, S Lozza, G Grilli, M Kunicki, S Morissette, C Paquette, J Gervais, F Bergeron, C Fraser, PE Carlson, GA St George-Hyslop, P Westaway, D
Citation: Ma. Chishti et al., Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695, J BIOL CHEM, 276(24), 2001, pp. 21562-21570
Changes in cognitive characteristics of Tg(APP)CRND8 mice at early stages of immunization with beta-amyloid peptide
Authors: Janus, C Pearson, J Horne, P Renlund, R Parisien, K Chishti, A Heslin, D Bergeron, C Fraser, P St George-Hyslop, P Westaway, D
Citation: C. Janus et al., Changes in cognitive characteristics of Tg(APP)CRND8 mice at early stages of immunization with beta-amyloid peptide, ALZHEIMER'S DISEASE, 2001, pp. 697-704
Transgenic mouse models of Alzheimer's disease
Authors: Janus, C Chishti, MA Westaway, D
Citation: C. Janus et al., Transgenic mouse models of Alzheimer's disease, BBA-MOL BAS, 1502(1), 2000, pp. 63-75
Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes
Authors: Chadwick, LH McCandless, HE Silverman, GL Schwartz, S Westaway, D Nadeau, JH
Citation: Lh. Chadwick et al., Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes, GENOMICS, 70(1), 2000, pp. 66-73
Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes
Authors: Janus, C D'Amelio, S Amitay, O Chishti, MA Strome, R Fraser, P Carlson, GA Roder, JC St George-Hyslop, P Westaway, D
Citation: C. Janus et al., Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes, NEUROBIOL A, 21(4), 2000, pp. 541-549
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
Authors: Janus, C Pearson, J McLaurin, J Mathews, PM Jiang, Y Schmidt, SD Chishti, MA Horne, P Heslin, D French, J Mount, HTJ Nixon, RA Mercken, M Bergeron, C Fraser, PE St George-Hyslop, P Westaway, D
Citation: C. Janus et al., A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease, NATURE, 408(6815), 2000, pp. 979-982
Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically
Authors: Grilli, M Lozza, G Brusa, R Casarini, M Uberti, D Rozmahel, R Westaway, D St George-Hyslop, P Memo, M Ongini, E
Citation: M. Grilli et al., Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically, P NAS US, 97(23), 2000, pp. 12822-12827
A beta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation
Authors: Niwa, K Younkin, L Ebeling, C Turner, SK Westaway, D Younkin, S Ashe, KH Carlson, GA Iadecola, C
Citation: K. Niwa et al., A beta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation, P NAS US, 97(17), 2000, pp. 9735-9740
Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells
Authors: Chen, FS Yang, DS Petanceska, S Yang, A Tandon, A Yu, G Rozmahel, R Ghiso, J Nishimura, M Zhang, DM Kawara, T Levesque, G Mills, J Levesque, L Song, YQ Rogaeva, E Westaway, D Mount, H Gandy, S St George-Hyslop, P Fraser, PE
Citation: Fs. Chen et al., Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells, J BIOL CHEM, 275(47), 2000, pp. 36794-36802
Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein- Expression in testis and ectopic production in the brains of Prnp(o/o) mice predisposed to Purkinje cell loss
Authors: Silverman, GL Qin, KF Moore, RC Yang, Y Mastrangelo, P Tremblay, P Prusiner, SB Cohen, FE Westaway, D
Citation: Gl. Silverman et al., Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein- Expression in testis and ectopic production in the brains of Prnp(o/o) mice predisposed to Purkinje cell loss, J BIOL CHEM, 275(35), 2000, pp. 26834-26841
Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP - Effect of protein age and deamidation
Authors: Qin, KF Yang, DS Yang, Y Chishti, MA Meng, LJ Kretzschmar, HA Yip, CM Fraser, PE Westaway, D
Citation: Kf. Qin et al., Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP - Effect of protein age and deamidation, J BIOL CHEM, 275(25), 2000, pp. 19121-19131
Examining the zinc binding site of the amyloid-beta peptide
Authors: Yang, DS McLaurin, J Qin, KF Westaway, D Fraser, PE
Citation: Ds. Yang et al., Examining the zinc binding site of the amyloid-beta peptide, EUR J BIOCH, 267(22), 2000, pp. 6692-6698
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex
Authors: Nishimura, M Yu, G Levesque, G Zhang, DM Ruel, L Chen, F Milman, P Holmes, E Liang, Y Kawarai, T Jo, E Supala, A Rogaeva, E Xu, DM Janus, C Levesque, L Bi, Q Duthie, M Rozmahel, R Mattila, K Lannfelt, L Westaway, D Mount, HTJ Woodgett, J Fraser, PE St George-Hyslop, P
Citation: M. Nishimura et al., Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex, NAT MED, 5(2), 1999, pp. 164-169
Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: Evidence for novel species-specific properties of human presenilin-1
Authors: Levesque, L Annaert, W Craessaerts, K Mathews, PM Seeger, M Nixon, RA Van Leuven, F Gandy, S Westaway, D St George-Hyslop, P De Strooper, B Fraser, PE
Citation: L. Levesque et al., Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: Evidence for novel species-specific properties of human presenilin-1, MOL MED, 5(8), 1999, pp. 542-554
Aberrant presenilin-1 expression downregulates LDL receptor-related protein (LRP): Is LRP central to Alzheimer's disease pathogenesis?
Authors: Van Uden, E Carlson, G St George-Hyslop, P Westaway, D Orlando, R Mallory, M Rockenstein, E Masliah, E
Citation: E. Van Uden et al., Aberrant presenilin-1 expression downregulates LDL receptor-related protein (LRP): Is LRP central to Alzheimer's disease pathogenesis?, MOL CELL NE, 14(2), 1999, pp. 129-140
Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein Doppel
Authors: Moore, RC Lee, IY Silverman, GL Harrison, PM Strome, R Heinrich, C Karunaratne, A Pasternak, SH Chishti, MA Liang, Y Mastrangelo, P Wang, K Smit, AFA Katamine, S Carlson, GA Cohen, FE Prusiner, SB Melton, DW Tremblay, P Hood, LE Westaway, D
Citation: Rc. Moore et al., Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein Doppel, J MOL BIOL, 292(4), 1999, pp. 797-817
Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-Golgi compartments of hippocampal neurons
Authors: Annaert, WG Levesque, L Craessaerts, K Dierinck, I Snellings, G Westaway, D George-Hyslop, PS Cordell, B Fraser, P De Strooper, B
Citation: Wg. Annaert et al., Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-Golgi compartments of hippocampal neurons, J CELL BIOL, 147(2), 1999, pp. 277-294
Risultati: 1-22 |