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Results: 1-10 |
Results: 10
Problems associated with in vitro assessment of drug inhibition of CYP3A4 and other P-450 enzymes and its impact on drug discovery
Authors: Wienkers, LC
Citation: Lc. Wienkers, Problems associated with in vitro assessment of drug inhibition of CYP3A4 and other P-450 enzymes and its impact on drug discovery, J PHARM TOX, 45(1), 2001, pp. 79-84
Interaction of delavirdine with human liver microsomal cytochrome P450: Inhibition of CYP2C9, CYP2C19, and CYP2D6
Authors: Voorman, RL Payne, NA Wienkers, LC Hauer, MJ Sanders, PE
Citation: Rl. Voorman et al., Interaction of delavirdine with human liver microsomal cytochrome P450: Inhibition of CYP2C9, CYP2C19, and CYP2D6, DRUG META D, 29(1), 2001, pp. 41-47
Triazolam substrate inhibition: Evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site
Authors: Schrag, ML Wienkers, LC
Citation: Ml. Schrag et Lc. Wienkers, Triazolam substrate inhibition: Evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site, DRUG META D, 29(1), 2001, pp. 70-75
Covalent alteration of the CYP3A4 active site: Evidence for multiple substrate binding domains
Authors: Schrag, ML Wienkers, LC
Citation: Ml. Schrag et Lc. Wienkers, Covalent alteration of the CYP3A4 active site: Evidence for multiple substrate binding domains, ARCH BIOCH, 391(1), 2001, pp. 49-55
Mechanism-based inactivation of cytochrome P4502B1 by 7-ethynylcoumarin verification of apo-P450 adduction by electrospray ion trap mass spectrometry
Authors: Regal, KA Schrag, ML Kent, UM Wienkers, LC Hollenberg, PF
Citation: Ka. Regal et al., Mechanism-based inactivation of cytochrome P4502B1 by 7-ethynylcoumarin verification of apo-P450 adduction by electrospray ion trap mass spectrometry, CHEM RES T, 13(4), 2000, pp. 262-270
Oxidation of the novel oxazolidinone antibiotic linezolid in human liver microsomes
Authors: Wynalda, MA Hauer, MJ Wienkers, LC
Citation: Ma. Wynalda et al., Oxidation of the novel oxazolidinone antibiotic linezolid in human liver microsomes, DRUG META D, 28(9), 2000, pp. 1014-1017
Topological alteration of the CYP3A4 active site by the divalent cation Mg2+
Authors: Schrag, ML Wienkers, LC
Citation: Ml. Schrag et Lc. Wienkers, Topological alteration of the CYP3A4 active site by the divalent cation Mg2+, DRUG META D, 28(10), 2000, pp. 1198-1201
Identification of cytochrome P4503A as the major subfamily responsible forthe metabolism of roquinimex in man
Authors: Tuvesson, H Wienkers, LC Gunnarsson, PO Seidegard, J Persson, R
Citation: H. Tuvesson et al., Identification of cytochrome P4503A as the major subfamily responsible forthe metabolism of roquinimex in man, XENOBIOTICA, 30(9), 2000, pp. 905-914
Hormonal effects on tirilazad clearance in women: Assessment of the role of CYP3A
Authors: Fleishaker, JC Pearson, LK Pearson, PG Wienkers, LC Hopkins, NK Peters, GR
Citation: Jc. Fleishaker et al., Hormonal effects on tirilazad clearance in women: Assessment of the role of CYP3A, J CLIN PHAR, 39(3), 1999, pp. 260-267
Cytochrome P-450-mediated metabolism of the individual enantiomers of the antidepressant agent reboxetine in human liver microsomes
Authors: Wienkers, LC Allievi, C Hauer, MJ Wynalda, MA
Citation: Lc. Wienkers et al., Cytochrome P-450-mediated metabolism of the individual enantiomers of the antidepressant agent reboxetine in human liver microsomes, DRUG META D, 27(11), 1999, pp. 1334-1340
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